GB2434580A - Inhibitory analogues to block receptors for microbial pathogenic determinants - Google Patents

Inhibitory analogues to block receptors for microbial pathogenic determinants

Info

Publication number
GB2434580A
GB2434580A GB0708711A GB0708711A GB2434580A GB 2434580 A GB2434580 A GB 2434580A GB 0708711 A GB0708711 A GB 0708711A GB 0708711 A GB0708711 A GB 0708711A GB 2434580 A GB2434580 A GB 2434580A
Authority
GB
United Kingdom
Prior art keywords
microbial pathogenic
inhibitory analogues
block receptors
pathogenic determinants
determinants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0708711A
Other versions
GB0708711D0 (en
Inventor
Alastair Sutherland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Glasgow
Glasgow Caledonian University
Original Assignee
University of Glasgow
Glasgow Caledonian University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Glasgow, Glasgow Caledonian University filed Critical University of Glasgow
Publication of GB0708711D0 publication Critical patent/GB0708711D0/en
Publication of GB2434580A publication Critical patent/GB2434580A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to inhibitory analogues of virulence factors that are capable of blocking receptors for microbial pathogenic determinants that contribute to disease symptoms, in order to reduce the presence of said symptoms. In particular, it relates to inhibitors that are able to act against the toxic effects of Clostridium difficile.
GB0708711A 2004-10-05 2007-05-04 Inhibitory analogues to block receptors for microbial pathogenic determinants Withdrawn GB2434580A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0422003.4A GB0422003D0 (en) 2004-10-05 2004-10-05 Inhibitory analogues to block receptors for microbial pathogenic determinants
PCT/GB2005/003836 WO2006038007A2 (en) 2004-10-05 2005-10-05 Inhibitory analogues to block receptors for microbial pathogenic determinants

Publications (2)

Publication Number Publication Date
GB0708711D0 GB0708711D0 (en) 2007-06-20
GB2434580A true GB2434580A (en) 2007-08-01

Family

ID=33428034

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB0422003.4A Ceased GB0422003D0 (en) 2004-10-05 2004-10-05 Inhibitory analogues to block receptors for microbial pathogenic determinants
GB0708711A Withdrawn GB2434580A (en) 2004-10-05 2007-05-04 Inhibitory analogues to block receptors for microbial pathogenic determinants

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GBGB0422003.4A Ceased GB0422003D0 (en) 2004-10-05 2004-10-05 Inhibitory analogues to block receptors for microbial pathogenic determinants

Country Status (2)

Country Link
GB (2) GB0422003D0 (en)
WO (1) WO2006038007A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998059053A1 (en) * 1997-06-20 1998-12-30 Queen Mary & Westfield College Immonogenic fragments of toxin a of clostridium difficile
WO2000061761A2 (en) * 1999-04-09 2000-10-19 Techlab, Inc. Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines
US20030129198A1 (en) * 1999-04-09 2003-07-10 Wilkins Tracy D. Methods to produce high levels of C. difficile toxins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998059053A1 (en) * 1997-06-20 1998-12-30 Queen Mary & Westfield College Immonogenic fragments of toxin a of clostridium difficile
WO2000061761A2 (en) * 1999-04-09 2000-10-19 Techlab, Inc. Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines
US20030129198A1 (en) * 1999-04-09 2003-07-10 Wilkins Tracy D. Methods to produce high levels of C. difficile toxins

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FEMS Microbiology Letters (1997), Vol 155, pp 45-54, "The C-terminal ligand-binding domain of...", Sauerborn et al *
Gastroenterology (1996); Vol 111, pp 433-438, "A receptor decoy inhibits the...", Castagliuolo et al *
Infection & Immunity (1998); Vol 66, pp 2018-2025, "Antibodies to recombinant Clostridium...", Kink et al *
Infection & Immunity (1999), Vol 67, pp 5124-5132, "Local and systemic neutralizing antibody...", Ward et al *

Also Published As

Publication number Publication date
GB0708711D0 (en) 2007-06-20
WO2006038007A2 (en) 2006-04-13
WO2006038007A3 (en) 2006-08-17
GB0422003D0 (en) 2004-11-03

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)