GB2328688A - Antitumoral Anthracycline Disaccharides - Google Patents

Antitumoral Anthracycline Disaccharides

Info

Publication number
GB2328688A
GB2328688A GB9823306A GB9823306A GB2328688A GB 2328688 A GB2328688 A GB 2328688A GB 9823306 A GB9823306 A GB 9823306A GB 9823306 A GB9823306 A GB 9823306A GB 2328688 A GB2328688 A GB 2328688A
Authority
GB
United Kingdom
Prior art keywords
antitumoral
disaccharides
anthracycline disaccharides
antitumoral anthracycline
chohch3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9823306A
Other versions
GB2328688B (en
GB9823306D0 (en
GB2328688A8 (en
Inventor
Anna Luisa Colombo
Giovanni Rivola
Lorena Luisa Fedeli
Solari Augusto Inventi
Andrea Pavesi
Marina Ripamonti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MINI RICERCA SCIENT TECNOLOG
Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST)
Original Assignee
MINI RICERCA SCIENT TECNOLOG
Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MINI RICERCA SCIENT TECNOLOG, Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST) filed Critical MINI RICERCA SCIENT TECNOLOG
Publication of GB9823306D0 publication Critical patent/GB9823306D0/en
Publication of GB2328688A publication Critical patent/GB2328688A/en
Publication of GB2328688A8 publication Critical patent/GB2328688A8/en
Application granted granted Critical
Publication of GB2328688B publication Critical patent/GB2328688B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

There are provided compounds of formula (I) wherein R represents -COCH3; -CHOHCH3; -COCH2OH, endowed with antitumor and antibacterial activity. Fermentation and chemical processes for their preparation are also described.
GB9823306A 1996-04-24 1997-04-11 Antitumoral Anthracycline Disaccharides Expired - Lifetime GB2328688B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI000819A IT1282379B1 (en) 1996-04-24 1996-04-24 ANTI-TUMORAL ANTHRACYCLINE DISACCARIDES.
PCT/EP1997/001818 WO1997040057A1 (en) 1996-04-24 1997-04-11 Antitumoral anthracycline disaccharides

Publications (4)

Publication Number Publication Date
GB9823306D0 GB9823306D0 (en) 1998-12-23
GB2328688A true GB2328688A (en) 1999-03-03
GB2328688A8 GB2328688A8 (en) 1999-03-12
GB2328688B GB2328688B (en) 1999-10-27

Family

ID=11374120

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9823306A Expired - Lifetime GB2328688B (en) 1996-04-24 1997-04-11 Antitumoral Anthracycline Disaccharides

Country Status (5)

Country Link
JP (1) JP3971801B2 (en)
DE (2) DE19781703T1 (en)
GB (1) GB2328688B (en)
IT (1) IT1282379B1 (en)
WO (1) WO1997040057A1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014853A1 (en) * 1979-02-03 1980-09-03 Zaidanhojin Biseibutsu Kagaku Kenkyukai Anthracycline derivatives, a process for their preparation and pharmaceutical compositions containing them
US4418192A (en) * 1981-04-23 1983-11-29 Sanraku-Ocean Co., Ltd. Anthracyclinone trisaccharide compounds
EP0131232A1 (en) * 1983-07-07 1985-01-16 Microbial Chemistry Research Foundation Stereoselective process for the preparation of anthracycline derivatives
EP0311054A2 (en) * 1987-10-06 1989-04-12 Mercian Corporation Anthracycline Antibiotics

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014853A1 (en) * 1979-02-03 1980-09-03 Zaidanhojin Biseibutsu Kagaku Kenkyukai Anthracycline derivatives, a process for their preparation and pharmaceutical compositions containing them
US4418192A (en) * 1981-04-23 1983-11-29 Sanraku-Ocean Co., Ltd. Anthracyclinone trisaccharide compounds
EP0131232A1 (en) * 1983-07-07 1985-01-16 Microbial Chemistry Research Foundation Stereoselective process for the preparation of anthracycline derivatives
EP0311054A2 (en) * 1987-10-06 1989-04-12 Mercian Corporation Anthracycline Antibiotics

Also Published As

Publication number Publication date
GB2328688B (en) 1999-10-27
ITMI960819A1 (en) 1997-10-24
DE19781703B4 (en) 2006-11-30
WO1997040057A1 (en) 1997-10-30
GB9823306D0 (en) 1998-12-23
GB2328688A8 (en) 1999-03-12
IT1282379B1 (en) 1998-03-20
DE19781703T1 (en) 1999-03-25
JP3971801B2 (en) 2007-09-05
JP2000508546A (en) 2000-07-11
ITMI960819A0 (en) 1996-04-24

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Expiry date: 20170410