GB2406569B - RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfe - Google Patents
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfeInfo
- Publication number
- GB2406569B GB2406569B GB0427955A GB0427955A GB2406569B GB 2406569 B GB2406569 B GB 2406569B GB 0427955 A GB0427955 A GB 0427955A GB 0427955 A GB0427955 A GB 0427955A GB 2406569 B GB2406569 B GB 2406569B
- Authority
- GB
- United Kingdom
- Prior art keywords
- growth factor
- vascular endothelial
- endothelial growth
- interfe
- short
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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- C12Y104/00—Oxidoreductases acting on the CH-NH2 group of donors (1.4)
- C12Y104/03—Oxidoreductases acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
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- C12Y114/19001—Stearoyl-CoA 9-desaturase (1.14.19.1), i.e. DELTA9-desaturase
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Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35858002P | 2002-02-20 | 2002-02-20 | |
| US36312402P | 2002-03-11 | 2002-03-11 | |
| PCT/US2002/017674 WO2002096927A2 (en) | 2001-05-29 | 2002-05-29 | Ribozyme based treatment of female reproductive diseases |
| US38678202P | 2002-06-06 | 2002-06-06 | |
| US39379602P | 2002-07-03 | 2002-07-03 | |
| US39934802P | 2002-07-29 | 2002-07-29 | |
| US40678402P | 2002-08-29 | 2002-08-29 | |
| US40837802P | 2002-09-05 | 2002-09-05 | |
| US40929302P | 2002-09-09 | 2002-09-09 | |
| US10/287,949 US20040102389A1 (en) | 1995-10-26 | 2002-11-04 | Nucleic acid-mediated treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R) |
| US10/306,747 US20030216335A1 (en) | 2001-11-30 | 2002-11-27 | Method and reagent for the modulation of female reproductive diseases and conditions |
| US44012903P | 2003-01-15 | 2003-01-15 | |
| GB0404898A GB2396864B (en) | 2002-02-20 | 2003-02-20 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB0427955D0 GB0427955D0 (en) | 2005-01-26 |
| GB2406569A GB2406569A (en) | 2005-04-06 |
| GB2406569B true GB2406569B (en) | 2005-07-20 |
Family
ID=40427642
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
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| GB0404898A Expired - Fee Related GB2396864B (en) | 2002-02-20 | 2003-02-20 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression |
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| GB0404898A Expired - Fee Related GB2396864B (en) | 2002-02-20 | 2003-02-20 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression |
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| EP (1) | EP1521768A4 (OSRAM) |
| JP (2) | JP2005517436A (OSRAM) |
| AU (1) | AU2003216323B2 (OSRAM) |
| CA (1) | CA2456444A1 (OSRAM) |
| GB (2) | GB2406569B (OSRAM) |
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| US20050148530A1 (en) * | 2002-02-20 | 2005-07-07 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| EP1627061B1 (en) * | 2001-05-18 | 2009-08-12 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA) |
| US20050222066A1 (en) * | 2001-05-18 | 2005-10-06 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| US20050054596A1 (en) * | 2001-11-30 | 2005-03-10 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| US20050075304A1 (en) * | 2001-11-30 | 2005-04-07 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| US20070203333A1 (en) * | 2001-11-30 | 2007-08-30 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| US20040138163A1 (en) * | 2002-05-29 | 2004-07-15 | Mcswiggen James | RNA interference mediated inhibition of vascular edothelial growth factor and vascular edothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| MXPA04010282A (es) | 2002-04-18 | 2005-08-18 | Acuity Pharmaceuticals Inc | Medios y metodos para la inhibicion especifica de genes en celulas y tejido de cns y/u ojo. |
| US7148342B2 (en) * | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
| US7807814B2 (en) * | 2003-12-23 | 2010-10-05 | The Trustees Of The University Of Pennsylvania | Compositions and methods for combined therapy of disease |
| WO2005123962A2 (en) * | 2004-06-14 | 2005-12-29 | The University Of Texas At Austin | Gene targeting in eukaryotic cells by group ii intron ribonucleoprotein particles |
| US20090142838A1 (en) * | 2004-06-14 | 2009-06-04 | Xiaoxia Cui | Methods for expressing rnp particles in eukaryotic cells |
| US8101741B2 (en) | 2005-11-02 | 2012-01-24 | Protiva Biotherapeutics, Inc. | Modified siRNA molecules and uses thereof |
| EP2029746B1 (en) * | 2006-06-12 | 2012-07-04 | Exegenics, Inc., D/b/a Opko Health, Inc. | Compositions and methods for sirna inhibition of angiogenesis |
| US7872118B2 (en) * | 2006-09-08 | 2011-01-18 | Opko Ophthalmics, Llc | siRNA and methods of manufacture |
| US20080287408A1 (en) * | 2007-05-14 | 2008-11-20 | Drugtech Corporation | Endometriosis treatment |
| CA2721333C (en) | 2008-04-15 | 2020-12-01 | Protiva Biotherapeutics, Inc. | Novel lipid formulations for nucleic acid delivery |
| WO2010005527A1 (en) | 2008-06-30 | 2010-01-14 | Angioblast Systems, Inc. | Treatment of eye diseases and excessive neovascularization using a combined therapy |
| SG171952A1 (en) * | 2008-12-04 | 2011-07-28 | Opko Ophthalmics Llc | Compositions and methods for selective inhibition of pro-angiogenic vegf isoforms |
| CA2746003C (en) * | 2008-12-04 | 2020-03-31 | Opko Curna, Llc | Treatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf |
| JP5766188B2 (ja) | 2009-07-01 | 2015-08-19 | プロチバ バイオセラピューティクス インコーポレイティッド | 固形腫瘍に治療剤を送達するための脂質製剤 |
| WO2011038160A2 (en) | 2009-09-23 | 2011-03-31 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing genes expressed in cancer |
| JP6002382B2 (ja) * | 2011-12-07 | 2016-10-05 | 株式会社バイオシンクタンク | 遺伝子発現阻害剤及び阻害方法 |
| PT2817287T (pt) | 2012-02-24 | 2018-12-28 | Arbutus Biopharma Corp | Lípidos catiónicos trialquílicos e seus métodos de utilização |
| US11572558B2 (en) | 2017-02-06 | 2023-02-07 | Nissan Chemical Corporation | Single-stranded oligonucleotide |
| US20230150926A1 (en) | 2020-03-17 | 2023-05-18 | Genevant Sciences Gmbh | Cationic lipids for lipid nanoparticle delivery of therapeutics to hepatic stellate cells |
| AU2021403156A1 (en) | 2020-12-18 | 2023-07-13 | Genevant Sciences Gmbh | Peg lipids and lipid nanoparticles |
| ES3017428T3 (en) | 2022-01-31 | 2025-05-12 | Genevant Sciences Gmbh | Ionizable cationic lipids for lipid nanoparticles |
| WO2025052278A1 (en) | 2023-09-05 | 2025-03-13 | Genevant Sciences Gmbh | Pyrrolidine based cationic lipids for lipid nanoparticle delivery of therapeutics to hepatic stellate cells |
| WO2025133951A1 (en) | 2023-12-21 | 2025-06-26 | Genevant Sciences Gmbh | Ionizable lipids suitable for lipid nanoparticles |
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| WO1997021808A1 (en) * | 1995-12-08 | 1997-06-19 | Hybridon, Inc. | Modified vegf antisense oligonucleotides |
| WO2002096927A2 (en) * | 2001-05-29 | 2002-12-05 | Ribozyme Pharmaceuticals, Incorporated | Ribozyme based treatment of female reproductive diseases |
| WO2004009769A2 (en) * | 2002-07-24 | 2004-01-29 | The Trustees Of The University Of Pennsylvania | COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOGENESIS |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030206887A1 (en) * | 1992-05-14 | 2003-11-06 | David Morrissey | RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA) |
| DE19956568A1 (de) * | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| US20030190635A1 (en) * | 2002-02-20 | 2003-10-09 | Mcswiggen James A. | RNA interference mediated treatment of Alzheimer's disease using short interfering RNA |
-
2002
- 2002-11-27 US US10/306,747 patent/US20030216335A1/en not_active Abandoned
-
2003
- 2003-02-20 GB GB0427955A patent/GB2406569B/en not_active Expired - Fee Related
- 2003-02-20 CA CA002456444A patent/CA2456444A1/en not_active Abandoned
- 2003-02-20 JP JP2003569803A patent/JP2005517436A/ja not_active Withdrawn
- 2003-02-20 EP EP03742833A patent/EP1521768A4/en not_active Withdrawn
- 2003-02-20 GB GB0404898A patent/GB2396864B/en not_active Expired - Fee Related
- 2003-02-20 AU AU2003216323A patent/AU2003216323B2/en not_active Ceased
-
2008
- 2008-06-05 JP JP2008148548A patent/JP2009000105A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997021808A1 (en) * | 1995-12-08 | 1997-06-19 | Hybridon, Inc. | Modified vegf antisense oligonucleotides |
| WO2002096927A2 (en) * | 2001-05-29 | 2002-12-05 | Ribozyme Pharmaceuticals, Incorporated | Ribozyme based treatment of female reproductive diseases |
| WO2004009769A2 (en) * | 2002-07-24 | 2004-01-29 | The Trustees Of The University Of Pennsylvania | COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOGENESIS |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2396864B (en) | 2005-03-02 |
| GB0404898D0 (en) | 2004-04-07 |
| GB2396864A (en) | 2004-07-07 |
| JP2009000105A (ja) | 2009-01-08 |
| GB0427955D0 (en) | 2005-01-26 |
| EP1521768A2 (en) | 2005-04-13 |
| AU2003216323A1 (en) | 2003-09-09 |
| EP1521768A4 (en) | 2005-07-06 |
| CA2456444A1 (en) | 2003-08-28 |
| GB2406569A (en) | 2005-04-06 |
| JP2005517436A (ja) | 2005-06-16 |
| AU2003216323B2 (en) | 2006-04-13 |
| US20030216335A1 (en) | 2003-11-20 |
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| Date | Code | Title | Description |
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| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20120220 |