GB2344592B - Retroviral vectors comprising a functional splice donor site and a functional splice acceptor site - Google Patents

Retroviral vectors comprising a functional splice donor site and a functional splice acceptor site

Info

Publication number
GB2344592B
GB2344592B GB0006992A GB0006992A GB2344592B GB 2344592 B GB2344592 B GB 2344592B GB 0006992 A GB0006992 A GB 0006992A GB 0006992 A GB0006992 A GB 0006992A GB 2344592 B GB2344592 B GB 2344592B
Authority
GB
United Kingdom
Prior art keywords
functional splice
site
retroviral vectors
functional
donor site
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0006992A
Other versions
GB0006992D0 (en
GB2344592A (en
Inventor
Chris Bebbington
Susan Mary Kingsman
Mark Uden
Alan John Kingsman
Kyriacos Mitrophanos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford Biomedica UK Ltd
Original Assignee
Oxford Biomedica UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9720465.5A external-priority patent/GB9720465D0/en
Application filed by Oxford Biomedica UK Ltd filed Critical Oxford Biomedica UK Ltd
Priority to GB0006992A priority Critical patent/GB2344592B/en
Publication of GB0006992D0 publication Critical patent/GB0006992D0/en
Publication of GB2344592A publication Critical patent/GB2344592A/en
Application granted granted Critical
Publication of GB2344592B publication Critical patent/GB2344592B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20111—Lyssavirus, e.g. rabies virus
    • C12N2760/20122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
    • C12N2810/6045—RNA rev transcr viruses
    • C12N2810/6054—Retroviridae
GB0006992A 1997-09-25 1998-09-23 Retroviral vectors comprising a functional splice donor site and a functional splice acceptor site Expired - Fee Related GB2344592B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB0006992A GB2344592B (en) 1997-09-25 1998-09-23 Retroviral vectors comprising a functional splice donor site and a functional splice acceptor site

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9720465.5A GB9720465D0 (en) 1997-09-25 1997-09-25 Dual-virus vectors
GB0006992A GB2344592B (en) 1997-09-25 1998-09-23 Retroviral vectors comprising a functional splice donor site and a functional splice acceptor site
PCT/GB1998/002867 WO1999015683A1 (en) 1997-09-25 1998-09-23 Retroviral vectors comprising a functional splice donor site and a functional splice acceptor site

Publications (3)

Publication Number Publication Date
GB0006992D0 GB0006992D0 (en) 2000-05-10
GB2344592A GB2344592A (en) 2000-06-14
GB2344592B true GB2344592B (en) 2002-09-11

Family

ID=26243942

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0006992A Expired - Fee Related GB2344592B (en) 1997-09-25 1998-09-23 Retroviral vectors comprising a functional splice donor site and a functional splice acceptor site

Country Status (1)

Country Link
GB (1) GB2344592B (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027470A1 (en) * 1993-05-28 1994-12-08 B.A. Bodenheimer & Co., Inc. Apparatus for removably mounting a generator unit
WO1996028563A1 (en) * 1995-03-09 1996-09-19 Bavarian Nordic Vectors carrying therapeutic genes encoding antimicrobial peptides for gene therapy
WO1998015636A1 (en) * 1996-10-10 1998-04-16 Henrik Garoff Alphavirus-retrovirus vectors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631162A (en) * 1993-06-11 1997-05-20 Massachusetts Institute Of Technology Retroviral vectors for transducing β-globin gene and β-locus control region derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027470A1 (en) * 1993-05-28 1994-12-08 B.A. Bodenheimer & Co., Inc. Apparatus for removably mounting a generator unit
WO1996028563A1 (en) * 1995-03-09 1996-09-19 Bavarian Nordic Vectors carrying therapeutic genes encoding antimicrobial peptides for gene therapy
WO1998015636A1 (en) * 1996-10-10 1998-04-16 Henrik Garoff Alphavirus-retrovirus vectors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Cell Research Vol. 7 (1) 1997. Zheng B et.al. pages 21-29 *
Faseb J. Vol. 11 (1)) 1997. Bilbao G et.al. pages 624-634 *
Nucl. Acid. Res. Vol. 18 (12) 1990. Morgenstern J P et.al. pages 3587-3596 *
Promega Product Catalogue 1997; pages 254-255 *

Also Published As

Publication number Publication date
GB0006992D0 (en) 2000-05-10
GB2344592A (en) 2000-06-14

Similar Documents

Publication Publication Date Title
ZA972222B (en) Management-capable splice cassette
GB9702579D0 (en) A tapered rib waveguide
IT1301781B1 (en) TOGETHER WITH BUCKLE
IL135291A (en) Fiber optic rotary joint
NO983304D0 (en) cable Anchoring
NO996441D0 (en) A connector
IL136581A0 (en) Procedure and system for the transmission of information and setting up of a telecommunication connection
GB2327883B (en) Pesticidal device
ZA983442B (en) Fibre optic splice closure
DE69801566D1 (en) POLYISOCYANATE XEROGELE
FR2750518B1 (en) SECURE GRAPHIC INTERFACE LAUNCHER
PL338382A1 (en) Dyeing agents
GB0120709D0 (en) Retroviral vectors comprising functional and non-functional splice donor and splice acceptor sites
GB9710105D0 (en) Splice closure
GB2344592B (en) Retroviral vectors comprising a functional splice donor site and a functional splice acceptor site
FR2760333B1 (en) BACKPACK
FR2767119B1 (en) RELEASABLE HINGE HOUSING AND SELF-SEALING LIPSTICK
GB9703312D0 (en) A waveguide
NO995005L (en) A new approach
HUP0003798A3 (en) A construction element
IT1293080B1 (en) WATERPROOF HINGES
GB2345062B (en) Retroviral vectors
IT1304154B1 (en) TOGETHER WITH BUCKLE
PL330286A1 (en) Chemical fibre spliced rope in the form of a hose
GB2332474B (en) A hinge

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20090923