GB2401789A - Heat-activated vapour generating device - Google Patents

Heat-activated vapour generating device Download PDF

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Publication number
GB2401789A
GB2401789A GB0311407A GB0311407A GB2401789A GB 2401789 A GB2401789 A GB 2401789A GB 0311407 A GB0311407 A GB 0311407A GB 0311407 A GB0311407 A GB 0311407A GB 2401789 A GB2401789 A GB 2401789A
Authority
GB
United Kingdom
Prior art keywords
sachet
vapour
substance
releasing
mitt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0311407A
Other versions
GB0311407D0 (en
Inventor
Keith Leslie Atkinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WARMWAYS HEALTHCARE HOLDINGS PLC
Original Assignee
WARMWAYS HEALTHCARE HOLDINGS P
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WARMWAYS HEALTHCARE HOLDINGS P filed Critical WARMWAYS HEALTHCARE HOLDINGS P
Priority to GB0311407A priority Critical patent/GB2401789A/en
Publication of GB0311407D0 publication Critical patent/GB0311407D0/en
Priority to PCT/GB2004/002138 priority patent/WO2004103852A1/en
Priority to US10/557,332 priority patent/US20060225728A1/en
Priority to EP04733594A priority patent/EP1633654A1/en
Publication of GB2401789A publication Critical patent/GB2401789A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00Disinfection, sterilisation or deodorisation of air
    • A61L9/015Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
    • A61L9/02Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air by heating or combustion
    • A61L9/03Apparatus therefor
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01MCATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
    • A01M1/00Stationary means for catching or killing insects
    • A01M1/20Poisoning, narcotising, or burning insects
    • A01M1/2022Poisoning or narcotising insects by vaporising an insecticide
    • A01M1/2061Poisoning or narcotising insects by vaporising an insecticide using a heat source
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00Containers or packages with special means for dispensing contents
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01MCATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
    • A01M2200/00Kind of animal
    • A01M2200/01Insects
    • A01M2200/012Flying insects
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0059Heating or cooling appliances for medical or therapeutic treatment of the human body with an open fluid circuit
    • A61F2007/006Heating or cooling appliances for medical or therapeutic treatment of the human body with an open fluid circuit of gas
    • A61F2007/0062Heating or cooling appliances for medical or therapeutic treatment of the human body with an open fluid circuit of gas the gas being steam or water vapour

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Insects & Arthropods (AREA)
  • Environmental Sciences (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Catching Or Destruction (AREA)

Abstract

A device for releasing a vapour comprises a first sachet of a vapour releasing substance and a second sachet containing a substance adapted, when activated, to initiate an exothermic reaction, the heat from the reaction being operative to release the vapour from the substance in the first sachet. The sachets may be inserted into a mitt, sleeve or pouch adapted to receive a first sachet on top of a second sachet. A packaging container 1 for the device is adapted to be deployed so as to form a pocket between lids 3, 4 to accept the mitt, sleeve or pouch. The exothermic reaction produced by the second sachet reaches an average temperature of around 40-60{C after about 2-4 hours. The first sachet contains beads impregnated with the vapour-releasing substance, which may be a decongestant or an insecticide or may be for ambience or aromatherapy use.

Description

1- 2401789 Heat-Activated Vapour Generating Device
Field of the invention
The present invention relates to devices for generating a vapour when activated by heat.
Background to the Invention
There are a variety of occasions and circumstances when a user may wish to produce a vapour. For example, when children develop blocked noses, congestion and head colds, it often has the direct effect of causing restless and sleepless nights. The knock-on effect is that parents also have restless nights.
Insect repellent vapours are also useful, if not essential, in certain climates.
Typically, these are aimed at mosquitoes and other flying insects that feed on human hosts, potentially with very harmful effects, such as malaria.
Tllere is also a growing belief in the beneficial effects of certain types of aroma on the wellbeing of the person(s) inhaling it. Such ''aromatllerapy'' is a growing market.
However, in all instances, the manner in which the aroma or vapour is released is often messy, cumbersome or just unpleasant. For example, the treatment of nasal congestion can be by means of a "rub" applied locally to the nose and/or chest areas.
Alternatively, a liquid can be applied to a tissue or handkerchief t'or application to the 2 0 nose or pillow so that the aroma can permeate the immediate vicinity of the person using the treatment. A further alternative is to use a porous block and a heat source located adjacent the block to drive ol'f the vapour from the liquid as the block is heated by the heat source. The charging and cleaning of such devices can be very time-consuming and messy. Often, a "night light" or "tea light" type of candle is used as the heat source.
2 5 There are possible health and safety issues with the use of a naked flame in a child's room overnight. Even electric versions of this basic device have their disadvantages.
More recently, nasal strips, for application to the nose, or adhesive patches have been made available to deliver vapour to the immediate environment of the person using the treatment. The el'fectiveness ol'adhesive patches is, of course, dependent on the patch 3 0 staying in place or being uncovered, eg if a child wearing a patch on its chest should sleep on its stomacll, thereby negating the effect of the released vapour.
Travellers to foreign countries often take with them an insect repellent l'or use in the evenings and/or overnight. These can conveniently consist of a holder that plugs - 2 - directly into a mains electricity socket. The holder has a plate heated by electricity. A tablet Impregnated with insecticide and/or insect repellent is inserted into the holder so as to rest ad jacent the heated plate. Tile heat activates the tablet and releases the insect repellent or insecticide. A similar kind of device to that just described can be used for aromatherapy or shnply to provide a pleasant ambient scent to a room.
Tile nature of the vapour itself is not particularly relevant to the invention. What is more important is the manner in which the vapour can be released by thermal activation, especially in environments where naked flames or a convenient supply of electrical heating energy is simply not available.
Tllere is therefore a need for a heat activated, vapour-generating device that overcomes these difficulties.
Summary of the Invention
The present invention provides, in one aspect, a device t'or releasing a vapour, the device comprising a first sachet of a vapour releasing substance and a second sachet containing a substance adapted, when activated, to initiate an exothermic reaction, the heat from said reaction operative to release the vapour from the substance in the first sachet.
Tlle device may further comprise a mitt, sleeve or pouch adapted to receive a first said sachet on top of a second said sachet.
2 0 The device may further comprise a packaging container adapted to be deployed so as to form a holder for the mitt, sleeve or pouch.
The first sachet preferably comprises an inner, tear-resistant sachet containing the exothermic material and an outer sachet containing said inner sachet, the outer sachet preventing air contacting the exothermic substance.
2 5 Tile exothermic reaction produced by the second sachet preferably reaches an average temperature of around 40-60 C after about 2-4 hours. More preferably, the exothermic reaction reaches an average temperature of around 55 C. The exothermic reaction preferably lasts t'or around 10- 12 hours.
The first sachet conveniently contains a plurality ol' beads impregnated with the 3 0 said vapour-releashlg substance. The beads are preferably placed inside an inner tear resistant sachet disposed within an outer sachet adapted to be opened for the inner sachet to be retrieved. - 3
lidvantageously the container comprises a box having a first lid portion adapted to close the box and a second lid portion adapted to be folded over the top of the first lid portion in spaced relation so as to create a space adapted to receive the mitt, sleeve or pouch when the device is activated.
The vapour released by said releasing substance may comprise a decongestant, an insect repellent, an insecticide or an aromatherapy agent.
In a second aspect, the invention provides a kit of parts for releasing a vapour, the kit comprising a container, a first sachet containing a substance adapted to release a vapour when heated, a second sachet containing a substance adapted, when activated, to initiate an exothermic reaction, and a mitt, sleeve or pouch adapted to receive a said first sachet and a said second sachet.
Brief Description of the Drawings
The invention will now be described with reference to the drawings, in which: Figure 1 is a schematic representation of a container deployed to permit release of a vapour from a sachet; and Figure 2 is a schematic representation of a mitt, sleeve or pouch for use with the sachets, with or without the container shown in Figure].
Detailed Description of the Illustrated Embodiments The device according to the invention consists of a heat generating sachet and a 2 0 vapour release sachet. The heat generating sachet consists of an inner container in which the ingredients for creating an exothermic reaction are disposed. The inner container is made of a tear-proof or tear-resistant material. The inner container and its contents are then disposed in an outer container. The outer container is preferably see- through, non breathable material and is designed to prevent air coming into contact with the inner 2 5 container until it is desired to deploy the device.
The ingredients for the heat-generating sachet are known per se and may be of the type used for hand, body and foot warmers. They are to be distinguished from sachets intended to be heated in a microwave oven and normally containing a gel. The present invention uses sachets that operate by creating an exothermic reaction within the sachet 3 0 when the ingredients of the sachet come into contact with the air. Hence the outer container.
The heat generating sachet is completely safe and does not get excessively hot in use. Typically, the sachet reaches an average temperature of around 40-60 C, preferably - 4 around 55 C, after about 3 hours use. The sachets will continue to generate heat for up to about 1()- 12 hours and possibly more in certain conditions.
The vapour-generating sachet similarly comprises a tear-resistant or tearproof inner container in which the ingredients are disposed. Preferably, the vapour-producing substance is impregnated into a plurality of small beads. In this way, the concentration of active substance can be more easily controlled.
As previously mentioned, the active substance can be medicinal in nature, an insecticide or insect repellent, or can simply create a pleasant aroma, which may itself have a therapeutic effect as in the case of aromatherapy substances. In order to prevent premature vapour release and/or for safety reasons, the inner container with its beads is preferably disposed in an outer container. This outer container is preferably see-through.
It prevents vapour release until the inner container is removed for the vapour releasing substance to be heated by the heat-generating sachet.
Although the exact composition of the vapour generating substance is not crucial to the operation of the device according to the invention, as an example' a fragrance may be selected from one or snore of eucalyptus, peppermint, menthol, lavender and rosewood.
Other potential ingredients include methyl salicylate.
In use, a vapour release sachet is removed from its outer container. Similarly, a heat-geerathlg, sachet is removed from its outer container. The former is placed on top of 2 0 the latter so that heat generated prom within the heat-generating sachet permeates through the vapour release sachet on top.
For convenience, the device preferably includes in its packaging a sleeve, mitt or pouch of soft, permeable material, such as a fleece-like material. The two sachets disposed as above can then be placed inside. It may be desirable to shake the loaded mitt, 2 5 pouch or sleeve gently t'rom side to side to ensure even distribution of the respective substances. 'I'he device is ultra-sale to carry or place under a pillow, for example, although it is recognised that dispersion of the vapour will thereby be reduced and is not recommended.
I'he loaded mitt, sleeve or pouch may be safely placed on any convenient surface 3 0 but normal precautions should be taken to prevent marking of delicate surfaces.
I'referably, however, the packaging for the product constitutes a dispenser for the device. As shown in Figure 1, the device is sold in a carton, generally indicated at 1. The carton consists of a box 2 with a lid 3 that would normally close the carton. However, the - 5 - carton also contains an inner lid 4, normally folded within the box. When deployed, first the inner lid 4 is opened and the lid 3 closed over the open box, for example by tucking in an edge (not shown) at the back of the box. What was originally the inner lid 4 is then brought over the top ol'the lid 3 and a tab 5, shown dotted in Figure 1, tucked into a slot (not visible in l-'igure 1) along the top edge of' the hinge line joining the lid 3 with the side of the box i:acing the front in Figure 1.
he lid 4 has two or more, preferably three, walls so that when deployed as shown in Figure 1, the lid 4 creates an arch over the lid 3 but leaves a space therebetween. The mitt, sleeve or pouch can then be placed on the lid 3, which thereby acts as a platform, but under cover of'the lid 4.
The lid 4 may be provided with apertures, such as star shapes 6, or any other suitable shapes, to provide a device of pleasing appearance but also to allow vapour released from the vapour release sachet to disperse more easily.
A typical mitt or pouch is illustrated in Figure 2. It consists ot'an envelope-type construction 7 with a closed end, an opening 8 and a closing flap 9. An alternative construction dispenses with the flap 9. A yet further alternative dispenses with both the flap and the closed end and consists simply oi'an open-ended sleeve. The material of the mitt, sleeve or pouch is preferably soft, for example fleece-like, and is permeable to the vapour released by the sachet.
2 0 It can therefore be appreciated that the present invention provides an easy-to-use, sel t:contahled device that needs no external energy source and which is capable of safely and conveniently providing several hours of vapour release for medicinal use, for comfort and/or Nor ambience and for many other uses, depending on the nature of the vapour release substance in the vapour release sachet. Moreover, so-called "travel" versions of 2 5 the device may be made available by suitably re-sizing and packaging the contents of the device. - 6

Claims (16)

  1. Claims 1. A device for releasing a vapour, the device comprising a first
    sachet of a vapour releasing substance and a second sachet containing a substance adapted, when activated, to initiate an exothermic reaction, the heat from said reaction operative to release the vapour prom the substance in the first sachet.
  2. 2. A device as claimed in claim l, further comprising a mitt, sleeve or pouch adapted to receive a first said sachet on top of a second said sachet.
  3. 3. A device as claimed in Claim 3, further comprising a packaging container adapted to be deployed so as to form a holder for the mitt, sleeve or pouch.
  4. 4. A device as claimed in any preceding claim, wherein said first sachet comprises an inner, tear-resistant sachet containing the exothermic substance and an outer sachet containing said inner sachet, the outer sachet preventing air contacting the exothermic substance.
  5. 5. A device as claimed in any preceding claim, wherein the exothermic reaction 2 0 produced by the second sachet reaches an average temperature of around 40-60 C after about 2-4 hours.
  6. 6. device as claimed in Claim 5, wherein the exothermic reaction reaches a temperature of around 55 C.
  7. 7. A device as claimed in Claim 5 or 6, wherein the exothermic reaction lasts for around 10- l 2 hours.
  8. 8. A device as claimed in any preceding claim, wherein said first sachet contains a 3 0 plurality of beads impregnated with the said vapour-releasing substance. - 7 -
  9. 9. A device as claimed in Claim 8, wherein the beads are placed inside an inner tear- resistant sachet disposed within an outer sachet adapted to be opened for the inner sachet to be retrieved.
  10. l O. device as claimed in Claim 3, wherein said container comprises a box having a first lid portion adapted to close the box and a second lid portion adapted to be folded over the top of the first lid portion in spaced relation so as to create a space adapted to receive the mitt, sleeve or pouch when the device is activated.
  11. 1 l. A device as claimed in any preceding claim, wherein said vapour released by said releasing substance comprises a decongestant.
  12. 12. A device as claimed in any of Claims I - I O. wherein said vapour released by said releasing substance comprises an insect repellent or an insecticide.
  13. 13. A device as claimed in any of Claims I - I O. wherein said vapour released by said releasing substance comprises an aromatherapy agent.
  14. l 4. A kit of parts for releasing a vapour, the kit comprising a container, a first sachet 2 0 containing a substance adapted to release a vapour when heated, a second sachet containing a substance adapted, when activated, to initiate an exothermic reaction, and a mitt, sleeve or pouch adapted to receive a said first sachet and a said second sachet.
  15. 15. A kit of parts as claimed in Clam 14, wherein said container is adapted to be 2 5 deployed so as to l'orm a holder for the mitt, sleeve or pouch.
  16. 16. A device, or a kit Departs, for releasing, a vapour, substantially as herein described with reference to the accompanying drawings.
GB0311407A 2003-05-19 2003-05-19 Heat-activated vapour generating device Withdrawn GB2401789A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB0311407A GB2401789A (en) 2003-05-19 2003-05-19 Heat-activated vapour generating device
PCT/GB2004/002138 WO2004103852A1 (en) 2003-05-19 2004-05-18 Heat-activated vapour generating device
US10/557,332 US20060225728A1 (en) 2003-05-19 2004-05-18 Heat-activated vapour generating device
EP04733594A EP1633654A1 (en) 2003-05-19 2004-05-18 Heat-activated vapour generating device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0311407A GB2401789A (en) 2003-05-19 2003-05-19 Heat-activated vapour generating device

Publications (2)

Publication Number Publication Date
GB0311407D0 GB0311407D0 (en) 2003-06-25
GB2401789A true GB2401789A (en) 2004-11-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
GB0311407A Withdrawn GB2401789A (en) 2003-05-19 2003-05-19 Heat-activated vapour generating device

Country Status (4)

Country Link
US (1) US20060225728A1 (en)
EP (1) EP1633654A1 (en)
GB (1) GB2401789A (en)
WO (1) WO2004103852A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006006652A1 (en) * 2004-07-14 2006-01-19 Mycoal Products Corporation Heating element
US20090000610A1 (en) * 2004-07-14 2009-01-01 Mycoal Products Corporation Microheater and Process For Producing the Same
GB2441111A (en) * 2006-08-25 2008-02-27 Warmways Holdings Plc Vapour-release device
US20090025735A1 (en) * 2007-07-25 2009-01-29 Lynda Lavigne Medical garment
US20130013036A1 (en) * 2011-07-07 2013-01-10 Jacqueline Zaragosa Aromatherapy Thermal Pad
ES2828967T3 (en) * 2015-10-29 2021-05-28 Tempra Tech Inc Portable heater for small quantities of consumer products
US9913924B2 (en) 2016-05-25 2018-03-13 S. C. Johnson & Son, Inc. Dispensing device
US10561127B2 (en) * 2016-09-09 2020-02-18 Verily Life Sciences Llc Blood feeding system using nonwoven fabric materials

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JPS5486624A (en) * 1977-12-20 1979-07-10 Toyo Ink Mfg Co Ltd Fumigating device having bullt-in heater
JPH029330A (en) * 1987-10-30 1990-01-12 Sanko Kagaku Kogyo Kk Smoking apparatus
JP2001157708A (en) * 1999-12-02 2001-06-12 Lion Corp Aromatic deodorant composition

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JPS6233102A (en) * 1985-08-07 1987-02-13 Okada Yoshiro Long acting insecticidal tool
WO1991007996A1 (en) * 1989-12-04 1991-06-13 The Clorox Company Fragrance device and method, chemically or mechanically activated
AU6767498A (en) * 1998-03-20 1999-10-18 Procter & Gamble Company, The Method for aroma delivery
JP2001294281A (en) * 2000-04-14 2001-10-23 Earth Chem Corp Ltd Hydrolytic exothermic container
JP2001299916A (en) * 2000-04-18 2001-10-30 Kao Corp Mask-shaped inhalator
JP2002354976A (en) * 2001-06-01 2002-12-10 Marin Gia:Kk Device for volatilizing drug

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Publication number Priority date Publication date Assignee Title
JPS5486624A (en) * 1977-12-20 1979-07-10 Toyo Ink Mfg Co Ltd Fumigating device having bullt-in heater
JPH029330A (en) * 1987-10-30 1990-01-12 Sanko Kagaku Kogyo Kk Smoking apparatus
JP2001157708A (en) * 1999-12-02 2001-06-12 Lion Corp Aromatic deodorant composition

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Title
WPI ABSTRACT ACCESSION NO. 1979-00238B [01] & JP 540086624 A (TOYO) 10.07.1979 *
WPI ABSTRACT ACCESSION NO. 1990-055317 [25] & JP 020009330 A (SANKO & JOHNSON) 12.01.1990 *
WPI ABSTRACT ACCESSION NO. 2001-505741 [56] & JP 2001157708 A (LION) 12.06.2001 *

Also Published As

Publication number Publication date
GB0311407D0 (en) 2003-06-25
WO2004103852A1 (en) 2004-12-02
US20060225728A1 (en) 2006-10-12
EP1633654A1 (en) 2006-03-15

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Legal Events

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COOA Change in applicant's name or ownership of the application

Owner name: WARMWAYS HEALTHCARE HOLDINGS PLC

Free format text: FORMER APPLICANT(S): ATKINSON, KEITH L

WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)