GB2358861A - Substances from porcine tissue - Google Patents

Substances from porcine tissue

Info

Publication number
GB2358861A
GB2358861A GB0110534A GB0110534A GB2358861A GB 2358861 A GB2358861 A GB 2358861A GB 0110534 A GB0110534 A GB 0110534A GB 0110534 A GB0110534 A GB 0110534A GB 2358861 A GB2358861 A GB 2358861A
Authority
GB
United Kingdom
Prior art keywords
porcine tissue
type
substances
porcine
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0110534A
Other versions
GB0110534D0 (en
Inventor
Khalid Gumaa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rademacher Group Ltd
Original Assignee
Rademacher Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rademacher Group Ltd filed Critical Rademacher Group Ltd
Publication of GB0110534D0 publication Critical patent/GB0110534D0/en
Publication of GB2358861A publication Critical patent/GB2358861A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Emergency Medicine (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The use of porcine tissue, and especially porcine liver acetone powder, as a source of P and A-type inositolphosphoglycans (IPGs) is disclosed. In particular, the A-type substances as obtainable from porcine tissue have the biological activities of inhibiting cAMP dependent protein kinase and inhibiting glucose stimulated lipogenesis, making them suitable for use as A-type IPG antagonists. These antagonists are useful for the treatment of conditions such as diabetes as they do not substantially affect insulin stimulated lipogenesis and act to lower blood glucose levels.
GB0110534A 1998-12-23 1999-12-23 Substances from porcine tissue Withdrawn GB2358861A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9828560.4A GB9828560D0 (en) 1998-12-23 1998-12-23 Substances from porcine tissue
PCT/GB1999/004384 WO2000038698A2 (en) 1998-12-23 1999-12-23 Substances from porcine tissue

Publications (2)

Publication Number Publication Date
GB0110534D0 GB0110534D0 (en) 2001-06-20
GB2358861A true GB2358861A (en) 2001-08-08

Family

ID=10844984

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB9828560.4A Ceased GB9828560D0 (en) 1998-12-23 1998-12-23 Substances from porcine tissue
GB0110534A Withdrawn GB2358861A (en) 1998-12-23 1999-12-23 Substances from porcine tissue

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GBGB9828560.4A Ceased GB9828560D0 (en) 1998-12-23 1998-12-23 Substances from porcine tissue

Country Status (3)

Country Link
AU (1) AU1878600A (en)
GB (2) GB9828560D0 (en)
WO (1) WO2000038698A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4446064A (en) * 1980-12-19 1984-05-01 The University Of Virginia Alumni Patents Foundation Insulin mediator substance
US4839466A (en) * 1986-04-11 1989-06-13 The Rockefeller University Insulin activity messengers
WO1998011117A1 (en) * 1996-09-11 1998-03-19 Rademacher Group Limited Cyclitol containing carbohydrates from human tissue which regulate glycogen metabolism
WO1998011116A1 (en) * 1996-09-11 1998-03-19 Rademacher Group Limited Cyclitol containing carbohydrates from human tissue which regulate lipogenic activity
WO1998011435A1 (en) * 1996-09-11 1998-03-19 Rademacher Group Limited Materials and methods relating to the diagnosis and treatment of diabetes and obesity

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4446064A (en) * 1980-12-19 1984-05-01 The University Of Virginia Alumni Patents Foundation Insulin mediator substance
US4839466A (en) * 1986-04-11 1989-06-13 The Rockefeller University Insulin activity messengers
WO1998011117A1 (en) * 1996-09-11 1998-03-19 Rademacher Group Limited Cyclitol containing carbohydrates from human tissue which regulate glycogen metabolism
WO1998011116A1 (en) * 1996-09-11 1998-03-19 Rademacher Group Limited Cyclitol containing carbohydrates from human tissue which regulate lipogenic activity
WO1998011435A1 (en) * 1996-09-11 1998-03-19 Rademacher Group Limited Materials and methods relating to the diagnosis and treatment of diabetes and obesity

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Biochimie, 1998, Vol. 80(12), pages 1063-1067 *
Comparative Biochemistry and Physiology, 1996, Vol. 115B(2), pages 223-241 *

Also Published As

Publication number Publication date
AU1878600A (en) 2000-07-31
WO2000038698A3 (en) 2000-10-26
WO2000038698A2 (en) 2000-07-06
GB0110534D0 (en) 2001-06-20
GB9828560D0 (en) 1999-02-17

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)