GB2535004B - A process for the preparation of Lenalidomide - Google Patents
A process for the preparation of LenalidomideInfo
- Publication number
- GB2535004B GB2535004B GB1522674.9A GB201522674A GB2535004B GB 2535004 B GB2535004 B GB 2535004B GB 201522674 A GB201522674 A GB 201522674A GB 2535004 B GB2535004 B GB 2535004B
- Authority
- GB
- United Kingdom
- Prior art keywords
- lenalidomide
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LVP-13-152A LV14985B (en) | 2013-10-14 | 2013-10-14 | Method for production of lenalidomide |
PCT/LV2014/000010 WO2015057043A1 (en) | 2013-10-14 | 2014-10-03 | A process for the preparation of lenalidomide |
Publications (3)
Publication Number | Publication Date |
---|---|
GB201522674D0 GB201522674D0 (en) | 2016-02-03 |
GB2535004A GB2535004A (en) | 2016-08-10 |
GB2535004B true GB2535004B (en) | 2019-01-02 |
Family
ID=51794944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1522674.9A Active GB2535004B (en) | 2013-10-14 | 2014-10-03 | A process for the preparation of Lenalidomide |
Country Status (3)
Country | Link |
---|---|
GB (1) | GB2535004B (en) |
LV (1) | LV14985B (en) |
WO (1) | WO2015057043A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3183244B1 (en) * | 2014-08-19 | 2019-04-10 | Synthon BV | Process for making crystalline form a of lenalidomide |
CN109400579B (en) * | 2017-08-18 | 2020-06-23 | 新发药业有限公司 | Production method of lenalidomide |
CN107337666B (en) * | 2017-08-30 | 2019-06-04 | 上海万巷制药有限公司 | It is a kind of for treating the preparation method of the lenalidomide of Huppert's disease |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1847532A1 (en) * | 2005-01-27 | 2007-10-24 | Kyowa Hakko Kogyo Co., Ltd. | Igf-1r inhibitor |
WO2010061209A1 (en) * | 2008-11-03 | 2010-06-03 | Generics [Uk] Limited | A crystalline form of lenalidomide and a process for its preparation |
WO2011111053A1 (en) * | 2010-03-08 | 2011-09-15 | Natco Pharma Limited | Anhydrous lenalidomide form-i |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2122290T3 (en) | 1993-06-25 | 1998-12-16 | Kumiai Chemical Industry Co | DERIVED FROM INDAZOLSULFONILUREA, ITS USE AND INTERMEDIARY FOR ITS PRODUCTION. |
US6281230B1 (en) | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
JP4494013B2 (en) | 2001-08-06 | 2010-06-30 | ザ チルドレンズ メディカル センター コーポレイション | Synthesis and antitumor activity of nitrogen-substituted thalidomide derivatives |
DE102006025317A1 (en) | 2006-05-31 | 2007-12-06 | Bayer Healthcare Aktiengesellschaft | Isoindolin-1-one, isoindolin-3-one and isoindoline-1,3-dione derivatives and their use |
MX2010009344A (en) | 2008-03-11 | 2012-09-28 | Reddys Lab Ltd Dr | Preparation of lenalidomide. |
AU2009314568B2 (en) | 2008-11-14 | 2016-01-21 | Concert Pharmaceuticals Inc. | Substituted dioxopiperidinyl phthalimide derivaties |
WO2010056384A1 (en) | 2008-11-17 | 2010-05-20 | Dr. Reddy's Laboratories Ltd. | Lenalidomide solvates and processes |
AU2010220204B2 (en) | 2009-03-02 | 2015-10-08 | Generics [Uk] Limited | Improved process |
CN101580501B (en) | 2009-06-01 | 2011-03-09 | 南京卡文迪许生物工程技术有限公司 | Synthetic method of 3-(substituted dihydro-isoindolone-2-group)-2,6-dioxopiperidine and intermediate thereof |
US20120184746A1 (en) | 2009-09-03 | 2012-07-19 | Ranbaxy Laboratories Limited | Process for the preparation of lenalidomide |
WO2011050962A1 (en) | 2009-10-29 | 2011-05-05 | Ratiopharm Gmbh | Acid addition salts of lenalidomide |
WO2011069608A1 (en) | 2009-12-09 | 2011-06-16 | Ratiopharm Gmbh | S-lenalidomide, polymorphic forms thereof and blend comprising s- und r-lenalidomide |
JP2013522236A (en) | 2010-03-12 | 2013-06-13 | セルジーン コーポレイション | Methods for treating non-Hodgkin lymphoma using lenalidomide, and gene and protein biomarkers as predictors |
-
2013
- 2013-10-14 LV LVP-13-152A patent/LV14985B/en unknown
-
2014
- 2014-10-03 WO PCT/LV2014/000010 patent/WO2015057043A1/en active Application Filing
- 2014-10-03 GB GB1522674.9A patent/GB2535004B/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1847532A1 (en) * | 2005-01-27 | 2007-10-24 | Kyowa Hakko Kogyo Co., Ltd. | Igf-1r inhibitor |
WO2010061209A1 (en) * | 2008-11-03 | 2010-06-03 | Generics [Uk] Limited | A crystalline form of lenalidomide and a process for its preparation |
WO2011111053A1 (en) * | 2010-03-08 | 2011-09-15 | Natco Pharma Limited | Anhydrous lenalidomide form-i |
Non-Patent Citations (4)
Title |
---|
A. N. BALAEV, K. A. OKHMANOVICH, V. E. FEDOROV: "Alternative synthesis of lenalidomide", PHARMACEUTICAL CHEMISTRY JOURNAL, vol. 46, no. 11, 1 February 2013 (2013-02-01), pages 676 - 678, XP055152353, ISSN: 0091150X, DOI: 10.1007/s11094-013-0868-7 * |
LUKE W. JUDD, ANTHONY P. DAVIS: "From cholapod to cholaphane transmembrane anion carriers: accelerated transport through binding site enclosure", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, vol. 46, no. 13, 1 January 2010 (2010-01-01), pages 2227, XP055152266, ISSN: 13597345, DOI: 10.1039/b927005a * |
MARIA BARBOSA, CASTRO BARBOSA, THIAGO JOS�, FIGUEIRA RAMOS, ANA CAROLINA SANTOS DE ARANTES, MARCO AUR�LIO MARTINS, PATR�CIA MACHAD: "Synthesis and Pharmacological Evaluation of Novel Phenyl Sulfonamide Derivatives Designed as Modulators of Pulmonary Inflammatory Response", MOLECULES, vol. 17, no. 12, 1 January 2012 (2012-01-01), pages 14651 - 14672, XP055152660, DOI: 10.3390/molecules171214651 * |
MULLER, G.W. CHEN, R. HUANG, S.-Y. CORRAL, L.G. WONG, L.M. PATTERSON, R.T. CHEN, Y. KAPLAN, G. STIRLING, D.I.: "Amino-substituted thalidomide analogs: potent inhibitors of TNF-@a production", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 9, no. 11, 7 June 1999 (1999-06-07), AMSTERDAM, NL, pages 1625 - 1630, XP004169632, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(99)00250-4 * |
Also Published As
Publication number | Publication date |
---|---|
LV14985A (en) | 2015-04-20 |
GB201522674D0 (en) | 2016-02-03 |
LV14985B (en) | 2015-06-20 |
WO2015057043A1 (en) | 2015-04-23 |
GB2535004A (en) | 2016-08-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
732E | Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977) |
Free format text: REGISTERED BETWEEN 20161208 AND 20161214 |