CN220603363U - Portable alternating current impedance analyzer, system and electrochemical sensor - Google Patents
Portable alternating current impedance analyzer, system and electrochemical sensor Download PDFInfo
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- CN220603363U CN220603363U CN202322110441.4U CN202322110441U CN220603363U CN 220603363 U CN220603363 U CN 220603363U CN 202322110441 U CN202322110441 U CN 202322110441U CN 220603363 U CN220603363 U CN 220603363U
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- 241000700605 Viruses Species 0.000 claims abstract description 33
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- 238000007781 pre-processing Methods 0.000 claims description 4
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims description 3
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- 238000001514 detection method Methods 0.000 abstract description 23
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- IKBJGZQVVVXCEQ-UHFFFAOYSA-N efonidipine hydrochloride Chemical compound Cl.CCO.CC=1NC(C)=C(C(=O)OCCN(CC=2C=CC=CC=2)C=2C=CC=CC=2)C(C=2C=C(C=CC=2)[N+]([O-])=O)C=1P1(=O)OCC(C)(C)CO1 IKBJGZQVVVXCEQ-UHFFFAOYSA-N 0.000 description 1
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- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Abstract
The utility model relates to the technical field of biological detection, and discloses a portable alternating current impedance analyzer, a system and an electrochemical sensor, wherein the portable alternating current impedance analyzer comprises: a housing; the electrode slot is arranged on the shell and is used for inserting an electrochemical sensor, and the electrochemical sensor is used for adding viruses to be detected; the power supply device is arranged inside the shell and is used for providing alternating current signals for the electrochemical sensor; and the processing device is arranged inside the shell and is used for carrying out signal processing on the detected signal of the electrochemical sensor and determining an analysis result. The alternating current impedance analyzer provided by the utility model is light, convenient to carry, suitable for being used in various places, fast in detection speed and more accurate in detection result.
Description
Technical Field
The utility model relates to the technical field of biological detection, in particular to a portable alternating current impedance analyzer.
Background
Among conventional virus detection methods, nucleic acid-based detection methods such as PCR, LAMP, etc. are commonly used. The methods need complex sample pretreatment and detection processes, have long detection time, have inaccurate detection results and need professional technicians to operate.
Electrochemical impedance analysis is an emerging virus detection technique that can detect viruses by measuring the impedance change of an alternating electric field. However, the electrochemical impedance analyzer on the market at present has large volume, heavy weight, inconvenient carrying and difficult flexible use in actual scenes.
Disclosure of Invention
In view of the above, the present utility model provides a portable ac impedance analyzer, a portable ac impedance analyzer system and a portable ac impedance sensor, so as to solve the technical problems of the prior art that the portable ac impedance analyzer is bulky and inconvenient to carry.
In a first aspect, the present utility model provides a portable ac impedance analyzer comprising:
a housing;
the electrode slot is arranged on the shell and is used for inserting an electrochemical sensor which is used for adding viruses to be detected;
the power supply device is arranged inside the shell and is used for providing alternating current signals for the electrochemical sensor;
and the processing device is arranged inside the shell and is used for carrying out signal processing on the detected signal of the electrochemical sensor and determining an analysis result.
The alternating current impedance analyzer provided in the embodiment, the power supply device and the processing device are arranged in the alternating current impedance analyzer shell, so that the alternating current impedance analyzer is light and convenient to carry, and is suitable for being used in various places. In addition, when the alternating current impedance analyzer is actually used for analysis, the virus to be detected is only added into the electrochemical sensor and then inserted into the electrode slot of the analyzer, so that the virus in the virus to be detected can be detected in a short time, the detection speed is high, and the use method is simple.
In an alternative embodiment, the analyzer further comprises:
the switch button, the data recording button and the reset button are all arranged on the surface of the shell;
wherein, after the data recording button is pressed, the analyzer starts recording the analysis result, and after the reset button is pressed, the analyzer is restored to the initial state.
In an alternative embodiment, a processing device includes:
a signal processor for preprocessing the detected signal of the electrochemical sensor;
and the data processor is connected with the signal processor and is used for converting the data processed by the signal processor into readable data.
In an alternative embodiment, the analyzer further comprises:
and the display device is used for displaying the analysis result.
In an alternative embodiment, the analyzer further comprises:
and the transmission interface is connected with the processing device.
In a second aspect, the present utility model provides an electrochemical sensor for insertion into a portable ac impedance analyzer, the electrochemical sensor comprising
The hand-held area is arranged on the head of the electrochemical sensor;
the sample adding area is arranged adjacent to the handheld area and is used for adding viruses to be detected;
the electrode array is arranged adjacent to the sample adding area and comprises a reference electrode, a working electrode and a counter electrode;
the electrode lead comprises an extension lead of a reference electrode, an extension lead of a working electrode and an extension lead of a counter electrode, and is arranged at the tail part of the electrochemical sensor and used for being electrically connected with an electrode slot of the alternating current impedance analyzer.
By adopting the electrochemical impedance analysis technology with high sensitivity, the virus with low concentration can be detected, so that the detection result is more accurate.
In an alternative embodiment, the working electrode has immobilized on its surface a molecular recognition layer containing antibodies or nucleic acid probes.
In an alternative embodiment, the working electrode surface is modified with colloidal gold.
In an alternative embodiment, the electrode array is 10mm by 10mm in size.
In a third aspect, the present utility model provides a portable ac impedance analysis system comprising: the analyzer and the electrochemical sensor.
The alternating current impedance analysis system is small in size, convenient to carry and suitable for being used in various places. In addition, the detection speed is high, the use method is simple, low-concentration viruses can be detected, and the accuracy of detection results is high.
Drawings
In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings that are needed in the description of the embodiments or the prior art will be briefly described, and it is obvious that the drawings in the description below are some embodiments of the present utility model, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic structural view of a specific example of an ac impedance analyzer according to an embodiment of the present utility model;
fig. 2 is a schematic structural view of a specific example of an electrochemical sensor according to an embodiment of the present utility model.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present utility model more apparent, the technical solutions of the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model, and it is apparent that the described embodiments are some embodiments of the present utility model, but not all embodiments of the present utility model. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
In the description of the present utility model, it should be noted that the directions or positional relationships indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. are based on the directions or positional relationships shown in the drawings, are merely for convenience of describing the present utility model and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present utility model, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; the two components can be directly connected or indirectly connected through an intermediate medium, or can be communicated inside the two components, or can be connected wirelessly or in a wired way. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.
In addition, the technical features of the different embodiments of the present utility model described below may be combined with each other as long as they do not collide with each other.
In some technologies, the apparatus for detecting and analyzing viruses is not only large in size and heavy in weight, but also slow in analysis speed, and is difficult to use in a practical scene flexibly.
In view of this, in this embodiment, a portable ac impedance analyzer is provided, which can be applied to fields of medical treatment, food safety, environmental monitoring, etc., such as hospitals, laboratories, airports, stations, etc., can be used for rapidly and accurately detecting viruses, and has a small volume. Fig. 1 is a schematic structural diagram of an ac impedance analyzer according to an embodiment of the present utility model, including a housing 1, an electrode slot 2, a power supply device (not shown in the figure), and a processing device (not shown in the figure), specifically as follows.
An electrode slot 2 arranged on the shell 1 for inserting an electrochemical sensor for adding viruses to be detected;
a power supply device arranged inside the casing 1 for providing an alternating current signal for the electrochemical sensor; that is, an alternating current electric field with adjustable frequency and amplitude can be provided, and different types of virus detection can be satisfied; the power supply is provided by a built-in rechargeable battery or an external power supply connected with a computer and the like.
Processing means, provided inside the casing 1, for performing signal processing on the detected signal of the electrochemical sensor and determining the analysis result.
The external dimension and the external shape of the alternating current impedance analyzer provided in the embodiment can be the same as those of a common USB flash disk, and the power supply device and the processing device are arranged in the shell of the alternating current impedance analyzer, so that the alternating current impedance analyzer is light and convenient to carry about, and is suitable for being used in various places. In addition, when the alternating current impedance analyzer is actually used for analysis, the virus to be detected is only added into the electrochemical sensor and then inserted into the electrode slot of the analyzer, so that the virus in the virus to be detected can be detected within 10s-10min, the detection speed is high, and the use method is simple. In addition, the alternating current impedance analyzer provided by the embodiment can detect low-concentration viruses by adopting a high-sensitivity electrochemical impedance analysis technology, and the detection result is more accurate.
The embodiment of the utility model mainly introduces the hardware structure of the alternating current impedance analyzer and the electrochemical sensor, and the structure of the alternating current impedance analyzer and the electrochemical sensor, the contained components, materials and the like are also required to be protected, so that the prior logic can be completely adopted for the contents of the methods of processing, analysis and the like.
In some alternative embodiments, the analyzer further comprises:
the switch button 3, the data recording button 4 and the reset button 5 are arranged on the surface of the shell;
wherein the analyzer starts recording the analysis result after the data recording button is pressed, and returns to an initial state after the reset button is pressed.
In some alternative embodiments, a processing device includes:
a signal processor for preprocessing the detected signal of the electrochemical sensor;
and the data processor is connected with the signal processor and is used for converting the data processed by the signal processor into readable data.
Preprocessing the detected signal of the electrochemical sensor includes: the detected signals are amplified and filtered, so that noise interference can be eliminated, and the detection accuracy is improved. The data processed by the signal processor can also be converted into readable results by the data processor. So that it can provide different output modes including digital, graphic, voice, etc., for example: and displaying whether viruses, the number of viruses and the like exist in the viruses to be detected on a display device.
In some alternative embodiments, the analyzer further comprises:
and a display device 6 for displaying the analysis result.
In some alternative embodiments, the analyzer further comprises:
and the transmission interface 7 is connected with the processing device. The data transmission and the result display can be realized by connecting the transmission interface 7 with external equipment such as a computer and the like.
The specific steps of the ac impedance analyzer provided in this embodiment may be as follows:
step 101, pressing a switch button 3 to start an alternating current impedance analyzer, observing an interface on a display device 6, and ensuring normal starting of the instrument;
step 102, under the condition that the electrochemical sensor is ensured to be in a safe state, the operation rules of the electrochemical sensor are followed, and the electrochemical sensor with viruses to be detected is prepared;
step 103, inserting an electrochemical sensor added with viruses to be detected into an electrode slot 2 of an alternating current impedance analyzer, and ensuring stable electrode connection and good contact;
104, after checking the electrode connection, pressing a data recording button 4 to start alternating current impedance test, providing a required alternating current signal, automatically measuring the alternating current impedance of the electrochemical sensor by an analyzer, processing the detected signal, displaying an analysis result on a display device 6 and recording the analysis result; if necessary, the test can be repeated to ensure the accuracy of the result;
step 105, after the test is completed, the reset button 5 is pressed, and the alternating current impedance analyzer is restored to an initial state so as to perform the next test;
step 106, after ensuring that the alternating current impedance analyzer is in a safe state, extracting the electrochemical sensor from the electrode slot 2, and disconnecting the electrode;
and 107, pressing the switch button 3 again to close the alternating current impedance analyzer. If the switch button 3 is not pressed after the electrode connection is disconnected, and the unused time exceeds 1 minute, the AC impedance analyzer is automatically turned off to save power.
There is also provided in this embodiment an electrochemical sensor for insertion into an ac impedance analyzer, which may be the portable ac impedance analyzer described above, and fig. 2 is a schematic structural view of an electrochemical sensor according to an embodiment of the present utility model, including a hand-held region 11, a sample application region 12, an electrode array 13, and an electrode lead 14, as follows.
A hand-held region 11 provided on the head of the electrochemical sensor;
the sample adding area 12 is arranged adjacent to the handheld area 11 and is used for adding viruses to be detected;
an electrode array 13 disposed adjacent to the sample application region 12, the electrode array 13 including a reference electrode 131, a working electrode 132, and a counter electrode 133;
the electrode lead 14 comprises an extension lead of the reference electrode 131, an extension lead of the working electrode 132 and an extension lead of the counter electrode 133, and the electrode lead 14 is arranged at the tail part of the electrochemical sensor and is used for being electrically connected with the electrode slot 2 of the alternating current impedance analyzer.
In this embodiment, the electrochemical impedance spectrum data may be analyzed by using a landel equivalent circuit (Randles equivalent circuit), that is, by analyzing the changes of the voltage and the current, the electrical properties and the reaction mechanism of the electrochemical system may be determined, so as to determine whether the virus exists in the virus to be detected.
While the landbis equivalent circuit is a common electrochemical reaction model, and is generally composed of an electrochemical reaction electrode and a capacitor. In this embodiment, the electrode array may serve as an electrochemical reaction electrode, and the double-layer capacitance between the electrode and the electrolyte may serve as a capacitor, so that impedance change is generated under the action of an ac signal, and whether a virus exists in the virus to be detected is analyzed according to the detected signal.
The electrochemical sensor provided in the embodiment can detect low-concentration virus by adopting a high-sensitivity electrochemical impedance analysis technology, so that the detection result is more accurate.
In some alternative embodiments, the working electrode has immobilized on its surface a molecular recognition layer containing antibodies or nucleic acid probes.
The molecular recognition layer refers to a thin layer composed of biological recognition elements that can specifically bind to target molecules. In the electrochemical sensor of the present patent, the molecular recognition layer may be composed of an antibody and an antigen. Antibodies may be generally immobilized on the surface of working electrode 132. When the antigen of interest is added to the electrochemical sensor through the sample addition zone 12, specific binding between the antibody and the antigen occurs. The function of the molecular recognition layer is to convert a biologically active event (e.g., binding of an antibody to an antigen) into a measurable electrochemical signal. Such signals can be measured and analyzed by reference electrode 131, working electrode 132, and counter electrode 133 to achieve quantitative detection of the target molecule.
It should be noted that, the specific binding between the antibody and the antigen, the conversion of the bioactive event into a measurable electrochemical signal, and the measurement and analysis by the reference electrode, the working electrode, and the counter electrode are all common technical means in the biological field, and will not be specifically described herein.
In some alternative embodiments, the working electrode surface is modified with colloidal gold. Colloidal gold is a signal amplifier and can be used for improving the detection sensitivity of an electrochemical sensor.
In some alternative embodiments, the distance between the reference electrode and the working electrode is less than 500 microns.
In some alternative embodiments, the electrode array has dimensions of 10mm by 10mm.
The electrode array comprises a plurality of microelectrodes, each microelectrode having a diameter of about 100 μm and a distance between the two electrodes of less than 500 μm, the electrode array being formed with dimensions of about 10mm by 10mm. The alternating current impedance analyzer is small in size, suitable for the alternating current impedance analyzer, capable of being carried at any time and suitable for being used in various places.
In this embodiment, a portable ac impedance analysis system is further provided, which includes the ac impedance analyzer and the electrochemical sensor.
The alternating current impedance analysis system provided in the embodiment is small in size, convenient to carry and suitable for being used in various places. In addition, the detection speed is high, the use method is simple, low-concentration viruses can be detected, and the accuracy of detection results is high.
Although embodiments of the present utility model have been described in connection with the accompanying drawings, various modifications and variations may be made by those skilled in the art without departing from the spirit and scope of the utility model, and such modifications and variations fall within the scope of the utility model as defined by the appended claims.
Claims (10)
1. A portable ac impedance analyzer, comprising:
a housing;
the electrode slot is arranged on the shell and is used for inserting an electrochemical sensor, and the electrochemical sensor is used for adding viruses to be detected;
the power supply device is arranged inside the shell and is used for providing alternating current signals for the electrochemical sensor;
and the processing device is arranged inside the shell and is used for carrying out signal processing on the detected signal of the electrochemical sensor and determining an analysis result.
2. The analyzer of claim 1, further comprising:
the switch button, the data recording button and the reset button are arranged on the surface of the shell;
wherein the analyzer starts recording the analysis result after the data recording button is pressed, and returns to an initial state after the reset button is pressed.
3. The analyzer of claim 1, wherein the processing means comprises:
a signal processor for preprocessing the detected signal of the electrochemical sensor;
and the data processor is connected with the signal processor and is used for converting the data processed by the signal processor into readable data.
4. The analyzer of claim 1, further comprising:
and the display device is used for displaying the analysis result.
5. The analyzer of claim 1, further comprising:
and the transmission interface is connected with the processing device.
6. An electrochemical sensor for insertion into a portable ac impedance analyzer, the electrochemical sensor comprising:
a hand-held region disposed at a head of the electrochemical sensor;
the sample adding area is arranged adjacent to the handheld area and is used for adding viruses to be detected;
the electrode array is arranged adjacent to the sample adding area and comprises a reference electrode, a working electrode and a counter electrode;
the electrode lead comprises an extension lead of the reference electrode, an extension lead of the working electrode and an extension lead of the counter electrode, and is arranged at the tail part of the electrochemical sensor and used for being electrically connected with an electrode slot of the alternating current impedance analyzer.
7. The electrochemical sensor according to claim 6, wherein a molecular recognition layer is immobilized on the surface of the working electrode, and the molecular recognition layer contains an antibody or a nucleic acid probe.
8. The electrochemical sensor according to claim 6, wherein the working electrode surface is modified with colloidal gold.
9. The electrochemical sensor according to claim 6, wherein the electrode array has dimensions of 10mm x 10mm.
10. A portable ac impedance analysis system, comprising:
the analyzer of any one of claims 1-5 and the electrochemical sensor of any one of claims 6-9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322110441.4U CN220603363U (en) | 2023-08-07 | 2023-08-07 | Portable alternating current impedance analyzer, system and electrochemical sensor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322110441.4U CN220603363U (en) | 2023-08-07 | 2023-08-07 | Portable alternating current impedance analyzer, system and electrochemical sensor |
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| Publication Number | Publication Date |
|---|---|
| CN220603363U true CN220603363U (en) | 2024-03-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322110441.4U Active CN220603363U (en) | 2023-08-07 | 2023-08-07 | Portable alternating current impedance analyzer, system and electrochemical sensor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220603363U (en) |
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2023
- 2023-08-07 CN CN202322110441.4U patent/CN220603363U/en active Active
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