GB2298138A - 4-(1H-2-Methylimidazo 4,5-c pyridinylmethyl)phenyl sulphonamide carboxylic acid derivatives as antagonists - Google Patents
4-(1H-2-Methylimidazo 4,5-c pyridinylmethyl)phenyl sulphonamide carboxylic acid derivatives as antagonistsInfo
- Publication number
- GB2298138A GB2298138A GB9606996A GB9606996A GB2298138A GB 2298138 A GB2298138 A GB 2298138A GB 9606996 A GB9606996 A GB 9606996A GB 9606996 A GB9606996 A GB 9606996A GB 2298138 A GB2298138 A GB 2298138A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- cycloalkenyl
- cycloalkyl
- group
- methylimidazo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compounds of formula (II), wherein R 1 represents hydrogen, -C 1 -C 6 alkyl, -C 2 -C 6 alkenyl, -C 2 -C 6 alkynyl, -COC 1 -C 6 alkyl, -CO 2 C 1 -C 6 alkyl, -(COC 1 -C 6 alkyl)phenyl, -(CO 2 C 1 -C 6 alkyl)phenyl, -(C 1 -C 6 alkyl)OC 1 -C 6 alkyl, -(C 1 -C 6 alkyl)SC 1 -C 6 alkyl, -(C 1 -C 6 alkyl)CO 2 C 1 -C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 4 -C 8 cycloalkenyl or a group -D wherein D represents a group (A) wherein n is an integer from 0 to 3, and each of R 3 and R 4 is independently hydrogen, -C 1 -C 6 alkyl, -C 2 -C 6 alkenyl, -C 2 -C 6 alkynyl, halogen, -CN, -CO 2 H, -CO 2 C 1 -C 6 alkyl, -CONH 2 , -CONHC 1 -C 6 alkyl, -CONH(C 1 -C 6 alkyl) 2 , -CHO, -CH 2 OH, -CF 3 , -OC 1 -C 6 alkyl, -SC 1 -C 6 alkyl, -SOC 1 -C 6 alkyl, -SO 2 C 1 -C 6 alkyl, -NH 2 or -NHCOMe; R 2 represents hydrogen, halogen, -C 1 -C 6 alkyl optionally substituted by one or more halogen atoms, -C 2 -C 6 alkenyl, -C 2 -C 6 alkynyl, -(C 1 -C 6 alkyl)CO 2 -C 1 -C 6 alkyl, -(C 1 -C 6 alkyl)SC 1 -C 6 alkyl, -(C 1 -C 6 alkyl)OC 1 -C 6 alkyl, -(C 1 -C 6 alkyl)N(C 1 -C 6 alkyl) 2 , -C 3 -C 8 cycloalkyl, -C 4 -C 8 cycloalkenyl, -(C 1 -C 6 alkyl)C 3 -C 8 cycloalkyl, -(C 1 -C 6 alkyl)C 4 -C 8 cycloalkenyl, -(C 1 -C 6 -alkyl)OC 3 -C 8 cycloalkyl,-(C 1 -C 6 alkyl)OC 4 -C 8 cycloalkenyl, -(C 1 -C 6 alkyl)SC 3 -C 8 cycloalkyl, -(C 1 -C 6 alkyl)SC 4 -C 8 cycloalkenyl, a side chain of a naturally occurring amino acid, a group -D as defined above or a -(C 1 -C 6 alkyl)OD group wherein D is as defined above; or a pharmaceutically or veterinarily acceptable salt thereof, are PAF inhibitors.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9606996A GB2298138B (en) | 1993-11-10 | 1994-11-09 | 4-(1h-2-methylimidazo 4,5-c pyridinylmethyl)phenyl sulphonamide carboxylic acid derivatives as antagonists |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939323162A GB9323162D0 (en) | 1993-11-10 | 1993-11-10 | 4-(1h-2-methylimidazo(4,5-c)pyridinylmethyl)phenylsulphonamid e derivatives as antagonists of paf |
PCT/GB1994/002460 WO1995013064A1 (en) | 1993-11-10 | 1994-11-09 | 4-(1h-2-methylimidazo 4,5-c pyridinylmethyl)phenyl sulphonamide carboxylic acid derivatives as antagonists |
GB9606996A GB2298138B (en) | 1993-11-10 | 1994-11-09 | 4-(1h-2-methylimidazo 4,5-c pyridinylmethyl)phenyl sulphonamide carboxylic acid derivatives as antagonists |
Publications (3)
Publication Number | Publication Date |
---|---|
GB9606996D0 GB9606996D0 (en) | 1996-06-05 |
GB2298138A true GB2298138A (en) | 1996-08-28 |
GB2298138B GB2298138B (en) | 1997-07-09 |
Family
ID=26303833
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB9606996A Expired - Fee Related GB2298138B (en) | 1993-11-10 | 1994-11-09 | 4-(1h-2-methylimidazo 4,5-c pyridinylmethyl)phenyl sulphonamide carboxylic acid derivatives as antagonists |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB2298138B (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992003423A1 (en) * | 1990-08-15 | 1992-03-05 | British Bio-Technology Limited | Benzimidazole derivatives, process for their preparation and application |
-
1994
- 1994-11-09 GB GB9606996A patent/GB2298138B/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992003423A1 (en) * | 1990-08-15 | 1992-03-05 | British Bio-Technology Limited | Benzimidazole derivatives, process for their preparation and application |
Also Published As
Publication number | Publication date |
---|---|
GB2298138B (en) | 1997-07-09 |
GB9606996D0 (en) | 1996-06-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20011109 |