Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1559147A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Products Ltd
Original Assignee
Roche Products Ltd
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Publication date
Application filed by Roche Products LtdfiledCriticalRoche Products Ltd
Priority to GB1559147ApriorityCriticalpatent/GB628305A/en
Publication of GB628305ApublicationCriticalpatent/GB628305A/en
C07D475/00—Heterocyclic compounds containing pteridine ring systems
C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Abstract
Folic acid is prepared by hydrogenating 2 - amino - 6 - hydroxy - 8 - pteridylaldehyde in an inert solvent or formic acid in the presence of p-aminobenzoyl-1-(+)-glutamic acid and a hydrogenation catalyst. When formic acid is used as the solvent, any formyl folic acid formed during the reaction is converted to folic acid by treatment with ammonia. In examples, 2 - amino - 6 - hydroxy - 8 - pteridylaldehyde is hydrogenated in accordance with the above process in formic acid solution in the presence of palladium charcoal. The numbering of the pteridine ring is as follows: <FORM:0628305/IV (b)/1>
GB1559147A1947-06-131947-06-13Process for the manufacture of folic acid
ExpiredGB628305A
(en)
Procedure for the preparation of pipericine derivatives, replaced in positions 1 and 4 by aral-cohylic groups of different nature (Machine-translation by Google Translate, not legally binding)
16ª--bromo-í~-pregnene-diol-(3ª-:17ª-)-one-(20)-formate-(3ª-) and a process for the manufacture of a í~-pregnene-diol-(3ª-,17ª-)-one-(20)-formate-(3ª-)
A procedure for the obtaining of 4-aminoalquilaminosalicºlicos ácidos and 4-monoalquilooxialquilaminosalicºlicos acids (Machine-translation by Google Translate, not legally binding)