GB2538046A - Essential oil containing wound preparations - Google Patents

Essential oil containing wound preparations Download PDF

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Publication number
GB2538046A
GB2538046A GB1505383.8A GB201505383A GB2538046A GB 2538046 A GB2538046 A GB 2538046A GB 201505383 A GB201505383 A GB 201505383A GB 2538046 A GB2538046 A GB 2538046A
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GB
United Kingdom
Prior art keywords
preparation
sugar
wounds
wound
essential oils
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB1505383.8A
Other versions
GB201505383D0 (en
Inventor
Robert Kaye David
Elizabeth Kaye Lauren
James Kaye Robert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to GB1505383.8A priority Critical patent/GB2538046A/en
Publication of GB201505383D0 publication Critical patent/GB201505383D0/en
Publication of GB2538046A publication Critical patent/GB2538046A/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Abstract

A preparation comprising a paste or solution containing one or more essential oils and non-reducing sugar for application to wounds. The sugar is preferably sucrose and may be obtained from sugar beet or sugar cane. The sugar may have particles of equivalent size to granulated sugar caster sugar or icing sugar. The preparation may be applied to wounds to aid wound healing, reduce odour, and may have antibacterial, antifungal or antiviral properties. The preparation may also be applied to, or incorporated into dressings for application to wounds. The preparation may be used to treat wounds in humans or animals.

Description

This invention relates to preparations combining sugar with essential oils for the treatment of wounds and related conditions. These preparations combine the wound healing properties of sugar with the antibacterial, antiviral, antifungal and anti-inflammatory properties of essential oils in a suitable formulation for application to wounds or to be incorporated into dressings to be applied to wounds for medical or veterinary use.
Background Sugar
The use of sugar to treat wounds has been known since ancient times. The use of sugar to promote wound healing is well established ( Biswas A, Bharara M. Hurst C, Gruessner R, Armstrong D, RHo H. Use of Sugar on the Healing of Diabetic Ulcers A Review. journal of Diabetes Science and Technology. 2010:4(5)1139-1145.) The use of thick and thin sugar pastes to promote wound healing has been reported at Northwick Park Hospital (Harrow UK) (V1iddieton,K and Seal,D Pharmaceutic°Haan-in./4985: 235 757-758.) They used varying combinations of caster and icing sugar, polyethylene glycol and hydrogen peroxide.
Essential oils Essential oils are volatile oils derived from plants or animals or their synthetic equivalents containing complex mixtures of compounds. The essential oils which may be incorporated into these preparations include, hut are not limited to, citronella, eucalyptus, geranium, lavender, lemongrass, orange, rosemary, palmarosa, patchouli, and peppermint.
Essential oils have been widely used in folk medicine to aid wound-healing. More recent research has shown their beneficial effects on wound healing. Eucalyptus oil has anti-inflammatory effects (Silva et al, Journal of Efhnophormocology 2003: 89 (2-3)277-283).
In addition some essential oils have antibacterial and antifungal activity (Carmen G, Hancu G. Antimicrobial and Antifungai Activity of Pc/argon/urn roseurn Essential Oils. Advanced Pharmaceutical Bulletin. 20114;4(Suppl 4.51.1.-5114. doi:113.5681/apb.2014.075.) Essential oils may also possess antiviral properties (Pilau MR, Alves SH, Weiblen R, Arenhart 5, Cueto AP, Lovato LT. Antiviral activity of the Lipplo groveolens (Mexican oregano) essential oil and its main compound carvacrol against human and animal viruses. Brazilian Journal of Microbiology. 2011;42(4):16116-2624.)
Description
The present invention comprises a solution or paste of non-reducing sugar, one or more essential oils and glycerol or polyethylene glycol. In addition water may be added to improve the theological properties of the mixture, the more water present the less viscous the product.
Additional components may be added to the preparation to improve the colour, stability or appearance of the preparation. In particular a buffer may be added to ensure the pH of the product is between 3.5 and 6.5 to improve the stability of the preparation and prevent separation of the phases.
The preparation is made by mixing the ingredients at room temperature. For small quantities the preparation may be made by mixing the ingredients in a pestle and mortar. For larger quantities the preparation may be made by mixing the ingredients in a food mixer. Usually the glycerol or polyethylene glycol is added to the sugar and mixed, with the essential oils added at the last stage of mixing. Water may also be incorporated during mixing to improve the rheological properties of the mixture. In general a thick paste is preferred for direct application to wounds or spreading onto a wound dressing. Thinner pastes may be used to fill deeper wounds or fistulas.
The preparation may be stored in a glass or plastic ointment jar. Thicker pastes may be stored in plastic or metal ointment tubes. The preparation may be stored at room temperature although in some examples the preparation may be refrigerated to improve stability.
The following are non-limiting embodiments of the invention:
Example 1
Caster sugar 200gm Icing sugar 300gm Glycerol 375m1 Lavender oil 10m1 The sugars are mixed to form a powder. The glycerol is added with stirring to form a smooth paste to which the essential oil is added with stirring.
The preparation may be used for application to wounds or to be incorporated into dressings to be applied to wounds for medical or veterinary use.
Example 2.
Caster sugar 200gm Icing sugar 300gm Glycerol 500m1 Lavender oil 10m1 The sugars are mixed to form a powder. The glycerol is added with stirring to form a smooth paste to which the essential oil is added with stirring.
The preparation may be used for application to wounds or to be incorporated into dressings to be applied to wounds for medical or veterinary use. This produces a thinner paste suitable for cavities.
Example 3.
Caster sugar 200gm Icing sugar 300gm Glycerol 375m1 Lavender oil 8m1 Rosemary oil 2m1 The sugars are mixed to form a powder. The glycerol is added with stirring to form a smooth paste to which the essential oils are added with stirring.
This example uses a combination of essential oils. The preparation may be used for application to wounds or to be incorporated into dressings to be applied to wounds for medical or veterinary use.
Example 4.
Caster sugar 200gm Icing sugar 300gm Glycerol 375m1 Lavender oil 20m1 The sugars are mixed to form a powder. The glycerol is added with stirring to form a smooth paste to which the essential oil is added with stirring.
The preparation may be used for application to wounds or to be incorporated into dressings to be applied to wounds for medical or veterinary use.
Example 5.
Caster sugar 200gm Icing sugar 300gm Glycerol 30m1 Water 30m1 Lavender oil 10m1 The sugars are mixed to form a powder. The glycerol is added with stirring to form a smooth paste to which the essential oil is added with stirring.
The preparation may be used for application to wounds or to be incorporated into dressings to be applied to wounds for medical or veterinary use.
Example 6
Preparations of the examples 1-5, mainly example 1 were applied to dressings and changed daily. The preparations were used on a variety of wounds. In all cases excellent and rapid wound healing was observed. There were no cases of infection in any of the wounds to which the preparation was applied.

Claims (17)

  1. Claims:- 1. A preparation comprising a paste or solution containing one or more essential oils and non-reducing sugar for application to wounds.
  2. 2. A preparation as claimed in claim 1, wherein the sugar is sucrose.
  3. 3. A preparation as claimed in claim 2, wherein the sucrose is obtained from sugar cane.
  4. 4. A preparation as claimed in claim 2, wherein the sucrose is obtained from sugar beet.
  5. 5. A preparation as claimed in any one of Claims 2 to 4, wherein the sugar is of icing sugar grade particle size.
  6. 6. A preparation as claimed in any one of Claims 2 to 4, wherein the sugar is of caster sugar grade particle size.
  7. 7. A preparation as claimed in any one of Claims 2 to 4, wherein the sugar is of granulated sugar grade particle size.
  8. 8. A preparation as claimed in any of the preceding claims containing one or more essential oils.
  9. 9. A preparation as claimed in any of the preceding claims which may be applied to a wound to promote wound healing.
  10. 10. A preparation as claimed in any of the preceding claims which may be applied to a wound to reduce odour.
  11. 11. A preparation as claimed in any of the preceding claims which may be applied to a wound for an antibacterial action.
  12. 12. A preparation as claimed in any of the preceding claims which may be applied to a wound for an antifungal action.
  13. 13. A preparation as claimed in any of the preceding claims which may be applied to a wound for an antiviral action.
  14. 14. A preparation as claimed in any of the preceding claims which may be incorporated into a wound dressing.
  15. 15. A preparation as claimed in any of the preceding claims which may be applied to a wound dressing.
  16. 16. A preparation as claimed in any of the preceding claims for veterinary use.
  17. 17. A preparation as claimed in any of the preceding claims for human use.
GB1505383.8A 2015-03-29 2015-03-29 Essential oil containing wound preparations Withdrawn GB2538046A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1505383.8A GB2538046A (en) 2015-03-29 2015-03-29 Essential oil containing wound preparations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1505383.8A GB2538046A (en) 2015-03-29 2015-03-29 Essential oil containing wound preparations

Publications (2)

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GB201505383D0 GB201505383D0 (en) 2015-05-13
GB2538046A true GB2538046A (en) 2016-11-09

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0103878A2 (en) * 1982-09-17 1984-03-28 Humán Oltoanyagtermelö és Kutato Intézet Preparations for treating outer skin wounds and process for their manufacture
US6623767B1 (en) * 1998-01-16 2003-09-23 Morice Andre Mixture containing honey, at least one essential oil and/or at least one essential oil derivative
WO2007045931A2 (en) * 2005-10-22 2007-04-26 Brightwake Limited Compositions and dressings for the treatment of wounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0103878A2 (en) * 1982-09-17 1984-03-28 Humán Oltoanyagtermelö és Kutato Intézet Preparations for treating outer skin wounds and process for their manufacture
US6623767B1 (en) * 1998-01-16 2003-09-23 Morice Andre Mixture containing honey, at least one essential oil and/or at least one essential oil derivative
WO2007045931A2 (en) * 2005-10-22 2007-04-26 Brightwake Limited Compositions and dressings for the treatment of wounds

Also Published As

Publication number Publication date
GB201505383D0 (en) 2015-05-13

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