GB2298138A - 4-(1H-2-Methylimidazo 4,5-c pyridinylmethyl)phenyl sulphonamide carboxylic acid derivatives as antagonists - Google Patents

4-(1H-2-Methylimidazo 4,5-c pyridinylmethyl)phenyl sulphonamide carboxylic acid derivatives as antagonists

Info

Publication number
GB2298138A
GB2298138A GB9606996A GB9606996A GB2298138A GB 2298138 A GB2298138 A GB 2298138A GB 9606996 A GB9606996 A GB 9606996A GB 9606996 A GB9606996 A GB 9606996A GB 2298138 A GB2298138 A GB 2298138A
Authority
GB
United Kingdom
Prior art keywords
alkyl
cycloalkenyl
cycloalkyl
group
methylimidazo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9606996A
Other versions
GB2298138B (en
GB9606996D0 (en
Inventor
Mark Whittaker
Andrew Miller
Stephen Arthur Bowles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Biotech Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939323162A external-priority patent/GB9323162D0/en
Application filed by British Biotech Pharmaceuticals Ltd filed Critical British Biotech Pharmaceuticals Ltd
Priority to GB9606996A priority Critical patent/GB2298138B/en
Publication of GB9606996D0 publication Critical patent/GB9606996D0/en
Publication of GB2298138A publication Critical patent/GB2298138A/en
Application granted granted Critical
Publication of GB2298138B publication Critical patent/GB2298138B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of formula (II), wherein R 1 represents hydrogen, -C 1 -C 6 alkyl, -C 2 -C 6 alkenyl, -C 2 -C 6 alkynyl, -COC 1 -C 6 alkyl, -CO 2 C 1 -C 6 alkyl, -(COC 1 -C 6 alkyl)phenyl, -(CO 2 C 1 -C 6 alkyl)phenyl, -(C 1 -C 6 alkyl)OC 1 -C 6 alkyl, -(C 1 -C 6 alkyl)SC 1 -C 6 alkyl, -(C 1 -C 6 alkyl)CO 2 C 1 -C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 4 -C 8 cycloalkenyl or a group -D wherein D represents a group (A) wherein n is an integer from 0 to 3, and each of R 3 and R 4 is independently hydrogen, -C 1 -C 6 alkyl, -C 2 -C 6 alkenyl, -C 2 -C 6 alkynyl, halogen, -CN, -CO 2 H, -CO 2 C 1 -C 6 alkyl, -CONH 2 , -CONHC 1 -C 6 alkyl, -CONH(C 1 -C 6 alkyl) 2 , -CHO, -CH 2 OH, -CF 3 , -OC 1 -C 6 alkyl, -SC 1 -C 6 alkyl, -SOC 1 -C 6 alkyl, -SO 2 C 1 -C 6 alkyl, -NH 2 or -NHCOMe; R 2 represents hydrogen, halogen, -C 1 -C 6 alkyl optionally substituted by one or more halogen atoms, -C 2 -C 6 alkenyl, -C 2 -C 6 alkynyl, -(C 1 -C 6 alkyl)CO 2 -C 1 -C 6 alkyl, -(C 1 -C 6 alkyl)SC 1 -C 6 alkyl, -(C 1 -C 6 alkyl)OC 1 -C 6 alkyl, -(C 1 -C 6 alkyl)N(C 1 -C 6 alkyl) 2 , -C 3 -C 8 cycloalkyl, -C 4 -C 8 cycloalkenyl, -(C 1 -C 6 alkyl)C 3 -C 8 cycloalkyl, -(C 1 -C 6 alkyl)C 4 -C 8 cycloalkenyl, -(C 1 -C 6 -alkyl)OC 3 -C 8 cycloalkyl,-(C 1 -C 6 alkyl)OC 4 -C 8 cycloalkenyl, -(C 1 -C 6 alkyl)SC 3 -C 8 cycloalkyl, -(C 1 -C 6 alkyl)SC 4 -C 8 cycloalkenyl, a side chain of a naturally occurring amino acid, a group -D as defined above or a -(C 1 -C 6 alkyl)OD group wherein D is as defined above; or a pharmaceutically or veterinarily acceptable salt thereof, are PAF inhibitors.
GB9606996A 1993-11-10 1994-11-09 4-(1h-2-methylimidazo 4,5-c pyridinylmethyl)phenyl sulphonamide carboxylic acid derivatives as antagonists Expired - Fee Related GB2298138B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9606996A GB2298138B (en) 1993-11-10 1994-11-09 4-(1h-2-methylimidazo 4,5-c pyridinylmethyl)phenyl sulphonamide carboxylic acid derivatives as antagonists

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939323162A GB9323162D0 (en) 1993-11-10 1993-11-10 4-(1h-2-methylimidazo(4,5-c)pyridinylmethyl)phenylsulphonamid e derivatives as antagonists of paf
PCT/GB1994/002460 WO1995013064A1 (en) 1993-11-10 1994-11-09 4-(1h-2-methylimidazo 4,5-c pyridinylmethyl)phenyl sulphonamide carboxylic acid derivatives as antagonists
GB9606996A GB2298138B (en) 1993-11-10 1994-11-09 4-(1h-2-methylimidazo 4,5-c pyridinylmethyl)phenyl sulphonamide carboxylic acid derivatives as antagonists

Publications (3)

Publication Number Publication Date
GB9606996D0 GB9606996D0 (en) 1996-06-05
GB2298138A true GB2298138A (en) 1996-08-28
GB2298138B GB2298138B (en) 1997-07-09

Family

ID=26303833

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9606996A Expired - Fee Related GB2298138B (en) 1993-11-10 1994-11-09 4-(1h-2-methylimidazo 4,5-c pyridinylmethyl)phenyl sulphonamide carboxylic acid derivatives as antagonists

Country Status (1)

Country Link
GB (1) GB2298138B (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992003423A1 (en) * 1990-08-15 1992-03-05 British Bio-Technology Limited Benzimidazole derivatives, process for their preparation and application

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992003423A1 (en) * 1990-08-15 1992-03-05 British Bio-Technology Limited Benzimidazole derivatives, process for their preparation and application

Also Published As

Publication number Publication date
GB2298138B (en) 1997-07-09
GB9606996D0 (en) 1996-06-05

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20011109