GB2551926A - Desorption electrospray ionisation ("DESI") imaging - Google Patents
Desorption electrospray ionisation ("DESI") imaging Download PDFInfo
- Publication number
- GB2551926A GB2551926A GB1714122.7A GB201714122A GB2551926A GB 2551926 A GB2551926 A GB 2551926A GB 201714122 A GB201714122 A GB 201714122A GB 2551926 A GB2551926 A GB 2551926A
- Authority
- GB
- United Kingdom
- Prior art keywords
- desi
- desorption electrospray
- electrospray ionisation
- imaging
- ion source
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000688 desorption electrospray ionisation Methods 0.000 title claims abstract 10
- 238000003384 imaging method Methods 0.000 title claims 3
- 238000000034 method Methods 0.000 claims abstract description 5
- 150000002500 ions Chemical class 0.000 claims abstract 8
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000012491 analyte Substances 0.000 claims abstract 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000004202 carbamide Substances 0.000 claims abstract 2
- 239000012313 reversal agent Substances 0.000 claims abstract 2
- 108010026552 Proteome Proteins 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 230000001594 aberrant effect Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000000751 protein extraction Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000000575 proteomic method Methods 0.000 description 1
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Abstract
A method is disclosed comprising applying a reversal agent, such as urea, to a formalin fixed tissue sample in order to reverse the effects of the fixation process. An ambient ionisation ion source such as a desorption electrospray ionisation ("DESI") ion source is used to generate analyte or analyte ions from multiple regions of the modified target so that an ion image of the modified target may be generated.
Description
714122.7 (51) INT CL:
G01N 33/68 (2006.01)
Date of Filing: | 07.03.: | |||
Date Lodged: | 04.09.: | |||
Priority Data: | ||||
(31) | 15038797 | (32) | 06.03.2015 | (33) |
(31) | 15038763 | (32) | 06.03.2015 | (33) |
(31) | 15038649 | (32) | 06.03.2015 | (33) |
(31) | 15038771 | (32) | 06.03.2015 | (33) |
(31) | 15038672 | (32) | 06.03.2015 | (33) |
(31) | 15038631 | (32) | 06.03.2015 | (33) |
(31) | 15038789 | (32) | 06.03.2015 | (33) |
(31) | 15160039 | (32) | 09.09.2015 | (33) |
(31) | 15183692 | (32) | 16.10.2015 | (33) |
GB
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GB
GB
GB
GB
GB
GB
GB (56) Documents Cited:
- TERESA RODRAGUEZ-RIGUEIRO ETAL, A novel procedure for protein extraction from formalin-fixed paraffin-embedded tissues, PROTEOMICS, DE, (20110601), vol. 11, no. 12, doi:10.1002/ pmic.201000809, ISSN 1615-9853, pages 2555 - 2559, XP055270705
- BELLET V ET AL, Proteomic analysis of RCL2 paraffin-embedded tissues, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, UNIVERSITY PRESS CAROL DAVILA, BUCHAREST, RO, vol. 12, no. 5B, doi:10.1111/
J.1582-4934.2007.00186.X, ISSN 1582-1838, (20081001), pages 2027 - 2036, (20081030), XP002530019 (86) International Application Data:
PCT/GB2016/050624 En 07.03.2016 (87) International Publication Data:
WO2016/142694 En 15.09.2016 (71) Applicant(s):
Micromass UK Limited
Stamford Avenue, Altrincham Road, WILMSLOW, SK9 4AX, United Kingdom (72) Inventor(s):
Steven Derek Pringle Emrys Jones Stephen O'Brien Zoltan Takats (74) Agent and/or Address for Service:
Dehns
St. Bride's House, 10 Salisbury Square, LONDON, EC4Y 8JD, United Kingdom
- BRIAN M. BALGLEY ETAL, Evaluation of Archival Time on Shotgun Proteomics of Formalin-Fixed and Paraffin-Embedded Tissues, JOURNAL OF PROTEOME RESEARCH., US, (20090206), vol. 8, no.
2, doi:10.1021/pr800503u, ISSN 1535-3893, pages 917
- 925, XP055270689
- YAN LI ET AL, Aberrant Mucin5B expression in lung adenocarcinomas detected by iTRAQ labeling quantitative proteomics and immunohistochemistry, CLINICAL PROTEOMICS, BIOMED CENTRAL LTD, LONDON, UK, (20131101), vol. 10, no. 1, doi:10.1186/1559-0275-10-15, ISSN 1559-0275, page 15, XP021166635
- OMID AZIMZADEH ETAL, Formalin-Fixed ParaffinEmbedded (FFPE) Proteome Analysis Using Gel-Free and Gel-Based Proteomics, JOURNAL OF PROTEOME RESEARCH., US, (20100903), vol. 9, no.
9, doi:10.1021/pr1004168, ISSN 1535-3893, pages 4710
- 4720, XP055270690
- GUSTAFSSON OVE J R ETAL, Proteomic developments in the analysis of formalin-fixed tissue, BIOCHIMICA ET BIOPHYSICA ACTA (BBA) PROTEINS & PROTEOMICS, (20141012), vol. 1854, no. 6, doi:10.1016/J.BBAPAP.2014.10.003, ISSN 1570-9639, pages 559 - 580, XP029124981
Claims (1)
- (58) Field of Search:INT CL G01NOther: EPO-lnternal, BIOSIS, EMBASE, WPI Data (54) Title of the Invention: Desorption electrospray ionisation (DESI) imaging Abstract Title: Desorption electrospray ionisation (DESI) imaging (57) A method is disclosed comprising applying a reversal agent, such as urea, to a formalin fixed tissue sample in order to reverse the effects of the fixation process. An ambient ionisation ion source such as a desorption electrospray ionisation (DESI) ion source is used to generate analyte or analyte ions from multiple regions of the modified target so that an ion image of the modified target may be generated.Fig. 11 «111
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB201503867A GB201503867D0 (en) | 2015-03-06 | 2015-03-06 | Ionisation of gaseous samles in rapid evaporative ionisation mass spectrometry (REIMS) |
GB201503877A GB201503877D0 (en) | 2015-03-06 | 2015-03-06 | In-vivo endoscopic tissue identification tool utilising rapid evaporative ionization mass spectrometry (REIMS) |
GB201503879A GB201503879D0 (en) | 2015-03-06 | 2015-03-06 | Rapid evaporative ionisation mass spectrometry (REIMS) applications |
GB201503863A GB201503863D0 (en) | 2015-03-06 | 2015-03-06 | Rapid evaporation ionization mass spectrometry (REIMS) imaging platform for direct mapping from bacteria growth media |
GB201503876A GB201503876D0 (en) | 2015-03-06 | 2015-03-06 | Rapid evaporative ionization mass spectrometry (REIMS) imaging platform for direct mapping from bulk tissue |
GB201503864A GB201503864D0 (en) | 2015-03-06 | 2015-03-06 | Heated rapid evaporative ionisation mass spectrometry ("REIMS") collision surface |
GBGB1503878.9A GB201503878D0 (en) | 2015-03-06 | 2015-03-06 | Liquid separator for endoscopic electrosurgical applications |
GBGB1516003.9A GB201516003D0 (en) | 2015-09-09 | 2015-09-09 | Rapid evaporative ionisation mass spectrometry (REIMS) applications |
GBGB1518369.2A GB201518369D0 (en) | 2015-10-16 | 2015-10-16 | Heated rapid evaporative ionisation mass spectrometry ("REIMS") collision surface |
PCT/GB2016/050624 WO2016142694A1 (en) | 2015-03-06 | 2016-03-07 | Desorption electrospray ionisation ("desi") imaging |
Publications (3)
Publication Number | Publication Date |
---|---|
GB201714122D0 GB201714122D0 (en) | 2017-10-18 |
GB2551926A true GB2551926A (en) | 2018-01-03 |
GB2551926B GB2551926B (en) | 2019-10-23 |
Family
ID=64658311
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GB201810823D0 (en) | 2018-06-01 | 2018-08-15 | Micromass Ltd | An inner source assembly and associated components |
CN111413393A (en) * | 2019-12-20 | 2020-07-14 | 杭州师范大学 | Method for rapidly detecting formaldehyde content in food by high-throughput reaction paper spray mass spectrometry |
GB202014233D0 (en) | 2020-01-24 | 2020-10-28 | Waters Technologies Corp | Sprayer assembly |
CN112525980B (en) * | 2020-11-26 | 2022-09-06 | 厦门大学 | Mass spectrometry detection method for melamine in dairy products |
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