GB2518406A

GB2518406A - A Safety Liquid Dispenser

Info

Publication number: GB2518406A
Application number: GB1316729.1A
Authority: GB
Inventors: Philip Mukoza Mpaata
Original assignee: SYROPS DESIGN Co Ltd
Current assignee: SYROPS DESIGN Co Ltd
Priority date: 2013-09-19
Filing date: 2013-09-19
Publication date: 2015-03-25
Anticipated expiration: 2033-09-19
Also published as: GB2518406B; GB2518406B8; GB2518406A8; GB201316729D0

Abstract

A device for dispensing liquid such as medication comprises a first fluidic connection for a container 14, a second fluidic connection for a syringe, and a conduit providing a fluidic pathway linking the two, the first fluidic connection comprising a child-proof lock means, the device comprising a recess adapted to receive the syringe and having the second fluidic connection within the recess, the recess having a recess access cap 38 that covers the syringe when in position in the recess and having a child-proof lock means to control access to the syringe. The fluidic pathway may comprise a valve means.

Description

A safety liquid disDenser

Field of the Invention

The present invention relates to devices for dispensing liquid and in particular to a device for dispensing liquid medication from a bottle in a safe and tamper-proof manner.

Background

In some situations it is desirable to extract an amount of liquid from a container such as a stock bottle and to dispense it by means of a syringe. The primary such situation is in dispensing liquid medication by means of an oral syringe. Typically the container has a child-proof lock such as a Cue-bc (RTM) system to limit unsafe access to the contents. Prior art devices to facilitate use of oral syringes with bottles exist, but require the syringe to be separated from the container and stored separately while a child-proof cap is replaced on the bottle. No system exists where the syringe can be stored ready for easy filling while protected by a child-proof lock means. Consequently, prior art oral syringe dosing from bottles is inconvenient, and where made more convenient is not protected by a child-proof lock system.

Integrating legal requirements such as ISO 8317: 2003 for child resistance and the ISO 13485 for Class I Medical devices (in which this design falls) has never been attempted before. The most popular conventional dosing device is the oral syringe, and the prior art does not include a design which links it with the Clic-loc (RTM) to initiate a dosing mechanism to draw liquid medicine from the bottle. Therefore, current children's dosing devices (especially oral syringes) and Clic-loc (RTM) closures do not feature in a single incorporated design. Neither do they feature a * child safety/resistance mechanism to keep both the syringe and the Clic-loc (RTM) * :*.; 30 intact as a single unit on the pharmaceutical bottle.

It is an object of the present invention to provide an improved device for dispensing liquid, in particular liquid medication, in which access to both the container and the dispensing means, for example an oral syringe, is protected by a child-proof lock means.

Prior Art

Accordingly a number of patent applications have been filed in an attempt to resolve the problem or similar, including the following: US20120103462 discloses an oral syringe of the type having a syringe barrel terminating in a syringe neck with a blunt orificed end is combined with a medication bottle provided with a self resealing elastomeric closure designed for admitting the syringe neck into the bottle while maintaining a sufficient liquid tight seal against the syringe neck to allow a dose of medication to be drawn from the bottle in an inverted condition of the bottle without significant leakage. The elastomeric closure may be initially unbroken and rupturable under urging of the orificed end for passing the syringe neck into the bottle, the closure resealing itself upon withdrawal of the syringe neck.

This device represents the present state of the art and does not include a safety lock means.

W0201257845 discloses a fluid safety dispenser system having a fluid storage container keyed to a fluid dispenser. The container having a valve body positionable in the opening of the container, the valve body having a plug member biased to allow fluid passage through the opening of the container when in a displaced position and to eliminate fluid passage through the opening of the container when the plug member is in a seated position. The keyed fluid dispenser assimilates a syringe and is releasably securable to the valve body for use in depressing the plug member by movement of a leaf spring when the keyed fluid dispenser is in position. The keyed fluid dispenser has indicia to provide for exact measurement and can be temporarily r *:* coupled to the container to provide ease of fluid transfer.

J 30 This device provides a syringe and container combination in which the container cap has a valve openable by the syringe, to prevent access to the contents other than using the syringe. However, it does not comprise a safety-lock means.

W0201 102893 discloses an adapter to be pressed into the neck of a bottle to receive a syringe for accessing the bottle contents by a syringe. The adapter has a distal end that extends into the bottle and a normally closed valve located at that distal end to prevent the contents from leaking out of the bottle if the bottle is inverted. An upper flange of the adapter seats against the top of the bottle and is recessed into the top of the bottle to prevent easy access to pry the adapter out of the bottle. A cap is also disclosed that is adapted to be pressed into the neck of a bottle. The cap has an upper lid that is hinged to a lower body to allow the upper hinge to move between a closed position sealing the bottle and an open position where the bottle is accessible by a syringe.

This device fits into the neck of a bottle to facilitate filling of a syringe and to keep the bottle closed when a syringe is not in place in the device.

US5484070 discloses a container closure having syringe tip connector which comprises a coupling for securing the closure to the container, a dispensing port for releasably connecting the tip of a syringe and a cap for sealing the dispensing port.

The closure has dual child-resistant capability in a "push and turn" mechanism for securing the coupling to the container and a latching flap type lid on the cap. The closure is especially useful for aspirating medication into a syringe for oral administration to children, adults or animals.

This device is suitable for use with a bottle having a child-proof lock but does not allow the syringe to remain in place while protected by a child-proof lock means.

Summary of the Invention *0*

* 25 According to the present invention there is provided a device for dispensing a liquid comprising: a housing comprising: (i) a liquid-tight connection for a screw-top liquid container, the connection r *: comprising a threaded receiving location, a sealing face adapted to receive *:*i 30 the lip of the container, and a first child-proof lock means adapted to control removal of the container from the housing, (ii) a conduit extending from the connection within the housing, (iii) a recess adapted to receive a syringe, the recess comprising an outer and an inner end, (iv) a fluidic connection at the inner end of the recess adapted to receive a nozzle provided on a syringe, the fluidic connection being in fluidic communication with the conduit; and a removable cap adapted to cover the recess provided by the housing, the cap and housing together comprising a second child-proof lock means adapted to control removal of the cap from the housing.

In preferred embodiments the housing is adapted such that when connected the container and the syringe are aligned adjacent one to another to provide a small footprint and convenient transport and storage solution.

In some embodiments the housing is formed in the manner of a handle comprising the recess. The recess may provide an opening at a first end of the handle. The axis of the handle may curve at the opposite end from the opening so as to present 1 the central axis of the container connection parallel to the axis of the recess. The fluidic pathway from the container to the fluidic connection may pass through a 180 degree change in orientation.

In some embodiments the device is adapted to have a first stable standing orientation in which the container is substantially vertical and upright and a second stable standing orientation in which the device is inverted and in which the container is substantially vertical and inverted. Advantageously therefore the device is capable :". of compact and stable storage.

S.....

* 25 When in the second standing orientation liquid from the container is permitted to *:: drain to fill the connection and the fluid conduit when the fluidic pathway through the conduit is open, for example when movement of liquid in the container is actuated by r *: the syringe to pull through a valve at the fluidic connection.

30 Advantageously when in the first standing orientation the fluid conduit empties into the container.

In some embodiments the housing comprises a stand means in the form of a substantially planar stand region. In this way the housing is adapted to provide the said second stable standing orientation for the device with the container substantially vertical and inverted.

In some embodiments the device is sized to fit with a specified container such that with the container and the recess cap in place the base of the container and the end of the recess cap are co-planar such that the device stands in the first stable standing orientation on both the bottom of the container and the outer end of the recess cap.

By child-proof lock means is meant a closure that resists a simple unscrew-to-open action. In such means typically a second action is needed to unscrew the closure, for example force exerted axially on the closure while turning; or for example force exerted radially on the closure while turning: or for example the need to align the closure in a specific rotational position in order to achieve an axial movement, which may then allow removal of the closure or a subsequent unscrewing action. Such closures are known in the art, and a number of suitable closures are adapted to be suitable for inclusion in the device of the invention. The first child-proof lock means provided at the connection between the container and the housing is adapted such that the closure forming part of the housing remains substantially stationary while in use, while the container is rotated. In this application, child-proof lock means in which an axial force is applied in combination with a rotatory movement to remove the container are particularly suitable.

Commercially available closure systems are for example available under the trade names Clic-loc (RTM) and Saf-loc (RTM) * 25 In some embodiments a child-proof lock means comprises a push-to-rotate mechanism in which the container or cap is pushed towards the housing in order to unscrew the container or cap. In some embodiments the child-proof lock means is a die-bc (RTM) or Saf-loc (RTM) mechanism. * ** * * * * *

* 30 In some embodiments the second child-proof lock means differs from the first means.

In some embodiments the second child-proof lock means is adapted to require the cap to be squeezed radially in order to be unscrewed.

In some embodiments the recess comprises a transparent material such that the syringe scale may be read when the syringe is in position within the recess.

In use, a container has its cap removed and is screwed into place upwards into the connection with the conduit extending below the liquid level in the container; the recess cap is removed and, if one is not already present, a syringe is slid into the recess and fitted to the fluid connection; the syringe plunger is manually withdrawn drawing liquid through the conduit and connection into the syringe. When the chosen amount has been filled into the syringe the syringe is removed from the recess, the valve closes automatically and the medicine is administered. The syringe may then be washed for reuse or disposed of; the syringe or a new one is inserted into the recess and the fluidic connection and the recess cap is replaced. Liquid medicine may remain in the conduit after first use, and is contained within the conduit by the valve means. Alternatively the container may accept the fluid, for example by a loosening of the container's screwthread fit, and consequent allowance of vacuum release.

In this way the device provides a convenient means to dispense liquid medicine from a bottle using an oral syringe, allowing the syringe to be connected to the bottle while protecting the connection with child-proof locking means. The syringe may be left connected to the bottle between dispenses or may be removed, and the fluidic connection to the bottle left disconnected, in both cases access to the fluidic connection being protected by the second child-proof lock means.

In preferred embodiments the device comprises a cut-off valve means in the fluidic pathway through the conduit and the fluidic connection.

* 25 In some embodiments the valve means is adapted to close the fluidic pathway when :::: the housing is oriented in a first and second ranges of orientations and to open it when the impelled by the syringe or in response to other pressure variations, wherein the valve comprises a dosing valve formed of a resiliently deformable material such as rubber or silicone with a split or other expandable lacuna. ** . * . * *e

In some other embodiments the valve means is adapted to close the fluidic pathway when the device is in the vertical standing orientation and to open the fluidic pathway when the device is in an orientation different from the standing orientation.

In some embodiments the valve means comprises a ball-valve actuated by gravity, the ball valve being adapted to close the fluidic pathway when the device is standing upright.

In some embodiments the valve is adapted to open when the device is turned upside down.

In preferred embodiments the valve is a check valve adapted to open when fluid flow is actuated by the syringe and to close when such actuation ceases.

In some embodiments the check valve comprises a spring loaded seal component adapted to close the fluidic pathway through the valve and to open in response to a pressure differential across the valve, for example as created by the syringe.

In some embodiments the valve is a manual valve adapted to be operated by a user.

In some embodiments the valve is provided as part of the fluidic connection.

In some embodiments the fluidic connection is adapted to receive the nozzle of a standard syringe.

In some embodiments the device further comprises a syringe and a hollow spigot component adapted to mount on the syringe nozzle, the spigot component and the * , fluidic connection being adapted to form a fluid-tight connection. * 25

In some embodiments the device comprises a syringe comprising a spigot component permanently attached to the syringe nozzle.

:.". In some embodiments the device comprises a syringe having a modified spigot configuration adapted to form a fluid-tight connection to the fluid connection.

In some embodiments the spigot comprises a tapering frustoconical exterior surface and the fluidic connection comprises a tapering frustoconical interior surface adapted to seal to the spigot surface.

In some embodiments the spigot comprises a raised circumferential profile at the apex of the frustoconical surface adapted to interfit with an 0-ring provided within the fluidic connection.

In preferred embodiments the interfit is achieved by a resiliently deforrnable 0 ring1 interfitting with a lipped syringe nozzle head.

In some embodiments the device comprises some or all of the following features: The cap may be coloured and may be provided in a range of colours, for example to differentiate the medicine in a one device from that in another.

The recess may comprise a window in the wall of the recess aligned axially along the wall so as to allow the syringe to be seen. In this way the scale on the syringe and the position of the syringe plunger may be seen while the syringe is filled.

The recess may be sized to accommodate a specific syringe size, for example to guide use of a specified syringe.

The recess may be sized to accommodate a syringe with a portion projecting from the recess, the cap being adapted to cover the projecting portion. In this way the syringe may be made easily accessible for removal from the recess. *. **

The recess and cap may be adapted such that the cap is closable over the specified fl..*.

* 25 syringe only if the syringe is properly located within the fluidic connection. In some embodiments the axial length of the volume defined by the recess and the cap is chosen to be sufficient to accommodate the syringe only when the spigot is fully home within the fluidic connection. In some embodiments the cap comprises a cap r *:* recess adapted to fit over the head of the syringe plunger only when the syringe is *". 30 axially positioned within the recess by the syringe nozzle or spigot being located within the fluidic connection. In some embodiments the fluidic connection is provided axially symmetrically located with the recess, and the cap recess is adapted to be axially aligned with the fluidic connection when in place on the housing.

The recess cap may comprise a tether connected to the housing, so as to prevent loss of the cap.

According to a second aspect the invention provides a method for dispensing a liquid using a device of the invention comprising the steps of: filling a container holding the liquid to the container connection; orienting the device to the second orientation position with the container inverted; and using a syringe located in the recess and connected to the fluidic connection within the recess to withdraw liquid from the container via the conduit.

In some embodiments the method comprises the additional step of removing a recess cap from the recess.

In some embodiments the method comprises the additional step of introducing a syringe into the recess and connecting it to the fluidic connection.

In some embodiments the method comprises the additional step of adding a spigot forming part of the invention to the syringe nozzle.

In some embodiments the method comprises the additional step of returning the device to the first vertical orientation after use.

Brief Descriøtion of Figures 0* *.

* * Figure 1 shows an isometric view of a first embodiment of the invention. 0*q..

* 25 Figure 2 shows a cross-section of the embodiment shown in figure 1 Figure 3 shows an isometric view of the embodiment shown in figure 1 with the stock bottle removed Figure 4 shows an exploded isometric view of the embodiment shown in figure 1 with a syringe adapted for use with the embodiment, and *: 30 Figure 5 shows an isometric view of the embodiment with syringe in place.

Detailed Description of Figures

Referring to figures 1 to 4 an embodiment of a device for dispensing a liquid according to the invention comprises: A housing 10 comprising: (i) a connection 12 for a screw-top liquid container 14, the connection comprising a threaded receiving location 16, a seating face 18 adapted to receive the lip 20 of the container, and a first child-proof lock means adapted to control removal of the container from the housing, (ii) a conduit 24 extending from the connection within the housing, (iii) a recess 26 adapted to receive a syringe 28, the recess comprising an outer end 30 and an inner end 32, (iv) a fluidic connection 34 at the inner end of the recess adapted to receive a nozzle 36 provided on a syringe, the fluidic connection being in fluidic communication with the conduit 24, and a removable cap 38 to cover the recess, the cap and housing together comprising a second child-proof lock means adapted to control removal of the cap from the housing.

The fluidic connection comprises a dosing valve, formed of resiliently deformable material. The recess includes a deformable rubber sealing 0 ring 13.

In this embodiment the housing is adapted such that when connected the container and the syringe are aligned adjacent one to another, the housing being formed in the manner of a handle 40 comprising the recess, the recess opening at a first end of the handle, the axis of the handle curving at the opposite end from the opening so as to present the central axis of the container connection parallel to the axis of the recess, the fluidic pathway from the container to the fluidic connection passing through a 180 degree change in orientation. *.o.. * 25

In this embodiment the device is adapted to have a first stable standing orientation in which the container is substantially vertical and upright and a second stable standing orientation in which the device is inverted and in which the container is substantially vertical and inverted. * S * 30 * * .

* In this embodiment the housing comprises a stand means in the form of a substantially planar stand region 42. In this way the housing is adapted to provide the said second stable standing orientation for the device with the container substantially vertical and inverted. In this position liquid from the container may drain to fill the connection and the fluid conduit when the fluidic pathway through the conduit is open, for example when movement of liquid in the container is actuated by the syringe.

In this embodiment the device is sized to fit with a specified container such that with the container and the recess cap in place the base 44 of the container and the end 46 of the recess cap are co-planar such that the device stands in the first standing orientation on both the bottom of the container and the outer end of the recess cap.

In this embodiment both the first and the second child-proof lock means comprise a push-to-rotate mechanism in which the container or cap is pushed towards the housing in order to unscrew the container or cap. The child-proof lock means may be a Clic-loc (RTM) or Saf-loc (RTM) mechanism.

In this embodiment the recess comprises a transparent window 48 such that the syringe scale may be read when the syringe is in position within the recess.

In this embodiment the device further comprises the valve provided as part of the fluidic connection, in the fluidic pathway 52 through the conduit and the fluidic connection, the valve means being adapted to open the fluidic pathway when the syringe actuates variation in pressure either side of the valve and to close the fluidic pathway when the device is in the first vertical standing orientation with the device standing on the base of the container and the end of the recess cap; and the syringe is not present. * S * * .

I 1.5*1

* 25 In some embodiments the valve means comprises a ball-valve actuated by gravity, the ball valve being adapted to close the fluidic pathway when the device is standing upright in the first vertical standing orientation.

* In an alternative embodiment the valve is a check valve adapted to open when fluid *: 30 flow is actuated by the syringe and to close when such actuation ceases, the check valve comprises a spring loaded seal component adapted to close the fluidic pathway through the valve and to open in response to a pressure differential across the valve, for example as created by the syringe.

In this embodiment the device further comprises a syringe 28 and a hollow spigot component 56 adapted to mount on the syringe nozzle 58, the spigot component and the fluidic connection being adapted to form a fluid-tight connection, the spigot further comprising a raised circumferential profile 64 at the apex and adapted to interfit with an 0-ring 66 provided within the fluidic connection.

The housing comprises an outer shell 70 having an internal structure comprising ribbing 72 to provide a rigid, lightweight structure as known in the art of injection moulding. The housing is formed from a first 74 and a second 76 housing portion adapted to join at a join line 78. In this way the housing may be conveniently moulded in two halves that may have the conduit, valve and fluidic connection inserted within them as separate components, the halves then being closed. The housing may be mounded in a first colour and the recess cap may be moulded in a second coloured material as suits the application. The housing and recess cap may be formed from mouldable polymers as known in the art.

The device may be sized to suit chosen containers and syringe sizes. In some embodiments the container is a 50m1, 60m1, lOOmI or a l5Oml bottle. In some embodiments the syringe has a capacity of 2.5nil, 5ml or 7.5m1. The device may be provided in the following non-limiting embodiments: Container volume (ml) Syringe dose capacity (ml) 2.5, 5, 7.5, 10 2.5. 5, 7.5, 10 5, 7.5, 10 5,7.5, 10 * * a * S

S

* S* a 55 * 20 The invention has been described by way of examples only and it will be appreciated *::: : that variation may be made to the above-mentioned embodiments without departing from the scope of invention. Firstly it will be understood that any features described in relation to any particular embodiment may be featured in combinations with other embodiments. a. * * * a * rt

With respect to the specification therefore, it is to be realised that the optimum dimensional relationships for the parts of the invention, to include variations in size, materials, shape, form, function and manner of operation, assembly and use1 are deemed readily apparent and obvious to one skilled in the art, and all equivalent relationships to those illustrated in the drawings and described in the specification are intended to be encompassed by the present invention.

Therefore, the foregoing is considered as illustrative only of the principles of the invention, with variation and implementation obvious and clear on the basis of either common general knowledge or of expert knowledge in the field concerned. Further, since numerous modifications and changes will readily occur to those skilled in the art, it is not desired to limit the invention to the exact construction and operation shown and described, and accordingly, all suitable modifications and equivalents may be resorted to, falling within the scope of the invention as set out in the accompanying claims. *. * * S S * * * * *e*e * * * ** S ** S. * * * S *. S * * St.

Claims

Claims 1. A device for dispensing a liquid comprising: a housing comprising: (i) a liquid-tight connection for a screw-top liquid container, the connection comprising a threaded receiving location, a sealing face adapted to receive the lip of the container, and a first child-proof lock means adapted to control removal of the container from the housing; (ii) a conduit extending from the connection within the housing; (iii) a recess adapted to receive a syringe, the recess comprising an outer and an inner end; and (iv) a fluidic connection at the inner end of the recess adapted to receive a nozzle provided on a syringe, the fluidic connection being in fluidic communication with the conduit; and a removable cap to cover the recess, the cap and housing together comprising a second child-proof lock means adapted to control removal of the cap from the housing.
2. A device according to claim I wherein the housing is adapted such that when connected the container and the syringe are aligned adjacent one to another.
3. A device according to claim 2 wherein the housing is formed in the manner of a handle comprising the recess, the recess providing an opening at a first end * of the handle, and in which the axis of the handle curves at the opposite end " 25 from the opening so as to present the central axis of the container connection parallel to the axis of the recess, the fluidic pathway from the container to the ** : fluidic connection passing through a 180 degree change in orientation.r
4. A device according to any claim above wherein the device is adapted to have a first stable standing orientation in which the container is substantially vertical and upright and a second stable standing orientation in which the device is inverted and in which the container is substantially vertical and inverted.
5. A device according to any claim above sized to fit with a specified container such that with the container and the recess cap in place the base of the container and the end of the recess cap are co-planar such that the device stands in the first stable standing orientation on both the bottom of the container and the outer end of the recess cap.
6. A device according to any claim above wherein the child-proof lock means is a closure in which an axial force is applied in combination with a rotatory movement to disconnect the closure.
7. A device according to any claim above wherein the child-proof lock means is a Clic-loc (RTM) or Saf-loc (RTM) mechanism.
8. A device according to any claim above wherein the second child-proof lock means differs from the first child-proof lock means.1 5
9. A device according to any claim above wherein the recess comprises a transparent material such that the syringe scale may be read when the syringe is in position within the recess.
10. A device according to any claim above further comprising a cut-off valve means in the fluidic pathway through the conduit and the fluidic connection.
11. A device according to claim 10 wherein the valve means is adapted to close the fluidic pathway when the housin9 is oriented in a first range of orientations and to open it when the housing is oriented in a second range of orientations. * 25*::::
12. A device according to claim 11 wherein the valve means is adapted to open the fluidic pathway when inverted difference in pressure to either side of the valve is accomplished. I. ** *s 30
13. A device according to claim 11 wherein the valve means is adapted to close the fluidic pathway when the device is in the first standing orientation with the container standing on its base.
14. A device according to any of claims 10 to 13 wherein the valve means comprises a ball-valve actuated by gravity.
15. A device according to any of claims 10 to 13 wherein the valve means is a theck valve adapted to open when fluid flow is actuated by the syringe and to close when such actuation ceases.
16. A device according to claim 15 wherein the check valve comprises a spring loaded seal component adapted to close the fluidic pathway through the valve and to open in response to a pressure differential across the valve.
17. A device according to claim 15 wherein the check valve comprises deformable material adapted to close the fluidic pathway through the valve and to open in response to a pressure differential across the valve.
18. A device according to any of claims 10 to 13 wherein the valve means is a manual valve adapted to be operated by a user.
19. A device according to any of claims 10 to 16 wherein the valve means is provided as part of the fluidic connection.
20. A device according to any claim above wherein the valve means comprises the fluidic connection is adapted to receive the nozzle of a standard syringe. ** * * * * *21. A device according to any claim above further comprising a syringe and a *fl.s* * hollow spigot component adapted to mount on the syringe nozzle, the spigot component and the fluidic connection being adapted to form a fluid-tight * * connection.22. A device according to any claim above comprising a syringe having a spigot *. component permanently attached to the syringe nozzle, S ** 23. A device according to claim 20 or claim 21 wherein the spigot comprises a tapering frustoconical exterior surface and the fluidic connection comprises a tapering frustoconical interior surface adapted to seal to the spigot surface.24. A device according to any claim above wherein the recess and cap are adapted such that the cap is closable over the specified syringe only if the syringe is properly located within the fluidic connection.25. A device according to claim 24 wherein the axial length of the volume defined by the recess and the cap is chosen to be sufficient to accommodate the syringe only when the spigot is fully home within the fluidic connection.26. A method for dispensing a liquid using a device of the invention comprising the steps of: fitting a container holding the liquid to the container connection; orienting the device to the second orientation position with the container inverted; and using a syringe located in the recess and connected to the fluidic connection within the recess to withdraw liquid from the container via the conduit.27. A method according to claim 26 comprising the additional step of removing a recess cap from the recess.28. A method according to claim 26 or 27 comprising the additional step of introducing a syringe into the recess and connecting it to the fluidic connection. * * * * **....: 29.A method according to any of claims 26 to 28 comprising the additional step * * of adding a spigot forming part of the invention to the syringe nozzle. **t * * * *. * ** ** * S * * S ** S * SS * *5