GB2415379A - Methyl-ß-orcinolcarboxylate from lichen (everniasrum cirrhatum) for use for the treatment of fungal infections and cancer - Google Patents
Methyl-ß-orcinolcarboxylate from lichen (everniasrum cirrhatum) for use for the treatment of fungal infections and cancer Download PDFInfo
- Publication number
- GB2415379A GB2415379A GB0522200A GB0522200A GB2415379A GB 2415379 A GB2415379 A GB 2415379A GB 0522200 A GB0522200 A GB 0522200A GB 0522200 A GB0522200 A GB 0522200A GB 2415379 A GB2415379 A GB 2415379A
- Authority
- GB
- United Kingdom
- Prior art keywords
- lichen
- methyl
- cirrhatum
- fungal infections
- orcinolcarboxylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010017533 Fungal infection Diseases 0.000 title abstract 2
- 208000031888 Mycoses Diseases 0.000 title abstract 2
- UUQHKWMIDYRWHH-UHFFFAOYSA-N Methyl beta-orcinolcarboxylate Chemical compound COC(=O)C1=C(C)C=C(O)C(C)=C1O UUQHKWMIDYRWHH-UHFFFAOYSA-N 0.000 title 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 abstract 1
- 241001230280 Hypotrachyna cirrhata Species 0.000 abstract 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 abstract 1
- 229960003942 amphotericin b Drugs 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 abstract 1
- 229960004022 clotrimazole Drugs 0.000 abstract 1
- 229960000988 nystatin Drugs 0.000 abstract 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 150000004291 polyenes Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/09—Lichens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to the new use of an already known biomolecule methyl- b -orcinol carboxylate of formula (I) isolated from a lichen (Everniastrum cirrhatum), for treating pathogenic fungal infections of humans that are resistant to polyene and azole antibiotics such as amphotericin B, nystatin, clotrimazole etc.
Description
GB 2415379 A continuation (72) cont Santosh Srivastava Subash Chandra
Verma Dharmendra Saikia Mahendra Pandurang Darokar Alit Kumar Shasany Anirban Pal (74) Agent and/or Address for Service: Abel & Imray Red Lion Street, LONDON, WC1R 4PQ United Kingdom
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0701454A GB2432530A (en) | 2003-03-31 | 2003-03-31 | Methyl-beta-orcinol carboxylate for use in treating fungal infections and antifungal compositions comprising it |
| GB0716892A GB2438552B (en) | 2003-03-31 | 2003-03-31 | Ethanolic extracts from lichen (Everniastrum Cirrhatum) for use for the treatment of fungal infections |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IN2003/000097 WO2004087128A1 (en) | 2003-03-31 | 2003-03-31 | Methyl-β-orcinolcarboxylate from lichen (everniastrum cirrhatum) for use for the treatment of fungal infections and cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB0522200D0 GB0522200D0 (en) | 2005-12-07 |
| GB2415379A true GB2415379A (en) | 2005-12-28 |
| GB2415379B GB2415379B (en) | 2007-10-31 |
Family
ID=33104946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB0522200A Expired - Fee Related GB2415379B (en) | 2003-03-31 | 2003-03-31 | Methyl-ß-orcinolcarboxylate from lichen (everniasrum cirrhatum) for use for the treatment of cancer |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JP4498930B2 (en) |
| AU (1) | AU2003226628A1 (en) |
| CA (1) | CA2521055A1 (en) |
| DE (1) | DE10394214T5 (en) |
| GB (1) | GB2415379B (en) |
| WO (1) | WO2004087128A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006137172A1 (en) * | 2005-06-24 | 2006-12-28 | Taiyo Kagaku Co., Ltd. | Pest control agent of fungi or parasites for fish |
| JP2010202562A (en) * | 2009-03-03 | 2010-09-16 | Ogawa & Co Ltd | Phenol-based antimicrobial agent |
| CN115989072A (en) * | 2020-07-27 | 2023-04-18 | 兽医医药动力学有限责任公司 | Lichen extract-based formulation for cervidae animals |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05271064A (en) * | 1991-11-27 | 1993-10-19 | Dainippon Jochugiku Co Ltd | Antibacterial agent for methicillin-resistant staphylococcus aureus and infection preventing method using the agent |
-
2003
- 2003-03-31 AU AU2003226628A patent/AU2003226628A1/en not_active Abandoned
- 2003-03-31 WO PCT/IN2003/000097 patent/WO2004087128A1/en active Application Filing
- 2003-03-31 CA CA002521055A patent/CA2521055A1/en not_active Abandoned
- 2003-03-31 DE DE10394214T patent/DE10394214T5/en not_active Withdrawn
- 2003-03-31 GB GB0522200A patent/GB2415379B/en not_active Expired - Fee Related
- 2003-03-31 JP JP2004570066A patent/JP4498930B2/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05271064A (en) * | 1991-11-27 | 1993-10-19 | Dainippon Jochugiku Co Ltd | Antibacterial agent for methicillin-resistant staphylococcus aureus and infection preventing method using the agent |
Non-Patent Citations (3)
| Title |
|---|
| Journal of Medicinal and Aromatic Plant Sciences Vol. 22-23, No. 4A-1A, 2000, pages 169-172 * |
| Journal of Natural Products Vol. 48, No. 1, 1985, pages 157-158 * |
| Journal of Natural Products Vol. 49, No. 6, 1986, pages 1159-1160 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006514969A (en) | 2006-05-18 |
| CA2521055A1 (en) | 2004-10-14 |
| GB2415379B (en) | 2007-10-31 |
| DE10394214T5 (en) | 2006-03-16 |
| WO2004087128A1 (en) | 2004-10-14 |
| JP4498930B2 (en) | 2010-07-07 |
| AU2003226628A1 (en) | 2004-10-25 |
| GB0522200D0 (en) | 2005-12-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TNSN06071A1 (en) | Use of modified cyclosporins for the treatment of hcv disorders | |
| CA2460939A1 (en) | Substituted pyrazolyl compounds for the treatment of inflammation | |
| TW200503708A (en) | Gyrase inhibitors and uses thereof | |
| MXPA03011197A (en) | Benzoylsulfonamides and sulfonylbenzamidines for use as antitumour agents. | |
| MY129319A (en) | Crystal forms of azithromycin | |
| AU2002358390A1 (en) | Novel compounds | |
| CY1105137T1 (en) | DERIVATIVES OF AMINOCYCLOHEXYL ETHERS AND THEIR USES | |
| MX2009004767A (en) | Liquid preparation comprising a complex of pimobendan and cyclodextrin. | |
| RS20050946A (en) | Pyrrolodihydroisoquinolines as pde10 inhibitors | |
| WO2006111681A3 (en) | Arrangement for sterilising objects by electron bombardment | |
| MXPA03011546A (en) | New use. | |
| WO2001036685A3 (en) | Differential gene expression in cancer | |
| CA2461567A1 (en) | Substituted pyrazolyl benzenesulfamide compounds for the treatment of inflammation | |
| AUPP589598A0 (en) | Novel peptides | |
| WO2005009951A3 (en) | Diphenyl substituted cycloalkanes, compositions containing such compounds and methods of use | |
| TWI256304B (en) | Pharmaceutical compositions based on azetidine derivatives | |
| GB2415379A (en) | Methyl-ß-orcinolcarboxylate from lichen (everniasrum cirrhatum) for use for the treatment of fungal infections and cancer | |
| Lei et al. | Riboflavin targets the cellular metabolic and ribosomal pathways of Candida albicans in vitro and exhibits efficacy against oropharyngeal candidiasis | |
| NO20033318D0 (en) | 2H-1-benzopyran derivatives, process of manufacture, and pharmaceutical compositions thereof | |
| DE60220179D1 (en) | SUBSTITUTED BENZOPYRANEES AS SELECTIVE AGONISTS ON THE ESTROGEN RECEPTOR BETA | |
| DE60209359D1 (en) | LÖSUNGSMITTELVERKLEBUNGSVERFAHREN | |
| AU2002326509A1 (en) | Dominant negative variants of methionine aminopeptidase 2 (metap2) and clinical uses thereof | |
| WO2003086271A3 (en) | Azole derivatives as antifungal agents | |
| GEP20074089B (en) | Triazole compounds useful in therapy | |
| TW200741815A (en) | Substrate processing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20120331 |