GB698863A - Process for the manufacture of compounds made by reacting components of the group consisting of the vitamin b complex and choline with adenylic acid or sodium adenylate - Google Patents
Process for the manufacture of compounds made by reacting components of the group consisting of the vitamin b complex and choline with adenylic acid or sodium adenylateInfo
- Publication number
- GB698863A GB698863A GB6137/48A GB613748A GB698863A GB 698863 A GB698863 A GB 698863A GB 6137/48 A GB6137/48 A GB 6137/48A GB 613748 A GB613748 A GB 613748A GB 698863 A GB698863 A GB 698863A
- Authority
- GB
- United Kingdom
- Prior art keywords
- adenylate
- acid
- vitamin
- adenylic
- choline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compounds are made by reacting adenylic acid or sodium adenylate with one or more components of the Vitamin B complex (including choline), or their acid salts. If free adenylic acid is reacted with an acid salt sodium hydroxide is added subsequently. The reaction takes place in aqueous solution or suspension, preferably with heat, and the product may be obtained solid by evaporation or addition of an organic solvent in which it is insoluble. The inorganic sodium salt may if desired be separated. The reactants are preferably used in stoichiometric proportions. Examples show the preparation of the following: (1) di-nicotinamide adenylate; (2) thiamine adenylate; (3) pyridoxin adenylate; (3) mono and diadenylates of riboflavin; (4) choline adenylate. The process is applicable to both yeast and muscle adenylic acids. The Specification as open to inspection under Sect. 91 refers to the use of other adenylates, viz. those of potassium, lithium, magnesium, zinc, manganese, iron, copper, cobalt and calcium. It also includes the subject-matter of Specification 698,864, and also describes products similar to those of that Specification but obtained from members of the Vitamin B series and amino-acids without adenylic acid. This subject-matter does not appear in the Specification as accepted.ALSO:Medicinal preparations comprise adenylic acid or sodium adenylate with one or more components of the vitamin B complex (including choline) or their acid salts. The materials may be mixed as a powder to be taken with water, or as tablets or capsules. Alternatively they may be reacted together to give a product which is probably a salt. When free adenylic acid is used with an acid salt, sodium hydroxide is added so that the pH may be suitable for injection. The inorganic sodium salt may be removed if desired. The reactants are preferably used in stoichiometrical proportions. Suitable products are thiamine adenylate, di-nicotin-amide adenylate, pyridoxin adenylate, riboflavin mono- and di-adenylate and choline adenylate. The process is applicable to both yeast and muscle adenylic acids. The Specification as open to inspection under Sect. 91 refers to the use of other adenylates, viz., those of potassium, lithium, manganese, zinc, magnesium, iron, copper, cobalt and calcium. It also includes the subject-matter of Specification 698,864, and also describes products similar to those of that Specification but containing members of the vitamin B series and amino-acids without adenylic acid. This subject-matter does not appear in the Specification as accepted.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US698863XA | 1944-06-21 | 1944-06-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB698863A true GB698863A (en) | 1953-10-28 |
Family
ID=22091814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB6137/48A Expired GB698863A (en) | 1944-06-21 | 1948-02-27 | Process for the manufacture of compounds made by reacting components of the group consisting of the vitamin b complex and choline with adenylic acid or sodium adenylate |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB698863A (en) |
-
1948
- 1948-02-27 GB GB6137/48A patent/GB698863A/en not_active Expired
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