GB201808916D0 - Utilisation of mid-infrared lasers for REIMS imaging and high throughput sampling - Google Patents

Utilisation of mid-infrared lasers for REIMS imaging and high throughput sampling

Info

Publication number
GB201808916D0
GB201808916D0 GBGB1808916.9A GB201808916A GB201808916D0 GB 201808916 D0 GB201808916 D0 GB 201808916D0 GB 201808916 A GB201808916 A GB 201808916A GB 201808916 D0 GB201808916 D0 GB 201808916D0
Authority
GB
United Kingdom
Prior art keywords
utilisation
mid
high throughput
infrared lasers
throughput sampling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1808916.9A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Priority to GBGB1808916.9A priority Critical patent/GB201808916D0/en
Publication of GB201808916D0 publication Critical patent/GB201808916D0/en
Priority to PCT/GB2019/051511 priority patent/WO2019229470A1/en
Priority to GB1907747.8A priority patent/GB2576078B/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • H01J49/049—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample with means for applying heat to desorb the sample; Evaporation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
    • H01J49/0463—Desorption by laser or particle beam, followed by ionisation as a separate step
    • G—PHYSICS
    • G02—OPTICS
    • G02F—OPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
    • G02F1/00—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
    • G02F1/35—Non-linear optics
    • G02F1/39—Non-linear optics for parametric generation or amplification of light, infrared or ultraviolet waves

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
GBGB1808916.9A 2018-05-31 2018-05-31 Utilisation of mid-infrared lasers for REIMS imaging and high throughput sampling Ceased GB201808916D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GBGB1808916.9A GB201808916D0 (en) 2018-05-31 2018-05-31 Utilisation of mid-infrared lasers for REIMS imaging and high throughput sampling
PCT/GB2019/051511 WO2019229470A1 (en) 2018-05-31 2019-05-31 Utilisation of mid-infrared lasers for rapid evaporative ionisation mass spectrometry imaging and high throughput sampling
GB1907747.8A GB2576078B (en) 2018-05-31 2019-05-31 Utilisation of mid-infrared lasers for rapid evaporative ionisation mass spectrometry imaging and high throughput sampling

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1808916.9A GB201808916D0 (en) 2018-05-31 2018-05-31 Utilisation of mid-infrared lasers for REIMS imaging and high throughput sampling

Publications (1)

Publication Number Publication Date
GB201808916D0 true GB201808916D0 (en) 2018-07-18

Family

ID=62872828

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB1808916.9A Ceased GB201808916D0 (en) 2018-05-31 2018-05-31 Utilisation of mid-infrared lasers for REIMS imaging and high throughput sampling
GB1907747.8A Active GB2576078B (en) 2018-05-31 2019-05-31 Utilisation of mid-infrared lasers for rapid evaporative ionisation mass spectrometry imaging and high throughput sampling

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB1907747.8A Active GB2576078B (en) 2018-05-31 2019-05-31 Utilisation of mid-infrared lasers for rapid evaporative ionisation mass spectrometry imaging and high throughput sampling

Country Status (2)

Country Link
GB (2) GB201808916D0 (en)
WO (1) WO2019229470A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201915843D0 (en) * 2019-10-31 2019-12-18 Micromass Ltd Ion source

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8901487B2 (en) * 2007-07-20 2014-12-02 George Washington University Subcellular analysis by laser ablation electrospray ionization mass spectrometry
US11289320B2 (en) * 2015-03-06 2022-03-29 Micromass Uk Limited Tissue analysis by mass spectrometry or ion mobility spectrometry
GB2551926B (en) * 2015-03-06 2019-10-23 Micromass Ltd Desorption electrospray ionisation ("DESI") imaging
EP3265823B1 (en) * 2015-03-06 2020-05-06 Micromass UK Limited Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue
WO2018026910A1 (en) * 2016-08-02 2018-02-08 Fluidigm Canada Inc. Sample imaging apparatus and method

Also Published As

Publication number Publication date
WO2019229470A1 (en) 2019-12-05
GB201907747D0 (en) 2019-07-17
GB2576078B (en) 2021-05-19
GB2576078A (en) 2020-02-05

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)