GB2436745A - Water soluble chitosan nanoparticle for delivering an anticancer agent and preparing method thereof - Google Patents
Water soluble chitosan nanoparticle for delivering an anticancer agent and preparing method thereofInfo
- Publication number
- GB2436745A GB2436745A GB0707402A GB0707402A GB2436745A GB 2436745 A GB2436745 A GB 2436745A GB 0707402 A GB0707402 A GB 0707402A GB 0707402 A GB0707402 A GB 0707402A GB 2436745 A GB2436745 A GB 2436745A
- Authority
- GB
- United Kingdom
- Prior art keywords
- soluble chitosan
- water soluble
- anticancer agent
- delivering
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001661 Chitosan Polymers 0.000 title abstract 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 7
- 239000002246 antineoplastic agent Substances 0.000 title abstract 4
- 239000002105 nanoparticle Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 125000003277 amino group Chemical group 0.000 abstract 3
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 239000012153 distilled water Substances 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 125000001165 hydrophobic group Chemical group 0.000 abstract 1
- 229940127084 other anti-cancer agent Drugs 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The present invention relates to a water soluble chitosan nanoparticle (WSC-NP) for delivering an anticancer agent and a preparing method thereof, more precisely, a water soluble chitosan nanoparticle for delivering an anticancer agent which has function of targeting on a wanted area by introducing a functional group in the location of highly reactive amine group and becomes an excellent gene carrier with the use of water soluble chitosan since the water soluble chitosan itself can combined with DNA having a negative electric charge(-) owing to the very strong positive electric charge(+) of its amine group, and a preparing method thereof. Therefore, a water-soluble chitosan nanoparticle for delivering an anticancer agent of the present invention can effectively envelope paclitaxel by introducing hydrophilic and hydrophobic groups in the position of highly reactive amine group of the water-soluble chitosan. A water soluble chitosan nanopaclitaxel prepared as the above has an excellent re-dispersion force, after freeze-drying, in distilled water and has an outstanding anticancer effect with its accumulation in tumor cells greater than that of the other anticancer agent carriers.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/KR2005/002988 WO2007029898A1 (en) | 2005-09-09 | 2005-09-09 | Water soluble chitosan nanoparticle for delivering an anticancer agent and preparing method thereof |
Publications (5)
| Publication Number | Publication Date |
|---|---|
| GB0707402D0 GB0707402D0 (en) | 2007-05-23 |
| GB2436745A true GB2436745A (en) | 2007-10-03 |
| GB2436745B GB2436745B (en) | 2011-03-16 |
| GB2436745A8 GB2436745A8 (en) | 2019-03-13 |
| GB2436745B8 GB2436745B8 (en) | 2019-03-13 |
Family
ID=37835997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB0707402.4A Expired - Fee Related GB2436745B8 (en) | 2005-09-09 | 2005-09-09 | Method for enhancing the solubility of paclitaxel |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP5116108B2 (en) |
| CN (1) | CN101273066B (en) |
| GB (1) | GB2436745B8 (en) |
| WO (1) | WO2007029898A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL221351B1 (en) * | 2012-03-14 | 2016-03-31 | Politechnika Warszawska | Method for obtaining polysaccharide nanoparticles |
| MX2014013826A (en) * | 2012-05-16 | 2018-04-24 | Singh Mewa | Pharmaceutical compositions for the delivery of substantially water-insoluble drugs. |
| KR101457478B1 (en) * | 2013-04-10 | 2014-11-06 | 순천대학교 산학협력단 | Composition for anti-green algae containing water soluble free amine chitosan and method removing green algaes using the same |
| CN106822906B (en) * | 2016-12-30 | 2020-08-04 | 四川大学 | Water-dispersible acid-responsive lymph-targeting slow-release carrier nano-carbon, preparation method and application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5916596A (en) * | 1993-02-22 | 1999-06-29 | Vivorx Pharmaceuticals, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN191203B (en) * | 1999-02-17 | 2003-10-04 | Amarnath Prof Maitra |
-
2005
- 2005-09-09 GB GB0707402.4A patent/GB2436745B8/en not_active Expired - Fee Related
- 2005-09-09 CN CN2005800515276A patent/CN101273066B/en active Active
- 2005-09-09 JP JP2008529900A patent/JP5116108B2/en active Active
- 2005-09-09 WO PCT/KR2005/002988 patent/WO2007029898A1/en active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5916596A (en) * | 1993-02-22 | 1999-06-29 | Vivorx Pharmaceuticals, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
Non-Patent Citations (3)
| Title |
|---|
| Biomaterials Vol. 23, No. 13, 2002, Nsereko et al, "Localized delivery of paclitaxel in solid tumors from biodegradable chitin microparticle formulations", pages 2723-2731. * |
| Bull. Korean Chem. Soc. Vol. 24, No. 9, 2003, Jang et al, "Characterization and modification of low molecular water-soluble chitosan for pharmaceutical application", pages 1303-1307. * |
| Eur. J. Pharm. Biopham. Vol. 57, 2004, Reul-Cariepy et al, "A thermosensitive chitosan-based hydrogel for the local delivery of paclitaxel", pages 56-63. * |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2436745B (en) | 2011-03-16 |
| GB2436745A8 (en) | 2019-03-13 |
| GB2436745B8 (en) | 2019-03-13 |
| JP2009507825A (en) | 2009-02-26 |
| CN101273066A (en) | 2008-09-24 |
| CN101273066B (en) | 2013-10-16 |
| GB0707402D0 (en) | 2007-05-23 |
| JP5116108B2 (en) | 2013-01-09 |
| WO2007029898A1 (en) | 2007-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 732E | Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977) |
Free format text: REGISTERED BETWEEN 20120906 AND 20120912 |
|
| S117 | Correction of errors in patents and applications (sect. 117/patents act 1977) |
Free format text: REQUEST FILED; REQUEST FOR CORRECTION UNDER SECTION 117 FILED ON 18 FEBRUARY 2019 |
|
| S117 | Correction of errors in patents and applications (sect. 117/patents act 1977) |
Free format text: CORRECTIONS ALLOWED; REQUEST FOR CORRECTION UNDER SECTION 117 FILED ON 18 FEBRUARY 2019 ALLOWED ON 11 MARCH 2019 |
|
| 732E | Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977) |
Free format text: REGISTERED BETWEEN 20190509 AND 20190515 |
|
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20230909 |