GB2344885A - Diagnostic device - Google Patents
Diagnostic device Download PDFInfo
- Publication number
- GB2344885A GB2344885A GB9828076A GB9828076A GB2344885A GB 2344885 A GB2344885 A GB 2344885A GB 9828076 A GB9828076 A GB 9828076A GB 9828076 A GB9828076 A GB 9828076A GB 2344885 A GB2344885 A GB 2344885A
- Authority
- GB
- United Kingdom
- Prior art keywords
- breath
- temperature
- detecting
- operable
- exhaled breath
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/411—Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Physiology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Device comprises means for detecting the temperature of exhaled breath along with the concentration of at least one gaseous component of the breath e.g, CO and/or NO as a diagnostic tool.
Description
DETECTOR
This invention relates to detectors.
It has been proposed to measure the level of gaseous components of exhaled breath, for example as a diagnostic tool. An example is a measurement of nitric oxide (NO) content, which can indicate a level of lung inflammation due to allergen challenge.
This invention provides apparatus for detecting the temperature of exhaled breath along with the level of at least one gaseous component of the exhaled breath.
Preferably the at least one gaseous component is NO, carbon monoxide (CO), or both.
Preferably the time dependence of the detected temperature and gas component levels are detected and/or analysed during at least a part of the duration of exhalation of a breath.
Preferably any results obtained with reference to an initial portion of the breath are discarded or disregarded. Preferably a flow rate of the exhaled breath is also detected; this information can in part be used to calibrate one or more of the other measurements.
An embodiment will now be described by way of example only.
Figure 1 schematically illustrates a sampling system. A tube 10 having a disposable mouthpiece 20 (for hygiene) has a temperature probe 30 supported at or near to the mouthpiece end of the tube (although it could be elsewhere in the air flow path). The probe 30, for example a thermocouple, is connecte to temperature detection circuitry 40.
A tube 50 taps off a proportion of the air exhaled into the mouthpiece and communicates with a detection apparatus 60 for NO & CO. Further tubes 70 (and there may be more) are used in conjunction with a flow rate detector 80 to detect rate of flow through the tube 10.
A restriction 90 imposes a back pressure against the exhalation, assisting in the proper detection of NO.
To avoid problems with so-called"dead space"air, results relating to a first part of the breath (e. g. the first 5 seconds or the first 250 ml) can be disregarded or discarded.
Figure 2 illustrates some preliminary results obtained for temperature measurement. Asthma sufferers are found to have a more rapid temperature rise time than"normal"patients. Kartagherner syndrome sufferers have a slower rise time but a higher asymptotic temperature. These results can be correlated with the detected
NO & CO levels to provide a more accurate diagnostic detection of these or other medical problems or situations.
Claims (7)
- CLAIMS 1. Diagnostic apparatus comprising means for detecting the temperature of exhaled breath along with the concentration of at least one gaseous component of the exhaled breath.
- 2. Apparatus according to claim 1, in which the at least one gaseous component is NO, carbon monoxide (CO), or both.
- 3. Apparatus according to claim 1 or claim 2, in which the detecting means is operable to detect the variation with time of the detected temperature and gas component levels during at least a part of the duration of exhalation of a breath.
- 4. Apparatus according to any one of the preceding claims, in which the detecting means is operable to discard any results obtained with reference to an initial portion of the breath are discarded or disregarded.
- 5. Apparatus according to any one of the preceding claims, comprising means for detecting a flow rate of the exhaled breath.
- 6. Apparatus according to claim 5, the apparatus being operable to calibrate one or more of the gas and temperature measurements in dependence on the detected flow rate.
- 7. Diagnostic apparatus substantially as hereinbefore described with reference to the accompanying drawings.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9828076A GB2344885A (en) | 1998-12-18 | 1998-12-18 | Diagnostic device |
PCT/GB1999/004340 WO2000036976A1 (en) | 1998-12-18 | 1999-12-17 | Detector |
AU18753/00A AU1875300A (en) | 1998-12-18 | 1999-12-17 | Detector |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9828076A GB2344885A (en) | 1998-12-18 | 1998-12-18 | Diagnostic device |
Publications (2)
Publication Number | Publication Date |
---|---|
GB9828076D0 GB9828076D0 (en) | 1999-02-17 |
GB2344885A true GB2344885A (en) | 2000-06-21 |
Family
ID=10844610
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB9828076A Withdrawn GB2344885A (en) | 1998-12-18 | 1998-12-18 | Diagnostic device |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU1875300A (en) |
GB (1) | GB2344885A (en) |
WO (1) | WO2000036976A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10110838A1 (en) * | 2001-03-06 | 2002-09-26 | Mlu Halle Wittenberg | Diagnosis of allergies, pseudo-allergies and intolerances, comprises measuring the increased concentrations of pentane and isoprene in the exhaled air after the administration of a trigger substance |
DE10231541A1 (en) * | 2002-07-11 | 2004-01-29 | Gäbler, Ralph, Dr. | Method for determining the response of a biological system |
CN105167776A (en) * | 2014-11-26 | 2015-12-23 | 深圳市一体医疗科技有限公司 | Lung monitoring system |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BG65874B1 (en) | 2005-07-27 | 2010-04-30 | ДУНЕВ Стефан | Device for measuring the temperature of exhaled air |
US8747325B2 (en) | 2010-07-16 | 2014-06-10 | Fundacao De Amparo A Pesquisa Do Estado De Sao Paulo (Fapesp) | Non-invasive method for diagnosing the severity of heart failure by extracting and analyzing acetone concentrations in captured exhaled breath |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3785774A (en) * | 1971-06-18 | 1974-01-15 | Borg Warner | Breath testing system with breath temperature sensor |
US4671298A (en) * | 1984-11-26 | 1987-06-09 | Meridian Medical Corporation | Isothermal rebreathing apparatus and method |
US4809810A (en) * | 1986-05-01 | 1989-03-07 | Autosense Corporation | Breath alcohol analyzer |
WO1994022686A1 (en) * | 1993-04-01 | 1994-10-13 | Alcohol Sensors International, Ltd. | Breath sensor apparatus |
US5383469A (en) * | 1992-01-31 | 1995-01-24 | Board Of Trustees Of The Leland Stanford Junior University | Neonatal hemolysis detection using end-tidal breath sampler and analyzer apparatus |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3884219A (en) * | 1973-04-02 | 1975-05-20 | Medical Monitor Systems | System for determining temperature and respiration rate |
DE2816499C2 (en) * | 1978-04-15 | 1981-02-19 | Draegerwerk Ag, 2400 Luebeck | Method and arrangement for the detection and separation of the alveolar air fraction from the breathing air |
GB2301440B (en) * | 1992-11-04 | 1997-04-16 | Fisher & Paykel | Medical airway temperature sensor |
US5518002A (en) * | 1993-10-22 | 1996-05-21 | Medtrac Technologies, Inc. | Portable electronic spirometric device |
US5622182A (en) * | 1994-06-27 | 1997-04-22 | Jaffe; Richard A. | System for measuring core body temperature in vivo |
-
1998
- 1998-12-18 GB GB9828076A patent/GB2344885A/en not_active Withdrawn
-
1999
- 1999-12-17 WO PCT/GB1999/004340 patent/WO2000036976A1/en active Application Filing
- 1999-12-17 AU AU18753/00A patent/AU1875300A/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3785774A (en) * | 1971-06-18 | 1974-01-15 | Borg Warner | Breath testing system with breath temperature sensor |
US4671298A (en) * | 1984-11-26 | 1987-06-09 | Meridian Medical Corporation | Isothermal rebreathing apparatus and method |
US4809810A (en) * | 1986-05-01 | 1989-03-07 | Autosense Corporation | Breath alcohol analyzer |
US5383469A (en) * | 1992-01-31 | 1995-01-24 | Board Of Trustees Of The Leland Stanford Junior University | Neonatal hemolysis detection using end-tidal breath sampler and analyzer apparatus |
WO1994022686A1 (en) * | 1993-04-01 | 1994-10-13 | Alcohol Sensors International, Ltd. | Breath sensor apparatus |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10110838A1 (en) * | 2001-03-06 | 2002-09-26 | Mlu Halle Wittenberg | Diagnosis of allergies, pseudo-allergies and intolerances, comprises measuring the increased concentrations of pentane and isoprene in the exhaled air after the administration of a trigger substance |
DE10110838C2 (en) * | 2001-03-06 | 2003-04-03 | Mlu Halle Wittenberg | Methods for the diagnosis of allergies, pseudo-allergies and intolerances |
DE10231541A1 (en) * | 2002-07-11 | 2004-01-29 | Gäbler, Ralph, Dr. | Method for determining the response of a biological system |
CN105167776A (en) * | 2014-11-26 | 2015-12-23 | 深圳市一体医疗科技有限公司 | Lung monitoring system |
Also Published As
Publication number | Publication date |
---|---|
WO2000036976A1 (en) | 2000-06-29 |
AU1875300A (en) | 2000-07-12 |
GB9828076D0 (en) | 1999-02-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |