GB625602A - New calciferol esters and their process of preparation - Google Patents

New calciferol esters and their process of preparation

Info

Publication number
GB625602A
GB625602A GB11999/47A GB1199947A GB625602A GB 625602 A GB625602 A GB 625602A GB 11999/47 A GB11999/47 A GB 11999/47A GB 1199947 A GB1199947 A GB 1199947A GB 625602 A GB625602 A GB 625602A
Authority
GB
United Kingdom
Prior art keywords
calciferol
pyridine
esters
acid chloride
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB11999/47A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Usines Chimiques des Laboratoires Francais
Original Assignee
Roussel Uclaf SA
Usines Chimiques des Laboratoires Francais
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA, Usines Chimiques des Laboratoires Francais filed Critical Roussel Uclaf SA
Publication of GB625602A publication Critical patent/GB625602A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Calciferol esters, e.g. calciferol benzoate, acetate propionate, oleate and chaulmoograte are obtained by converting pure Vitamin D2 into the ester by means of an acid chloride in the presence of pyridine and benzene or another solvent for Vitamin D2 and the ester thereof, which does not react with the other reagents present and which is such that pyridine and the acid chloride do not cause splitting of the solution into distinct phases. Excess of acid chloride and pyridine is removed with sodium bicarbonate and hydrochloric acid and the products are purified by crystallisation in acetone or an acetone-methanol mixture. Detailed examples are given.
GB11999/47A 1946-05-23 1947-05-03 New calciferol esters and their process of preparation Expired GB625602A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR625602X 1946-05-23

Publications (1)

Publication Number Publication Date
GB625602A true GB625602A (en) 1949-06-30

Family

ID=8987820

Family Applications (1)

Application Number Title Priority Date Filing Date
GB11999/47A Expired GB625602A (en) 1946-05-23 1947-05-03 New calciferol esters and their process of preparation

Country Status (1)

Country Link
GB (1) GB625602A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0603726A2 (en) * 1992-12-21 1994-06-29 Bristol-Myers Squibb Company Nutritional compositions containing vitamin d esters

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0603726A2 (en) * 1992-12-21 1994-06-29 Bristol-Myers Squibb Company Nutritional compositions containing vitamin d esters
EP0603726B1 (en) * 1992-12-21 2002-04-17 Bristol-Myers Squibb Company Nutritional compositions containing vitamin d esters

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