GB723708A - Process for the preparation of an inoculation material for use against sleeping sickness - Google Patents
Process for the preparation of an inoculation material for use against sleeping sicknessInfo
- Publication number
- GB723708A GB723708A GB23494/52A GB2349452A GB723708A GB 723708 A GB723708 A GB 723708A GB 23494/52 A GB23494/52 A GB 23494/52A GB 2349452 A GB2349452 A GB 2349452A GB 723708 A GB723708 A GB 723708A
- Authority
- GB
- United Kingdom
- Prior art keywords
- trypanosomes
- rats
- trypanosome
- infected
- sleeping sickness
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/005—Trypanosoma antigens
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
An inoculation material against animal and human trypanosomiasis (sleeping sickness) is prepared in manner known per se using trypanosomes which in their form resemble or are identical with the trypanosomes occurring in infected glossina (tsetse flies) said trypanosomes being killed before or during the preparation of the inoculation material. Such trypanosomes may be obtained from species such as Trypanosoma gambiense, Trypanosoma brucei, Trypanosoma rhodesiense or Trypanosoma equiperdum by (a) immunising rats with the water-insoluble constituents of trypanosomes killed by cold e.g. -80 DEG C. (CO2 and acetone) and suspended in aqueous saline solution, and then, for example after 4 to 10 days, infecting the rats with living trypanosomes; (b) infecting rats with trypanosomes and treating them with chemotherapeutic agents known to be effective against sleeping sickness e.g. germanin (sodium salt of m-aminobenzoyl m-amino-p-methyl benzoyl-1-naphthylamino 4, 6, 8-trisulphonic acid) and tryparsamide preferably with simultaneous injection of glycocoll; (c) selection of the odd spontaneously produced form occuring sometimes when rats are infected with trypanosomes; and (d) infecting rats with trypanosomes which have gone through may recidivations e.g. a rat infected with a trypanosome is treated with a sleeping sickness drug and their serum isolated after 6 days. A mouse infected with the same species of trypanosome is treated with the prepared blood serum. After 6 to 9 days a recidivated form of the trypanosome appears. This form is transferred to a rat and the process is repeated until the tsetse fly trypanosome form occurs spontaneously. An inoculum material is obtained by e.g. taking the blood of rats infected with the desired form of trypanosome, mixing with a citrate solution and centrifuging out the trypanosomes, which are recentrifuged and suspended in physiological saline solution to which 0.5 per cent. formaldehyde has been added. Specification 429,449 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE723708X | 1951-09-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB723708A true GB723708A (en) | 1955-02-09 |
Family
ID=6633197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB23494/52A Expired GB723708A (en) | 1951-09-21 | 1952-09-18 | Process for the preparation of an inoculation material for use against sleeping sickness |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB723708A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4298596A (en) * | 1979-03-29 | 1981-11-03 | Burroughs Wellcome Co. | Trypanosoma cruzi glycoprotein vaccine for inducing immunity to Chagas' disease |
-
1952
- 1952-09-18 GB GB23494/52A patent/GB723708A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4298596A (en) * | 1979-03-29 | 1981-11-03 | Burroughs Wellcome Co. | Trypanosoma cruzi glycoprotein vaccine for inducing immunity to Chagas' disease |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB697351A (en) | Improved process for the manufacture of nerve sedatives | |
| GB723708A (en) | Process for the preparation of an inoculation material for use against sleeping sickness | |
| Becker et al. | Experimental infection of chickens with influenza A/Tern/South Africa/1961 and Chicken/Scotland/1959 viruses: I. Clinical picture and virology | |
| Reinhardt et al. | Cell Count, Rate of Flow, and Protein Content of Cervical Lymph in the Rat. | |
| Sarkar | Action mechanism of cobra venom, cardiotoxin and allied substances on muscle contraction | |
| Jones | The liver as a source of bacterial agglutinin | |
| Yates et al. | The chicken-embryo-lethal-orphan (CELO) virus as a tissue-culture contaminant | |
| DE2165401C3 (en) | Inactivated combination vaccine for immunizing poultry against infections of the respiratory system | |
| SU895427A1 (en) | Method of treating hoof putrefaction of sheeps and goats | |
| Whitmire et al. | Effect of cortisone on experimental murine typhus in mice | |
| Quilligan et al. | The action of terramycin on the growth of strains of influenza, herpes simplex, and rabies viruses in chick embryos and mice | |
| DE424197C (en) | Process for the production of a nutrient medium for influenza bacilli and for the production of vaccines from them | |
| Farkas | Tissue Toxicity of the Germicides Iodine and Bromine. | |
| US2220331A (en) | Remedy for infection by cocci and process of manufacturing it | |
| Modell et al. | Acute Toxicity of Mercurial Diuretics. | |
| Chung | Propagation of Sindbis virus, Murray Valley encephalitis virus and Getah virus | |
| RU2119334C1 (en) | Anthelmintic agent | |
| SU137631A1 (en) | Method for preserving semen of farm animals | |
| Frenkel et al. | Cultivation of foot-and-mouth disease virus in explanted epithelial tissue of the bovine rumen | |
| SU65873A1 (en) | Method for preparing dry complex salt of silver lactates and 3,6-diamino-10-methyacridinium | |
| SU94043A1 (en) | A method for the manufacture of hydroxide aluminum formol-vaccine against aujesky disease of farm animals | |
| SU105849A1 (en) | The method of producing tetraethylthiopirophosphate | |
| DE859513C (en) | Process for the production of a therapeutic colloidal calcium phosphate preparation | |
| Schofield et al. | The isolation and identification of the virus of Newcastle disease in Trinidad | |
| Mathur | Antigenic variation of Trypanosoma (Trypanozoon) evansi in the mosue host, with related studies on culture and on transmission |