GB2535004B - A process for the preparation of Lenalidomide - Google Patents

A process for the preparation of Lenalidomide

Info

Publication number
GB2535004B
GB2535004B GB1522674.9A GB201522674A GB2535004B GB 2535004 B GB2535004 B GB 2535004B GB 201522674 A GB201522674 A GB 201522674A GB 2535004 B GB2535004 B GB 2535004B
Authority
GB
United Kingdom
Prior art keywords
lenalidomide
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1522674.9A
Other versions
GB201522674D0 (en
GB2535004A (en
Inventor
Kalvins Ivars
Ponomarjovs Jurijs
Varaceva Larisa
Cernobrovijs Aleksandrs
Lebedevs Antons
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
A S Grindex
Original Assignee
A S Grindex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A S Grindex filed Critical A S Grindex
Publication of GB201522674D0 publication Critical patent/GB201522674D0/en
Publication of GB2535004A publication Critical patent/GB2535004A/en
Application granted granted Critical
Publication of GB2535004B publication Critical patent/GB2535004B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB1522674.9A 2013-10-14 2014-10-03 A process for the preparation of Lenalidomide Active GB2535004B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LVP-13-152A LV14985B (en) 2013-10-14 2013-10-14 Method for production of lenalidomide
PCT/LV2014/000010 WO2015057043A1 (en) 2013-10-14 2014-10-03 A process for the preparation of lenalidomide

Publications (3)

Publication Number Publication Date
GB201522674D0 GB201522674D0 (en) 2016-02-03
GB2535004A GB2535004A (en) 2016-08-10
GB2535004B true GB2535004B (en) 2019-01-02

Family

ID=51794944

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1522674.9A Active GB2535004B (en) 2013-10-14 2014-10-03 A process for the preparation of Lenalidomide

Country Status (3)

Country Link
GB (1) GB2535004B (en)
LV (1) LV14985B (en)
WO (1) WO2015057043A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3183244B1 (en) * 2014-08-19 2019-04-10 Synthon BV Process for making crystalline form a of lenalidomide
CN109400579B (en) * 2017-08-18 2020-06-23 新发药业有限公司 Production method of lenalidomide
CN107337666B (en) * 2017-08-30 2019-06-04 上海万巷制药有限公司 It is a kind of for treating the preparation method of the lenalidomide of Huppert's disease

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1847532A1 (en) * 2005-01-27 2007-10-24 Kyowa Hakko Kogyo Co., Ltd. Igf-1r inhibitor
WO2010061209A1 (en) * 2008-11-03 2010-06-03 Generics [Uk] Limited A crystalline form of lenalidomide and a process for its preparation
WO2011111053A1 (en) * 2010-03-08 2011-09-15 Natco Pharma Limited Anhydrous lenalidomide form-i

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
ES2122290T3 (en) 1993-06-25 1998-12-16 Kumiai Chemical Industry Co DERIVED FROM INDAZOLSULFONILUREA, ITS USE AND INTERMEDIARY FOR ITS PRODUCTION.
US6281230B1 (en) 1996-07-24 2001-08-28 Celgene Corporation Isoindolines, method of use, and pharmaceutical compositions
JP4494013B2 (en) 2001-08-06 2010-06-30 ザ チルドレンズ メディカル センター コーポレイション Synthesis and antitumor activity of nitrogen-substituted thalidomide derivatives
DE102006025317A1 (en) 2006-05-31 2007-12-06 Bayer Healthcare Aktiengesellschaft Isoindolin-1-one, isoindolin-3-one and isoindoline-1,3-dione derivatives and their use
MX2010009344A (en) 2008-03-11 2012-09-28 Reddys Lab Ltd Dr Preparation of lenalidomide.
AU2009314568B2 (en) 2008-11-14 2016-01-21 Concert Pharmaceuticals Inc. Substituted dioxopiperidinyl phthalimide derivaties
WO2010056384A1 (en) 2008-11-17 2010-05-20 Dr. Reddy's Laboratories Ltd. Lenalidomide solvates and processes
AU2010220204B2 (en) 2009-03-02 2015-10-08 Generics [Uk] Limited Improved process
CN101580501B (en) 2009-06-01 2011-03-09 南京卡文迪许生物工程技术有限公司 Synthetic method of 3-(substituted dihydro-isoindolone-2-group)-2,6-dioxopiperidine and intermediate thereof
US20120184746A1 (en) 2009-09-03 2012-07-19 Ranbaxy Laboratories Limited Process for the preparation of lenalidomide
WO2011050962A1 (en) 2009-10-29 2011-05-05 Ratiopharm Gmbh Acid addition salts of lenalidomide
WO2011069608A1 (en) 2009-12-09 2011-06-16 Ratiopharm Gmbh S-lenalidomide, polymorphic forms thereof and blend comprising s- und r-lenalidomide
JP2013522236A (en) 2010-03-12 2013-06-13 セルジーン コーポレイション Methods for treating non-Hodgkin lymphoma using lenalidomide, and gene and protein biomarkers as predictors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1847532A1 (en) * 2005-01-27 2007-10-24 Kyowa Hakko Kogyo Co., Ltd. Igf-1r inhibitor
WO2010061209A1 (en) * 2008-11-03 2010-06-03 Generics [Uk] Limited A crystalline form of lenalidomide and a process for its preparation
WO2011111053A1 (en) * 2010-03-08 2011-09-15 Natco Pharma Limited Anhydrous lenalidomide form-i

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
A. N. BALAEV, K. A. OKHMANOVICH, V. E. FEDOROV: "Alternative synthesis of lenalidomide", PHARMACEUTICAL CHEMISTRY JOURNAL, vol. 46, no. 11, 1 February 2013 (2013-02-01), pages 676 - 678, XP055152353, ISSN: 0091150X, DOI: 10.1007/s11094-013-0868-7 *
LUKE W. JUDD, ANTHONY P. DAVIS: "From cholapod to cholaphane transmembrane anion carriers: accelerated transport through binding site enclosure", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, vol. 46, no. 13, 1 January 2010 (2010-01-01), pages 2227, XP055152266, ISSN: 13597345, DOI: 10.1039/b927005a *
MARIA BARBOSA, CASTRO BARBOSA, THIAGO JOS�, FIGUEIRA RAMOS, ANA CAROLINA SANTOS DE ARANTES, MARCO AUR�LIO MARTINS, PATR�CIA MACHAD: "Synthesis and Pharmacological Evaluation of Novel Phenyl Sulfonamide Derivatives Designed as Modulators of Pulmonary Inflammatory Response", MOLECULES, vol. 17, no. 12, 1 January 2012 (2012-01-01), pages 14651 - 14672, XP055152660, DOI: 10.3390/molecules171214651 *
MULLER, G.W. CHEN, R. HUANG, S.-Y. CORRAL, L.G. WONG, L.M. PATTERSON, R.T. CHEN, Y. KAPLAN, G. STIRLING, D.I.: "Amino-substituted thalidomide analogs: potent inhibitors of TNF-@a production", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 9, no. 11, 7 June 1999 (1999-06-07), AMSTERDAM, NL, pages 1625 - 1630, XP004169632, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(99)00250-4 *

Also Published As

Publication number Publication date
LV14985A (en) 2015-04-20
GB201522674D0 (en) 2016-02-03
LV14985B (en) 2015-06-20
WO2015057043A1 (en) 2015-04-23
GB2535004A (en) 2016-08-10

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