GB2529501B - Fast method to analyse blood samples for the identification of hemoglobin variants using electron transfer dissociation - Google Patents

Fast method to analyse blood samples for the identification of hemoglobin variants using electron transfer dissociation

Info

Publication number
GB2529501B
GB2529501B GB1505522.1A GB201505522A GB2529501B GB 2529501 B GB2529501 B GB 2529501B GB 201505522 A GB201505522 A GB 201505522A GB 2529501 B GB2529501 B GB 2529501B
Authority
GB
United Kingdom
Prior art keywords
identification
blood samples
electron transfer
transfer dissociation
fast method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1505522.1A
Other versions
GB201505522D0 (en
GB2529501A (en
Inventor
Anderson Malcolm
Mark Brown Jeffery
Paul Williams Jonathan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Publication of GB201505522D0 publication Critical patent/GB201505522D0/en
Publication of GB2529501A publication Critical patent/GB2529501A/en
Application granted granted Critical
Publication of GB2529501B publication Critical patent/GB2529501B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/0072—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by ion/ion reaction, e.g. electron transfer dissociation, proton transfer dissociation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/795—Porphyrin- or corrin-ring-containing peptides
    • G01N2333/805—Haemoglobins; Myoglobins
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0036—Step by step routines describing the handling of the data generated during a measurement

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
GB1505522.1A 2014-03-31 2015-03-31 Fast method to analyse blood samples for the identification of hemoglobin variants using electron transfer dissociation Active GB2529501B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1405782.2A GB201405782D0 (en) 2014-03-31 2014-03-31 Fast method to analyse blood samples for the identification of hemoglobin variants using electron transfer dissociation

Publications (3)

Publication Number Publication Date
GB201505522D0 GB201505522D0 (en) 2015-05-13
GB2529501A GB2529501A (en) 2016-02-24
GB2529501B true GB2529501B (en) 2018-12-19

Family

ID=50737757

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB1405782.2A Ceased GB201405782D0 (en) 2014-03-31 2014-03-31 Fast method to analyse blood samples for the identification of hemoglobin variants using electron transfer dissociation
GB1505522.1A Active GB2529501B (en) 2014-03-31 2015-03-31 Fast method to analyse blood samples for the identification of hemoglobin variants using electron transfer dissociation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GBGB1405782.2A Ceased GB201405782D0 (en) 2014-03-31 2014-03-31 Fast method to analyse blood samples for the identification of hemoglobin variants using electron transfer dissociation

Country Status (1)

Country Link
GB (2) GB201405782D0 (en)

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Anal. Chem., Vol.85, 2013, Acosta-Martin, A. E. et al., "Quantitative mass spectrometry analysis...", pp.7971-7975 *
J. Am. Soc. Mass Spec., Vol.25, 2014, Lermyte, F. et al., "ETD allows for native surface mapping...", pp.343-350 *
J. Am. Soc. Mass Spectrometry, Vol.23, 2012, Coelho, D. et al., "Electron transfer dissociation mass...", pp.1750-1756 *
J. Am. Soc. Mass Spectrometry, Vol.23, 2012, Edwards, R.L. et al., "Top-down proteomics...", pp.1921-1930 *

Also Published As

Publication number Publication date
GB201505522D0 (en) 2015-05-13
GB201405782D0 (en) 2014-05-14
GB2529501A (en) 2016-02-24

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