GB2331521A - Vaccine preparations - Google Patents

Vaccine preparations

Info

Publication number
GB2331521A
GB2331521A GB9900976A GB9900976A GB2331521A GB 2331521 A GB2331521 A GB 2331521A GB 9900976 A GB9900976 A GB 9900976A GB 9900976 A GB9900976 A GB 9900976A GB 2331521 A GB2331521 A GB 2331521A
Authority
GB
United Kingdom
Prior art keywords
microorganism
methods
animal
vaccine
vaccine preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9900976A
Other versions
GB2331521B (en
GB9900976D0 (en
Inventor
Paul Andrew Barrow
Margaret Ann Lovell
Arthur Keith Turner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Minister of Agriculture Fisheries and Food UK
Original Assignee
Minister of Agriculture Fisheries and Food UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minister of Agriculture Fisheries and Food UK filed Critical Minister of Agriculture Fisheries and Food UK
Publication of GB9900976D0 publication Critical patent/GB9900976D0/en
Publication of GB2331521A publication Critical patent/GB2331521A/en
Application granted granted Critical
Publication of GB2331521B publication Critical patent/GB2331521B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/42—Salmonella
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention provides a live gut-colonising microorganism (e.g. Salmonella) capable of evoking an immune response in an animal (e.g. a chicken) for use as a vaccine, characterised in that the microorganism has a specific mutation which impairs its ability to colonise the alimentary tract of the animal. Preferably the microorganism is attenuated, and/or has a negative serological marker, and/or expresses antigens from heterologous organisms. Preferably the mutation comprises the inactivation of a gene selected from: hupA, dksA, rfaY, sipC or clpB. Also disclosed are associated methods generating the vaccines, pharmaceutical preparations, methods of protecting aninals and the products of these methods.
GB9900976A 1996-07-17 1997-07-15 Vaccine preparations Expired - Fee Related GB2331521B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9615022.2A GB9615022D0 (en) 1996-07-17 1996-07-17 Vaccine preparations
PCT/GB1997/001932 WO1998002523A1 (en) 1996-07-17 1997-07-15 Vaccine preparations

Publications (3)

Publication Number Publication Date
GB9900976D0 GB9900976D0 (en) 1999-03-10
GB2331521A true GB2331521A (en) 1999-05-26
GB2331521B GB2331521B (en) 2000-09-06

Family

ID=10797070

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB9615022.2A Pending GB9615022D0 (en) 1996-07-17 1996-07-17 Vaccine preparations
GB9900976A Expired - Fee Related GB2331521B (en) 1996-07-17 1997-07-15 Vaccine preparations

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GBGB9615022.2A Pending GB9615022D0 (en) 1996-07-17 1996-07-17 Vaccine preparations

Country Status (4)

Country Link
EP (1) EP0912721A1 (en)
AU (1) AU3552797A (en)
GB (2) GB9615022D0 (en)
WO (1) WO1998002523A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6110455A (en) * 1999-01-20 2000-08-29 Ms Bioscience Method for encouraging poultry to distribute and ingest competitive exclusion products
EP1443959A1 (en) * 2001-11-12 2004-08-11 Pharmacia & Upjohn Company Salmonella vaccine
AU2004224425B2 (en) 2003-02-06 2010-06-24 Aduro Biotech Modified free-living microbes, vaccine compositions and methods of use thereof
ES2382332T3 (en) 2003-02-06 2012-06-07 Aduro Biotech Attenuated listeria to enter non-phagocytic cells, vaccines comprising this listeria and methods of use thereof
US7695725B2 (en) 2003-02-06 2010-04-13 Aduro Biotech Modified free-living microbes, vaccine compositions and methods of use thereof
UA100370C2 (en) 2006-12-11 2012-12-25 Мериал Лимитед METHOD OF VACCINATION OF BIRDS AGAINST SALMONELL
BRPI1102019A2 (en) * 2011-04-19 2013-06-25 Unicamp construction process of mutant attenuated lineage of a pathogenic bacterium, vaccine, vaccine vector and use of said vaccine
CN105462907A (en) * 2015-11-02 2016-04-06 四川农业大学 Attenuation salmonella typhimurium and construction method and application

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5389368A (en) * 1987-06-04 1995-02-14 Washington University Avirulent microbes and uses therefor
WO1995024475A1 (en) * 1994-03-08 1995-09-14 The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Vaccine compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5389368A (en) * 1987-06-04 1995-02-14 Washington University Avirulent microbes and uses therefor
WO1995024475A1 (en) * 1994-03-08 1995-09-14 The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Vaccine compositions

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
EPIDEMIOL.INFECT., 1990 104 (3) 427-442 " FURTHER STUDIES ONTHE INHIBITION..." BERCHIERI ET AL *
FEMS MICROBIOLOGY LETTERS, 1995 131 (2) 153-159 "INTERFERENCE BETWEEN SALMONELLA.." IBA AM ET AL *
INT.J.FOOD MICRIBIOLOGY, 1997 35 (3) 223-230 "COMPARATIVE STUDY OF THE PROTECTIVE.." METHNER ET AL *

Also Published As

Publication number Publication date
GB9615022D0 (en) 1996-09-04
EP0912721A1 (en) 1999-05-06
WO1998002523A1 (en) 1998-01-22
AU3552797A (en) 1998-02-09
GB2331521B (en) 2000-09-06
GB9900976D0 (en) 1999-03-10

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20010715