GB2303962A - Tandem mass spectrometry apparatus - Google Patents

Tandem mass spectrometry apparatus

Info

Publication number
GB2303962A
GB2303962A GB9625017A GB9625017A GB2303962A GB 2303962 A GB2303962 A GB 2303962A GB 9625017 A GB9625017 A GB 9625017A GB 9625017 A GB9625017 A GB 9625017A GB 2303962 A GB2303962 A GB 2303962A
Authority
GB
United Kingdom
Prior art keywords
time
flight
electrostatic
mass spectrometry
mirror
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9625017A
Other versions
GB9625017D0 (en
GB2303962B (en
Inventor
Peter John Derrick
David John Reynolds
Alexander Alekseevich Makarov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Warwick
Original Assignee
University of Warwick
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9410864A external-priority patent/GB9410864D0/en
Application filed by University of Warwick filed Critical University of Warwick
Priority to GB9625017A priority Critical patent/GB2303962B/en
Priority claimed from PCT/GB1995/001252 external-priority patent/WO1995033279A1/en
Publication of GB9625017D0 publication Critical patent/GB9625017D0/en
Publication of GB2303962A publication Critical patent/GB2303962A/en
Application granted granted Critical
Publication of GB2303962B publication Critical patent/GB2303962B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers
    • H01J49/405—Time-of-flight spectrometers characterised by the reflectron, e.g. curved field, electrode shapes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Electron Tubes For Measurement (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

Tandem mass spectrometry apparatus comprises a serial arrangement of an ion source (10), a first time-of-flight means (20, 80), a collision cell (40) to generate fragment ions and a second time-of-flight analyser (50). The second time-of-flight analyser comprises an ion mirror (51,52) which is arranged to produce a quadratic field along or at an angle to the optical axis of the apparatus. The first time-of-flight analyser may comprise a sequential S configuration of toroidal or cylindrical electrostatic analysers (70) or may comprise two electrostatic lenses (80,96) to either side of an ion mirror or may comprise an electrostatic lens (80). The first time-of-flight analysers thus comprise electrostatic field means for providing spatial focusing of ions in all three dimensions at or near the entrance to the ion mirror of the second time-of-flight analyser (50). The spatial focusing, concomitant with time focusing, is the essential requirement for the quadratic field mirror to give high resolution.
GB9625017A 1994-05-31 1995-05-31 Tandem mass spectrometry apparatus Expired - Lifetime GB2303962B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9625017A GB2303962B (en) 1994-05-31 1995-05-31 Tandem mass spectrometry apparatus

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9410864A GB9410864D0 (en) 1993-12-01 1994-05-31 Tandem mass spectrometry system
GB9625017A GB2303962B (en) 1994-05-31 1995-05-31 Tandem mass spectrometry apparatus
PCT/GB1995/001252 WO1995033279A1 (en) 1994-05-31 1995-05-31 Tandem mass spectrometry apparatus

Publications (3)

Publication Number Publication Date
GB9625017D0 GB9625017D0 (en) 1997-01-15
GB2303962A true GB2303962A (en) 1997-03-05
GB2303962B GB2303962B (en) 1998-07-08

Family

ID=26304970

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9625017A Expired - Lifetime GB2303962B (en) 1994-05-31 1995-05-31 Tandem mass spectrometry apparatus

Country Status (1)

Country Link
GB (1) GB2303962B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2295720B (en) * 1994-11-29 1998-07-29 Bruker Franzen Analytik Gmbh Device and method for the improved mass resolution of a time-of-flight mass spectrometer with ion reflector
GB2361806A (en) * 2000-03-13 2001-10-31 Univ Warwick Time of flight mass spectrometry apparatus
GB2386248A (en) * 2001-10-15 2003-09-10 Bruker Daltonik Gmbh Reflector time of flight mass spectrometer including second ion selector acting as a mask to unwanted ions
GB2406436A (en) * 2000-03-13 2005-03-30 Univ Warwick A tandem time-of-flight mass spectrometer

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2045338A1 (en) * 1969-09-15 1971-03-18 Shell Int Research Run time mass spectrometer
EP0403965A2 (en) * 1989-06-23 1990-12-27 Bruker-Franzen Analytik GmbH MS-MS-flight time mass spectrometer
EP0408288A1 (en) * 1989-07-12 1991-01-16 Kratos Analytical Limited An ion mirror for a time-of-flight mass spectrometer
EP0456517A2 (en) * 1990-05-11 1991-11-13 Kratos Analytical Limited Time-of-flight mass spectrometer
DE4134905A1 (en) * 1990-10-18 1992-04-23 Unisearch Ltd TANDEM MASS SPECTROMETER BASED ON FLIGHT TIME ANALYSIS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202563A (en) * 1991-05-16 1993-04-13 The Johns Hopkins University Tandem time-of-flight mass spectrometer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2045338A1 (en) * 1969-09-15 1971-03-18 Shell Int Research Run time mass spectrometer
EP0403965A2 (en) * 1989-06-23 1990-12-27 Bruker-Franzen Analytik GmbH MS-MS-flight time mass spectrometer
EP0408288A1 (en) * 1989-07-12 1991-01-16 Kratos Analytical Limited An ion mirror for a time-of-flight mass spectrometer
EP0456517A2 (en) * 1990-05-11 1991-11-13 Kratos Analytical Limited Time-of-flight mass spectrometer
DE4134905A1 (en) * 1990-10-18 1992-04-23 Unisearch Ltd TANDEM MASS SPECTROMETER BASED ON FLIGHT TIME ANALYSIS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
International Journal of Mass Spectrometry and Ion Processes, Vol 103, No 2/03, pages 117-128 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2295720B (en) * 1994-11-29 1998-07-29 Bruker Franzen Analytik Gmbh Device and method for the improved mass resolution of a time-of-flight mass spectrometer with ion reflector
GB2361806A (en) * 2000-03-13 2001-10-31 Univ Warwick Time of flight mass spectrometry apparatus
GB2406436A (en) * 2000-03-13 2005-03-30 Univ Warwick A tandem time-of-flight mass spectrometer
GB2361806B (en) * 2000-03-13 2005-06-08 Univ Warwick Time of flight mass spectrometry apparatus
GB2406436B (en) * 2000-03-13 2005-06-08 Univ Warwick Time of flight mass spectrometry apparatus
GB2386248A (en) * 2001-10-15 2003-09-10 Bruker Daltonik Gmbh Reflector time of flight mass spectrometer including second ion selector acting as a mask to unwanted ions
GB2386248B (en) * 2001-10-15 2005-09-07 Bruker Daltonik Gmbh Method and apparatus for obtaining fragment-ion spectra using time-of-flight mass spectrometer

Also Published As

Publication number Publication date
GB9625017D0 (en) 1997-01-15
GB2303962B (en) 1998-07-08

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Expiry date: 20150530