GB679087A - Culturing antibiotic-producing actinomycetes in liquid media containing fats or the fatty acids therefrom - Google Patents

Culturing antibiotic-producing actinomycetes in liquid media containing fats or the fatty acids therefrom

Info

Publication number
GB679087A
GB679087A GB4157/51A GB415751A GB679087A GB 679087 A GB679087 A GB 679087A GB 4157/51 A GB4157/51 A GB 4157/51A GB 415751 A GB415751 A GB 415751A GB 679087 A GB679087 A GB 679087A
Authority
GB
United Kingdom
Prior art keywords
oil
streptomyces
culturing
fatty acids
actinomycetes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4157/51A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of GB679087A publication Critical patent/GB679087A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P29/00—Preparation of compounds containing a naphthacene ring system, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/42—Cobalamins, i.e. vitamin B12, LLD factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
    • C12P19/48—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin
    • C12P19/50—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin having two saccharide radicals bound through only oxygen to adjacent ring carbon atoms of the cyclohexyl radical, e.g. ambutyrosin, ribostamycin
    • C12P19/52—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin having two saccharide radicals bound through only oxygen to adjacent ring carbon atoms of the cyclohexyl radical, e.g. ambutyrosin, ribostamycin containing three or more saccharide radicals, e.g. neomycin, lividomycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
    • C12P19/54—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being bound directly to a nitrogen atom of two or more radicals, e.g. streptomycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A method of culturing antibiotic producing actinomycetes comprises culturing the actinomycetes in contact with a liquid nutrient medium including as an assimilable source of carbon and energy a substance which is a member of the group consisting of (1) fats and (2) fatty acids having at least 14 carbon atoms in the molecule, the amount of any other assimilable source of carbon and energy in the medium being substantially less than the total caloric requirement of the culture. Thus the carbohydrate content of the culture medium is replaced wholly or in part by such a fat or fatty acid, or mixture of two or more such substances, on a weight basis, or preferably on a caloric basis. The liquids are preferred; the solids are melted before mixing in the culture medium, or may be dispersed therein during the sterilization step. Specified fats are lard oil, soybean oil, linseed oil, cottonseed oil, peanut oil, coconut oil, corn oil, castor oil, sesame oil, palm oil, tallow, sperm oil, olive oil, tristearin, tripalmitin, triolein and trilaurin. Suitable fatty acids are stearic, palmitic, oleic, linoleic and myristic acids. Comminuted whole seeds, e.g. ground, crushed or macerated with water, may be used especially beans, peanuts, cottonseed and linseed. Examples relate to the culturing of (a) streptomyces griscus (streptomycin), streptomyces fradiae (neomycia) and streptomyces aureofaciens (aureomycin). Other microorganisms specified are streptomyces lavendulae (streptothricin) and streptomyces venezuelae (chloromycetin).
GB4157/51A 1950-02-25 1951-02-20 Culturing antibiotic-producing actinomycetes in liquid media containing fats or the fatty acids therefrom Expired GB679087A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US679087XA 1950-02-25 1950-02-25

Publications (1)

Publication Number Publication Date
GB679087A true GB679087A (en) 1952-09-10

Family

ID=22079198

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4157/51A Expired GB679087A (en) 1950-02-25 1951-02-20 Culturing antibiotic-producing actinomycetes in liquid media containing fats or the fatty acids therefrom

Country Status (1)

Country Link
GB (1) GB679087A (en)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2793165A (en) * 1953-09-23 1957-05-21 American Cyanamid Co Employment of peroxide formation inhibitor in nutrient media containing triglyceride oil
US2833696A (en) * 1954-03-01 1958-05-06 Abbott Lab Culture process for erythromycin a
US2888385A (en) * 1952-11-28 1959-05-26 Grandel Felix Process of making a preparation containing lipases and oxidases
US2890989A (en) * 1957-07-01 1959-06-16 Ralph F Anderson Method for the production of carotenes
US2911339A (en) * 1957-11-27 1959-11-03 American Cyanamid Co Streptomyces aureofaciens fermentation process
US2927057A (en) * 1955-07-15 1960-03-01 Wisconsin Alumni Res Found Oligomycin and process of preparing the same
US2959521A (en) * 1959-01-12 1960-11-08 Grain Processing Corp Process for preparing beta-carotene
US2959522A (en) * 1959-01-12 1960-11-08 Grain Processing Corp Process for preparing beta-carotene
US3516909A (en) * 1967-08-08 1970-06-23 American Cyanamid Co Fermentative biosynthesis of tetracycline antibiotics
US4564594A (en) * 1983-06-30 1986-01-14 E. I. Du Pont De Nemours And Company Fermentation process for production of carboxylic acids
US4877731A (en) * 1988-06-27 1989-10-31 E. I. Du Pont De Nemours And Company Fermentation process for carboxylic acids
US5047338A (en) * 1986-05-29 1991-09-10 International Minerals & Chemical Corp. Polyester Antibiotic preparation
US5049495A (en) * 1986-05-29 1991-09-17 International Minerals & Chemical Corp. Fermentation method for producing polyether antibiotics
US5198358A (en) * 1991-08-28 1993-03-30 Merck & Co., Inc. Microorganism for producing C-31 desmethyl FR-900520 cyclic hemiketal immunosuppressant agent

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2888385A (en) * 1952-11-28 1959-05-26 Grandel Felix Process of making a preparation containing lipases and oxidases
US2793165A (en) * 1953-09-23 1957-05-21 American Cyanamid Co Employment of peroxide formation inhibitor in nutrient media containing triglyceride oil
US2833696A (en) * 1954-03-01 1958-05-06 Abbott Lab Culture process for erythromycin a
US2927057A (en) * 1955-07-15 1960-03-01 Wisconsin Alumni Res Found Oligomycin and process of preparing the same
US2890989A (en) * 1957-07-01 1959-06-16 Ralph F Anderson Method for the production of carotenes
US2911339A (en) * 1957-11-27 1959-11-03 American Cyanamid Co Streptomyces aureofaciens fermentation process
US2959521A (en) * 1959-01-12 1960-11-08 Grain Processing Corp Process for preparing beta-carotene
US2959522A (en) * 1959-01-12 1960-11-08 Grain Processing Corp Process for preparing beta-carotene
US3516909A (en) * 1967-08-08 1970-06-23 American Cyanamid Co Fermentative biosynthesis of tetracycline antibiotics
US4564594A (en) * 1983-06-30 1986-01-14 E. I. Du Pont De Nemours And Company Fermentation process for production of carboxylic acids
US5047338A (en) * 1986-05-29 1991-09-10 International Minerals & Chemical Corp. Polyester Antibiotic preparation
US5049495A (en) * 1986-05-29 1991-09-17 International Minerals & Chemical Corp. Fermentation method for producing polyether antibiotics
US4877731A (en) * 1988-06-27 1989-10-31 E. I. Du Pont De Nemours And Company Fermentation process for carboxylic acids
US5198358A (en) * 1991-08-28 1993-03-30 Merck & Co., Inc. Microorganism for producing C-31 desmethyl FR-900520 cyclic hemiketal immunosuppressant agent

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