GB2333609A - Salicylate inhibition of Acanthamoeba attachment to contact lenses - Google Patents

Salicylate inhibition of Acanthamoeba attachment to contact lenses Download PDF

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Publication number
GB2333609A
GB2333609A GB9801585A GB9801585A GB2333609A GB 2333609 A GB2333609 A GB 2333609A GB 9801585 A GB9801585 A GB 9801585A GB 9801585 A GB9801585 A GB 9801585A GB 2333609 A GB2333609 A GB 2333609A
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GB
United Kingdom
Prior art keywords
acanthamoeba
attachment
contact lens
contact lenses
sodium salicylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9801585A
Other versions
GB2333609B (en
GB9801585D0 (en
Inventor
Prof Alan Tomlinson
David Seal
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Individual
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Individual
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Publication date
Application filed by Individual filed Critical Individual
Priority to GB9801585A priority Critical patent/GB2333609B/en
Publication of GB9801585D0 publication Critical patent/GB9801585D0/en
Publication of GB2333609A publication Critical patent/GB2333609A/en
Application granted granted Critical
Publication of GB2333609B publication Critical patent/GB2333609B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Sodium salicylate, at 30mM to 300mM concentration, prevents the attachment of the free-living amoeba Acanthamoeba to contact lenses with or without associated bacterial biofilm. If sodium salicylate is added to disinfecting or overnight soaking solutions for contact lenses, within contaminated storage cases, the risk of Acanthamoeba keratitis will be greatly reduced by preventing attachment of the amoeba to the contact lens and its transmission to the surface of the eye.

Description

SALICYLATE INHIBITION OF ACANTRAMOEBA ATTACHMENT TO CONTACT LENSES This invention relates to a concentration of sodium salicylate that prevents attachment of a free-living amoeba, in particular Acanthamoeba, to contact lenses.
Contact lenses are worn, by approximately 30 million people, to correct visual acuity instead of wearing spectacles. They are produced from rigid materials and soft (hydrogel) materials, the latter being associated with infection by free-living amoebae, in particular Acanthamoeba; in the UK such amoebic infection has been recorded in 1: 6750 contact lens wearers per year.
The majority of contact lenses are replaced on a yearly or monthly basis with the minority being disposed of on a daily wear basis only. The contact lens is soaked overnight in a storage case, often contaminated with Acanthamoeba from tap water washing, during which time Acanthamoeba can attach to the contact lens. When the contact lens is taken out of the storage case in the morning, the lens acts as a vehicle to carry this organism to the surface of the eye to cause invasive infection.
30 mM sodium salicylate in solution, such as a contact lens storage case solution, prevents the attachment ofAcanthamoeba to contact lenses, with or without an associated bacterial biofilm, and hence reduces the chance for transfer of the Acanthamoeba from the storage case to the eye, so preventing a risk of infection to the wearer.

Claims (3)

  1. CLAIMS 1) A concentration of sodium salicylate at 30mM contact lens storage case solution will prevent the attachment ofAcanthamoeba to the contact lens within the storage case so preventing transmission of Acanthamoeba from the storage case to the eye attached to the contact lens.
  2. 2) A concentration from 30 to 300mM sodium salicylate will have the same effect as Claim 1.
  3. 3) The addition of sodium salicylate at 30 to 300mM concentration to contact lens disinfecting fluids and overnight storage soaking solutions will reduce the risk of Acanthamoeba infection of the eye by preventing attachment of the amoeba to the contact lens within the storage case.
GB9801585A 1998-01-27 1998-01-27 Salicylate inhibition of amoebic attachment to contact lenses Expired - Fee Related GB2333609B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9801585A GB2333609B (en) 1998-01-27 1998-01-27 Salicylate inhibition of amoebic attachment to contact lenses

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9801585A GB2333609B (en) 1998-01-27 1998-01-27 Salicylate inhibition of amoebic attachment to contact lenses

Publications (3)

Publication Number Publication Date
GB9801585D0 GB9801585D0 (en) 1998-03-25
GB2333609A true GB2333609A (en) 1999-07-28
GB2333609B GB2333609B (en) 2002-07-24

Family

ID=10825874

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9801585A Expired - Fee Related GB2333609B (en) 1998-01-27 1998-01-27 Salicylate inhibition of amoebic attachment to contact lenses

Country Status (1)

Country Link
GB (1) GB2333609B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004030710A1 (en) * 2002-09-30 2004-04-15 Bausch & Lomb Incorporated Compositions with enhanced antimicrobial efficacy against acanthamoebae
AT501545A1 (en) * 2005-02-23 2006-09-15 Obwaller Andreas Dr CLEANING AGENT FOR CONTACT LENSES
EP1852133A2 (en) * 2002-09-30 2007-11-07 Bausch & Lomb Incorporated Compositions with enhanced antimicrobial efficacy against acanthamoebae
US8735648B2 (en) 2010-02-08 2014-05-27 Cornell University Model system of Acanthamoeba keratitis syndrome and method for selecting a treatment thereof
US20150191690A1 (en) * 2014-01-06 2015-07-09 Lawrence Livermore National Security, Llc Compositions and methods for pathogen transport

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07157747A (en) * 1993-12-10 1995-06-20 Hoya Corp Washing agent for contact lens

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07157747A (en) * 1993-12-10 1995-06-20 Hoya Corp Washing agent for contact lens

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WPI Accession No 95-252493/199533 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004030710A1 (en) * 2002-09-30 2004-04-15 Bausch & Lomb Incorporated Compositions with enhanced antimicrobial efficacy against acanthamoebae
JP2006501301A (en) * 2002-09-30 2006-01-12 ボシュ・アンド・ロム・インコーポレイテッド Compositions with enhanced antimicrobial efficacy against acanthamoebae
EP1852133A2 (en) * 2002-09-30 2007-11-07 Bausch & Lomb Incorporated Compositions with enhanced antimicrobial efficacy against acanthamoebae
EP1852133A3 (en) * 2002-09-30 2009-08-26 Bausch & Lomb Incorporated Compositions with enhanced antimicrobial efficacy against acanthamoebae
AT501545A1 (en) * 2005-02-23 2006-09-15 Obwaller Andreas Dr CLEANING AGENT FOR CONTACT LENSES
AT501545B1 (en) * 2005-02-23 2007-10-15 Obwaller Andreas Dr CLEANING AGENT FOR CONTACT LENSES
US8735648B2 (en) 2010-02-08 2014-05-27 Cornell University Model system of Acanthamoeba keratitis syndrome and method for selecting a treatment thereof
US20150191690A1 (en) * 2014-01-06 2015-07-09 Lawrence Livermore National Security, Llc Compositions and methods for pathogen transport
US9243222B2 (en) * 2014-01-06 2016-01-26 Lawrence Livermore National Security, Llc Compositions and methods for pathogen transport

Also Published As

Publication number Publication date
GB2333609B (en) 2002-07-24
GB9801585D0 (en) 1998-03-25

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Legal Events

Date Code Title Description
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20130127