GB2332712A - Valve for aerosol container - Google Patents
Valve for aerosol container Download PDFInfo
- Publication number
- GB2332712A GB2332712A GB9715855A GB9715855A GB2332712A GB 2332712 A GB2332712 A GB 2332712A GB 9715855 A GB9715855 A GB 9715855A GB 9715855 A GB9715855 A GB 9715855A GB 2332712 A GB2332712 A GB 2332712A
- Authority
- GB
- United Kingdom
- Prior art keywords
- valve
- seal
- metering chamber
- stem
- dispensed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
- B65D83/44—Valves specially adapted therefor; Regulating devices
- B65D83/52—Valves specially adapted therefor; Regulating devices for metering
- B65D83/54—Metering valves ; Metering valve assemblies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
- B65D83/38—Details of the container body
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
- B65D83/75—Aerosol containers not provided for in groups B65D83/16 - B65D83/74
- B65D83/752—Aerosol containers not provided for in groups B65D83/16 - B65D83/74 characterised by the use of specific products or propellants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S277/00—Seal for a joint or juncture
- Y10S277/935—Seal made of a particular material
- Y10S277/944—Elastomer or plastic
- Y10S277/945—Containing fluorine
Abstract
An aerosol container, for dispensing metered doses of an aerosol formulation such as salmeterol xinafoate medicament suspended in liquefied HFA134a, comprises a valve body 1 having a valve stem 7 through which the formulation is dispensed. The valve stem 7 is sealed by valve seals 9,12 which are made from a peroxide cured nitrile rubber comprising a fluorine-containing polymer such as fluorocarbon polymer polytetrafluoroethane (PTFE) which, due to its low coefficient of friction, acts as a lubricant against the valve stem 7. This ensures a smooth operation of the valve, and reduces the deposition of formulation which can cause valve sticking.
Description
PG3304 1 VALVE FOR AEROSOL CONTAINER 233271,2 This invention relates to a
valve for an aerosol container with the aid of which a quantity of the contents thereof can be dispensed. The invention has particular application to the dispensing of metered doses of medicaments, though it is applicable to the dispensing of aerosols generally.
The continuing use of aerosol formulations comprising conventional chlorofluorocarbon propellants is being debated due to the suspected role of such propellants in atmospheric depletion of ozone. Accordingly, formulations based on alternative propellants such as HFA-134a (1,1,1,2tetrafluoroethane) and HFA-227 (1,1,1,2,3,3,3-heptafluoropropane) are being developed to replace those conventional propellants thought to contribute to atmospheric ozone depletion.
Containers for aerosol formulations commonly comprise a vial body coupled to a valve. The valve comprises a valve stem through which the formulations is dispensed. Generally the valve includes a rubber valve seal intended to allow reciprocal movement of the valve stem while preventing leakage of propellant from the container.
It has been found that some conventional devices for delivering aerosols suffer impaired performance when used in connection with HFA-134a or HFA-227.
Selection of suitable materials for use in valves to contain aerosol formulations based on these alternative propellants is complicated by interactions between the valve component materials and the formulation components, including the propellant. In conventional devices, particularly with some drug formulations the valve stem tends to stick, pause, or drag during the actuation cycle with the result that the user perceives an unsmooth action as the valve stem is depressed and released. This may be partly caused by the drug to be dispensed from the container sedimenting or precipitating out of the drug propellant suspension or solution formulation and depositing on the internal valve components, the presence of drug on the sliding interface between valve stem and seal creating increased friction during operation.
PG3304 2 International Patent Application No. PCT/US94/06900 describes an aerosol valve wherein the rubber valve seal is made of a composition specially selected to minimise leakage of the propellant through the interface between the valve seal and valve stem upon firing. Smoothness of operation is also improved with some formulations compared to devices involving conventional thermoset rubber seals. However, although such seal compositions may improve valve performance, they do not prevent build up of deposit on the valve components, and the problem of unsmooth action may persist.
It is an object to provide a valve with improved smoothness of operation which alleviates the problem of valve sticking.
According to the present invention there is provided a valve for an aerosol container for dispensing a suspension of a substance in a liquid propellant contained therein, the valve comprising a valve body defining an aperture, a seal mounted at the aperture, and a valve stem having a dispensing passage, the valve stem being moveable through the seal such that in a first position the valve is closed to prevent the substance to be dispensed from entering the dispensing passage, and in a second position the valve is open to allow the substance to be dispensed through the dispensing passage, characterised in that the seal is made from a material comprising a fluorinated polymer.
Fluorinated polymers suitable for this purpose include polytetrafluoroethane (PTFIE), ethylenetetrafluoroethylene (IETFIE), perfluoroalkoxyalkane (PFA), fluorinated ethylene propylene (FIEP), vinyid ie nefl uo ride (PVDF), and chlorinated ethylene tetrafluoroethylene.
PTFE has been found to be particularly advantageous as a lubricant due to its low coefficient of friction. Furthermore, PTFE significantly reduces the problem of drug deposition on the surface of the seal contacting the valve stem, so removing one of the causes of valve sticking. Micronised PTFE can be incorporated in a straight forward manner as part of the filler material for standard peroxide cured nitrile-based rubber seals in a normal mixing process.
Alternatively, the surface of the seal component may be subjected to a PG3304 3 fluorination process. PTFE is also non-toxic, an important consideration for aerosol devices for dispensing medicaments.
Suitably, the seal is made from a material which comprises up to 20 parts of PTFE in 100 parts of base polymer.
Suitably, the valve is a metering valve comprising a metering chamber, a transfer passage through which a quantity of substance to be dispensed can pass from the container into the metering chamber, wherein in the first position the dispensing passage is isolated from the metering chamber by means of a first seal and the metering chamber is in communication with the container via the transfer passage, and in the second position the dispensing passage is in communication with the metering chamber and the transfer passage is isolated from the metering chamber by means of a second seal. The second seal may advantageously also be made of a material comprising a fluorinated polymer like the first seal.
Suitably the substance to be dispensed is a medicament suspended or dissolved in liquefied HFA134a.
Medicaments suitable for this purpose are, for example for the treatment of respiratory disorders such as asthma, bronchitis, chronic obstructive pulmonary diseases and chest infections. Additional medicaments may be selected from any other suitable drug useful in inhalation therapy and which may be presented as a suspension. Appropriate medicaments may thus be selected from, for example, analgesics, e.g. codeine, dihydromorphine, ergotamine, fentanyl or morphine; anginal preparations, e.g. diltiazem; antiallergics, e.g. cromoglycate, ketotifen or neodocromil; antfinfectives e.g. cephaiosporins, penicillins, streptomycin, sulphonamides, tetracyclines and pentamidine; antihistamines, e.g. methapyrilene anti-inflammatories, e.g. fluticasone propionate, beclomethasone dipropionate, flunisolide, budesonide or triamcinolone acetonide; antitussives, e.g. noscapine; bronchodilators, e.g. salmeterol, salbutamol, ephedrine, adrenaline, fenoterol, formoterol, isoprenaline, metaproterenol, phenylephrine, phenylpropanola mine, pirbuterol, reproterol, rimiterol, terbutaline, isoetharine, tulobuterol orciprenaline, or(+4- amino-3,5- PG3304 4 d ich loro-.a-[[[6-[2-(2-pyhd inyi)ethoxy]-hexyil a mi no] methyl] benzenemethanol; diuretics, e.g. amiloride; anti chol inergics e.g. ipratropium, atropine or oxitropium; hormones, e,g, cortisone, hydrocortisone or prednisolone; xanthines e.g.
aminophylline, choline theophyllinate, lysine theophyllinate or theophylline and therapeutic proteins and peptides, e.g. insulin or glucagon. It will be clear to a person skilled in the art that, where appropriate, the medicaments may be used in the form of salts (e.g. as alkali metal or amine salts or as acid addition salts) or as esters (e.g. lower alkyl esters) or as solvates (e.g. hydrates) to optimise the activity andlor stability of the medicament. Preferred medicaments are salbutamoL salbutamol sulphate, salmeterol, salmeterol xinafoate, fluticasone propionate, beclomethasone dipropionate and terbutaline sulphate. It is to be understood that the suspension or solution of medicament may consist purely of one or more active ingredients.
Preferably the medicament is salmeterol xinafoate, salbutamol sulphate, fluticasone propionate or a combination thereof.
The invention will now be described further with reference to the accompanying drawing in which Figure 1 is a section through a metering valve according to the invention.
A valve according to the invention is shown in Figure 1 and comprises a valve body 1 sealed in a ferrule 2 by means of crimping, the ferrule itself being set on the neck of a container (not shown) with interposition of a gasket 3 in a wellknown manner. The container is filled with a suspension of salmeterol xinafoate a in liquid propellant HFA1 34a.
The valve body 1 is formed at its lower part with a metering chamber 4, and its upper part with a sampling chamber 5 which also acts as a housing for a return spring 6. The words "uppeC' and "loweC' are used for the container when it is in a use orientation with the neck of the container and valve at the lower end of the container which corresponds to the orientation of the valve as shown in Figure 1. Inside the valve body 1 is disposed a valve stem 7, a part 8 of which extends outside the valve through a first lower stem seal 9 and ferrule 2. The stem part PG3304 8 is formed with an inner axial or longitudinal canal 10 opening at the outer end of the stem and in communication with a radial passage 11.
The upper portion of stem 7 has a diameter such that it can pass slidably through an opening in a second upper stem seal 12 and will engage the periphery of that opening sufficiently to provide a seal. Both seals 9 and 12 are made from a peroxide cured nitrile rubber comprising 15 parts of PTFE in 100 parts of base polymer, the former component having the effect of reducing the friction between the seals and valve stem during actuation, as explained below.
PTFE also has the effect of reducing any build up of drug deposition on the surface of the seal contacting the valve stem, the presence of which on the sliding interface between the valve stem and seal could otherwise cause increased friction during actuation. Upper stem seal 12 is held in position against a step 13 formed in the valve body 1 between the said lower and upper parts by a sleeve 14 which defines the metering chamber 4 between lower stem seal 9 and upper stem seal 12. The valve stem 7 has a passage 15 which, when the stem is in the inoperative position shown, provides a communication between the metering chamber 4 and sampling chamber 5, which itself communicates with the interior of the container via orifice 16 formed in the side of the valve body 1.
Valve stem 7 is biased downwardly to the inoperative position by return spring 6 and is provided with a shoulder 17 which abuts against lower stem seal 9. In the inoperative position as shown in Figure 1 shoulder 17 abuts against lower stem seal 9 and radial passage 11 opens below lower stem seal 9 so that the metering chamber 4 is isolated from canal 10 and suspension inside cannot escape.
A ring 18 having a "U" shaped cross section extending in a radial direction is disposed around the valve body below orifice 16 so as to form a trough 19 around the valve body. As seen in Figure 1 the ring is formed as a separate component having an inner annular contacting rim of a diameter suitable to provide a friction fit over the upper part of valve body 1, the ring seating against step 13 below the orifice 16. However, the ring 18 may alternatively be formed as an integrally moulded part of valve body 1.
PG3304 6 To use the device the container is first shaken to homogenise the suspension within the container The user then depresses the valve stem 7 against the force of the spring 6. When the valve stem is depressed both ends of the passage 15 come to lie on the side of upper stem seal 12 remote from the metering chamber 4. Thus a dose is metered within the metering chamber. Continued depression of the valve stem will move the radial passage 11 into the metering chamber 4 while the upper stem seal 12 seals against the valve stem body. Thus, the metered dose can exit through the radial passage 11 and the outlet canal 10.
Releasing the valve stem causes it to return to the illustrated position under the force of the spring 6. The passage 15 then once again provides communication between the metering chamber 4 and sampling chamber 5. Accordingly, at this stage liquid passes under pressure from the container through orifice 16, through the passage 15 and thence into the metering chamber 4 to fill it.
It has been found that the valve described above offers consistently smoother actuation throughout its life compared with valves using conventional nitrile based rubber seals having no PTFE when used to dispense the same product.
The following table presents a comparison of the mean friction energy generated in valves during actuation of two aerosol containers having standard nitrile-based rubber seals against two containers having PTFE impregnated seals at different stages during the life of the containers.
Valve Friction Energy (mJ) Start of can After 100 actuations After 200 actuations Standard 40 50 52 With PTFE 38 40 40 impregnated seals The containers used to generate this data contained a suspension of salbutamol sulphate in liquefied HFA1 34a, and the results illustrate the consistently reduced PG3304 7 level of friction present in valves according to the invention compared with valves having conventional seals.
it will be understood that the present disclosure is for the purpose of illustration only and the invention extends to modifications, variations and improvements thereto.
The application of which this description and claims form part may be used as a basis for priority in respect of any subsequent application. The claims of such subsequent application may be directed to any feature or combination of features described herein. They may take the form of product, method or use claims and may include, by way of example and without limitation, one or more of the following claims:
PG3304 8
Claims (1)
- Claims1. Valve for an aerosol container for dispensing a suspension or solution of a substance in a liquid propellant contained therein, the valve comprising a valve body defining an aperture, a seal mounted at the aperture, and a valve stem having a dispensing passage, the valve stem being slideably moveable through the seal such that in a first position the valve is closed to prevent the substance to be dispensed from entering the dispensing passage, and in a second position the valve is open to allow the substance to be dispensed through the dispensing passage, characterised in that the seal is made from a material comprising a fluorinated polymer.2. Valve according to claim 1, wherein the seal is made from a material which comprises up to 20% PTFE.3. Valve according to claim 1 or 2, wherein the valve is a metering valve comprising a metering chamber, a transfer passage through which a quantity of substance to be dispensed can pass from the container into the metering chamber, wherein in the first position the dispensing passage is isolated from the metering chamber and the metering chamber is in communication with the container via the transfer passage, and in the second position the dispensing passage is in communication with the metering chamber and the transfer passage is isolated from the metering chamber.5. Valve according to claim 4, wherein, the substance to be dispensed is a medicament suspended in liquefied HFA134a.6.xinafoate.Valve according to claim 5, wherein the medicament is salmeterol
Priority Applications (26)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9715855A GB2332712A (en) | 1997-07-29 | 1997-07-29 | Valve for aerosol container |
BR9811060-8A BR9811060A (en) | 1997-07-29 | 1998-07-27 | Valve for an aerosol can, valve seal, and aerosol can |
EA200000083A EA002060B1 (en) | 1997-07-29 | 1998-07-27 | Valve for aerosol container |
ES98945097T ES2202893T3 (en) | 1997-07-29 | 1998-07-27 | AEROSOL CONTAINER THAT INCLUDES A VALVE. |
AU92550/98A AU744384B2 (en) | 1997-07-29 | 1998-07-27 | Valve for aerosol container |
HU0003817A HUP0003817A3 (en) | 1997-07-29 | 1998-07-27 | Valve for aerosol container |
DE69815851T DE69815851T2 (en) | 1997-07-29 | 1998-07-27 | AEROSOL CAN CONTAINING A VALVE |
AT98945097T ATE243645T1 (en) | 1997-07-29 | 1998-07-27 | AEROSOL CAN CONTAINING A VALVE |
CA002297983A CA2297983A1 (en) | 1997-07-29 | 1998-07-27 | Valve for aerosol container |
KR1020007000936A KR20010022357A (en) | 1997-07-29 | 1998-07-27 | Valve for aerosol container |
IDW20000191A ID24099A (en) | 1997-07-29 | 1998-07-27 | VALVE FOR EROSOL CONTAINERS |
IL13336298A IL133362A0 (en) | 1997-07-29 | 1998-07-27 | Valve for aerosol container |
TR2000/00203T TR200000203T2 (en) | 1997-07-29 | 1998-07-27 | Valve for aerosol container. |
NZ501662A NZ501662A (en) | 1997-07-29 | 1998-07-27 | Valve for aerosol container with seal comprising polytetrafluoroethane (PTFE) |
PCT/EP1998/004681 WO1999006303A1 (en) | 1997-07-29 | 1998-07-27 | Valve for aerosol container |
CN98806178A CN1127432C (en) | 1997-07-29 | 1998-07-27 | Valve for aerosol container |
CZ2000330A CZ2000330A3 (en) | 1997-07-29 | 1998-07-27 | Valve for aerosol container |
EP98945097A EP0999987B1 (en) | 1997-07-29 | 1998-07-27 | Aerosol container comprising a valve |
PL98337519A PL337519A1 (en) | 1997-07-29 | 1998-07-27 | Aerosol container valve |
YU71799A YU71799A (en) | 1997-07-29 | 1998-07-27 | Valve for aerosol container |
JP2000505076A JP2001512044A (en) | 1997-07-29 | 1998-07-27 | Valves for aerosol containers |
US09/446,163 US6345740B1 (en) | 1997-07-29 | 1998-07-27 | Valve for aerosol container |
IS5299A IS5299A (en) | 1997-07-29 | 1999-12-14 | Pressure spray tank cap |
HR9715855.4A HRP990418A2 (en) | 1997-07-29 | 1999-12-30 | Valve for aerosol container |
NO20000365A NO20000365L (en) | 1997-07-29 | 2000-01-25 | Aerosol tank valve |
HK00105549A HK1026407A1 (en) | 1997-07-29 | 2000-09-04 | Aerosol container comprising a valve |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9715855A GB2332712A (en) | 1997-07-29 | 1997-07-29 | Valve for aerosol container |
Publications (3)
Publication Number | Publication Date |
---|---|
GB9715855D0 GB9715855D0 (en) | 1997-10-01 |
GB2332712A true GB2332712A (en) | 1999-06-30 |
GB2332712A8 GB2332712A8 (en) | 1999-09-24 |
Family
ID=10816548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB9715855A Withdrawn GB2332712A (en) | 1997-07-29 | 1997-07-29 | Valve for aerosol container |
Country Status (26)
Country | Link |
---|---|
US (1) | US6345740B1 (en) |
EP (1) | EP0999987B1 (en) |
JP (1) | JP2001512044A (en) |
KR (1) | KR20010022357A (en) |
CN (1) | CN1127432C (en) |
AT (1) | ATE243645T1 (en) |
AU (1) | AU744384B2 (en) |
BR (1) | BR9811060A (en) |
CA (1) | CA2297983A1 (en) |
CZ (1) | CZ2000330A3 (en) |
DE (1) | DE69815851T2 (en) |
EA (1) | EA002060B1 (en) |
ES (1) | ES2202893T3 (en) |
GB (1) | GB2332712A (en) |
HK (1) | HK1026407A1 (en) |
HR (1) | HRP990418A2 (en) |
HU (1) | HUP0003817A3 (en) |
ID (1) | ID24099A (en) |
IL (1) | IL133362A0 (en) |
IS (1) | IS5299A (en) |
NO (1) | NO20000365L (en) |
NZ (1) | NZ501662A (en) |
PL (1) | PL337519A1 (en) |
TR (1) | TR200000203T2 (en) |
WO (1) | WO1999006303A1 (en) |
YU (1) | YU71799A (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2332712A (en) * | 1997-07-29 | 1999-06-30 | Glaxo Group Ltd | Valve for aerosol container |
GB9814717D0 (en) * | 1998-02-23 | 1998-09-02 | Bespak Plc | Improvements in drug delivery devices |
GB9805938D0 (en) * | 1998-03-19 | 1998-05-13 | Glaxo Group Ltd | Valve for aerosol container |
FR2776741B1 (en) * | 1998-03-30 | 2000-05-19 | Valois Sa | IMPROVED DOSER VALVE |
GB9918626D0 (en) | 1999-08-07 | 1999-10-13 | Glaxo Group Ltd | Valve |
GB9918627D0 (en) | 1999-08-07 | 1999-10-13 | Glaxo Group Ltd | Valve |
WO2001028887A1 (en) | 1999-10-16 | 2001-04-26 | Glaxo Group Limited | Device housing for an aerosol container |
ATE312639T1 (en) * | 2000-05-23 | 2005-12-15 | Glaxo Group Ltd | AEROSOL CONTAINER FOR SALMETEROL XINAFOATE |
JP2002331260A (en) | 2001-05-10 | 2002-11-19 | Bioactis:Kk | Gas spray valve and charging implement used for charging gas |
FR2833584B1 (en) * | 2001-12-13 | 2004-04-23 | Valois Sa | FLUID PRODUCT DISTRIBUTION VALVE AND FLUID PRODUCT DISPENSING DEVICE HAVING SUCH A VALVE |
WO2004022142A1 (en) * | 2002-09-06 | 2004-03-18 | 3M Innovative Properties Company | Metering valve for a metered dose inhaler providing consistent delivery |
FR2852301B1 (en) * | 2003-03-13 | 2006-02-10 | Valois Sas | DEVICE FOR DISPENSING FLUID PRODUCT |
WO2005014078A2 (en) * | 2003-07-28 | 2005-02-17 | 3M Innovative Properties Company | Diaphragm seal for use in a medicinal aerosol |
CA2536876A1 (en) * | 2003-08-29 | 2005-03-17 | Glaxo Group Limited | Pharmaceutical metered dose inhaler and methods relating thereto |
FR3024521B1 (en) * | 2014-07-29 | 2017-02-24 | Nemera La Verpilliere | AEROSOL DISPENSING VALVE COMPRISING A SEAL |
FR3049275B1 (en) * | 2016-03-23 | 2019-07-19 | Aptar France Sas | DOSING VALVE AND DEVICE FOR DISPENSING FLUID PRODUCT COMPRISING SUCH A VALVE |
GB201702408D0 (en) | 2017-02-14 | 2017-03-29 | Norton (Waterford) Ltd | Inhalers and related methods |
GB201702406D0 (en) | 2017-02-14 | 2017-03-29 | Norton (Waterford) Ltd | Inhalers and related methods |
GB201702407D0 (en) | 2017-02-14 | 2017-03-29 | Norton (Waterford) Ltd | Inhalers and related methods |
FR3065891B1 (en) * | 2017-05-05 | 2021-12-24 | Aptar France Sas | METERING VALVE AND FLUID PRODUCT DISTRIBUTION DEVICE COMPRISING SUCH A VALVE. |
KR20220164894A (en) | 2021-06-07 | 2022-12-14 | 서준범 | Moving-dwelling house |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2144386A5 (en) * | 1971-06-30 | 1973-02-09 | Union Carbide Corp | Self-lubricating aerosol valve stem - of mixed acetal nd fluorocarbon |
US5027986A (en) * | 1989-06-09 | 1991-07-02 | Heinzel Irving Charles | Actuating valve for aerosol foam product |
WO1996032344A1 (en) * | 1995-04-13 | 1996-10-17 | Glaxo Group Limited | Metered-dose aerosol valve |
WO1996032150A1 (en) * | 1995-04-14 | 1996-10-17 | Glaxo Wellcome Inc. | Metered dose inhaler for salmeterol |
WO1997016360A1 (en) * | 1995-10-31 | 1997-05-09 | Valois S.A. | Low-friction valve stem |
WO1999006303A1 (en) * | 1997-07-29 | 1999-02-11 | Glaxo Group Limited | Valve for aerosol container |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5027A (en) * | 1847-03-20 | Box fob jotjbnals | ||
US3595589A (en) * | 1969-08-26 | 1971-07-27 | Du Pont | Composite gasket |
GB9200148D0 (en) * | 1992-01-06 | 1992-02-26 | Minnesota Mining & Mfg | Aerosol valves |
US5551706A (en) * | 1993-04-20 | 1996-09-03 | W. L. Gore & Associates, Inc. | Composite gasket for sealing flanges and method for making and using same |
CA2166970C (en) | 1993-07-15 | 2000-12-19 | Oh-Seung Kwon | Seals for use in an aerosol delivery device |
KR102126382B1 (en) | 2014-02-19 | 2020-06-25 | 삼성디스플레이 주식회사 | Organic light-emitting display apparatus |
-
1997
- 1997-07-29 GB GB9715855A patent/GB2332712A/en not_active Withdrawn
-
1998
- 1998-07-27 TR TR2000/00203T patent/TR200000203T2/en unknown
- 1998-07-27 PL PL98337519A patent/PL337519A1/en not_active Application Discontinuation
- 1998-07-27 DE DE69815851T patent/DE69815851T2/en not_active Expired - Lifetime
- 1998-07-27 WO PCT/EP1998/004681 patent/WO1999006303A1/en not_active Application Discontinuation
- 1998-07-27 YU YU71799A patent/YU71799A/en unknown
- 1998-07-27 EA EA200000083A patent/EA002060B1/en not_active IP Right Cessation
- 1998-07-27 BR BR9811060-8A patent/BR9811060A/en not_active IP Right Cessation
- 1998-07-27 EP EP98945097A patent/EP0999987B1/en not_active Expired - Lifetime
- 1998-07-27 AU AU92550/98A patent/AU744384B2/en not_active Ceased
- 1998-07-27 CZ CZ2000330A patent/CZ2000330A3/en unknown
- 1998-07-27 US US09/446,163 patent/US6345740B1/en not_active Expired - Lifetime
- 1998-07-27 AT AT98945097T patent/ATE243645T1/en not_active IP Right Cessation
- 1998-07-27 NZ NZ501662A patent/NZ501662A/en unknown
- 1998-07-27 CN CN98806178A patent/CN1127432C/en not_active Expired - Fee Related
- 1998-07-27 HU HU0003817A patent/HUP0003817A3/en unknown
- 1998-07-27 KR KR1020007000936A patent/KR20010022357A/en not_active Application Discontinuation
- 1998-07-27 IL IL13336298A patent/IL133362A0/en unknown
- 1998-07-27 CA CA002297983A patent/CA2297983A1/en not_active Abandoned
- 1998-07-27 ID IDW20000191A patent/ID24099A/en unknown
- 1998-07-27 ES ES98945097T patent/ES2202893T3/en not_active Expired - Lifetime
- 1998-07-27 JP JP2000505076A patent/JP2001512044A/en active Pending
-
1999
- 1999-12-14 IS IS5299A patent/IS5299A/en unknown
- 1999-12-30 HR HR9715855.4A patent/HRP990418A2/en not_active Application Discontinuation
-
2000
- 2000-01-25 NO NO20000365A patent/NO20000365L/en not_active Application Discontinuation
- 2000-09-04 HK HK00105549A patent/HK1026407A1/en not_active IP Right Cessation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2144386A5 (en) * | 1971-06-30 | 1973-02-09 | Union Carbide Corp | Self-lubricating aerosol valve stem - of mixed acetal nd fluorocarbon |
US5027986A (en) * | 1989-06-09 | 1991-07-02 | Heinzel Irving Charles | Actuating valve for aerosol foam product |
WO1996032344A1 (en) * | 1995-04-13 | 1996-10-17 | Glaxo Group Limited | Metered-dose aerosol valve |
WO1996032150A1 (en) * | 1995-04-14 | 1996-10-17 | Glaxo Wellcome Inc. | Metered dose inhaler for salmeterol |
WO1997016360A1 (en) * | 1995-10-31 | 1997-05-09 | Valois S.A. | Low-friction valve stem |
WO1999006303A1 (en) * | 1997-07-29 | 1999-02-11 | Glaxo Group Limited | Valve for aerosol container |
Also Published As
Publication number | Publication date |
---|---|
YU71799A (en) | 2001-09-28 |
EP0999987B1 (en) | 2003-06-25 |
NO20000365D0 (en) | 2000-01-25 |
US6345740B1 (en) | 2002-02-12 |
EP0999987A1 (en) | 2000-05-17 |
EA002060B1 (en) | 2001-12-24 |
ATE243645T1 (en) | 2003-07-15 |
CN1127432C (en) | 2003-11-12 |
GB9715855D0 (en) | 1997-10-01 |
EA200000083A1 (en) | 2000-08-28 |
NZ501662A (en) | 2001-09-28 |
IS5299A (en) | 1999-12-14 |
DE69815851T2 (en) | 2004-04-22 |
AU9255098A (en) | 1999-02-22 |
WO1999006303A1 (en) | 1999-02-11 |
ID24099A (en) | 2000-07-06 |
JP2001512044A (en) | 2001-08-21 |
CZ2000330A3 (en) | 2001-11-14 |
CN1261854A (en) | 2000-08-02 |
DE69815851D1 (en) | 2003-07-31 |
CA2297983A1 (en) | 1999-02-11 |
ES2202893T3 (en) | 2004-04-01 |
BR9811060A (en) | 2000-09-19 |
NO20000365L (en) | 2000-01-25 |
PL337519A1 (en) | 2000-08-28 |
AU744384B2 (en) | 2002-02-21 |
TR200000203T2 (en) | 2000-07-21 |
HRP990418A2 (en) | 2000-04-30 |
GB2332712A8 (en) | 1999-09-24 |
HK1026407A1 (en) | 2000-12-15 |
KR20010022357A (en) | 2001-03-15 |
HUP0003817A3 (en) | 2001-08-28 |
IL133362A0 (en) | 2001-04-30 |
HUP0003817A2 (en) | 2001-03-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU741641B2 (en) | Valve for aerosol container | |
EP0999987B1 (en) | Aerosol container comprising a valve | |
US7383970B2 (en) | Valve with a two-component seal | |
US6843392B1 (en) | Valve with a valve stem wiper | |
IL137750A (en) | Valve for aerosol container | |
EP1324796A1 (en) | Medicament dispenser | |
EP1144272B1 (en) | Valve | |
US20040129737A1 (en) | Valves for use in containers having valve stems slidably movable within round-edged sealing rings | |
MXPA99011989A (en) | Valve for aerosol container | |
MXPA99011752A (en) | Valve for aerosol container | |
CZ9904721A3 (en) | Valve for aerosol container |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |