GB2344885A - Diagnostic device - Google Patents

Diagnostic device Download PDF

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Publication number
GB2344885A
GB2344885A GB9828076A GB9828076A GB2344885A GB 2344885 A GB2344885 A GB 2344885A GB 9828076 A GB9828076 A GB 9828076A GB 9828076 A GB9828076 A GB 9828076A GB 2344885 A GB2344885 A GB 2344885A
Authority
GB
United Kingdom
Prior art keywords
breath
temperature
detecting
operable
exhaled breath
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB9828076A
Other versions
GB9828076D0 (en
Inventor
Peter Barnes
Sergei Kharitonov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boditech Diagnostics Ltd
Original Assignee
Boditech Diagnostics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boditech Diagnostics Ltd filed Critical Boditech Diagnostics Ltd
Priority to GB9828076A priority Critical patent/GB2344885A/en
Publication of GB9828076D0 publication Critical patent/GB9828076D0/en
Priority to PCT/GB1999/004340 priority patent/WO2000036976A1/en
Priority to AU18753/00A priority patent/AU1875300A/en
Publication of GB2344885A publication Critical patent/GB2344885A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/411—Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Physiology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Device comprises means for detecting the temperature of exhaled breath along with the concentration of at least one gaseous component of the breath e.g, CO and/or NO as a diagnostic tool.

Description

DETECTOR This invention relates to detectors.
It has been proposed to measure the level of gaseous components of exhaled breath, for example as a diagnostic tool. An example is a measurement of nitric oxide (NO) content, which can indicate a level of lung inflammation due to allergen challenge.
This invention provides apparatus for detecting the temperature of exhaled breath along with the level of at least one gaseous component of the exhaled breath.
Preferably the at least one gaseous component is NO, carbon monoxide (CO), or both.
Preferably the time dependence of the detected temperature and gas component levels are detected and/or analysed during at least a part of the duration of exhalation of a breath.
Preferably any results obtained with reference to an initial portion of the breath are discarded or disregarded. Preferably a flow rate of the exhaled breath is also detected; this information can in part be used to calibrate one or more of the other measurements.
An embodiment will now be described by way of example only.
Figure 1 schematically illustrates a sampling system. A tube 10 having a disposable mouthpiece 20 (for hygiene) has a temperature probe 30 supported at or near to the mouthpiece end of the tube (although it could be elsewhere in the air flow path). The probe 30, for example a thermocouple, is connecte to temperature detection circuitry 40.
A tube 50 taps off a proportion of the air exhaled into the mouthpiece and communicates with a detection apparatus 60 for NO & CO. Further tubes 70 (and there may be more) are used in conjunction with a flow rate detector 80 to detect rate of flow through the tube 10.
A restriction 90 imposes a back pressure against the exhalation, assisting in the proper detection of NO.
To avoid problems with so-called"dead space"air, results relating to a first part of the breath (e. g. the first 5 seconds or the first 250 ml) can be disregarded or discarded.
Figure 2 illustrates some preliminary results obtained for temperature measurement. Asthma sufferers are found to have a more rapid temperature rise time than"normal"patients. Kartagherner syndrome sufferers have a slower rise time but a higher asymptotic temperature. These results can be correlated with the detected NO & CO levels to provide a more accurate diagnostic detection of these or other medical problems or situations.

Claims (7)

  1. CLAIMS 1. Diagnostic apparatus comprising means for detecting the temperature of exhaled breath along with the concentration of at least one gaseous component of the exhaled breath.
  2. 2. Apparatus according to claim 1, in which the at least one gaseous component is NO, carbon monoxide (CO), or both.
  3. 3. Apparatus according to claim 1 or claim 2, in which the detecting means is operable to detect the variation with time of the detected temperature and gas component levels during at least a part of the duration of exhalation of a breath.
  4. 4. Apparatus according to any one of the preceding claims, in which the detecting means is operable to discard any results obtained with reference to an initial portion of the breath are discarded or disregarded.
  5. 5. Apparatus according to any one of the preceding claims, comprising means for detecting a flow rate of the exhaled breath.
  6. 6. Apparatus according to claim 5, the apparatus being operable to calibrate one or more of the gas and temperature measurements in dependence on the detected flow rate.
  7. 7. Diagnostic apparatus substantially as hereinbefore described with reference to the accompanying drawings.
GB9828076A 1998-12-18 1998-12-18 Diagnostic device Withdrawn GB2344885A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB9828076A GB2344885A (en) 1998-12-18 1998-12-18 Diagnostic device
PCT/GB1999/004340 WO2000036976A1 (en) 1998-12-18 1999-12-17 Detector
AU18753/00A AU1875300A (en) 1998-12-18 1999-12-17 Detector

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9828076A GB2344885A (en) 1998-12-18 1998-12-18 Diagnostic device

Publications (2)

Publication Number Publication Date
GB9828076D0 GB9828076D0 (en) 1999-02-17
GB2344885A true GB2344885A (en) 2000-06-21

Family

ID=10844610

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9828076A Withdrawn GB2344885A (en) 1998-12-18 1998-12-18 Diagnostic device

Country Status (3)

Country Link
AU (1) AU1875300A (en)
GB (1) GB2344885A (en)
WO (1) WO2000036976A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10110838A1 (en) * 2001-03-06 2002-09-26 Mlu Halle Wittenberg Diagnosis of allergies, pseudo-allergies and intolerances, comprises measuring the increased concentrations of pentane and isoprene in the exhaled air after the administration of a trigger substance
DE10231541A1 (en) * 2002-07-11 2004-01-29 Gäbler, Ralph, Dr. Method for determining the response of a biological system
CN105167776A (en) * 2014-11-26 2015-12-23 深圳市一体医疗科技有限公司 Lung monitoring system

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BG65874B1 (en) 2005-07-27 2010-04-30 ДУНЕВ Стефан Device for measuring the temperature of exhaled air
US8747325B2 (en) 2010-07-16 2014-06-10 Fundacao De Amparo A Pesquisa Do Estado De Sao Paulo (Fapesp) Non-invasive method for diagnosing the severity of heart failure by extracting and analyzing acetone concentrations in captured exhaled breath

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3785774A (en) * 1971-06-18 1974-01-15 Borg Warner Breath testing system with breath temperature sensor
US4671298A (en) * 1984-11-26 1987-06-09 Meridian Medical Corporation Isothermal rebreathing apparatus and method
US4809810A (en) * 1986-05-01 1989-03-07 Autosense Corporation Breath alcohol analyzer
WO1994022686A1 (en) * 1993-04-01 1994-10-13 Alcohol Sensors International, Ltd. Breath sensor apparatus
US5383469A (en) * 1992-01-31 1995-01-24 Board Of Trustees Of The Leland Stanford Junior University Neonatal hemolysis detection using end-tidal breath sampler and analyzer apparatus

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3884219A (en) * 1973-04-02 1975-05-20 Medical Monitor Systems System for determining temperature and respiration rate
DE2816499C2 (en) * 1978-04-15 1981-02-19 Draegerwerk Ag, 2400 Luebeck Method and arrangement for the detection and separation of the alveolar air fraction from the breathing air
GB2301440B (en) * 1992-11-04 1997-04-16 Fisher & Paykel Medical airway temperature sensor
US5518002A (en) * 1993-10-22 1996-05-21 Medtrac Technologies, Inc. Portable electronic spirometric device
US5622182A (en) * 1994-06-27 1997-04-22 Jaffe; Richard A. System for measuring core body temperature in vivo

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3785774A (en) * 1971-06-18 1974-01-15 Borg Warner Breath testing system with breath temperature sensor
US4671298A (en) * 1984-11-26 1987-06-09 Meridian Medical Corporation Isothermal rebreathing apparatus and method
US4809810A (en) * 1986-05-01 1989-03-07 Autosense Corporation Breath alcohol analyzer
US5383469A (en) * 1992-01-31 1995-01-24 Board Of Trustees Of The Leland Stanford Junior University Neonatal hemolysis detection using end-tidal breath sampler and analyzer apparatus
WO1994022686A1 (en) * 1993-04-01 1994-10-13 Alcohol Sensors International, Ltd. Breath sensor apparatus

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10110838A1 (en) * 2001-03-06 2002-09-26 Mlu Halle Wittenberg Diagnosis of allergies, pseudo-allergies and intolerances, comprises measuring the increased concentrations of pentane and isoprene in the exhaled air after the administration of a trigger substance
DE10110838C2 (en) * 2001-03-06 2003-04-03 Mlu Halle Wittenberg Methods for the diagnosis of allergies, pseudo-allergies and intolerances
DE10231541A1 (en) * 2002-07-11 2004-01-29 Gäbler, Ralph, Dr. Method for determining the response of a biological system
CN105167776A (en) * 2014-11-26 2015-12-23 深圳市一体医疗科技有限公司 Lung monitoring system

Also Published As

Publication number Publication date
WO2000036976A1 (en) 2000-06-29
AU1875300A (en) 2000-07-12
GB9828076D0 (en) 1999-02-17

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)