GB2592122A - Polyphosphazene as an antiperspirant active ingredient - Google Patents

Abstract

An antiperspirant composition is disclosed comprising a polyphosphazene salt as defined therein as the antiperspirant active agent. Furthermore, a cosmetic method is disclosed for reducing body perspiration and/or reducing body odour caused by perspiration, in which said antiperspirant cosmetic composition is applied to the human skin and left at the site of application for at least one hour. Also disclosed is the use of said polyphosphazene salt to reduce body perspiration and/or reducing body odour caused by perspiration. The polyphosphazene salt replaces aluminium salts which can attack textiles in clothing.

Description

POLYPHOSPHAZENE AS AN ANTIPERSPIRANT ACTIVE INGREDIENT

TECHNICAL FIELD

[0001] The present invention relates to a method for reducing body perspiration and/or reducing body odour caused by perspiration, in which an antiperspirant cosmetic composition comprising polyphosphazene is applied to the human skin and left at the site of application for at least one hour.

BACKGROUND

[0002] Besides skin care, the care of your own body includes the care of your hair and nails as well as dental and oral care. The aim of personal hygiene is primarily to avoid diseases and body odours that are perceived as unpleasant. This is achieved in particular through the use of cosmetics and care products which can influence the natural formation of sweat or the associated body odour. In particular, fragrances are used to mask odours and antimicrobial substances to control the formation of degradation products in sweat, which are primarily responsible for the unpleasant smell of sweat. In addition, the secretion of the so-called eccrine sweat glands leads, among other things, to underarm wetness and unpleasant wet spots on clothing. Eccrine perspiration per se can essentially be reduced by the use of antiperspirants containing aluminium salts, whereby the reduction of perspiration is achieved by a temporary blockage or constriction of the excretory ducts of the sweat glands.

[0003] Aluminium salts or mixtures of zirconium and aluminium salts are generally used as antiperspirants. The halides and hydroxyhalides of these compounds have proved to be particularly effective, with which a reduction in the amount of perspiration by from about 20 to about 60% has been observed. However, these compounds have the disadvantage that they can cause unpleasant skin irritation for users and also lead to textile soiling.

[0004] Some formulations that do not contain aluminium compounds are known.

[0005] DE 10 2017 215 322 describes an antiperspirant comprising at least one branched homo-polyethyleneimine, wherein the homo-polyethyleneimine has a proportion of amino groups with three non-hydrogen atom residues of 20 to 35 mol%, based on the molar amount of all amino groups in the homo-polyethyleneimine. The antiperspirant aims to achieve an improved antiperspirant effect and less staining of textiles.

[0006] DE 10 2013 225 620 discloses an antiperspirant without aluminium-containing compounds containing at least one substance selected from the group consisting of cosmetic oils that are liquid at 20°C and 1013 hPa, perfumes and waxes and lysozyme, the addition of the lysozyme resulting in the closure of the sweat glands.

[0007] Despite previous approaches to provide antiperspirants without aluminium-containing compounds, there is still a need for effective, skin-friendly and compatible agents that lead to an effective reduction of perspiration without attacking textiles, such as T-shirts.

DETAILED DESCRIPTION

[0008] The following detailed description is merely exemplary in nature and is not intended to limit the disclosure or the application and uses of the subject matter as described herein. Furthermore, there is no intention to be bound by any theory presented in the preceding background or the following detailed description [0009] The above object(s) is achieved, in a first aspect of the invention, by an antiperspirant cosmetic composition for reducing body perspiration and/or for reducing body odour caused by perspiration, which comprises at least one polyphosphazene of the general formula (I) (I) wherein, at least one of R1 and I:12 independently form a salt with a suitable anion.

[0010] Preferably, the antiperspirant cosmetic composition comprises: i) one or more polyphosphazene of the general formula (I) R1 R2 (I) and ii) at least one anion, where at least le or R2 are selected such that they form a salt with the anion.

[0011] Without being bound to a specific theory, it is assumed that the compound from the group of polyphosphazenes leads to a temporary constriction of the sweat glands, similar to aluminium-containing compounds, so that the formation of underarm wetness is effectively reduced. However, unlike aluminium-containing compounds, no skin irritation or staining of textiles was observed when using the agent according to the invention.

[0012] As used herein, the term "antiperspirant" means the decrease or reduction of perspiration of the eccrine sweat glands of the human body.

[0013] The antiperspirant cosmetic composition comprises at least one polyphosphazene according to the above formula (I), wherein at least one of the radicals Itl and R2 independently form salts with suitable anions. Only R1 can form a salt with the anion or only R2 can form a salt with the anion. Preferably, both RI and R2 form a salt with the anion. Preferably, the polyphosphazenes according to the invention, or their salts, are water-soluble.

[0014] The anion can be derived from both organic and inorganic compounds. Preferably, the anion is selected from the group consisting of chloride, phosphate, polyphosphates, sulphate, sulphonate, phosphonate, citrate, formate, acetate, fumarate, glutarate, lactate, malate, gluconate, malonate, pyruvate, tartrate or salts of amino acids, and hydro forms and mixtures thereof In a particularly preferred form, the anion is selected from the group consisting of chloride, phosphate and sulphate. Particularly preferably, at least about 50%, preferably at least about 95% and most preferably from about 99 to about 100% by weight of the anions contained in the antiperspirant cosmetic composition are chloride ions.

[0015] Preferably, the cosmetic composition thus comprises both the at least one polyphosphazene according to formula (I) and at least one anion, wherein the anion is particularly preferably a chloride ion. Accordingly, R1 and R2 each independently form preferably ionic chlorides.

[0016] It and R2 in the general formula (I) can thus be the same, but it is also possible according to the invention that RI and R2 are different from each other. Preferably 11.2 and R2 are the same.

[0017] In a preferred embodiment, R' and R2 are independently selected from -H, alkyl, alkyloxy, aryloxy, amino, alkylamino, aryl amino, alkanol, polyol, carboxyl, carbonyl structures, amino acid derivatives, BO-, PO-and/or EO/P0-and their adducts with other molecules, betaine, -(CI-2)1-X-R3 where m is 0 to 10, X is selected from N or S or 0 or P, and each R3 is independently -H, -alkyl, -alkenyl, -aryl, alkyloxy, aryloxy, amino, alkylamino, aryl amino, alkanol, polyol, carboxyl, carbonyl structures, -betaine, amino acid derivatives, E0-, PO-and/or EO/P0-and their adducts with other molecules (with EO: Ethylene oxide, PO: Propylene oxide). Preferably, the side groups R', le are thus able to form ionic salts with the anion. Suitable are, for example, cationically charged amino groups or alkylamino groups. Instead of an amino group in which X = N, it is also possible that a sulphur, oxygen or phosphorus is present instead of nitrogen. For example, R1 and/or 122 may also represent ethoxylates or amino acid esters.

[0018] X may be directly bound to the phosphorus of the polyphosphazene backbone However, it is also possible that an alkyl chain -(CH2).-is present. If no alkyl group is present and thus Xis directly bound to the phosphorus, m = 0. If an alkyl chain is present, m = Ito 10, preferably Ito 5 or Ito 3.

[0019] At least one radical Rl can be attached to the X in the side chains R.' or R.2. Rl can be a residue depending on X. Likewise, 2 or more radicals are to be understood here, which are necessary to saturate the selected X. For example, if X is N, there would be two R3 residues present, whereas if X is 0, only one le residue is present. If two or more radicals le are present, they are independently selected from -H, -alkyl, -alkenyl, -aryl, alkyloxy, aryloxy, amino, alkylamino, aryl amino, alkanol, polyol, carboxyl, carbonyl structures, amino acid derivatives, EO-, PO-and/or EO/P0-as well as their adducts with other molecules, or -betaine.

[0020] If R1 is an alkyl radical, this is preferably selected from -(CpH2p+i), where p is preferably from about 1 to about 18, in particular from about 2 to about 6, preferably about 3, about 4 or about S. Longer alkyl chains lead to poorer solubility and thus poorer applicability in a cosmetic product.

[0021] If R3 is an aryl group, it is preferably selected from -phenyl, -naphthyl, -anthryl or -phenanthryl.

[0022] If 122 is an alkenyl group, it applies similarly to the alkyl group that the C-chain length is preferably limited to 18 carbon atoms, since here too the solubility of the polyphosphate is adversely affected for the desired use if the chains are too long. The alkenyls can have one or more double bonds. Preferably, they have one, two or three double bonds.

[0023] According to the invention, the polyphosphazene may be present in a linear structure, as also shown in the general formula (I). In addition, ring-shaped and star-shaped structures, such as those exhibited by dendrimers, are also conceivable. However, it is also possible that the polyphosphazenes are present in a cyclic network structure (cyclolinear or cyclomatrix). Such a network structure is preferred in the present case, as it enables particularly good effectiveness. In the following, a cyclolinear and a network-like representation of the polyphosphazenes are schematically shown, which represent variants of the preferred network structure.

R2 R1 R2,R3

N N

pp2 I z N \ p-R2 R1 " N" cyclolinear R1 R1 W R1 W R1 cyclomatrix

_

N ' N N,P.'N Ri 11 1

WRI

R2 R2 R2 R2 \ / \ / N N N 'N illll" ' R. -.1D R2 P.., :.14-R1

N I

R'.+ R N ezi [0024] In the cyclomatrix, IC and/or R2 are chosen to be suitable for cross-linking the polyphosphazene rings together. Rl are terminal residues here, while R2 represent cross-linking residues. The selection from Rl and R2 corresponds to the general preferred structure, with 113 modified accordingly so that it binds not only to X but also at the opposite end to P of the polyphosphazene structure. If, for example, IC is -CH2-CH3, R3 in the cyclomatrix structure would be -CH2-CH2-.

10025] The polyphosphazenes according to the invention usually have several residues R' and R2. These can be the same or different throughout the molecule. Preferably, all R1 are the same and all R2 are the same, where R1 and R2 may be the same or different from one another.

10026] Preferably, the molecular weight of the polyphosphazene compound according to the invention is from about 75 to about 300000 daltons, more preferably from about 250 to about 50000 daltons, in particular from about 300 to about 10000 daltons, more preferably from about 400 to about 8000 daltons.

[0027] The cosmetic composition according to the invention is characterised in particular by its good skin compatibility, which is achieved, inter alia, by the fact that the composition has a pH value which is below the natural pH value of the skin, so that irritations caused by an excessively alkaline environment of the skin can be avoided. Therefore, in a preferred embodiment, the cosmetic composition according to the invention has a pH of from about 2 to about 8.5, preferably from about 2.2 to about 7.5, particularly preferably from about 2.5 to about 4.5, determined at 22 °C. The pH of the cosmetic composition according to the invention can be adjusted, for example, with inorganic or organic acids, whereby the use of hydrochloric acid, in particular, has provided good results. Therefore, in a preferred embodiment, the pH value of the cosmetic composition according to the invention is adjusted to a value of from about 2 to about 7.5, preferably from about 2.5 to about 4.5, by means of hydrochloric acid.

[0028] Preferably, the cosmetic composition contains the at least one polyphosphazene in a proportion of from about 1 to about 40%, preferably from about 1.5 to about 15%, particularly preferably from about 2 to about 10%. The composition may comprise a polyphosphazene or mixtures of different polyphosphazenes. Preferably, the composition contains one polyphosphazene If the composition contains several different polyphosphazenes, the amounts given relate to the total amount of polyphosphazene based on the total weight of the composition.

[0029] According to the invention, the antiperspirant cosmetic composition contains an aqueous cosmetic carrier. The aqueous carrier may be in the form of a mixture of water with other solvents, the other solvents being, in particular, alcohols or compounds containing several hydroxyl groups. The antiperspirant cosmetic composition contains free water preferably in an amount of from about 0.1 to about 99 C'o by weight, based on the total weight of the antiperspirant cosmetic product. Further preferably, the antiperspirant cosmetic composition contains free water in a total amount of from about Ito about 96% by weight, preferably from about 15 to about 88% by weight, more preferably from about 30 to about 75% by weight, based on the total weight of the antiperspirant cosmetic composition. The aqueous cosmetic carrier may also contain ethanol in embodiments of the invention. For example, the cosmetic composition of the present invention may contain from about 0.1 to about 98 wt% or from about 0.5 to about 75 or from about Ito about 50 wt% of an alcohol, based on the total weight of the antiperspirant cosmetic composition. The alcohol is preferably a C i-C4-alcohol and/or a C2-C6 alcohol with at least one hydroxy group. Preferred examples of such alcohols are ethanol, ethylene glycol, isopropanol, 1,2-propylene glycol, 1,3-propylene glycol, glycerol, n-butanol, 1,3-butylene glycol 1,4-butanediol, 1,2-butanediol and mixtures thereof In particular, the alcohol is ethanol.

[0030] Preferably, the carrier contains polar esters of lactic acid, citric acid or carbonic acid with Ci-C4 alcohols and their anhydrides. Particularly preferred esters are triethyl citrates or propylene carbonates. The ester is preferably present in a total amount of from 0 to about 15% by weight, preferably from about 1 to about 10% by weight, particularly preferably from about 2 to about 6% by weight, each based on the total weight of the cosmetic composition.

[0031] Depending on the desired application and form of application, the cosmetic composition may comprise further components, in particular auxiliary substances. These are preferably those selected from the group of carrier material, solvent, perfume oil, emulsifier, solubiliser, cosmetic oils, consistency enhancer/thickener, propellant gas, pH-adjusting agent, surfactant, chelating agents, skin-cooling active ingredients, skin-caring active ingredients, waxes, preservatives, plant extracts, absorbers and mixtures of these excipients. Suitable means are known to the specialist.

[0032] The cosmetic composition preferably further comprises at least one emulsifier, wherein the composition may be in the form of a suspension, a clear solution, an oil-in-water emulsion or a water-in-oil emulsion. In this form, the application of the cosmetic composition has proven to be particularly user-friendly, for example by spraying or as a roll-on.

[0033] According to the invention, both anionic, cationic and non-ionic emulsifiers are suitable, whereby non-ionic emulsifiers are particularly preferred. In a preferred form, the cosmetic composition therefore contains at least one non-ionic emulsifier. The emulsifier is preferably contained in the cosmetic composition in an amount of from about 0.05 to about 15% by weight, preferably from about 0.2 to about 10% by weight, more preferably from about 1.0 to about 4% by weight and in particular from about 1.5 to about 3% by weight, in each case based on the total weight of the cosmetic composition. Experts know of suitable emulsifiers for use in antiperspirants. In the context of the present invention, non-ionic emulsifiers with an HLB value of from about 7 to about 20 have proved particularly suitable when the composition according to the invention is an oil-in-water emulsion. Therefore, a version is preferred in which the cosmetic composition contains a non-ionic emulsifier with an HLB value of from about 7 to about 20. A preferred emulsifier for use in the cosmetic composition is a polyethylene glycol derivative, especially polyethylene glycol derivatives of hydrogenated castor oil. If the cosmetic composition is in the form of a water-in-oil emulsion, the HLB value of the non-ionic emulsifier is preferably from about 1 to about 7. Therefore, a version is preferred in which the cosmetic composition contains a non-ionic emulsifier with an HLB value of from about 1 to about 7. Mixtures of emulsifiers having an HLB value of from about 1 to about 7 with those having an H LB value of from about 7 to about 20 are also included according to the invention.

[0034] According to the invention, it may be necessary to use so-called solubilizers. With the help of these very polar emulsifiers/surfactants with a high HLB value, clear solutions of cosmetic oils and/or perfume oils in water or water-alcohol or water-glycol or water-alcoholglycol mixtures can be produced, for example. The use of alkyl polyglucosides or polyglycerol esters as solubiliser is particularly preferred.

[0035] In a preferred form, the cosmetic composition is in the form of a sprayable water-in- oil emulsion, which can be sprayed by means of a propellant. In this case, the propellant is preferably present in an amount of from about Ito about 98% by weight, preferably from about 20 to about 90% by weight, preferably from about 30 to about 85% by weight, in particular from about 40 to about 75% by weight, based on the total weight of the cosmetic composition. The total weight of the cosmetic composition is the sum of the weight of all components of the cosmetic composition including the propellant. Preferred propellants (propellant gases) are propane, propene, n-butane, iso-butane, iso-butene, n-pentane, pentene, i so-pentane, i so-pentene, methane, ethane, dimethyl ether, nitrogen, air, oxygen, nitrous oxide, 1,1,1,3-tetrafluoroethane, heptatluoro-n-propane, pertluoroethane, monochlorodifluoromethane, 1,1-difluoroethane, tevafluoropropenes, both individually and in mixtures thereof Hydrophilic propellants, such as carbon dioxide, can also be used advantageously in the sense of the present invention if the proportion of hydrophilic gases is chosen to be low and lipophilic propellant (e.g. propane/butane) is present in excess. Propane, n-butane, iso-butane and mixtures of these propellants are particularly preferred. It has been shown that the use of n-butane or iso-butane as the sole propellant gas may be particularly preferred in accordance with the invention.

[0036] The application of the antiperspirant cosmetic composition can be carried out by means of various methods. According to a preferred embodiment, the antiperspirant cosmetic composition is packaged as a spray application. The spray application is carried out with a spray device which contains in a container a filling of the liquid, viscous-flowable, suspension-like or powder-like antiperspirant cosmetic composition used according to the invention. The filling can be under the pressure of a propellant as previously described (pressurised gas cans, pressurised gas packs, aerosol packs), or it can be a mechanically operated pump sprayer without propellant (pump sprays/ squeeze bottle). The atomisation of the antiperspirant cosmetic composition can be carried out physically, mechanically or electromechanically, for example by piezoelectric effects or electric pumps.

[0037] However, it may be equally preferred if the cosmetic composition is present as an oil-in-water emulsion. In this case, the cosmetic composition is preferably sprayed as propellant-free pump spray or squeeze spray or applied as roll-on.

[0038] The cosmetic composition may further contain at least one oil component, preferably in an amount of from about 0.05 to about 50% by weight, based on the total weight of the cosmetic composition. The oil component is preferably one selected from the group of (i) volatile silicone oils, especially volatile cyclic and linear silicone oils; (ii) volatile non-silicone oils, especially liquid paraffin oils, isoparaffin oils, ester oils and organic alcohols; (iii) nonvolatile silicone oils; (iv) non-volatile non-silicone oils; and (v) mixtures thereof Preferably the oil component is a volatile or non-volatile cosmetic oil selected from the group consisting of cyclic and linear silicone oils and non-silicone oils. Volatile cosmetic oils are those which at 20°C and 1013 hPa have a vapour pressure of from 2.66 to 40,000 Pa, preferably from about 10 to about 12,000 Pa, more preferably from about 13 to about 3,000 Pa and especially from about 15 to about 500 Pa. Non-volatile cosmetic oils are those which have a vapour pressure of less than 2.66 Pa at 20°C and 1013 hPa. According to the invention, the preferred silicone oils are those selected from linear polyalkylsiloxanes with a kinematic viscosity at 25 °C of from about 5 cSt to about 2000 cSt, preferably from about 10 to about 350 cSt and especially from about 5 to about 100 cSt. Suitable compounds are available under the trade name Dow Corning® 200. Other oils preferred by the invention are selected from the esters of dimers of unsaturated C12-C22 fatty acids with monohydric linear, branched or cyclic C2-C8 alcohols or with polyhydric linear or branched C7-C6 alcohols.

[0039] According to the invention, it may be preferable to use mixtures of volatile silicone oils and volatile non-silicone oils as this gives a drier skin feel. Furthermore, it may be preferable to use a non-volatile silicone oil and/or a non-volatile non-silicone oil to mask insoluble components, such as talcum, or ingredients dried on the skin [0040] The use of blends of non-volatile and volatile cosmetic oils is particularly preferred, as this allows parameters such as skin feel, visibility of the residue and stability of the antiperspirant cosmetic product to be adjusted, thus better adapting the product to the needs of the consumer.

[0041] The cosmetic composition not only has an antiperspirant effect but can also be used to cover odours. To this end, the cosmetic composition preferably contains at least one fragrance. In the context of the present invention, "fragrance" is understood to mean substances with a molecular weight of from 74 to 300 g/mol, which contain at least one osmophoric group in the molecule and have an odour and/or taste, i.e. which are able to excite the receptors of the hair cells of the olfactory system. Osmophoric groups are groups cova1ently bound to the molecular skeleton in the form of hydroxy groups, formyl groups, oxo groups, alkoxycarbonyl groups, nitrile groups, azide groups, etc. In the context of the present invention, perfume oils, perfumes or perfume oil components which are liquid at 20 °C and 1013 hPa are understood in particular. The fragrance is preferably contained in the cosmetic composition is an amount of from about 0.001 to about 10% by weight, especially from about 0.005 to about 9% by weight, more preferably from about 0.1 to about 7% by weight, especially preferably from about 0.2 to about 6% by weight and especially from about 0.2 to about 2% by weight, in each case based on the total weight of the cosmetic composition according to the invention.

[0042] In order to further support the antiperspirant and odour-reducing effect of the cosmetic composition, the cosmetic composition preferably also contains one or more deodorant active ingredients. According to the invention, the use of certain deodorant active ingredients has proven to be particularly advantageous. It is therefore preferred that the at least one deodorant active ingredient is selected from the group of 0) aryl sulphatase inhibitors, betaglucuronidase inhibitors, aminoacylase inhibitors, esterase inhibitors, lipase inhibitors, lipoxigenase inhibitors and cystathionine-13-lyase inhibitors; (ii) a-monoalkylglycerol ethers with a branched or linear saturated or unsaturated, optionally hydroxyl ated C6-C22 alkyl radical, in particular a-(2-ethylhexyl)glycerol ethers, (iii) alcohols, in particular phenoxyethanol, benzylheptanol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, tropolone and butyloctanoic acid; (iv) germ-inhibiting perfume oils; (v) prebiotically active components; (vi) trialkyl citric acid esters, in particular tri ethyl citrate; (vii) active substances which reduce the number of skin germs from the group of staphylococci, coryne bacteria, anaerococci and micrococci involved in odour formation or inhibit their growth; (viii) active substances which reduce the number of skin germs from the group of staphylococci, coryne bacteria, anaerococci and micrococci involved in odour formation or inhibit their growth. (viii) zinc and silver compounds, in particular zinc phenolsulphonate, zinc ricinoleate, bischloride(-1)-octahydroxy-pentazinc, zinc citrate and silver lactate; (ix) organohalogen compounds, in particular triclosan, chl orhexi dine and chlorhexidine gluconate, (x) benzalkonium halides, in particular benzalkonium chloride and benzethonium chloride; (xi) quaternary ammonium compounds, in particular cetylpyridinium chloride; (xii) antimicrobially active carbonates, phosphates and sulphates, in particular sodium bicarbonate, cocamidopropyl PG-dimonium chloride phosphates, di sodium pyrophosphate and soya morpholinium ethosulphates, (xiii) lantibiotics, (xiv) aluminium and aluminium zirconium salts; (xv) bispyridines, especially octenidine; (xvi) antimicrobial acids, especially caprylic hydroxamic acid, carnesolic acid, tartaric acid and 2-butyloctanoic acid, (xvii) polyglycerol esters, especially polyglycery1-3 caprylates; (xviii) sorbitan esters and lactones, in particular sorbitan captylate and glucono-1,5-lactone; (xix) and mixtures thereof, in particular phenoxyethanol and/or caprylylglycol and/or 1,2-hexanediol and/or tropolone and/or a-(2-ethylhexyl)glycerol ether and/or 2-butyloctanoic acid and/or ffiethyl citrate. The use of these active ingredients leads not only to a high and long-lasting perfume and a high storage stability, but also to a high and long-lasting deodorizing effect.

[0043] The cosmetic composition may take different forms depending on the intended use.

Preferably, the cosmetic composition is in the form of an emulsion, a solution, a dispersion, a suspension or an aerosol. The cosmetic composition can be applied in the form of a spray, a pen, a soft solid, a cream, a gel or a roll-on. In some cases, it has also proved to be advantageous to apply the cosmetic composition on or in a disposable substrate, for example in the form of cloths, pads or puffs. In a preferred form, the cosmetic composition is present as an anhydrous/low water formulation with a water concentration of <5%, e.g. as a dispersion.

[0044] Depending on the intended use, the cosmetic composition may therefore be in solid, semi-solid, liquid, disperse, emulsified, suspended, gel, multi-phase or powder form. For the purposes of the present invention, the term "liquid" also includes any kind of solid dispersions in liquids. Furthermore, multi-phase cosmetic composition according to the present invention are defined as products which have at least two different phases with a phase separation and in which the phases can be arranged horizontally, i.e. one above the other, or vertically, i.e. next to each other. The application can be done for example with a roller ball applicator, a pump sprayer or with a fixed pen.

[0045] In the context of the present invention, it was surprisingly found that polyphosphazenes or salts thereof can inhibit sweating. Therefore, a second aspect of the invention is the use of a compound selected from the group of polyphosphazenes for inhibiting and/or reducing perspiration, wherein the polyphosphazene has the general formula (I) R' N=P--R2-n (I), where at least one of R' and 12.2 are independently selected from -H, alkyl, a1kyloxy, aryloxy, amino, alkylamino, aryl amino, alkanol, polyol, carboxyl, carbonyl structures, amino acid derivatives, EO-, PO-and/or EO/P0-and their adducts with other molecules, betaine, -(CFOniX-Rl' where m is 0 to 10, Xis selected from N or S or 0 or P, and each ftl is independently -H, -alkyl, -alkenyl, alkyloxy, aryloxy, amino, alkylamino, aryl amino, alkanol, polyol, carboxyl, carbonyl structures, -betaine, amino acid derivatives, EO-, PO-and/or EO/P0-and their adducts with other molecules.

[0046] Another aspect of the present invention is a non-therapeutic cosmetic method for preventing and/or reducing perspiration of the body, in which an antiperspirant cosmetic composition according to the invention is applied to the skin, in particular to the skin of the armpits, and is preferably left on the skin for at least about 1 hour, preferably for at least about 2 hours, preferably for at least about 4 hours, in particular for at least about 6 hours

Examples:

100471 The present invention is explained in more detail on the basis of the following examples, which are by no means to be understood as a limitation of the inventive idea.

100481 Different formulations were prepared which contain oligomers according to the invention. The formulations described cosmetic compositions in the sense of the present invention without, however, being limiting for the present invention. Other formulations are of course possible. Exemplarily, the chloride salt of P,P-di(methylamino)-phosphazene polymer (molecular weight <5000 Dalton) was used NHC 1,

N :

A HU-13 as the polyphosphazene according to the invention. Inventive compositions are reproduced below. The pH value was adjusted to the specified pH value in each case using hydrochloric acid in water as an example. Unless otherwise stated, the quantities stated refer to mass %.

[0049] The formulations according to the invention can be applied by means of a suitable spray system. Suitable are e.g. pumping atomizers, atomization by means of air (squeeze) or propellant-containing aerosols. Suitable propellants are air, nitrous oxide, nitrogen, carbon dioxide, or other compressed gases or defined quantities of liquefied gases such as propane, butane, isobutane and/or dimethyl ether. 15; 20; 25; or 30% up to 98% of the formulation was filled with suitable propellants e.g. propane, butane, isobutane, dimethyl ether (alone or in combination) (pressure 1.6-7 bar) to 100% in an aerosol pack. All quantities of raw materials refer to the propellant-free, gas-free formulation (quantities in mass [0050] Depending on the viscosity, the formulations can also be applied as a viscous liquid from a roll-on or as a viscous cream from a tube, jar or suitable dispenser. Alternatively, the formulations according to the invention can also be used as antiperspirant wipes by impregnating suitable substrates, e.g. fleece, with the formulation. 1 3

100511 Sprayable antiperspirant microemulsions Example 1.1 1.2 1.3 1.4 Lauryl glucoside, approx. 50% AS 1.7 1.7 - 1.7 Decyl glucoside, approx. 50 % AS 1.15 1.4 2.4 1.4 Glycerol monooleate 0.7 0.7 - 0.7 Dioctyl ether 4 4 0.1 4 Octyldodecanol 1 1 0.02 1 Perfume 1 1 1 1 Polyphosphazene according to the invention or its salt 20 5 10 4 Propylene glycol 5 - 20 10 Glycerine - - 5 - 2-Benzylheptanol 0.5 - - -Triethyl citrate - 0.5 2.0 0.5 Hydrochloric acid in water pH 3.5 pH 4.5 pH 3.0 pH 3.8 Water demin. ad 100 ad 100 ad 100 ad 100 100521 Antiperspirant emulsion (0/W) Example 2.1 2.2 2.3 2.4 2.5 Propylene glycol 5 - - - 10 Polyphosphazene according to the invention or its salt 10 20 4 2 7 Steareth-2 2.4 2.2 2.2 2.5 2.5 Steareth-21 1.6 L4 1.4 L5 1.5 Perfume 1.2 1.0 1.0 1.2 1.2 PPG-15 Stearyl ether 0.5 L5 1.5 2.0 2.0 Aluminium starch ocetenyl succinates 0. I - - - - 1.0 0.5 1.0 1.0 IFF Silica Caps Slurry, approx. 30-40% perfume content1.5 Active deodorant ingredient 1 0.5 3 1 1.0 Hydrochloric acid in water pH 3.5 pH 4.5 pH 3.0 pH 3.8 pH 3.5 Water demin. ad ad ad ad ad 100.0 100.0 100.0 100.0 100.00 [0053] Antiperspirant emulsion (0/W) Example 3.1 3.2 3.3 3.4 3.5 Steareth-2 2.4 2.8 3.0 2.5 2.4 Steareth-21 1.5 2.0 3.0 4.0 1.5 Perfume 1.2 1.0 0.7 1.2 1.2 PPG-15 Stearyl ether 0.5 3.0 4.0 2.0 0.5 Polyphosphazene according to the invention or its20 salt 5 7 3 10 Propylene glycol 10 Tetratrasodium EDTA 0.1 0.05 0.08 0.2 0.1 Benzalkonium chloride 0.1 0.05 0.08 0.1 0.1 Active deodorant ingredient 1 0.5 3 1 1 Hydrochloric acid in water pH 3.5 pH 4.5 pH 3.0 pH 3.8 pH 3.5 Water demin. ad ad ad ad ad 100.0 100.0 100.0 100.0 100.0 [0054] Antiperspirant solution Example 4.1 4.2 4.3 4.4 Alcohol denat. (96%, cosmetic grade) 25 30 30 Polyphosphazene according to the invention or its salt 3 10 7 5 Propylene glycol 25 Propylencarbonat 10 5 PEG-40 Hydrogenated castor oil 0.5 2.0 Phenoxyethanol 1.0 1.0 1.0 1.0 Benzalkonium chloride 0.1 0.08 0.08 Cocami dopropyl PG-Di m oni um Chlorides Phosphates 0.5 0.4 0.4 Perfume 1.0 1.0 1.0 1.0 Hydrochloric acid in water pH 3.5 pH 4.5 pH 3.0 pH 3.8 Water demin. ad 100 ad 100 ad 100 ad 100 [0055] Antiperspirant solution Example 14.5 41.6 41.7 1 1 Alcohol denat. (96%, cosmetic grade) 11 15 1 110 1 I ! Polyphosphazene according to the invention or its salt 110 1 17 1 Il4 1 Propylene glycol 1 140! 1 Propylencarbonat 110 15 Triethyl citrate 1! ! Emulsifier! Solubilizer TILB 1-18 0.5 12 10.5 i ! Phenoxyethanol 11.0 11.0! 11.0 1 2-Benzylheptanol 10.3 10.1 1 0.4 1 Cocamidopropyl PG-Dimonium Chlorides Phosphates 0.5 0.3 0.4 Perfume 11.0 11.0 11.0 1 Hydrochloric acid in water kpli 3.5 VI 4.5 H 3.5 Water demin. ad 100 lad 100 i ad 100 1 i [0056] Antiperspirant solution

Example 4.8 4.9 4.10

Alcohol denat. (cosmetic grade) ad 100 ad 100 ad 100 Polyphosphazene according to the invention or its salt 15 7 3 Propylene glycol 10 Propylencarbonat 10 5 10 Tri ethyl citrate 3.0 Emulsifier 0.5 2 Phenoxyethanol 1.0 1.0 1.0 2-Benzylheptanol 0.3 0. I 0 Cocamidopropyl PG-Dimonium Chlorides Phosphates 0.5 0.3 0.4 Perfume 1.0 1.0 1.0 Hydrochloric acid in water pH 3.5 pH 4.0 pH 4.5 [00571 W/O Emulsion Antiperspirant

Example 5.1 5.2 5.3

Polyphosphazene according to the invention or its salt 10 3 7 CI 0-C13 -I soalkanes 8.9 8.9 Cyclopentasiloxane 8.9 PEG/PPG-18/18 Dimethicone 2.0 1.4 1.4 lsoceteth-20 0.5 0.5 0.5 Dimethicone 4.2 4.2 4.2 Isopropyl myristate 9.0 9.0 9.0 Propylene glycol 25 20 Phenoxyethanol 0.5 0.5 0.5 Perfume 2.5 2.5 2.5 Hydrochloric acid in water pH 3.5 pH 4.0 pH 4.5 Water demin. ad 100 ad 100 ad 100 100581 W/O Emulsion Antiperspirant

Example 5.4 5.5 5.6

Polyphosphazene according to the invention or its salt 20 10 5 Propylene glycol 10 25 Triethyl citrate 6.0 12.0 Ethylhexyl pa1mitate 7.0 13.0 PEG/PPG-18/18 Dimethicone 1.0 0.8 2.0 Dimethicone 2.0 L6 4.0 Dimethicone 5 cst 10.5 15.0 7.0 Active deodorant ingredient 0.1 1.0 7.0 Magnesium sulphate 7H20 5 2 4 Phenoxyethanol 0.5 LO 0.5 Perfume 2.5 5.0 4.0 Hydrochloric acid in water pH 3.5 pH 4.0 pH 4.5 Water demin. ad 100 ad 100 ad 100 [0059] Antiperspirant emulsion based on phase inversion technology

Example 6.1 6.2 6.3

Glyceryl stearate, ceteareth-20, ceteareth-12, cetearyl alcohol, Cetyl palmitate 5 3.5 5 Ceterath-12 3 13 3 Cetearylisononanoate 5 6 5 Dicaprylylcarbonate 5 8 5 Glycerine 0.1 0.2 0.1 Perfume 1 1 1 Polyphosphazene according to the invention or its salt 10 8 4 Hydrochloric acid in water pH 3.5 pH 4.0 pH 4.5 Water demin. ad 100 ad 100 ad 100 [0060] Antiperspirant -Pencil based on an 0/W emulsion Example 7.1 7.2 7.3 7.4 7.5 Ethylene glycol distearate 12.5 P.5 -Ethylene glycol monostearate 1- 1- ,.5 Pentaerythr tyldistearate 1 1 1 1 1 i p.o I I I i Palmitic acid, stearic acid (1:1) 13.5 P.5 13.5 13 1 1 1 1 Ceteareth-20 10.8 0.8 0.8 10.8 0.8 i i i i i ! 1 1 ! ! Ceteareth-30 J.8 J.8 1.8 1) .8.8.8.8 11' r r 1 Diisopropyl adipate 6 6 6 16 6 Cocoglycerides (Schmelzpunkt 30 -32 °C) 14 4 4 '4 4 Cetyl palmitate 15 15 15 15 15 i 1 ki k 4 Hydrogenated castor oil 114 114 1 1 1 1 1 Cetearyl behenate 15 15 15 15 15 1 1 1 1 1 Talcum powder 110 110 110 110 110 1 1 1 1 1 Perfume 1 11.2 11.2 1 1 11.2 111.2 r1.2 1 1 Ethylhexyl glycerol ether 0.6 1 11 1 0.6 0.6 10.6 0.61 Polyphosphazene according to the invention or 3 15 10 5 7 its salt Propylene glycol 10 1 Hydrochloric acid in water pH 3.0 pH 4.0 pH 4.5 pH 3.5 pH 4.0 Water demin. ad ad ad ad ad 100.0 100.0 100.0 100.0 100.0 [0061] Antiperspirant emulsion (0/W)

Example 8.1 82 8.3

Polyphosphazene according to the invention or ts salt 5 3 10 Steareth-2 2.4 2.2 2.2 Steareth-21 1.6 1.4 1.4 Perfume 1.2 1.0 1.0 PPG-15 Stearyl ether 0.5 1.5 1.5 Aluminium starch ocetenyl succinates 0.1 Additives for conservation 2.0 1.0 3.0 Active deodorant ingredient 2 1 0.5 Hydrochloric acid in water pH 4.0 pH 4.5 pH 3.0 Water demin. ad 100.0 ad 100.0 ad 100.0 [0062] Antiperspirant roll-on / alcoholic/watery Example 10.1 10.2 10.3 Alcohol denat. (96%, cosmetic grade) 30.0 30.0 30.0 Ceteareth-10 2.0 2.0 2.0 Ceteareth-30 2.0 2.0 2.0 Polyphosphazene according to the invention or its salt 5 10 20 Propylene glycol 20 Hydroxyethyl cellulose 0.5 0.5 0.5 Cocamidopropyl PG-Dimonium Chlorides Phosphates 0.4 0.4 0.4 Perfume 0.8 0.8 0.8 Hydrochloric acid in water pH 4.0 pH 4.5 pH 3.5 Water demin. ad 100 ad 100 ad 100 [0063] Antiperspirant solution Example 10.4 10.5 10.6 Alcohol denat. (96%, cosmetic grade) 30 10 Polyphosphazene according to the invention or its salt 10 5 2 Propylene glycol 20 Propylcncarbonat 5 10 5 Triethyl citrate 3.0 Emulsifier! Solubilizer HLB 1-18 0.5 2 0.5 Hydroxyethyl cellulose 0.5 0.4 0.2 Phenoxyethanol 1.0 1.0 1.0 2-Benzylheptanol 0.3 0.1 0 Cocamidopropyl PG-Dimonium Chlorides Phosphates 0.5 0.3 0.4 Perfume 1.0 1.0 1.0 Hydrochloric acid in water pH 4.0 pH 3.5 pH 3.0 Water demin. ad 100 ad 100 ad 100 [0064] Solid W/O antiperspirant emulsion Example 111.1! 111.2! 111.3! Polyphosphazene according to the invention or its salt 110! ,c p 0 ! Propylene glycol 113.0 1 Cyclohexasiloxane 1 pm 1 16.0! C12-15 alkyl benzoate 18.0 2.0 1 8.0 Cetyl PEG/PPG-10/1 Dimethicone 11.2 1 11.2 1 11.2 1 Polyethylen-Wax (MW= 500 g/mol, Smp = 83 bis 81 °C) 110.0 1 110.0 1 110.0 1 Polyalphaolefin wax (MW = 1800 g/mol, Smp = 41 °C) 0.1 1 0. t 1 p.1 1 Polysaccharide 12.00 1 10.5 1 0.5 1 Tetrasodium EDTA 1 10.05 10 05 ! - 1 * -1! Deodorant Active 11 10.5 1.0 1 1 Perfume 11 11! 11 ! Hydrochloric acid in water pH 4.0 pH 3.5 pi H 3.0 Water demin. 1125.0 1 1125.0 1 k5.0! [0065] W/O Antiperspirant gel

Example 12.1 12.2

Cyclopentasiloxane 14.0 14.0 B s-PEG/PPG-14/14 Dimethicone 2.5 3.0 Alcohol denat. (96%, cosmetic grade) 10.0 10.0 Aluminium chlorohydrate, approx. 50% AS 40.0 40.0 Polyphosphazene according to the invention or ts salt 10 5 Propanediol 15 Active deodorant ingredient 1 0.5 Perfume 1.0 1.0 Hydrochloric acid in water pH 4.0 pH 3.5 Water demin. ad 100 ad 100 [0066] Antiperspirant Emulsion Roll on

Example 13.1 13.2

Sodium stearoyl glutamate 0.5 0.7 Stearyl alcohol 2.5 1.5 Caprylic/caprin triglycerides 2.5 2.5 Polyglycery1-3 Dicitrate/Stearate 1.0 0.8 Hydroxyethyl cellulose 0.25 0.25 Polyphosphazene according to the invention or its salt 10 3 Propylene glycol 5 Active deodorant ingredient 1 1.0 Perfume 1 1 Hydrochloric acid in water pH 4.0 pH 3.5 Water demin. ad 100 ad 100 100671 Antiperspirant Cream

Example 114.1

Ceteareth-10 11.5 Ceteareth-20 11.5 1 Behenyl alcohol! 143.5! Cilyceryl stearate 15 Hexyldecanol, Hexyldecyl laurate (1:1) 112.5 D methicone (350 Cst) 12 Cyclopentasiloxane 11 Allantoin 10.3 Polyphosphazene according to the invention or its salt '15 Additive for conservation 11 Perfume 1 11.3 Active deodorant ingredient 10.5 Hydrochloric acid in water kpH 3 1 Water demin. ! iad 100 [0068] While at least one exemplary embodiment has been presented in the foregoing detailed description, it should be appreciated that a vast number of variations exist. It should also be appreciated that the exemplary embodiment or exemplary embodiments are only examples, and are not intended to limit the scope, applicability, or configuration of the various embodiments in any way. Rather, the foregoing detailed description will provide those skilled in the art with a convenient road map for implementing an exemplary embodiment as contemplated herein. It being understood that various changes may be made in the function and arrangement of elements described in an exemplary embodiment without departing from the scope of the various embodiments as set forth in the appended claims.

Claims (10)

1. CLAIMS: An antiperspirant cosmetic composition comprising at least one water-soluble polyphosphazene of the general formula (I) RI / N=P R2 (I); and ii) at least one anion, where at least R1 or R2 are selected such that they form a salt with the anion.
2. 2. An antiperspirant cosmetic composition according to claim 1, wherein n is in the range of from 1 to 2000, preferably of from 3 to 170, in particular of from 10 to 90
3. 3. An antiperspirant cosmetic composition according to claim 1 or claim 2, wherein RI and R2 are independently selected from -H, alkyl, alkyloxy, aryloxy, amino, alkylamino, aryl amino, alkanol, polyol, carboxyl, carbonyl structures, amino acid derivatives, BO-, PO-and/or E0/P0-and their adducts with other molecules, betaine, -(012)1-X-R3 where m = 0 to 10, Xis selected from N or S or 0 or P, and each R3 is independently -H, -alkyl, -alkenyl, -aryl, alkyloxy, aryloxy, amino, alkylamino, aryl amino, alkanol, polyol, carboxyl, carbonyl structures, -betaine, amino acid derivatives, HO-, PO-and/or L0/P0-and their adducts with other molecules
4. 4. An antiperspirant cosmetic composition according to claim 3, wherein the alkyl is selected from -(CpH2p+1), where p is from Ito 18, preferably from Ito 6.
5. 5. An antiperspirant cosmetic composition according to any one of claims 1 to 4, wherein the polyphosphazene is linear or in a ring or network structure, preferably in a network structure.
6. 6. An antiperspirant cosmetic composition according to any one of claims 1 to 5, wherein the polyphosphazene has a molecular weight of from 75 to 300,000 daltons, preferably from 250 to 50,000 daltons, preferably from 300 to 10,000 daltons, more preferably from 400 to 8,000 daltons.
7. 7 An antiperspirant cosmetic composition according to any one of claims 1 to 6, comprising at least one anion per N=P group of the polyphosphazene according to formula (I), preferably two anions per N=P group.
8. 8. An antiperspirant cosmetic composition according to any one of claims 1 to 7, wherein the anion is selected from chloride, phosphate, polyphosphates, sulphate, sulphonate, phosphonate, citrate, formate, acetate, fumarate, gluconate, glutarate, lactate, malate, malonate, pyruvate, tartrate, and hydro forms and mixtures thereof, preferably selected from chloride, phosphate and sulphate.
9. 9. An antiperspirant cosmetic composition according to any one of claims 1 to 8, wherein the cosmetic composition contains less than 1% by weight, preferably 0% by weight, based on the total weight of the cosmetic composition, of antiperspirant aluminium and/or aluminium zirconium salts 10. A cosmetic method for reducing perspiration of the body and/or for reducing body odour caused by perspiration, comprising applying an antiperspirant cosmetic composition according to any one of claims 1 to 9 to human skin and leaving the antiperspirant cosmetic composition on the site of application for at least 1 hour.1 E Use of at least one water-soluble polyphosphazene of the general formula (1) for reducing body perspiration and/or for reducing body odour caused by perspiration RilIN =.7p n wherein and 122 are independently selected from 41, alkyl-, alkyloxy-, myloxy-, amino-, alkylamino-, my] amino-, alkanol, polyol, carboxyl, carbonyl structures, amino acid derivatives, BO-, PO-and/or EO/P0-and their adducts with other molecules, betaine, -(CM)111-X113, where m is 0 to
10. 10, Xis selected from N or S or 0 or P, and each 113 is independently -H, -alkyl, -alkenyl, -aryl, alkyloxy, aryloxy, amino, alkylamino, aryl amino, alkanol, polyol, carboxyl, carbonyl structures, -betaine, amino acid derivatives, HO-, PO-and/or EO/P0-and their adducts with other molecules.