GB2333454B - Substituted aromatic compounds for treatment of antibiotic resistant infections - Google Patents
Substituted aromatic compounds for treatment of antibiotic resistant infectionsInfo
- Publication number
- GB2333454B GB2333454B GB9909183A GB9909183A GB2333454B GB 2333454 B GB2333454 B GB 2333454B GB 9909183 A GB9909183 A GB 9909183A GB 9909183 A GB9909183 A GB 9909183A GB 2333454 B GB2333454 B GB 2333454B
- Authority
- GB
- United Kingdom
- Prior art keywords
- treatment
- aromatic compounds
- substituted aromatic
- antibiotic resistant
- resistant infections
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/24—Anthracenes; Hydrogenated anthracenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7938398P | 1998-03-26 | 1998-03-26 | |
PCT/US1999/006494 WO1999048461A2 (fr) | 1998-03-26 | 1999-03-25 | Composes aromatiques substitues pour le traitement d'infections resistant aux antibiotiques |
Publications (3)
Publication Number | Publication Date |
---|---|
GB9909183D0 GB9909183D0 (en) | 1999-06-16 |
GB2333454A GB2333454A (en) | 1999-07-28 |
GB2333454B true GB2333454B (en) | 2000-08-09 |
Family
ID=22150207
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB9909183A Expired - Fee Related GB2333454B (en) | 1998-03-26 | 1999-03-25 | Substituted aromatic compounds for treatment of antibiotic resistant infections |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1066035A4 (fr) |
JP (1) | JP2002507557A (fr) |
AU (1) | AU3012699A (fr) |
CA (1) | CA2325689A1 (fr) |
GB (1) | GB2333454B (fr) |
WO (1) | WO1999048461A2 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100506870C (zh) | 2001-03-08 | 2009-07-01 | 宾夕法尼亚州大学理事会 | 作为抗感染药的表面两亲聚合物 |
WO2004082634A2 (fr) | 2003-03-17 | 2004-09-30 | The Trustees Of The University Of Pennsylvania | Polymeres et oligomeres a surface amphiphile et leurs utilisations |
DE10316081A1 (de) * | 2003-04-08 | 2004-10-21 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
DE102010055322A1 (de) * | 2010-12-21 | 2012-06-21 | Christian-Albrechts-Universität Zu Kiel | Antibakteriell und antimykotisch wirkende Substanzen |
AU2018240172C1 (en) | 2017-03-20 | 2019-10-24 | Novo Nordisk Health Care Ag | Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators |
CN113226356A (zh) | 2018-09-19 | 2021-08-06 | 福马治疗股份有限公司 | 活化丙酮酸激酶r |
US10675274B2 (en) | 2018-09-19 | 2020-06-09 | Forma Therapeutics, Inc. | Activating pyruvate kinase R |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4327022A (en) * | 1973-08-16 | 1982-04-27 | Sterling Drug Inc. | Heterocyclic alkyl naphthols |
IL60530A (en) * | 1979-08-16 | 1984-10-31 | American Cyanamid Co | Animal feed compositions useful as growth promotors and for reduction of fat in animals,comprising phenylethanolamine derivatives and certain such novel compounds |
GB9107843D0 (en) * | 1991-04-12 | 1991-05-29 | Patterson Laurence H | Anti-cancer compounds |
WO1997007792A1 (fr) * | 1995-08-25 | 1997-03-06 | Department Of The Army, Us Government | Compositions de desbutylhalofantrine et leur utilisation |
-
1999
- 1999-03-25 EP EP99911497A patent/EP1066035A4/fr not_active Withdrawn
- 1999-03-25 CA CA002325689A patent/CA2325689A1/fr not_active Abandoned
- 1999-03-25 WO PCT/US1999/006494 patent/WO1999048461A2/fr not_active Application Discontinuation
- 1999-03-25 AU AU30126/99A patent/AU3012699A/en not_active Abandoned
- 1999-03-25 GB GB9909183A patent/GB2333454B/en not_active Expired - Fee Related
- 1999-03-25 JP JP2000537515A patent/JP2002507557A/ja not_active Withdrawn
Non-Patent Citations (13)
Title |
---|
Chem Abs No 76:21121 & E.A.Nodiff et al, J.Med.Chem, 1971, 14(10), 921-925 * |
Chem Abs No 77:147532 & W.T.Colwell et al, J.Med.Chem, 1972,15(7), 771-775 * |
Chem Abs No 77:96751 & E.A.Nodiff et al, J.Med.Chem, 1972, 15(7), 775-780 * |
Chem Abs No 79:142773 & P.N.Craig et al, J.Med.Chem, 1973, 16(6), 661-667 * |
Chem Abs No 80:10268 & P.L.Chien et al, J.Med.Chem, 1973 16(10), 1093-1096 * |
Chem Abs No 81:163214 & L.C.Washburn et al, J.Med.Chem., 1974, 17(7), 676-682 * |
Chem Abs No 83:188214 & E.A. Nodiff et al, J.Med.Chem., 1975, 18(10), 1011-1019 * |
Chem abs No 84:12318 & J.S. Gillespie et al, J.Med.Chem, 1975, 18(12), 1223-1227 * |
Chem Abs No 90:132704 & L.H.Schmidt et al, Antimicrom.AgentsChemother, 1978, 14(3), 292-314 * |
Chem Abs No 90:161936 & K.H.Kim et al, Antimicrob.Agents.Chemother, 1979, 22(4), 366-391 * |
Chem Abs No 90:48247 & D.A.Shamblee et al, J.Med.Chem., 197922(1), 86-89 * |
Chem Abs No 95:90810 & P.Berntsson., Acta.Pharm.Suec., 1981,18(3), 149-178 * |
Chem Abst No 104:101941 & R.Franke et al, Quant.Struct-Ac Chem.Biol., 1985, 4(2), 51-63 * |
Also Published As
Publication number | Publication date |
---|---|
WO1999048461A3 (fr) | 1999-12-16 |
EP1066035A4 (fr) | 2001-05-09 |
WO1999048461A2 (fr) | 1999-09-30 |
GB9909183D0 (en) | 1999-06-16 |
JP2002507557A (ja) | 2002-03-12 |
AU3012699A (en) | 1999-10-18 |
EP1066035A2 (fr) | 2001-01-10 |
GB2333454A (en) | 1999-07-28 |
CA2325689A1 (fr) | 1999-09-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20030325 |