GB2578187B - Droplet actuation - Google Patents

Droplet actuation Download PDF

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Publication number
GB2578187B
GB2578187B GB1911169.9A GB201911169A GB2578187B GB 2578187 B GB2578187 B GB 2578187B GB 201911169 A GB201911169 A GB 201911169A GB 2578187 B GB2578187 B GB 2578187B
Authority
GB
United Kingdom
Prior art keywords
droplet actuation
droplet
actuation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1911169.9A
Other versions
GB201911169D0 (en
GB2578187A (en
Inventor
Ma Hanbin
Su Yang
Nathan Arokia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangdong Acxel Micro & Nano Tech Co Ltd
Original Assignee
Guangdong Acxel Micro & Nano Tech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangdong Acxel Micro & Nano Tech Co Ltd filed Critical Guangdong Acxel Micro & Nano Tech Co Ltd
Priority to GB1911169.9A priority Critical patent/GB2578187B/en
Publication of GB201911169D0 publication Critical patent/GB201911169D0/en
Publication of GB2578187A publication Critical patent/GB2578187A/en
Application granted granted Critical
Publication of GB2578187B publication Critical patent/GB2578187B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
    • G02B26/004—Optical devices or arrangements for the control of light using movable or deformable optical elements based on a displacement or a deformation of a fluid
    • G02B26/005—Optical devices or arrangements for the control of light using movable or deformable optical elements based on a displacement or a deformation of a fluid based on electrowetting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427—Electrowetting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials Engineering (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
GB1911169.9A 2018-09-28 2018-09-28 Droplet actuation Active GB2578187B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1911169.9A GB2578187B (en) 2018-09-28 2018-09-28 Droplet actuation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1911169.9A GB2578187B (en) 2018-09-28 2018-09-28 Droplet actuation
GB1815819.6A GB2577536A (en) 2018-09-28 2018-09-28 Droplet actuation

Publications (3)

Publication Number Publication Date
GB201911169D0 GB201911169D0 (en) 2019-09-18
GB2578187A GB2578187A (en) 2020-04-22
GB2578187B true GB2578187B (en) 2022-10-05

Family

ID=64108995

Family Applications (3)

Application Number Title Priority Date Filing Date
GB1815819.6A Withdrawn GB2577536A (en) 2018-09-28 2018-09-28 Droplet actuation
GB1911168.1A Expired - Fee Related GB2577607B (en) 2018-09-28 2018-09-28 Droplet actuation
GB1911169.9A Active GB2578187B (en) 2018-09-28 2018-09-28 Droplet actuation

Family Applications Before (2)

Application Number Title Priority Date Filing Date
GB1815819.6A Withdrawn GB2577536A (en) 2018-09-28 2018-09-28 Droplet actuation
GB1911168.1A Expired - Fee Related GB2577607B (en) 2018-09-28 2018-09-28 Droplet actuation

Country Status (2)

Country Link
CN (1) CN109603931B (en)
GB (3) GB2577536A (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2577536A (en) * 2018-09-28 2020-04-01 Acxel Tech Ltd Droplet actuation
CN110888231B (en) * 2019-05-16 2022-10-14 南京邮电大学 Light beam adjuster based on dielectric wetting liquid prism array
CN110665556A (en) * 2019-09-30 2020-01-10 浙江大学 Reusable single-layer digital microfluidic chip based on hydrophobic film and rapid preparation method
US20230202106A1 (en) * 2020-05-30 2023-06-29 The Board Of Trustees Of The University Of Illinois Apparatuses, systems and methods for electrohydrodynamic (ehd) material deposition
CN113368914A (en) * 2021-06-07 2021-09-10 岭南师范学院 3D printing integrated digital microfluidic chip structure and manufacturing method

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018234445A1 (en) * 2017-06-21 2018-12-27 Base4 Innovation Limited Microdroplet manipulation device
CN109603931A (en) * 2018-09-28 2019-04-12 苏州奥素液芯电子科技有限公司 A kind of electrowetting dielectric drop actuation means and its manufacturing method
WO2019099304A1 (en) * 2017-11-14 2019-05-23 Illumina, Inc. Digital fludic cartridge with inlet gap height larger than outlet gap height

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DE10352535A1 (en) * 2003-11-07 2005-06-16 Steag Microparts Gmbh A microstructured separator and method of separating liquid components from a liquid containing particles
EP1761819A1 (en) * 2004-06-23 2007-03-14 Koninklijke Philips Electronics N.V. Bi-stable electrowetting optical element and driving method therefore
KR101451955B1 (en) * 2007-08-24 2014-10-21 어드밴스드 리퀴드 로직, 아이엔씨. Bead manipulations on a droplet actuator
US20110033887A1 (en) * 2007-09-24 2011-02-10 Fang Nicholas X Three-Dimensional Microfabricated Bioreactors with Embedded Capillary Network
KR20110112946A (en) * 2010-04-08 2011-10-14 엘지디스플레이 주식회사 Electrowetting display device
US20120288672A1 (en) * 2011-05-12 2012-11-15 Iain Rodney George Ogilvie Solvent vapor bonding and surface treatment methods
US9441308B2 (en) * 2012-02-16 2016-09-13 Lester F. Ludwig Three-dimensional microfluidic micro-droplet arrays for electronic integrated circuit and component cooling, energy-harvesting, chemical and biochemical microreactors, miniature bioreactors, and other applications
US8981789B2 (en) * 2012-04-16 2015-03-17 Sharp Kabushiki Kaisha Active matrix device and method of driving the same
CN103406162A (en) * 2013-07-05 2013-11-27 复旦大学 Accurate droplet generation method based on electrowetting-on-dielectric digital microfluidic chip
CN106206409B (en) * 2015-05-08 2019-05-07 华邦电子股份有限公司 Stack electronic device and its manufacturing method
CN104941703B (en) * 2015-05-27 2018-02-02 上海交通大学 Micro-fluidic chip method is prepared using 3D printing template and modularization assembling
US9539573B1 (en) * 2015-06-23 2017-01-10 Sharp Kabushiki Kaisha EWOD device with calibrated serial dilution function
CN105233887B (en) * 2015-08-31 2017-06-23 中国科学院深圳先进技术研究院 A kind of micro-droplet drive part based on dielectric wetting and preparation method thereof
US10113985B2 (en) * 2015-09-15 2018-10-30 Sharp Life Science (Eu) Limited Active matrix device and method of driving
WO2017214177A1 (en) * 2016-06-07 2017-12-14 The Regents Of The University Of California Detecting compounds in microfluidic droplets using mass spectrometry
US20180059056A1 (en) * 2016-08-30 2018-03-01 Sharp Life Science (Eu) Limited Electrowetting on dielectric device including surfactant containing siloxane group
EP3357576B1 (en) * 2017-02-06 2019-10-16 Sharp Life Science (EU) Limited Microfluidic device with multiple temperature zones
CN107315246A (en) * 2017-05-11 2017-11-03 南京邮电大学 A kind of photoswitch based on medium electrowetting effect

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018234445A1 (en) * 2017-06-21 2018-12-27 Base4 Innovation Limited Microdroplet manipulation device
WO2019099304A1 (en) * 2017-11-14 2019-05-23 Illumina, Inc. Digital fludic cartridge with inlet gap height larger than outlet gap height
CN109603931A (en) * 2018-09-28 2019-04-12 苏州奥素液芯电子科技有限公司 A kind of electrowetting dielectric drop actuation means and its manufacturing method

Also Published As

Publication number Publication date
GB201911168D0 (en) 2019-09-18
GB2577607A (en) 2020-04-01
GB201815819D0 (en) 2018-11-14
GB201911169D0 (en) 2019-09-18
GB2577607B (en) 2023-05-17
CN109603931B (en) 2021-07-27
GB2578187A (en) 2020-04-22
GB2577536A (en) 2020-04-01
CN109603931A (en) 2019-04-12

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