GB2435190A - Gastrin and cholecystokinin receptor ligands - Google Patents

Gastrin and cholecystokinin receptor ligands

Info

Publication number
GB2435190A
GB2435190A GB0711660A GB0711660A GB2435190A GB 2435190 A GB2435190 A GB 2435190A GB 0711660 A GB0711660 A GB 0711660A GB 0711660 A GB0711660 A GB 0711660A GB 2435190 A GB2435190 A GB 2435190A
Authority
GB
United Kingdom
Prior art keywords
gastrin
receptor ligands
cholecystokinin receptor
cholecystokinin
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0711660A
Other versions
GB0711660D0 (en
Inventor
Iain Mair Mcdonald
David John Dunstone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
James Black Foundation Ltd
Original Assignee
James Black Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by James Black Foundation Ltd filed Critical James Black Foundation Ltd
Publication of GB0711660D0 publication Critical patent/GB0711660D0/en
Publication of GB2435190A publication Critical patent/GB2435190A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention relates to a compound of formula (I) wherein the variables are as defined in the specification. The compound is useful for the treatment of gastrin related disorders.
GB0711660A 2004-11-15 2007-06-15 Gastrin and cholecystokinin receptor ligands Withdrawn GB2435190A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0425196A GB0425196D0 (en) 2004-11-15 2004-11-15 Gastrin and cholecystokinin receptor ligands
PCT/GB2005/004359 WO2006051312A1 (en) 2004-11-15 2005-11-14 Gastrin and cholecystokinin receptor ligands

Publications (2)

Publication Number Publication Date
GB0711660D0 GB0711660D0 (en) 2007-07-25
GB2435190A true GB2435190A (en) 2007-08-15

Family

ID=33523766

Family Applications (2)

Application Number Title Priority Date Filing Date
GB0425196A Ceased GB0425196D0 (en) 2004-11-15 2004-11-15 Gastrin and cholecystokinin receptor ligands
GB0711660A Withdrawn GB2435190A (en) 2004-11-15 2007-06-15 Gastrin and cholecystokinin receptor ligands

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB0425196A Ceased GB0425196D0 (en) 2004-11-15 2004-11-15 Gastrin and cholecystokinin receptor ligands

Country Status (2)

Country Link
GB (2) GB0425196D0 (en)
WO (1) WO2006051312A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2015001880A (en) 2012-08-16 2015-05-11 Bayer Pharma AG 2,3-benzodiazepines.
CN105263919A (en) 2013-02-19 2016-01-20 拜耳医药股份有限公司 Bicyclo 2,3-benzodiazepines and spirocyclically substituted 2,3-benzodiazepines
JP2016513118A (en) 2013-02-22 2016-05-12 バイエル ファーマ アクチエンゲゼルシャフト 4-substituted pyrrolo- and pyrazolodiazepines
US20160009725A1 (en) 2013-02-22 2016-01-14 Bayer Pharma Aktiengesellschaft Pyrrolo- and pyrazolo-triazolodiazepines as bet-protein inhibitors for treating hyperproliferative diseases
CA2929858C (en) 2013-11-22 2022-03-29 CL BioSciences LLC Gastrin antagonists (eg yf476, netazepide) for treatment and prevention of osteoporosis
WO2015121226A1 (en) * 2014-02-13 2015-08-20 Bayer Pharma Aktiengesellschaft 6-substituted 2,3-benzodiazepines
WO2017005711A1 (en) * 2015-07-09 2017-01-12 Bayer Pharma Aktiengesellschaft Phosphorous-and sulfur-substituted benzodiazepine derivatives

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993012817A1 (en) * 1991-12-20 1993-07-08 Warner-Lambert Company Therapeutic combinations useful in the treatment of gastroesophageal reflux disease
WO2003041714A1 (en) * 2001-11-13 2003-05-22 James Black Foundation Limited Benzotriazepines as gastrin and cholecystokinin receptor ligands
WO2004101533A1 (en) * 2003-05-12 2004-11-25 Janssen Pharmaceutica, N.V. 1, 3, 4-benzotriazepin-2-one salts and their use as cck receptor ligands

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993012817A1 (en) * 1991-12-20 1993-07-08 Warner-Lambert Company Therapeutic combinations useful in the treatment of gastroesophageal reflux disease
WO2003041714A1 (en) * 2001-11-13 2003-05-22 James Black Foundation Limited Benzotriazepines as gastrin and cholecystokinin receptor ligands
WO2004101533A1 (en) * 2003-05-12 2004-11-25 Janssen Pharmaceutica, N.V. 1, 3, 4-benzotriazepin-2-one salts and their use as cck receptor ligands

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Progress in Medicinal Chemistry, 2000, Vol.37, Chambers et al., pp.45-81. *
Zh. Org. Khim., 1996, Vol.32(4), Bogza et al., pp.596-603 & Beilstein Abstract Acc. No.6147978 and BRNs 8162668, 8162759, 8165432, 8167284 and 8168321. *

Also Published As

Publication number Publication date
WO2006051312A1 (en) 2006-05-18
GB0711660D0 (en) 2007-07-25
GB0425196D0 (en) 2004-12-15

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)