GB2546683B - Methods of producing betatrophin from pancreatic progenitor cells differentiated using FGF - Google Patents
Methods of producing betatrophin from pancreatic progenitor cells differentiated using FGFInfo
- Publication number
- GB2546683B GB2546683B GB1706843.8A GB201706843A GB2546683B GB 2546683 B GB2546683 B GB 2546683B GB 201706843 A GB201706843 A GB 201706843A GB 2546683 B GB2546683 B GB 2546683B
- Authority
- GB
- United Kingdom
- Prior art keywords
- fgf
- methods
- progenitor cells
- cells differentiated
- pancreatic progenitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/65—MicroRNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
- C12N2506/025—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells from extra-embryonic cells, e.g. trophoblast, placenta
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1706843.8A GB2546683B (en) | 2013-11-26 | 2013-11-26 | Methods of producing betatrophin from pancreatic progenitor cells differentiated using FGF |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1706843.8A GB2546683B (en) | 2013-11-26 | 2013-11-26 | Methods of producing betatrophin from pancreatic progenitor cells differentiated using FGF |
GB1511132.1A GB2523696B (en) | 2012-11-30 | 2013-11-26 | Methods of differentiating stem cells to pancreatic progenitor cells by modulating miR-124 |
Publications (3)
Publication Number | Publication Date |
---|---|
GB201706843D0 GB201706843D0 (en) | 2017-06-14 |
GB2546683A GB2546683A (en) | 2017-07-26 |
GB2546683B true GB2546683B (en) | 2017-12-13 |
Family
ID=59010899
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1706843.8A Active GB2546683B (en) | 2013-11-26 | 2013-11-26 | Methods of producing betatrophin from pancreatic progenitor cells differentiated using FGF |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB2546683B (en) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006091766A2 (en) * | 2005-02-24 | 2006-08-31 | Jau-Nan Lee | Human trophoblast stem cells and use thereof |
WO2009132083A2 (en) * | 2008-04-22 | 2009-10-29 | President And Fellows Of Harvard College | Compositions and methods for promoting the generation of pdx1+ pancreatic cells |
EP2233566A1 (en) * | 2009-03-17 | 2010-09-29 | Vrije Universiteit Brussel | Generation of pancreatic progenitor cells |
WO2012068170A2 (en) * | 2010-11-15 | 2012-05-24 | Jau-Nan Lee | Generation of neural stem cells from human trophoblast stem cells |
US20120264209A1 (en) * | 2006-05-02 | 2012-10-18 | Jon Odorico | Methods and devices for differentiating pluripotent stem cells into cells of the pancreatic lineage |
-
2013
- 2013-11-26 GB GB1706843.8A patent/GB2546683B/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006091766A2 (en) * | 2005-02-24 | 2006-08-31 | Jau-Nan Lee | Human trophoblast stem cells and use thereof |
US20120264209A1 (en) * | 2006-05-02 | 2012-10-18 | Jon Odorico | Methods and devices for differentiating pluripotent stem cells into cells of the pancreatic lineage |
WO2009132083A2 (en) * | 2008-04-22 | 2009-10-29 | President And Fellows Of Harvard College | Compositions and methods for promoting the generation of pdx1+ pancreatic cells |
EP2233566A1 (en) * | 2009-03-17 | 2010-09-29 | Vrije Universiteit Brussel | Generation of pancreatic progenitor cells |
WO2012068170A2 (en) * | 2010-11-15 | 2012-05-24 | Jau-Nan Lee | Generation of neural stem cells from human trophoblast stem cells |
Non-Patent Citations (5)
Title |
---|
Biological Chemistry, vol. 389, 2008, Lovis et al, 'Regulation of the expression of components of the exocytotic machinery...' pp. 305-312 * |
Cell Research, vol. 17, 2007, Jiang et al, 'In vitro derivation of functional insulin-producing cells...' pp. 333-344 * |
Journal of Biological Chemistry, vol. 282 issue 27, 2007, Baroukh et al, 'MicroRNA-124a regulates Foxa2 expression...' pp. 19575-19588 * |
Mechanisms of Development, vol. 128, 2011, Xu et al, 'Activin, BMP and FGF pathways cooperate...' pp. 412-427 * |
PLoS ONE, volume 7 issue 12, 2012, Lee et al, 'Ectopic pregnancy-derived human trophoblastic stem cells...' article e52491. Available online at https://doi.org/10.1371/journal.pone.0052491 [Accessed 18 May 2017] * |
Also Published As
Publication number | Publication date |
---|---|
GB201706843D0 (en) | 2017-06-14 |
GB2546683A (en) | 2017-07-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
R108 | Alteration of time limits (patents rules 1995) |
Free format text: EXTENSION APPLICATION Effective date: 20170727 |