GB497659A - Manufacture of 2-alkyl-tetrahydrobenzselenazoles - Google Patents
Manufacture of 2-alkyl-tetrahydrobenzselenazolesInfo
- Publication number
- GB497659A GB497659A GB17351/37A GB1735137A GB497659A GB 497659 A GB497659 A GB 497659A GB 17351/37 A GB17351/37 A GB 17351/37A GB 1735137 A GB1735137 A GB 1735137A GB 497659 A GB497659 A GB 497659A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cyclohexanone
- alkyl
- thio
- seleno
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
Abstract
2-Alkyl-tetrahydrobenzthiazoles and 2-alkyl-tetrahydrobenzselenazoles are prepared by causing an ortho-halogen-cyclohexanone to react with a thio-fatty acid amide or a seleno-fatty acid amide or a substituted thio- or seleno-fatty acid amide. The compounds have the general formula <FORM:0497659/IV/1> where Y=sulphur or selenium, and R=an alkyl or a substituted alkyl group. The reaction is preferably conducted at a raised temperature. In examples: (1) o-chloro-cyclohexanone and thio-acetamide are heated together, and the reaction product treated with caustic soda, and the oil so liberated extracted with ether. The residue on evaporation of the ether is distilled under reduced pressure to give 2-methyl-tetra-hydro - benzothiazole; (2) o - chloro - cyclohexanone, alcohol and seleno-acetamide are heated together, the reaction product is taken up in water and filtered from the precipitated selenium. Caustic soda is added to the filtrate to precipitate the 2-methyl-tetrahydro-benzselenazole; (3) o-chloro-cyclohexanone and thio-propionamide are heated together and the product treated with caustic soda to give 2-ethyl-tetrahydrobenzothiazole.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE497659X | 1936-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB497659A true GB497659A (en) | 1938-12-22 |
Family
ID=6545208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB17351/37A Expired GB497659A (en) | 1936-07-29 | 1937-06-22 | Manufacture of 2-alkyl-tetrahydrobenzselenazoles |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB497659A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4208420A (en) * | 1977-10-24 | 1980-06-17 | Laboratoires Jacques Logeais | New benzo [d] thiazole derivatives, process for their preparation and their therapeutic applications |
-
1937
- 1937-06-22 GB GB17351/37A patent/GB497659A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4208420A (en) * | 1977-10-24 | 1980-06-17 | Laboratoires Jacques Logeais | New benzo [d] thiazole derivatives, process for their preparation and their therapeutic applications |
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