GB2465464A - Wireless device for confirmatory diagnosis of cystic fibrosis through analysis of sweat chloride - Google Patents
Wireless device for confirmatory diagnosis of cystic fibrosis through analysis of sweat chloride Download PDFInfo
- Publication number
- GB2465464A GB2465464A GB0919789A GB0919789A GB2465464A GB 2465464 A GB2465464 A GB 2465464A GB 0919789 A GB0919789 A GB 0919789A GB 0919789 A GB0919789 A GB 0919789A GB 2465464 A GB2465464 A GB 2465464A
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- Prior art keywords
- sweat
- module
- transmitter
- analyzer
- cystic fibrosis
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- 210000004243 sweat Anatomy 0.000 title claims abstract description 48
- 201000003883 Cystic fibrosis Diseases 0.000 title claims abstract description 17
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 title claims abstract description 14
- 238000003745 diagnosis Methods 0.000 title claims abstract description 14
- 238000004458 analytical method Methods 0.000 title abstract description 22
- 238000012360 testing method Methods 0.000 claims abstract description 14
- 150000002500 ions Chemical class 0.000 claims abstract description 11
- QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 claims abstract description 6
- QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229960001416 pilocarpine Drugs 0.000 claims abstract description 6
- 238000005259 measurement Methods 0.000 claims abstract description 5
- 230000002093 peripheral effect Effects 0.000 claims abstract description 5
- 230000006698 induction Effects 0.000 claims abstract 2
- 230000006870 function Effects 0.000 claims description 6
- YKFROQCFVXOUPW-UHFFFAOYSA-N 4-(methylthio) aniline Chemical compound CSC1=CC=C(N)C=C1 YKFROQCFVXOUPW-UHFFFAOYSA-N 0.000 claims description 2
- 229960001963 pilocarpine nitrate Drugs 0.000 claims description 2
- 230000000638 stimulation Effects 0.000 claims description 2
- 101001004851 Cicer arietinum Legumin Proteins 0.000 claims 1
- -1 ion chloride Chemical class 0.000 claims 1
- 238000003032 molecular docking Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 11
- 239000012491 analyte Substances 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 230000002457 bidirectional effect Effects 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229940127243 cholinergic drug Drugs 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000004313 potentiometry Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B10/0064—Devices for taking samples of body liquids for taking sweat or sebum samples
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
- A61B5/4261—Evaluating exocrine secretion production
- A61B5/4266—Evaluating exocrine secretion production sweat secretion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48785—Electrical and electronic details of measuring devices for physical analysis of liquid biological material not specific to a particular test method, e.g. user interface or power supply
- G01N33/48792—Data management, e.g. communication with processing unit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physiology (AREA)
- Endocrinology (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Databases & Information Systems (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Computer Networks & Wireless Communication (AREA)
- Human Computer Interaction (AREA)
- Optics & Photonics (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Wireless equipment for confirmatory diagnosis of cystic fibrosis through sweat testing, which includes a module of analyzer / transmitter (1), with box (2), built- in microprocessor (5) for sweat induction analysis (6) through chloride measurement device (7), radio antenna (8) with a transmitter, battery (13) switch (14), and sensor card wiring connector (9) single-use, which has two iontophoresis electrodes (10), and ion-selective electrodes (11), built-in connector (12) to the module, and a module terminal / receiver (3), with box (4) desktop keyboard (15), a LCD (16) microprocessor (17), USB connections (18) for peripherals, radio antenna (21) with receiver to get data "live" from analyzer module / transmitter (1), powered by batteries or wall electrical socket. Aspects of the invention include producing a sweat sample using the principle of iontophoresis with pilocarpine.
Description
WIRELESS DEVICE FOR CONFIRMATORY DIAGNOSIS OF CYSTIC FIBROSIS
THROUGH ANALYSIS OF SWEAT CHLORIDE
BACKGROUND OF ThE INVENTION
The invention describes a wireless device for confirmatory diagnosis of cystic fibrosis, through sweat analysis, of pediatdc patients. A number of innovative and advantageous features are provided by the present invention, which will be descdbed in detail. Together they pose a significant improvement over what was already known in this field.
Cystic fibrosis is an autosomal and multisystem disease, which among other symptoms, is characterized by altered conceniration of electrolytes in secrefion.
Ps with many other diseases, their early detection is a key point for treatment, because it allows a dinical control of it, being their diagnosis confirmed by running sweat test.
In summary form, the sweat test consists of three main phases: -Producing the sweat sample. The preferred technique is recognized as iontophoresis with pilocarpine. A cholinergic drug coupled to the pilocarpine stimulates sweat glands. Sweat obtained in this way is functionally identical to sweat produced physiologically.
-Collecting the sweat sample is a very sensitive procedure. Because only a small amount of sweat is collected, it must be done without suffering any contamination and without any evaporation.
-Analysis of sweat sample. There are three groups of methods currently employed: quantitative methods require accurate measurement of sample weight, elution of the sample from absorbent gauze, and a time-consuming manual titration specific for chloride ions.
This is the classic Gibson Cooke method, which is no longer used. Ion selective electrodes have been tried, but no available equipment can perform the analysis on microliter quantities of the sample. Semi-quantitative, and non-specific methods, determine the electrolyte concentration by conductivity, and purely qualitative methods are available, based on visual analysis of color change.
For more than ten years, the field of sweat analysis has been without any kind of innovative technological advancement, rendering much of the available equipment and instrumentation obsolete.
The general problem of existing methodologies is that they are very laborious; pose a nuisance for the patient, in this case children, and lack needed sensitivity for a conclusive result.
On the other hand, all the existing equipment for analysis operated with cables connected to the patient, except those that are wireless at the stage of obtaining sweat. The system used to perform the analysis is not confirmatory, which means that instruments are inaccurate for determining the level of chloride in the analysis of sweat.
BRIEF SUMMARY OF ThE INVENTION
It should be noted, therefore, that the existence of a wireless device for measuring chloride in sweat, applied to the detection of cystic fibrosis is unknown to the inventor. A technical and structural constituency is submitted similar to those advocated by the present invention, which aims to provide answers to the problems, described above, using a method based on an ion selective electrode, which detects the ions for which they were designed. The invention also greatly decreases the problems arising from the sample's manipulation that may occur during the collection of sweat.
Specifically, the object of the invention consists of a wireless device to measure concentration of chloride in the sweat of patients with symptoms, family history, or genetic profile suggestive of cystic fibrosis. Analysis is by through ion selective electrode, using the principle of iontophoresis with pilocarpine to obtain the sweat. Unlike methods currently employed for sweat analysis, the present invention does not actually collect the sweat. It performs the measurement at the point of emission through a selective electrode, placed in the area of stimulation, and which also determines in situ the quantitative value of chloride conceniration.
Thus, the equipment proposed by the invention is by itself an obvious novelty within its scope. Accordingly, the present invention is a portable and self-contained instrument for diagnosis and confirmation of cystic fibrosis through the simultaneous use of the chloride ion selective sensors and impedance microsensors. The system is implemented for stimulating the producfion of sweat in a faster way and at lower cost. This sensitive system of detection is based on a disposable card, meaning that the invention can be a wreless apparatus for performing the sweat test.
The equipment may be comprised of two individual units.
First, there is a remote unit, which integrates the sweat generator. The device performs iontopheresis of pilocarpine, the chloride measuring electrodes, and a radio transmitter for sending the analysis information.
Second, there is a receiver unit for collecting data from the remote analyzer module, displaying and recording test results in the internal data base memory.
The remote unit may consist of a box or case, fitted with Velcro (TM) straps suitable for coupling to the body area of the patient. Electronics are incorporated inside, having a microprocessor that is responsible for doing all the tasks described above, a radio antenna for remote-unit communication, and internal wiring that connects this module with the single-use sensor card that will be placed at its base.
This disposable sensor card, at the same time, may consist of two electrodes that allow the generation of sweat by specific reagent incorporated and using the technique called iontophoresis, two electrodes that allow the analysis of the sweat generated by the iontophoresis system, capable of determining the concentration of chloride ions, and a connection port that allows the card to be connected to the module to form a single piece.
With regard to the receiver unit, the receiver unit may be composed of a desktop box or case, which houses all electronic components and provides a screen of liquid crystal display (LCD). All data is provided from the remote unit, including status indication, fault analysis, communication with peripheral devices, such as a printer and I or a computer connected to it via USB port, and a keyboard that, among other functions, allows the user to move through the menu generated by software, for example, to change setup values, such as starting points of operation, merging functions, and selecting conversion factors, in addition to assuring the proper functioning of peripheral devices.
The receiver unit also may have a radio antenna to communicate in bidirectional mode with remote unit.
This wireless equipment may confirm the diagnosis of cystic fibrosis through sweat testing suggested by the invention. A selecve ion electrode allows the user to advantageously detect the concentration of an analyte of sweat in concentrations as low as 5 mmol/l, because this electrode is designed to be highly selective, discriminating against other ions that are typically found in sweat.
This fact makes the equipment of the invention much more reliable when it has to give a reading, compared with currently used equipment based only in conductivity method, which can have more false readings due to interference in the analyte, because this system only measures the ease with which a sample of sweat allows the transport of electricfty through it. Therefore, by increasing the level of salts in the sample, the conductivity increases significantly, and although all the ionic salts are good conductors of electricily, the analyte that is required to be verified, in order to see whether a child has cystic fibrosis or not, is only found in a certain type of salt.
The new wireless equipment for confirmatory diagnosis of cystic fibrosis testing through sweat analysis, is therefore an innovative invention with structural characteristics and constituents unknown so far. Together with its practical usefulness, the present invention has sufficient basis for the privilege of exdusivity that is sought.
BRIEF DESCRIP11ON OF ThE DRAWINGS To complement the description being used and in order to provide better understanding of the characteristics of the invention, a set of drawings is accompanying this description, as an integral part thereof. The set of drawings are illustrative and not limiting.
Figure 1 shows a schematic view of the wireless equipment for confirmatory diagnosis of cystic fibrosis testing, through sweat analysis, according to the invention, which illustrate the main elements thereof.
Figure 2 shows a schematic view of the bottom of the remote unit, showing the disposable sensor card as well as the elements integrated with the card.
DETIJLED DESCRIPTION OF THE INVEN11ON
In view of the above figures and reference numerals herein, the drawings illustrate an example of a preferred embodiment of the wireless equipment for confirmatory diagnosis of cystic fibrosis testing through sweat analysis, which includes the parts that are listed and described in detail below.
Thus, as shown in Figure 1, the equipment consists of a remote unit (1), inside a box or case (2), fitted with Velcro (TM) for coupling to the body area of the patient's convenience, and a receiver unit (3), based on a benchtop box or case (4) that hosts all of its internal components and is intended to receive the data coming from remote unit (1), display and non-volatile memory, both remote and base modules are connected by radio waves.
The box (2) remote unit (1) includes an analog microprocessor (5), which is responsible for carrying out the functions of generation of sweat (6) and analysis by measuring chloride (7), a radio antenna (8) with its corresponding remote unit, and internal wiring that enables connecfion to an sensor card (9) single-use sensor, located at its base. As shown in Figure 2, two iontophoresis electrodes (10) are provided, leading pilocarpine nitrate, which penetrates the skin and stimulates sweat Two ion selective electrodes (11) enable the analysis of the sweat generated by the above iontophoresis electrodes (10), and an area of connection (12) that allows the sensor card to connect to the module.
It should be noted that the remote analyzer module I transmitter (1) is battery powered (13) and contains as well an intelligent switch (14) for the choice of several options.
For its part, the box (4) terminal I receiver (3) incorporates a keyboard (15), allowing navigation in the menu generated by the software tool, LCD screen (16) where all the data processed is displayed from analyzer module I transmitter (1), a microprocessor (17), equipped with software that controls all functions, as well as one or more USB connections (18) for peripheral devices such as a printer (19) and! or a computer (20).
The module terminal I receiver (3) also has a radio antenna (21) with its corresponding receiver module to communicate data bidirectional from the analyzer module I transmitter (1). It can be powered by a convenfional battery (not shown) or plugged into a wall socket.
Sufficiently described the nature of this invention, as well as how to implement it, it should be noted that, within its essence, can be implemented in other forms of conduct that could be different than this one used as an example, and for which the protection is sought, provided that no alteration, change or modification of its fundamental prinaple.
It could be possible to extend the system to measure others ions or substances excreted by sweat, that can be analyzed directly on the skin by direct potentiometry or any other method of analysis.
Claims (4)
- CLAI MS1. Wireless equipment for confirmatory diagnosis of cystic fibrosis through sweat testing, designed to measure chloride in sweat concentration by system of selective ions, using the principle of iontophoresis with pilocarpine, for sweat induction comprising: an analyzer I transmitter (1) module, fitted in a box or case (2), strapped with "Velcro" for docking in the area that suits the patient's body, incorporating sweat generator, sweat generated analyzer and data transmitter, performing the measurement direcUy into selective electrode placed on the stimulation area; and a terminal I receiver (3) module having a box or case (4) with all components inside for data reception coming from the analyzer module I transmitter (1), and to display and record the data in memory, both modules are connected by radio frequency.
- 2. Wireless equipment for confirmatory diagnosis of cystic fibrosis testing based on sweat, according to claim 1, characterized by the fact that the analyzer I transmitter (1) module casing (2) incorporates a microprocessor (5) to handle and perform sweat generation functions (6) and sweat testing sensor device for chloride measurement (7), a radio antenna (8) with its corresponding quantitative ion chloride concentration transmitter to the module (3), powered by cell or battery (13) and regular mains voltage socket as well as a switch (14) built with wiring that allows connection to an analyzer card (9) of a single use.
- 3. Wireless equipment for confirmatory diagnosis of cystic fibrosis testing in sweat, according to any previous claim, characterized by the fact that the card analyzer (9) that contact with the skin of the patient, has two iontophoresis electrodes (10), with pilocarpine nitrate, one or more selective ion electrodes (11), and connection area to the module.
- 4. Wireless equipment for confirmatory diagnosis of cystic fibrosis testing through sweat, according to any previous claim, characterized by the fact that the casing (4) terminal I receiver (3) incorporates a keyboard (15) to choose the menu selections generated by the software, an LCD screen (16) where all data from analyzer module I transmitter are displayed (1), a microprocessor (17), equipped with software that controls all functions, as well as one or more USB connections (18), for connecting peripherals, such printer (19) and I or a serial computer connection (20), and it also has a radio antenna (21) with its corresponding receiver module to send commands to, and receive data from analyzer module I transmitter (1), also powered by batteries or by connecting to regular wall electrical socket.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/277,273 US20100130843A1 (en) | 2008-11-24 | 2008-11-24 | Wireless device for confirmatory diagnosis of cystic fibrosis through analysis of sweat chloride |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB0919789D0 GB0919789D0 (en) | 2009-12-30 |
| GB2465464A true GB2465464A (en) | 2010-05-26 |
Family
ID=40957624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB0919789A Withdrawn GB2465464A (en) | 2008-11-24 | 2009-11-12 | Wireless device for confirmatory diagnosis of cystic fibrosis through analysis of sweat chloride |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20100130843A1 (en) |
| CH (1) | CH699966A2 (en) |
| CZ (1) | CZ2009776A3 (en) |
| DE (1) | DE102009044594A1 (en) |
| FR (1) | FR2938744A3 (en) |
| GB (1) | GB2465464A (en) |
| NL (1) | NL2002819C2 (en) |
| SE (1) | SE0950784A1 (en) |
| SK (1) | SK500522009A3 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2013243541B2 (en) | 2012-04-04 | 2017-04-06 | United States Of America As Represented By The Secretary Of The Air Force | Sweat simulation, collection and sensing systems |
| US10888244B2 (en) | 2013-10-18 | 2021-01-12 | University Of Cincinnati | Sweat sensing with chronological assurance |
| CA2927213A1 (en) | 2013-10-18 | 2015-04-23 | University Of Cincinnati | Sweat sensing with chronological assurance |
| CA2927211A1 (en) | 2013-10-18 | 2015-04-23 | University Of Cincinnati | Devices for integrated, repeated, prolonged, and/or reliable sweat stimulation and biosensing |
| US11129554B2 (en) | 2014-05-28 | 2021-09-28 | University Of Cincinnati | Sweat monitoring and control of drug delivery |
| US10639015B2 (en) | 2014-05-28 | 2020-05-05 | University Of Cincinnati | Devices with reduced sweat volumes between sensors and sweat glands |
| EP3148430A4 (en) | 2014-05-28 | 2018-05-16 | University of Cincinnati | Advanced sweat sensor adhesion, sealing, and fluidic strategies |
| WO2016007944A2 (en) * | 2014-07-11 | 2016-01-14 | University Of Cincinnati | Combinatorial sensing of sweat biomarkers using potentiometric and impedance measurements |
| US20170245788A1 (en) | 2014-09-22 | 2017-08-31 | University Of Cincinnati | Sweat sensing with analytical assurance |
| EP3244348A1 (en) | 2014-10-15 | 2017-11-15 | Eccrine Systems, Inc. | Sweat sensing device communication, security and compliance |
| EP3256049A4 (en) | 2015-02-13 | 2018-07-25 | University of Cincinnati | Devices for integrated indirect sweat stimulation and sensing |
| CN104835301A (en) * | 2015-04-22 | 2015-08-12 | 北京柏惠维康科技有限公司 | Wireless data transmission device for medical equipment |
| US10646142B2 (en) | 2015-06-29 | 2020-05-12 | Eccrine Systems, Inc. | Smart sweat stimulation and sensing devices |
| WO2017044731A1 (en) * | 2015-09-09 | 2017-03-16 | University Of Cincinnati | Mechanically co-located sweat stimulation and sensing |
| US20180317833A1 (en) | 2015-10-23 | 2018-11-08 | Eccrine Systems, Inc. | Devices capable of fluid sample concentration for extended sensing of analytes |
| WO2017075402A1 (en) * | 2015-10-30 | 2017-05-04 | University Of Cincinnati | Sweat sensing devices with electromagnetically shielded sensors, interconnects, and electronics |
| US10674946B2 (en) | 2015-12-18 | 2020-06-09 | Eccrine Systems, Inc. | Sweat sensing devices with sensor abrasion protection |
| US11241174B2 (en) | 2016-06-07 | 2022-02-08 | International Business Machines Corporation | Wearable device for monitoring bodily fluids |
| US10471249B2 (en) | 2016-06-08 | 2019-11-12 | University Of Cincinnati | Enhanced analyte access through epithelial tissue |
| WO2018006087A1 (en) | 2016-07-01 | 2018-01-04 | University Of Cincinnati | Devices with reduced microfluidic volume between sensors and sweat glands |
| US11832801B2 (en) * | 2016-07-11 | 2023-12-05 | Arizona Board Of Regents On Behalf Of Arizona State University | Sweat as a biofluid for analysis and disease identification |
| US10405794B2 (en) | 2016-07-19 | 2019-09-10 | Eccrine Systems, Inc. | Sweat conductivity, volumetric sweat rate, and galvanic skin response devices and applications |
| US10736565B2 (en) | 2016-10-14 | 2020-08-11 | Eccrine Systems, Inc. | Sweat electrolyte loss monitoring devices |
| US11123011B1 (en) | 2020-03-23 | 2021-09-21 | Nix, Inc. | Wearable systems, devices, and methods for measurement and analysis of body fluids |
| CN116723879A (en) * | 2020-12-30 | 2023-09-08 | 佐治亚科技研究公司 | Method and device for inducing sweat for medical diagnosis |
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| WO1994000048A1 (en) * | 1992-06-30 | 1994-01-06 | Hermann Marsoner | Device with sensors to detect a value depending on the chloride and/or sodium concentration, and measuring and control device therefor |
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| JP2007533346A (en) * | 2003-08-15 | 2007-11-22 | アニマス・テクノロジーズ・リミテッド・ライアビリティ・カンパニー | Microprocessor, device, and method for use in monitoring physiological analytes |
| EP1670356A1 (en) * | 2003-09-03 | 2006-06-21 | Life Patch International, Inc. | Personal diagnostic devices and related methods |
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2008
- 2008-11-24 US US12/277,273 patent/US20100130843A1/en not_active Abandoned
-
2009
- 2009-04-29 NL NL2002819A patent/NL2002819C2/en not_active IP Right Cessation
- 2009-10-23 SE SE0950784A patent/SE0950784A1/en not_active Application Discontinuation
- 2009-11-12 GB GB0919789A patent/GB2465464A/en not_active Withdrawn
- 2009-11-17 CH CH01766/09A patent/CH699966A2/en not_active Application Discontinuation
- 2009-11-17 FR FR0958080A patent/FR2938744A3/en active Pending
- 2009-11-19 SK SK50052-2009A patent/SK500522009A3/en not_active Application Discontinuation
- 2009-11-20 DE DE102009044594A patent/DE102009044594A1/en not_active Withdrawn
- 2009-11-20 CZ CZ20090776A patent/CZ2009776A3/en unknown
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| EP0084792A1 (en) * | 1982-01-11 | 1983-08-03 | Medtronic, Inc. | Non-invasive diagnosis method |
| US5036861A (en) * | 1990-01-11 | 1991-08-06 | Sembrowich Walter L | Method and apparatus for non-invasively monitoring plasma glucose levels |
| WO1999058051A1 (en) * | 1998-05-13 | 1999-11-18 | Cygnus, Inc. | Monitoring of physiological analytes |
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| WO2008151274A1 (en) * | 2007-06-05 | 2008-12-11 | Owen Davis | Device and system for montioring contents of perspiration |
Also Published As
| Publication number | Publication date |
|---|---|
| IE20090885A1 (en) | 2010-06-23 |
| DE102009044594A1 (en) | 2010-05-27 |
| CH699966A2 (en) | 2010-05-31 |
| SE0950784A1 (en) | 2010-05-25 |
| FR2938744A3 (en) | 2010-05-28 |
| NL2002819C2 (en) | 2010-05-26 |
| CZ2009776A3 (en) | 2010-08-11 |
| SK500522009A3 (en) | 2010-06-07 |
| GB0919789D0 (en) | 2009-12-30 |
| US20100130843A1 (en) | 2010-05-27 |
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Legal Events
| Date | Code | Title | Description |
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| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |