GB2511408A

GB2511408A - Massage oil for deep sleep

Info

Publication number: GB2511408A
Application number: GB1323139.4A
Authority: GB
Inventors: Kyung-Bok Lee; Young-Sook Kang
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-01-21
Filing date: 2013-12-31
Publication date: 2014-09-03
Anticipated expiration: 2033-12-31
Also published as: GB2511408B8; GB2511408B; GB201323139D0; WO2014112676A1; KR101296920B1; CN105188726A

Abstract

A massage oil for deep sleep comprising a mixture of (i) a valerian oil, (ii) a lavender oil, (iii) a chamomile roman oil as well as a base oil, characterised in that oils (i), (ii) and (iii) are present in a combined total of 2-5% by weight of the said mixture with respect to the base oil. The weight ratio of valerian oil, lavender oil and chamomile roman oil present respectively is 1: 1.5-2.5: 1.5-2.5. The massage oil has an excellent effect on treating insomnia and in particular, exhibits a remarkable effect of relieving sleep disorders in dementia patients.

Description

MASSAGE OIL FOR DEEP SLEEP

TECHNICAL FIELD

[0001] The present invention relates to a massage oil for deep sleep, and more particularly, to a massage oil for deep sleep in order to relieve sleep disorders.

BACKGROUND

[0002] Generally, insomnia, also a sleep disorder, is a symptom which does not allow one to maintain an adequate amount of steep time or quality of sleep such that one cannot accumulate enough energy and immunity to sustain a normal life.

1 0 Insomnia leads to a low quality of life, a decrease in productivity at work, and low drive. Risk factors for insomnia may be psychological and mental factors such as advanced age, chronic diseases, pain, night work, concerns and stress, an inadequate sleep environment, and drugs such as cough medicine, diet drugs, and steroids.

Hyperstenia of a corticotrophin releasing factor (CRF) neuron is a key factor in chronic insomnia. Signs of insomnia include lethargy, a feeling of fatigue, weakness of memory and concentration, and an irascible temper.

[0003] Insomnia is divided into primary insomnia and secondary insomnia.

Secondary insomnia refers to sleep disorders induced by health problems such as dementia or depression. Almost one third of American adults do not get enough sleep, and about 10 to 15% of them complain of insomnia (Michael 0, et al. 2006).

Insomnia increases with age so that 45°i of seniors aged 65 to 79 have experienced insomnia. A change in sleep architecture occurs as we get older or having sleep disorders. As people get older, slow-wave sleep (hereinafter, referred as "SWS") is decreased, and rapid-eye-movement (REM) sleep is decreased by 2 to 3% (Gagnon J. F, et Al., 2008). The sleep pattern of seniors shows an increased incidence of waking up at night and decreased SWS. Dementia patients have been increasing two-fold each year and have increased by 25% until 2010 (Jeffery L, C. et al, 1999). 25 to 35% of Alzheimer patients have steep disorders (Gabelle A. et al. 2010). Brain degeneration in dementia increases the severity and frequency of sleep disorders.

Also, sleep stages I and 2 are increased and sleep stages 3 and 4, REM sleep, and total sleep time are decreased, Behavioral problems lead to sleep disorders, which cause one to rise earlier and get more sleep than usuaL The frequency of waking up at night is increased (Denis S. et al., 2009).

[0004] Sleep has a periodical pattern and is performed in four stages. Sleep architecture consists of AWS, REM, NREM, and SWS. REM sleep is exhibited every 90 minutes to 120 minutes, which corresponds to 20-25% of total sleep.

During REM sleep, so-called paradoxical sleep, sympathetic nerves are activated.

There is no dreaming during NREM sleep. NREM sleep corresponds to 75-80% of total sleep. SWS, also referred as deep sleep, corresponds to sleep of stages 3 and 4.

All stages of sleep are controlled by the hypothalamus. Thus, sleep architecture is selected as an objective tool for sleep disorders, In a study in about 1960 by Juvet et al., sleep and waking up were represented by a certain neurotransmitter.

[0005] With dementia, choline is inactivated by the degeneration of the cerebral cortex and cholinergic neurons. The loss of stages 3 and 4 is shown in dementia.

Histamine, glutamine, catecholamine, and cortisol affect waking up from sleep.

Moreover, a choline system relates to the activation of choline and a woken-up state from sleep. However, 5-HT, GABA, and adenosine play an important role in inducing SWS (Jones, BE., 2006). In light of this, a neuroendocrine hormone serves as a biomarker for evaluating insomnia. SWS has ties to a decrease in cortisol concentration in blood, and sleep deprivation relates to an increase in cortisol concentration in blood.

[0006] The activation of sympathetic nerves is increased during REM sleep and decreased during NRETVI and SWS sleep (Alexandros N. et al., 1998). In a study by Andrea R. et al., a sleep parameter of seven patients with severe primary insomnia showed a correlation with a cortisol concentration in blood for the first four hours (21:00-0] :00) measured at night. In a study by Johns, MW. et al,, cortisol concentration was increased in 24-hour urine excreted from people with a lack of sleep. Also, in a study by Vgontzas, A. N. et al., a cortisol concentration in 24-hour 1 0 urine showed a positive correlation to the total wake time in mild insomnia cases (Andrea R., 2002). In a study by Alexandros N, et al,, the concentration of cortisol, norepinephrine (NE), DOPAC, DHPG, and, GH in 24-hour urine showed a positive relation with the total wake time in 15 insomnia patients (Alexandros N. et al., 1998).

A sleep GABA receptor is also present in PPT, and suppresses REM sleep by 1 5 suppressing the activation of the REM-ON cell through the activation of a GABAB receptor in a GABA system (Jagadish u. et al,, 2004). Insomnia is treated with sleeping drugs such as benzodi azepines or nonbenzodiazepines (zolpidem, zolpi clone, and eszopiclone).

[0007] The consistent use of benzodiazepinie-based sleeping drugs, however, results in drug dependence, bad quality of sleep, deterioration in cognitive ftmnction, and a decreased drug effect, and therefore, many people use complementary and alternative medicines. For such complementary and alternative medicines, there are various therapies such as acupuncture, massage, yoga, and herb therapy which employs medicinal herbs and plant.

[0008] As an conventional composition using herb therapy for relieving insomnia, "composition of fermented fatty oregano" is disclosed in Korean Patent Publication No.l0-2008-004L156. The composition of fennented fatty oregano is obtained by separating liquid through pulverization and filtration after fermenting 65 wt% of fresh oregano, and 35 wt% of a grape seed oil which is a vegetable and edible oil at 35°C for 30 days, wherein the fresh oregano is obtained by: harvesting an oregano plant (the stem, leaf, and flower); removing impurities; and pulverizing the resultant while preventing the excretion ofjuice, [0009] However, while the effect of treating insomnia in alternative medicine such as acupuncture, massage and yoga, as well as conventional herb therapies has 1 0 been acknowledged to some degree, it is unclear that the effects are significant, and particularly, its effects on deep sleep of dementia patients with sleep disorders are not known.

SUMMARY

1 5 [0010] To resolve conventional problems described above, the present invention is directed to having excellent effect of treating insomnia and relieving secondary insomnia induced by psychiatric diseases such as dementia, schizophrenia, neurasthenia, and depression.

[0011] To resolve the problems above, according to one aspect of the present invention, a massage oil for deep sleep is provided, wherein the massage oil for deep sleep contains a valerian oil, a lavender oil, and a chamomile roman oil by mixing at a weight ratio of 1:1.5-2.5:1.5-2.5, and a content of the mixture consisting of the valerian oil, the lavender oil, and the chamomile roman oil is 2 to 5 wt% with respect to a base oil.

BRIEF DESCRIPTION OF THE DRAWINGS

[0012] FIG. I is a diagram illustrating a massage oil for deep sleep, according to an example of the present invention,

DETAILED DESCRIPTION OF EMBODIMENTS

[0013] The present invention may be variously modified and may include various examples. However, particular examples are exemplarily illustrated in the drawings and will be described in detail. It will be understood that the particular examples do not limit the present invention rather encompasses all variations, equivalents and substitutes included in the sprit of the present invention.

[0014] Hereinafter, examples according to the present invention will be described in detail with reference to the accompanying drawings. Lilce reference numerals denote same or coresponding elements regardless of figure numbers, and repetitive description therefor will be omitted herein.

[0015] FIG. 1 is a diagram illustrating a massage oil for deep sleep, according to an example of the present invention.

[0016] Referring to FIGI, the massage oil according to an example of the present invention contains a valerian oil, a lavender oil and a chamomile roman oil after mixing. The massage oil according to the present invention means that a mixture of a valerian oil, a lavender oil, and a chamomile roman oil may be included by containing these oils after mixing, and in addition, the massage oil may additionally contain other oils or a material for massage, etc. Also, the mixture of the valerian oil, the lavender oil, and the chamomile roman oil may be mixed in a base oil. As an example of the base oil, ajojoba oil may be used. In this case, an oil which has little effect or no function on deep sleep may be used as the base oil, arid various oils besides the jojoba oil mentioned above may be used as well. As such, the valerian oil is mixed with the lavender oil and the chamomile roman oil to thereby create a synergyeffect of relieving or treating insomnia, particularly secondary insomnia induced by psychological diseases such as dementia, schizophrenia, neurasthenia, and depression by exhibiting synergy [0017] When the valerian oil, the lavender oil, and the chamomile roman oil are diluted in the base oil, the massage oil for deep sleep according to an example of the present invention may contain the mixture of the valerian oil, the lavender oil, and the chamomile roman oil at 2 to 5 wt% with respect to the base oil, for example a jojoba oil, This is because if a content of the mixture of a valerian oil, a lavender oil, and a chamomile roman oil exceeds 5 Wt9'O with respect to the base oil, skin irradiation is induced, and if a content of the mixture is less than 2 wt%, deep sleep effect is significantly reduced, As such, the massage oil for deep sleep according to an example of the present invention contains the valerian oil, the lavender oil and the chamomile roman oil by diluting these oils in the joj oba oil, wherein the total amount of the valerian oil, the lavender oil, and the chamomile roman oil may be contained at 2 to 5 wt% based on the weight of the jojoba oil, For an example, the mixture of the valerian oil, the lavender oil, and the chamomile roman oil may be contained at 3 wt% with respect to the base oil, e.g. jojoba oil.

[0018] Also, the valerian oil, the lavender oil, and the chamomile roman oil may be mixed at a weight ratio of 1:1,5-2.5: 1.5-2.5, for an example, valerian oil, lavender oil, and chamomile roman oil may be mixed at a weight ratio of 1:2:2.

[0019] The valerian oil is a natural oil extracted from a root of Va/er/au (?fficiulafis and may contain, as ingredients, 22 to 26 wt% of bornyl acetate and 11 to 15 wt% of valeranone sesquiterpenes, and, for an example, may contain 23.92 wt% of bornyl acetate, 1243 wtYo of valeranone sesquiterpenes and a small amount of valerenic acid derivertives, [0020] The lavender oil is a natural oil extracted from Lcivencler angustfo/ici, and may contain, as ingredients, 35 to 41 Wt% of linalool which is a monoterpene, and 38 to 46 wt% of linalyl acetate, and for an example, may contain 38% of linalool, 42% of linalyl acetate, and a small amount of I.8-cineole (camphor).

[0021] The chamomile roman oil is a natural oil extracted from a flower of (hwnaernelwn nob/Ic' L., and may contain, as ingredients, 14 to 18 wt% of methyl-angelate, 10 to 14 wt% of 3-methylpentyl isobutyrate, and 4 to 25 wt% of angelate, and for an example, may contain 16 wt% of methyl-angelate, 12 wt% of 3-methylpentyl isobutyrate, 15 wt% of angelate and a small amount of apigenin glycoside which is a flavonoid.

[0022] The jojoba oil is unsaturated alcohol extracted from a seed of Simmonclsia chinc'ns/s, [0023] In examples I to 3 according to the present invention and comparative examples I to 4, the presence or albescence of effect on sleep and the degree of the effect were compared using biomarkers which are serotonin in blood, and NE and cortisol in urine.

[0024] EXAMPLE I

[0025] Ajojoba oil and a blending oil A were mixed at a weight ratio of 100:3, wherein the blending oil A was obtained by mixing a valerian oil, a lavender oil, and a chamomile roman oil at a weight ratio of 1:2:2. The jojoba oil, the valerian oil, the lavender oil, and the chamomile roman oil used herein were products of Absolute, Co., in U.K. The jojoba oil was unsaturated alcohol extracted from a seed of Simmondsia chinensis, Also, the valerian oil was a natural oil extracted from a root of Valer/an of/ic/nails, and included 23.92 wt% of bornyl acetate, 12.43 wt% of valeranone sesquiterpenes, and a small amount of valerenic aicd derivatives. Also, the lavender oil was a natural oil extracted from Lavender angustifolia, and included 38% of linalool, 42% of linalyl acetate, and a small amount of 1. 8-cineole (camphor).

Also, the chamomile roman oil was a natural oil extracted from a flower of Chamaemeiurn nob/ic L., and included 16% of methyl-angelate, 12% of 3-methylpentyl isobutyrate, 15% of angelate, and a small amount of apigenin glycoside.

[0026] EXAMPLE 2

[0027] Ajojoba oil and a blending oil B were mixed at a weight ratio of 100:3, wherein the blending oil B was obtained by mixing a valerian oil, a lavender oil, and a chamomile roman oil at a weight ratio of 1:3:1. The jojoba oil, the valerian oil, the lavender oil, and the chamomile oil used herein were products of Absolute, Co., in U.K. The jojoba oil was unsaturated alcohol extracted from a seed of Sirnrnondsia chinensis. Also, the valerian oil was a natural oil extracted from a root of Vaierian offecinails, and included 23.92 wt% of bornyl acetate, 12.43 wt% of valeranone sesquiterpenes, and a small amount of valerenic aicd derivatives, Also, the lavender oil was a natural oil extracted from Lavender angusiifoiia, and included 38% of linalool, 42% of linalyl acetate, and a small amount of 1.8-cineole (camphor). Also, the chamomile roman oil was a natural oil extracted from a flower of Charnaerneium nob/ic L., and included 16% of methyl-angelate, 12% of 3-methylpentyl isobutyrate, 15% of angelate, and a small amount of apigenin glycoside.

[0028] EXAMPLE 3

[0029] Ajojoba oil and a blending oil C were mixed at a weight ratio of 100:3, wherein the blending oil C was obtained by mixing a valerian oil, a lavender oil, and a chamomile roman oil at a weight ratio of 1:1:3. The jojoba oil, the valerian oil, the a lavender oil, and the chamomile roman oil used herein were products of Absolute, Co., in U.K. The jojoba oil was unsaturated alcohol extracted from a seed of Simmoncisia chinensis. Also, the valerian oil was a natural oil extracted from a root of Va/er/ten ojilcinalis, and included 23.92 wt% of bornyl acetate, 12.43 wt% of valeranone sesquiterpenes, and a small amount of valerenic aicd derivatives. Also, the lavender oil was a natural oil extracted from Lavender angustifolia, and included 38% of linalool, 42% of linalyl acetate, and a small amount of I.8-cineole (camphor).

Also, the chamomile roman oil was a natural oil extracted from a flower of (haenaerne/wn nob//c L., and included 1 6% of methyl-angelate, 12% of 3-methylpentyl isobutyrate, 15% of angelate, and a small amount of apigenin glycoside.

[0030] COMPARATIVE EXAMPLES 1 TO 4 [0031] Comparative example used a jojoba oil, and comparative example 2 used a diluent of a valerian oil which was diluted in ajojoba oil at a weight ratio of 3:100. Comparative example 3 used a diluent of a lavender oil which was diluted in a jojoba oil at a ratio of 3:100, and comparative example 4 used a diluent of chamomile roman oil which was diluted in a jojoba oil at a weight ratio of 3:100, Here, the jojoba oil, the valerian oil, the lavender oil, and the chamomile roman oil were undiluted, cmde liquid which is the same as oils used in examples 1 to 3, respectively.

[0032] Experimental subject [0033] 13 dementia patients, who were diagnosed dementia by a doctor and entered a nursing home, used a urine bag or movable urinals and showed sleep disorders, are subjected to experiments. The present study has been approved through examination of University Bioethics Committee, and persons who had a consent of a legal guardian noticed to University Bioethics Committee are subjected to the present study. An age bracket of persons subjected to the experiment ranged from 7] to 94, and an average age was 836. The male to female ratio was 8:5, [0034] Measuring tool [0035] Insomnia severity index herein was insomnia severity index developed by Morin which was translated by Korean Sleep Research Society and consists of seven questions in five-point scale. For confidence, Cronbach's alpha=O.89.

[0036] O-7=no clinically significant insomnia [0037] 8-14=subthreshold insomnia [0038] 15-21 clinical insomnia (moderate severity) [0039] 22-28=clinical insomnia (severe) [0040] Sleep of participants were checked every night, and specifically, an observer observed and wrote frequency of naps, whether the participants woke up during sleep at night or not, and total amount of sleep time every day.

[0041] Study method 1 5 [0042] Before and after performing two weeks massage, sample collection was performed and a subject filled in a questionnaire and a sleep diary. Massage was performed two hours prior to sleep for two weeks in an order of comparative examples 1 to 4 and examples 1 to 3 described above. Massage was performed on the subject for two weeks with each massage oil, and then the subject has a break time of two weeks, [0043] Sample collection and treating method [0044] Prior to massage, a skin test, and blood pressure and body temperature measurement were performed. Blood was collected prior to massage and also collected at about nine o'clcok of a day after performing two-weeks massage, and urine was then collected for 24 hours from a day before. Thereafter, analysis was performed on concentrations, at before and after experiment, of 5-HI, which is a neurotransmitter, in blood, of NE and of free cortisol in the urine collected for 24 hours. To quantify 5-I-IT in a blood sample, 3 ml of blood was collected in a SSI tube to which EDTA was added, then clotted for 30 minutes, and thereafter centrifuged at 3,000 rpm for 10 minutes. After rapid centriftigation, on'y 1.5 ml of semm was transferred to a serum separation tube, and then immediately cryopreserved, After storing for N days, the serum was thawed. In the case of free cortisol, at least 1 ml of 24-hour urine was transferred to a serum separation tube or a 1.5 ml tube without a preservative and the samp'e was cryopreserved. In the case of 1 0 urine NE, at least S ml of 24-hour urine was transferred to a serum separation tube or a 1.5 ml tube after adding 2% of 6N HC1 with respect to an amount of a specimen, and then sample was cryopreserved.

[0045] Method for analyzing sample [0046] IIPLC system and condition [0047] Method for analyzing 5-HT: Sample was analyzed by HPLC (ClinRep®Complete kit, Shimadzu/l-litachi). Analyzing conditions were as follows.

[0048] Column was a ClinRep serotonin column, and a temperature of a column oven was 30°C. A flow rate was 1.Oml/min, an amount of an injection was 2Ojil, and an injection interval was 10 minutes. As an electrochemical detector, Recipe detector EC3000 was used. Retention time of 5-HT was about 4.9 minutes and that of TS was about 6.3 minutes. IS was analyzed under conditions of 2 ml of 50% MeOH for a moving phase, and N-methylserotonin 100 ng.

[0049] Method for analyzing free cortisol and NE of 24-hour urine: A sample was requested to Green Cross Cooperation Research Center and analyzed through a radioimmuno-assay.

[0050] Statistical processing [0051] All experimental results were shown as average ± standard error, Data analysis was performed by using paired t-test. By comparing a difference between before and after performing each oil massage in the same group, if p<O.O5, the result was considered significant.

[0052] Study result [0053] Subjects of the present study were 13 persons in total who were diagnosed as dementia by a doctor and entered a nursing home. A male to female ratio corresponded to 8:5. An average score of mini-mental state examination (MMSE-K: total point is 30; 24 points or more correspond to normal; 20-23 points correspond to suspected dementia; tS-t9 points correspond to suspected mild dementia; N points or less correspond to suspected severe dementia) was 9,2±1.9 which corresponds to suspected severe dementia, An average age was 81.6±2,5, Neuropsychiatric iventor-y questionnaire (hereinafter, NPI-Q) is designed for 1 5 evaluating behaviors and neuropsychological disorders of dementia patients and measures severity of behavioral disorders shown by patients and stress of a guardian caused by the behavioral disorders, wherein the behavioral disorders shown by patients are 12 disorders; that is, delusion, hallucination, agitation, anxiety, apathy, hypersensitivity, happiness, derailment motor behaviors, disturbance of night behaviors, dysphoria, and disinhibition. NPI-Q consists of 12 questions in total.

High score means that the degree of a behavioral problem is severe, and stress of a guardian is high. An average score of NPI-Q was 6.6+1.3, and an average score of depression of seniors was 6. 1+1.2.

[0054] As shown in table 1 below, prior to massage with oils according to respective examples and comparative examples for a dementia patient: an average blood 5-HT concentration was 107+4 ng/day(normal value: 200 ng/ml or less); an average free cortisol concentration in 24-hour urine was 32.0±2,2 ug/day (normal value: 20-90 ug/day); an average NE concentration in 24-hour urine was 20,6±0.9 ug/day (normal value: 15-80 ug/day); an average frequency of naps for two weeks was 10.6+0.2; an average frequency of waking up for two weeks was 10.2±0.3; and 1St score was 17,1±0.5. Oils according to respective examples and comparative examples were used for massaging the same subject for two weeks, and then two weeks of a wash-out period was followed. For a concentration change before and after two-week massage, comparative example 3 showed a significant decrease in 1 0 free cortisol in 24-hour urine, while comparative example 4 showed a significant increase in NE in 24-hour urine. However, comparative examples 1 and 2 did not show a significant change in a blood 5-NT concentration and a concentration of neurotransmitter (NE, and free cortisol) in 24-hour urine before and after massage.

[0055] [Table 1]

<.;ii± <aip' 1 rI-p4r''-e Axir;o;9 t.Ofl1paL.it exi, I...,..

[ k" A -. -,-.. S< U " P, U "< <,ej, * I ± )* t" -t. .sfl 4±O. ."± 7 1 5 iI11h'iAf. :I1:.IiL. iJLI11.I.[I.

[0056] As shown in table 2 below, in consideration of a difference in neurotransmitter concentration between individuals, a concentration change rate between before-and after-massage, which was measured in each oil, an experimental group was compared with a concentration change rate in the jojoba oil, a control group. Comparative example 2 sho%ved a significant increase in 5-HT, and comparative example 3 showed a decrease in free cortisol in urine, Comparative example 4 showed an increase in 5-HT and a decrease in free cortisol.

[0057] [Table 2]

"1' %F..8'"iPIO -.. ,(? t 5 tN 5 4 Eta.. 8 pft4 \ ., .Sj t')'( 8 at -" C' teetc.crto. 11 *C\ Lk.4't..JS t.+tY mj.'.t. b [0058] According to tables 3 and 4 below, examples 1 to 3 exhibit a synergy effect of the valerian oil, the lavender oil, and the chamomile roman oil, In example 1, the valerian oil, which has bad smell, was introduced at a smallest proportion, while the lavender oil and the chamomile oil were mixed at a ratio of same amount, The oil in example 1, showed a significant increase in a blood concentration of 5-HT in a change between before and after, In a change rate compared with that before massage, the oil in example showed an increase in a 5-HT blood concentration by 0.64+0.05, which was a higher value than other oils, and a decrease in a free cortisol 1 0 concentration, and thus showed a better synergy effect than changes in individual oils.

The increasing rate is a value exhibiting a range of a normal level, and exhibits an effect which was increased by two times in comparison with the case after treating with valerian oil alone. Also, in accordance with a guidance for skin toxicity by International Federation of Aromatherapy and a guidance for cosmetic safety (FDA in USA), a containing ratio of an essential oil, was 3 wt?/b or less which is a standard for application, and therefore, in the delimited range according to the standard, the containing ratio in the blending oil A (oil used in example I) was an optimized ratio at which pharmacological efficacy can be expressed.

[0059] Although, the oil in example 2 did not change before and after massage, a concentration change rate of 5-HT between before-and after-massage in the oil of example 2 showed a significant increase, Also, a change of NE concentration in urine between before-and after-massage in the oil of example 3 showed a significant increase. However, concentration change rates of 5-HT, free cortisol, and NE between before-and after-massage were not changed. Therefore, it can be understood that the valerian oil, the lavender oil, and the chamomile roman oil exhibited a synergy effect on deep sleep, and the synergy effect was attributed to a mixing ratio. Particularly, it can be understood that, among all examples and comparative examples, example I exhibits the best change in a neurotransmitter which has an effect on sleep.

[0060] [Table 3]

-_________________ ______________________ -E-np?..Y . Ah' A 41 r' ) i2 C LN Pi U t---- -..l.,,1, S'' 4 r), $4t3 +

[0061] [Table 4]

[0062] According to the present invention, the massage oil for deep sleep has an excellent effect on treating insomnia and particularly exhibits a remarkable effect on relieving sleep disorder in a dementia patient.

[0063] More particularly, as described herein, it can be understood that a blood 5-HT concentration is significantly increased by the valerian oil contained at a specified ratio in a base oil, wherein the valerian oil is mixed with the lavender oil and the chamomile roman oil. An increase in the 5-HT neurotransmitter exhibits anti-depression, sleep, and anti-anxiety effects, It can be found that simply the mixture of the chamomile roman oil and the lavender oil does not lead to a significant increase in 5-HT. In the present invention, increasing a 5-HT concentration in blood becomes a major pharmacological mechanism. In the case of an oil of 3 wt%, there is no significant effect before or after a change in 5-HT concentration. Thus, only an oil in which the lavender oil and the chamomile roman oil are mixed in the valerian oil shows an increase in a 5-HT concentration in blood from before to after.

[0064] Also, in the present invention, in the case where each of the lavender oil, the chamomile roman oil, and the valerian oil are added by 3 wt% respectively, skin irritation occurs and thereby an allergic response and toxicity are exhibited. Thus, to increases 5-UT concentration while maintaining the total concentration within 3 wt%, other ratios than provided by the present invention show no increase in 5-UT concentration. Therefore, the present invention has the excellent functions of antianxiety, sleep, treating depression through a 5-HT increasing mechanism and 1 0 increasing 5-HT concentration in blood.

[0065] According to one aspect, thc present invention has an excellent effect of treating insomnia, and an excellent effect of treating secondary insomnia induced by psychiatric disorders such as schizophrenia, neurasthenia, depression, and also dementia.

1 5 [0066] Although the present invention has been described with reference to the accompanying drawing, various modifications and changes can be made thereto without departing from the technical spirit of the present invention, Therefore, the present invention is not limited described examples rather defined by claims as well as equivalents claims.

Claims

CLAIMSI. A massage oil for deep sleep comprising a valerian oil, a lavender oil, and a chamomile roman oil formed by mixing the valerian oil, the lavender oil, and the chamomile roman oil at a weight ratio of I: 1.5-2.5 1.5-2.5, the massage oil being characterized in that 2-5 wt% of a mixture consisting of the valerian oil, the lavender oil, and the chamomile roman oil is contained with respect to a base oil.
2. A massage oil for deep sleep comprising: a base oil; a valerian oil; a lavender oil; and a chamomile roman oil; wherein the valerian oil, the lavender oil and the chamomile roman oil are present in a weight ratio of 1: 1.5-2,5: 1.5-2.5, aM wherein the combined content of the valerian oil, the lavender oil, and the chamomile roman oil is in the range 2-5 wt% with respect to the base oil.
3. The massage oil for deep sleep of claim t or claim 2, characterized in that the valerian oil is a natural oil extracted from a root of Vcslerian officince/is, and contains 22 to 26 wt% of bornyl acetate and lIto 15 wt% of valeranone sesquiterpenes.
4. The massage oil for deep sleep of any preceding claim, characterized in that the lavender oil is a natural oil extracted from Lavender angustifofia, and contains 35 to 41 wt9o of linalool which is a monoterpene and 38 to 46 wt9o of linalyl acetate.
5. The massage oil for deep sleep of any preceding claim, characterized in that the chamomile roman oil is a natural oil extracted from a flower of Chaniaeme turn nob/fe L., and contains 14 to t8 wt% of methyl-angelate, 10 to t4 wt% of 3-methylpentyl isobutyrate, and 4 to 25 wt% of angelate.