GB2375112A - Combinatorial protein domains - Google Patents

Combinatorial protein domains Download PDF

Info

Publication number
GB2375112A
GB2375112A GB0217404A GB0217404A GB2375112A GB 2375112 A GB2375112 A GB 2375112A GB 0217404 A GB0217404 A GB 0217404A GB 0217404 A GB0217404 A GB 0217404A GB 2375112 A GB2375112 A GB 2375112A
Authority
GB
United Kingdom
Prior art keywords
protein
chimaeric
designed
consist solely
sequence segments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0217404A
Other languages
English (en)
Other versions
GB0217404D0 (en
Inventor
Lutz Riechmann
Greg Winter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Domantis Ltd
Original Assignee
Domantis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0002492A external-priority patent/GB0002492D0/en
Priority claimed from GB0016346A external-priority patent/GB0016346D0/en
Priority claimed from GB0019362A external-priority patent/GB0019362D0/en
Application filed by Domantis Ltd filed Critical Domantis Ltd
Publication of GB0217404D0 publication Critical patent/GB0217404D0/en
Publication of GB2375112A publication Critical patent/GB2375112A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GB0217404A 2000-02-03 2001-02-02 Combinatorial protein domains Withdrawn GB2375112A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0002492A GB0002492D0 (en) 2000-02-03 2000-02-03 Combinatorial protein domains
US18032600P 2000-02-04 2000-02-04
GB0016346A GB0016346D0 (en) 2000-07-03 2000-07-03 Combinatorial protein domains
GB0019362A GB0019362D0 (en) 2000-08-07 2000-08-07 Combinational protein Domains
PCT/GB2001/000445 WO2001057065A2 (fr) 2000-02-03 2001-02-02 Domaine de protéines combinatoire

Publications (2)

Publication Number Publication Date
GB0217404D0 GB0217404D0 (en) 2002-09-04
GB2375112A true GB2375112A (en) 2002-11-06

Family

ID=27447768

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0217404A Withdrawn GB2375112A (en) 2000-02-03 2001-02-02 Combinatorial protein domains

Country Status (7)

Country Link
EP (1) EP1252319A2 (fr)
JP (1) JP2003523742A (fr)
AU (1) AU3040101A (fr)
CA (1) CA2399809A1 (fr)
GB (1) GB2375112A (fr)
NO (1) NO20023606L (fr)
WO (1) WO2001057065A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004101790A1 (fr) 2003-05-14 2004-11-25 Domantis Limited Procede de recuperation de polypeptides qui se deplient de façon reversible a partir d'un repertoire de polypeptides
KR20100018040A (ko) 2007-06-06 2010-02-16 도만티스 리미티드 프로테아제 내성 폴리펩티드를 선택하는 방법
TW200944231A (en) 2007-11-30 2009-11-01 Glaxo Group Ltd Antigen-binding constructs
ES2688621T3 (es) 2008-12-05 2018-11-05 Glaxo Group Limited Métodos para seleccionar polipéptidos resistentes a proteasa
WO2010097386A1 (fr) 2009-02-24 2010-09-02 Glaxo Group Limited Constructions de liaison d'antigène
CA2753287A1 (fr) 2009-02-24 2010-09-02 Glaxo Group Limited Constructions de liaison d'antigene
CA2753263A1 (fr) 2009-02-24 2010-09-02 Glaxo Group Limited Constructions multivalentes et/ou multispecifiques de liaison au rankl
US20130236467A1 (en) 2010-11-24 2013-09-12 Jeremy Griggs Multispecific antigen binding proteins targeting hgf
WO2013014208A2 (fr) 2011-07-27 2013-01-31 Glaxo Group Limited Constructions de liaison à un antigène
EP3561703B1 (fr) * 2018-04-25 2021-01-20 Bayer AG Identification d'appariement de domaines variables des chaînes légères et lourdes d'anticorps
WO2023140360A1 (fr) * 2022-01-20 2023-07-27 京都府公立大学法人 Molécule mimétique d'anticorps

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995021914A1 (fr) * 1994-02-10 1995-08-17 Pasteur Merieux Serums Et Vaccins Procede de preparation d'une banque multicombinatoire de vecteurs d'expression de genes d'anticorps
WO1997032017A1 (fr) * 1996-02-26 1997-09-04 Morphosys Gesellschaft Für Proteinoptimierung Mbh Nouvelle methode pour l'identification de sequences d'acides nucleiques codant pour deux (poly)peptides interactifs, ou plus
WO1999058655A2 (fr) * 1998-05-13 1999-11-18 Diversys Limited Methode de selection
WO2001042432A2 (fr) * 1999-12-08 2001-06-14 Medical Research Council Procedes de production de nouvelles enzymes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995021914A1 (fr) * 1994-02-10 1995-08-17 Pasteur Merieux Serums Et Vaccins Procede de preparation d'une banque multicombinatoire de vecteurs d'expression de genes d'anticorps
WO1997032017A1 (fr) * 1996-02-26 1997-09-04 Morphosys Gesellschaft Für Proteinoptimierung Mbh Nouvelle methode pour l'identification de sequences d'acides nucleiques codant pour deux (poly)peptides interactifs, ou plus
WO1999058655A2 (fr) * 1998-05-13 1999-11-18 Diversys Limited Methode de selection
WO2001042432A2 (fr) * 1999-12-08 2001-06-14 Medical Research Council Procedes de production de nouvelles enzymes

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Chem. & Biology 1999, 8, pp.R91-R105 - O'Brien et al. *
Gene 2000, 242(2), pp.369-379 - Flajolet et al. *
Nature 1998, 391, pp.288-291 - Crameri et al. *
Nature 2000, 403, pp.617-622 - Altamirano et al. *
Proc. Natl. Acad. Sci. USA 1998, 95, pp.9813-9818 - Hopfner et al. *
Proc. Natl. Acad. Sci. USA 1999, 96, pp.3562-3567 - Ostermeier et al. *
Proc. Natl. Acad. Sci. USA 2000, 97(18), pp.10068-73 - Riechmann et al. *

Also Published As

Publication number Publication date
WO2001057065A2 (fr) 2001-08-09
AU3040101A (en) 2001-08-14
EP1252319A2 (fr) 2002-10-30
NO20023606L (no) 2002-10-02
WO2001057065A3 (fr) 2002-01-31
CA2399809A1 (fr) 2001-08-09
JP2003523742A (ja) 2003-08-12
NO20023606D0 (no) 2002-07-30
GB0217404D0 (en) 2002-09-04

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)