GB514103A - Improvements in and relating to the preparation of hippuric acid derivatives - Google Patents
Improvements in and relating to the preparation of hippuric acid derivativesInfo
- Publication number
- GB514103A GB514103A GB616738A GB616738A GB514103A GB 514103 A GB514103 A GB 514103A GB 616738 A GB616738 A GB 616738A GB 616738 A GB616738 A GB 616738A GB 514103 A GB514103 A GB 514103A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hippuric acid
- diiodo
- hydroxy
- caustic soda
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
514,103. Hippuric acid derivatives. GLAXO LABORATORIES, Ltd., BLOUNT, B. K., and RESUGGAN, J. C. L. Feb. 26, 1938, No. 6167. Sample furnished. [Class 2 (iii)] 4-Hydroxy-3:5-diiodo-hippuric acid is prepared by condensing an acyl derivative of p-hydroxy benzoic acid halide with glycine, removing the acyl group and iodinating the resulting phydroxy-hippuric acid with or without previous isolation of the reaction product. Iodinating agents specified are iodine, iodine and caustic soda, iodine chloride or a mixture of sodium iodate and sodium iodide. The condensation is preferably carried out in the presence of a basic substance. The product may be treated with suitable acylating, alkylating, or substituted alkylating agents and are useful in pyelography. In the examples : (1) p-acetoxy benzoic acid chloride is condensed with glycine in the presence of caustic soda and the resulting p-hydroxy-hippuric acid was crystallized and then treated with iodine in caustic soda solution yielding 4-hydroxy-3:5-diiodo-hippuric acid; (2) 3:5-diiodo-4-hydroxy-hippuric acid is treated with acetic anhydride in caustic soda solution yielding 4-acetoxy-3:5-diiodo-hippuric acid ; (3) 3:5-diiodo-4-hydroxy-hippuric acid is treated with dimethyl sulphate in caustic soda solution yielding 3:5-diiodo-4-methoxy-hippuric acid. A sample furnished under Sect. 2 (5) comprises 4-carboxymethoxy-3:5-diiodo-hippuric acid prepared by treating 4-hydroxy-3:5-diiodo-hippuric acid (prepared as in example (1) with chloracetic acid in the presence of caustic soda.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB616738A GB514103A (en) | 1938-02-26 | 1938-02-26 | Improvements in and relating to the preparation of hippuric acid derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB616738A GB514103A (en) | 1938-02-26 | 1938-02-26 | Improvements in and relating to the preparation of hippuric acid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB514103A true GB514103A (en) | 1939-10-31 |
Family
ID=9809628
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB616738A Expired GB514103A (en) | 1938-02-26 | 1938-02-26 | Improvements in and relating to the preparation of hippuric acid derivatives |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB514103A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2680133A (en) * | 1951-08-24 | 1954-06-01 | Mallinckrodt Chemical Works | Iodine-containing amino-benzoyl derivatives of amino acids |
US2813118A (en) * | 1953-07-16 | 1957-11-12 | American Cystoscope Makers Inc | X-ray contrast compounds |
-
1938
- 1938-02-26 GB GB616738A patent/GB514103A/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2680133A (en) * | 1951-08-24 | 1954-06-01 | Mallinckrodt Chemical Works | Iodine-containing amino-benzoyl derivatives of amino acids |
US2813118A (en) * | 1953-07-16 | 1957-11-12 | American Cystoscope Makers Inc | X-ray contrast compounds |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Pokorny | New compounds. Some chlorophenoxyacetic acids | |
GB514103A (en) | Improvements in and relating to the preparation of hippuric acid derivatives | |
LaForge et al. | A new constituent isolated from southern prickly-ash bark | |
Woodward | 2, 4-Dibromo-α-oestradiol | |
Dyson et al. | LXV.—The inhibitory effect of substituents in chemical reactions. Part I. The reactivity of the amino-group in substituted arylamines | |
US2599497A (en) | Basic stilbene derivatives | |
Butler et al. | Cinchona alkaloids in pneumonia. I. miscellaneous alkaloids and some hydrocupreine ethers | |
Hodgson et al. | 260. The replacement of the diazonium by the nitro-group. Part III. Decompositions by cupro-cupri sulphite | |
Wolf | The determination of lactic acid | |
US2316825A (en) | p-nitrobenzene sulphinamide | |
US3218340A (en) | Steroid nitrite ester and process therefor | |
Brady et al. | XXXI.—The methylation of the oximes of benzil. Part II. The monomethyl ethers of the benzildioximes | |
SU23411A1 (en) | Method for producing mercury-substituted in the core of dimethoxybenzoic acid derivative | |
AT269380B (en) | Process for the preparation of new 7α-methylestratriene derivatives | |
Kleene | New Compounds. α-Naphthylcyclohexanol-1 | |
Lauer et al. | Ethers of p-Hydroxybenzoic Acid as Derivatives for the Identification of Alkyl Halides | |
Schmidt et al. | Studies in the Biphenyl Series. IV. The Iodination of the Acetate, Benzoate and Benzenesulfonate of 4-Hydroxybiphenyl1 | |
Kremers et al. | Observations on the Rare Earths. LII. The Preparation of Rare Earth Bromates from the Perchlorates | |
SU124433A3 (en) | The method of synthesis of steroid bases and their salts of General formula A | |
GB430282A (en) | The manufacture of new alkylated 5:5-phenylethyl-hydantoins | |
SU105849A1 (en) | The method of producing tetraethylthiopirophosphate | |
CH236169A (en) | Process for the preparation of a new ester. | |
Plant et al. | 220. C-acetylation of α′ β′-naphthindole (4: 5-benzindole) derivatives | |
Kitasato et al. | 102. Preliminary synthetic experiments in the morphine group. Part III. Some derivatives of papaveroline and laudanosoline | |
Idler et al. | The Isolation of n-Octanyl Alcohol from a Marine Tube Worm |