GB2274235A - Carotenoid food supplement - Google Patents
Carotenoid food supplement Download PDFInfo
- Publication number
- GB2274235A GB2274235A GB9324188A GB9324188A GB2274235A GB 2274235 A GB2274235 A GB 2274235A GB 9324188 A GB9324188 A GB 9324188A GB 9324188 A GB9324188 A GB 9324188A GB 2274235 A GB2274235 A GB 2274235A
- Authority
- GB
- United Kingdom
- Prior art keywords
- composition
- carotene
- carotenoids
- lycopene
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/01—Instant products; Powders; Flakes; Granules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/40—Colouring or decolouring of foods
- A23L5/42—Addition of dyes or pigments, e.g. in combination with optical brighteners
- A23L5/43—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives
- A23L5/44—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives using carotenoids or xanthophylls
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
Abstract
A diet supplement composition containing powdered, dried fruits and vegetables rich in alpha-carotene, beta-carotene and lycopene encapsulated in a gelatin capsule in an edible oil.
Description
CAROTEDIOID FOOD SUPPLEMENT ECH!TICAL FIELD
This invention is in the field of food supplements to provide carotenoids at optimal ingestion levels.
BCKGOUID Aki Carotenoids are the most numerous group of pigments in nature. They play a critical role in electron transport reactions in plants and are indispensable to healthy functioning of human beings and most animals. The full extent of their role in physiology is not known but experimental evidence indicates that carotenoids may be necessary for proper functioning of the immune system and for pro-tecting tissue from ultraviolet damage.
They may reduce chemically induced neoplasia and malignant cell transformation.
Carotenoids are found in fruits and vegetables and an adequate intake of carotenoids, the amount recommended by government agencies and the medical profession, requires ingestion of far more fruits and vegetables than the average diets of persons in the United States and other nations in the
Western culture provide. Among better-known carotenoids are alpha-carotene, beta-carotene and lycopene. In addition to being found in fruits and vegetables, beta-carotene is synthesized and the synthetic compound is commercially available. However, there are hundreds of lesser-studied carotenoids that are found in fruits and vegetables, hereinafter referred to collectively as vegetables, and those lesser-known carotenoids are not present in synthetic preparations such as beta-carotene.The lesser-known carotenoids may play an important (albeit, not fully explored) role in human health as indicated by illnesses or malfunctioning of persons in the Western culture whose diets do not contain enough vegetables. Many of these illnesses or malfunctions are less frequent among persons in populations where diets include large amounts of vegetables. The beneficial effects of lesserstudied or unknown carotenoids may be due to their direct effectiveness in trace amounts or to catalytic or synergistic effects that they-exert with the better-known and more thoroughly studied carotenoids such as beta-carotene. Synthetic carotenoids also lack natural distributions of structural differences in their molecules, such as cis- and trans- forms which occur in natural proportions in vegetables. This phenomenon is observed in many ways.For example, when experimental animals are fed either natural or synthetic beta-carotene, liver analyses show at least ten-fold higher levels of beta-carotene in those animals fed the natural form.
DISCLOSURE OF THE INVENTION
This invention is a composition useful as a dietary supplement which provides adequate carotenoid ingestion to persons regardless of the inadequacy of their diets with respect to their vegetable intake. The composition of this invention not only provides adequate quantities of known carotenoids to the diet but it additionally provides the natural level of lesser known and even unknown carotenoids so that the ingestion of a full spectrum of carotenoids in naturally balanced proportions is achieved by supplementing the diet with the composition of this invention.
This invention is an encapsulated composition of powdered vegetable material in an edible oil base. The composition comprises vegetable material that provides alphacarotene, beta-carotene and lycopene in proportion to each other of about 20 percent to aluout 40 percent alpha-carotene, about 55 percent to about 80 percent beta-carotene, and about 3 percent to about 20 percent lycopene - the percentayes being the weight relationships of those three carotenoids to each other. By providing those carotenoids in that proportion from vegetable materials, the whole array of carotenoids in approximately the balanced composition relationships found in the diet is provided in the composition of this invention.Vegetables that contain high quantities of alpha- and beta-carotene do not contain high quantities of lycopene but they have their own array of other carotenoids. However, those vegetables providing high concentrations of lycopene have an array of carotenoids that are different from the other carotenoids in those vegetables providing high quantities of alpha- and beta-carotene. It has been found that supplyiny a carotenoid content in the proportions noted above from vegetable sources of those carotenoids provides virtually the entire array of carotenoids in the appropriate distribution to duplicate the carotenoid ingestion from a balanced diet rich in vegetables.The carotenoids contained in vegetables not only include different carotenoids than those produced synthetically but additionally the carotenoids found in vegetables are superior to synthetic carotenoids because they differ in such things as structural distribution - for example, between cis- and trans- isomers.
Different vegetables contain different carotenoids, and even when they contain the same carotenoids they are in different proportions. For example, carrots are perhaps the best known source of beta-carotene but they contain no lycopene, while tomatoes are a rich source of lycopene but contain very little beta-carotene. Spinach is rich in lutein but has no lycopene and relatively little alpha-carotene. Each vegetable also contains an array of carotenoids that are lesser known, and no vegetable contains all of them.
All carotenoids are contained in the lipid portion of vegetables, so there is an option to use oleoresins extracted from vegetables or powdered, dried vegetables in the compositions of this invention. The decision to use powders or oleoresins is usually based on the cost or availability of oleoresins and the need to adjust the texture or viscosity of the composition. Most carotenoids survive carefully controlled processes such as spraydrying, freeze-drying, powdering, and extraction quite well. The composition of this invention, accordingly, provides a level of alpha-carotene, beta-carotene and lycopene that supplements the usual Western-culture diet to provide the proper intake of those three carotenoids.In addition, the composition of this invention, by being made from vegetable oleoresins and powdered vegetables, contains a whole array of natural carotenoids - those that have never been studied and those that are not non - and even the known carotenoids are provided in the proper structural distribution that one gets from a balanced diet of vegetables.
DETAILED DESCRIPTION OF THE I1TVENTIOT A composition embodying tis invention was made haviny the following ingredients on a weight basis.
Ingredient Percent
Carrot oleoresin 26.1
Red bell pepper oleoresin 3.0
Peach powder 3.7
Strawberry powder 3.7
Tomato powder 44.9
Spinach powder 14.9
Apricot powder 3.7
The carrot and red pepper oleoresins were obtained by extraction from carrots and red bell pepper bodies respectively.
The carrot oleoresin was bright oranye, virtually flavorless and readily miscible in water. The red bell pepper oleoresin was a red liquid having the aroma of red bell peppers and very mild red bell pepper flavor.
The powdered material was all obtained by spray- or freeze-drying the noted ingredient and subdividing it to a powder form according to known techniques. The spinach was subjected to low-pressure steaming in a chamber for sufficient time to kill bacteria after which it was freeze-dried and powdered. Dried spinach and dried peach were powdered together to deal with the natural hygroscopicity of peach powder. The carotenoidcontaining materials were blended with vegetable oil and lecithin to provide an appropriate texture for encapsulating in a gelatin capsule. The materials were encapsulated in amounts providing 1.5 mg of beta-carotene, 0.5 mg of alpha-carotene and 0.4 mg of lycopene per capsule. The encapsulated materials also supplied other carotenoids that occur naturally in the powders and oleoresins stated in Table 1.
Eleven healthy men and women volunteers between 22 and 52 years of age participated in a study to test if the supplement raised blood carotenoid level. The volunteers had no history of chronic disease, they were taking no medications, they did not smoke, and they were all within 10 percent of ideal body weight for their heights. None of the volunteers had an unconventional dietary pattern, such as vegetarianism. Those volunteers who had been taking carotene-containing supplements stopped doing so two weeks before the study began. All of the volunteers were evaluated for such factors as weight, blood pressure, pulse and temperature at the beginning of the study, two weeks after the beginning of the study, and weekly thereafter.
The study lasted six weeks. During this entire time the diets of the volunteers were self-selected from lowcarotenoid foods on a list of foods provided to them. The volunteers were also given a list of carotenoid-containing foods that they were to avoid during the study. The recommended daily diets of the volunteers contained less than 0.4 mg of betacarotene and alpha-carotene and no lycopene. After two weeks cn the low-carotelloid diet the volunteers began taking sit of the capsules described above daily. This period was called the supplementation period and it continued for the next four weeks.
A fasting blood sample was collected from each volunteer before the beginning of the stud to establish a baseline serum carotenoid level for each subject that was characteristic of his or her own diet and physiologic absorption characteristics for carotenoids. The base-lines were for alphacarotene, beta-carotene and lycopene only. Blood samples were also collected after two weeks on the low carotenoid diet and weekly during the supplementation period. The samples were collected in accordance with recognized medical techniques, centrifuged to obtain plasma, and analyzed for alpha-carotene, beta-carotene and lycopene by the HPLC method of Bieri et al.
Table 2 below reports the data resulting from these tests. The columns headed A are the base-line readings of each volunteer at the start of the test. The columns headed B are the readings after two weeks on the low carotenoid diet at which time the supplementation period began. The columns headed C are the readings at the end of the study - that is, six weeks from the beginning of the study and four weeks from the beginning of the supplementation period. All reported values are in nanograms per milliliter of serum.
TABLE 2 Beta-Carotene Alpha-Carotene Lvcopene Volunteer A B C A B C A B C
1 1028 526 1065 422 241 541 728 433 302
2 530 371 1346 169 110 617 275 166 263
3 255 120 365 96 50 238 448 285 400
4 981 571 1170 177 125 428 254 151 238
5 73 21 72 80 20 56 180 126 125
6 156 111 377 44 33 240 437 213 172
7 341 290 1222 129 98 419 292 205 354
8 578 238 578 245 141 236 590 232 216
9 630 435 1254 302 154 495 453 316 343
10 302 169 907 110 79 510 780 284 225
11 154 107 204 43 45 145 856 692 724
From Table 2 it is evident that the data establish the general trend that two weeks on a low carotenoid diet significantly diminished the serum alpha- and beta-carotene levels of the volunteers.The data also establish that the composition of this invention taken in the four-week supplementation period restored the serum alpha- and betacarotene levels to the base-line level or in excess of the baseline level for each volunteer.
The data reporting lycopene levels were less conclusive. In yeneral there was a significant reduction in lycopene levels between the base-line levels and the start of the supplementation period but the supplementation period did not restore base-line levels. fIowever, plasma lycopene levels are known to respond slower to changes in dietary intake than alphaor beta-carotene levels. Lycopene supplementation initially stabilized lycopene plasma levels preventiny further decline. It is hypothesized that if the study had been prolonged, gradual increases in lycopene levels to or in excess of the base-line levels would be observed. The weekly tests for serum lycopene bear out this hypothesis. For all but two of the volunteers there was a rising trend in serum lycopene in the final week of the supplementation period.Specifically, the data for the final week were:
Volunteer Fifth week Sixth week
1 312 302
2 220 263
3 174 400
4 168 238
5 20 125
6 135 172
7 101 354
8 77 216
9 281 343
10 274 225
11 705 724
As noted above, the volunteers were healthy persons before the test started. They were also healthy persons after the test ended. They noticed no subjective changes in their health during the six weeks of the test. It is known that serum carotenoid levels are accurate indicators of the availability of these essential compounds for maintaining yood health and that temporary periods of low serum carotenoid levels have no affect on the health of the average individual. However, chronic low carotenoid serum levels may cause health deterioration problems.
The study demonstrates that regular ingestion of the composition of this invention will maintain serum carotenoid levels even with a diet that is almost devoid of carotenoids. Its regular use will provide a person with significant ingestion of carotenoids regardless of the vegetable content of that person's usual diet.
Claims (8)
1. A composition comprising a suspension of powdered materials in an edible oil, said powdered materials comprising a mixture of dried, vegetables, said composition containing alphacarotene, beta-carotene and lycopene in proportion to one another on a weight basis of from about 20% to about 40% alpha-carotene, from about 55 to about 80t beta-carotene and from about 3% to about 20% lycopene.
2. The composition of claim 1 wherein said edible oil comprises carrot oleoresin.
3. The composition of claim 1 wherein said edible oil comprises red bell pepper oleoresin.
4. The composition of claim 1 wherein said powdered material comprises spinach powder.
5. The composition of claim 1 wherein said powdered material comprises tomato powder.
6. The composition of claim 1 enclosed in a gelatin capsule.
7. The composition of claim 6 wherein said capsule contains from about 500 to about 1000 milligrams of said composition.
8. A composition enclosed in a gelatin capsule comprising from about 150 to about 200 mg of carrot oleoresin, from about 30 to about 50 mg of red bell pepper oleoresin, from about 100 to about 400 mg of powdered, dried tomato, and from about 50 to about 200 mg of powdered, dried spinach.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US375793A | 1993-01-13 | 1993-01-13 |
Publications (3)
Publication Number | Publication Date |
---|---|
GB9324188D0 GB9324188D0 (en) | 1994-01-12 |
GB2274235A true GB2274235A (en) | 1994-07-20 |
GB2274235B GB2274235B (en) | 1996-06-26 |
Family
ID=21707440
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB9324188A Expired - Lifetime GB2274235B (en) | 1993-01-13 | 1993-11-24 | Carotenoid food supplement |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB2274235B (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2301775A (en) * | 1995-06-07 | 1996-12-18 | Howard Foundation | High dosage lutein and zeaxanthin for macula therapy |
EP0759294A2 (en) * | 1995-06-15 | 1997-02-26 | Mutsunori Fujiwara | Hypercholesterolemia therapeutic agent |
EP0793491A1 (en) * | 1994-12-22 | 1997-09-10 | Henkel Corporation | Pharmaceutical compositions comprising lycopene |
WO1997047278A1 (en) * | 1996-06-12 | 1997-12-18 | Laboratoire Oenobiol | Composition having tanning and sun-screening activity, and cosmetic uses thereof |
FR2749757A1 (en) * | 1996-06-12 | 1997-12-19 | Oenobiol Sa Lab | Composition having cosmetic tanning and sun-screen activity |
US5858700A (en) * | 1997-04-03 | 1999-01-12 | Kemin Foods, Lc | Process for the isolation and purification of lycopene crystals |
US6262109B1 (en) | 1995-12-22 | 2001-07-17 | Henkel Corporation | Methods of preventing and/or treating high serum levels of cholesterol and/or lipids |
US6329432B2 (en) | 1993-06-28 | 2001-12-11 | The Howard Foundation | Mesozeaxanthin formulations for treatment of retinal disorders |
US8163303B2 (en) * | 1998-05-12 | 2012-04-24 | N.V. Nutricia | Nutritional composition for the treatment of pressure ulcers |
CN102845538A (en) * | 2012-07-03 | 2013-01-02 | 江南大学 | Edible oil product rich in lycopene with cis-configuration and preparation method thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2236655A (en) * | 1989-09-18 | 1991-04-17 | Yoshio Tanaka | "Process for producing encapsulated foodstuff" |
GB2265074A (en) * | 1989-09-25 | 1993-09-22 | Yoshio Tanaka | Process for producing encapsulated foodstuff |
GB2265072A (en) * | 1990-01-30 | 1993-09-22 | Yoshio Tanaka | Process for producing encapsulated foodstuff |
GB2265073A (en) * | 1990-03-23 | 1993-09-22 | Yoshio Tanaka | Process for producing encapsulated foodstuff |
-
1993
- 1993-11-24 GB GB9324188A patent/GB2274235B/en not_active Expired - Lifetime
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2236655A (en) * | 1989-09-18 | 1991-04-17 | Yoshio Tanaka | "Process for producing encapsulated foodstuff" |
GB2265074A (en) * | 1989-09-25 | 1993-09-22 | Yoshio Tanaka | Process for producing encapsulated foodstuff |
GB2265072A (en) * | 1990-01-30 | 1993-09-22 | Yoshio Tanaka | Process for producing encapsulated foodstuff |
GB2265073A (en) * | 1990-03-23 | 1993-09-22 | Yoshio Tanaka | Process for producing encapsulated foodstuff |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6329432B2 (en) | 1993-06-28 | 2001-12-11 | The Howard Foundation | Mesozeaxanthin formulations for treatment of retinal disorders |
EP0793491A4 (en) * | 1994-12-22 | 2000-01-12 | Henkel Corp | Pharmaceutical compositions comprising lycopene |
EP0793491A1 (en) * | 1994-12-22 | 1997-09-10 | Henkel Corporation | Pharmaceutical compositions comprising lycopene |
US6362221B1 (en) | 1994-12-22 | 2002-03-26 | Cognis Corporation | Compositions containing natural lycopene and natural tocopherol |
GB2301775A (en) * | 1995-06-07 | 1996-12-18 | Howard Foundation | High dosage lutein and zeaxanthin for macula therapy |
GB2301775B (en) * | 1995-06-07 | 1999-08-04 | Howard Foundation | Treatment of age-related macular degeneration with carotenoids |
EP0759294A2 (en) * | 1995-06-15 | 1997-02-26 | Mutsunori Fujiwara | Hypercholesterolemia therapeutic agent |
EP0759294A3 (en) * | 1995-06-15 | 1999-12-01 | Mutsunori Fujiwara | Hypercholesterolemia therapeutic agent |
US6262109B1 (en) | 1995-12-22 | 2001-07-17 | Henkel Corporation | Methods of preventing and/or treating high serum levels of cholesterol and/or lipids |
WO1997047278A1 (en) * | 1996-06-12 | 1997-12-18 | Laboratoire Oenobiol | Composition having tanning and sun-screening activity, and cosmetic uses thereof |
FR2749758A1 (en) * | 1996-06-12 | 1997-12-19 | Oenobiol Sa Lab | COMPOSITION WITH BRONZING AND PHOTOPROTECTIVE ACTIVITY AND ITS AESTHETIC APPLICATIONS |
FR2749757A1 (en) * | 1996-06-12 | 1997-12-19 | Oenobiol Sa Lab | Composition having cosmetic tanning and sun-screen activity |
US5858700A (en) * | 1997-04-03 | 1999-01-12 | Kemin Foods, Lc | Process for the isolation and purification of lycopene crystals |
US8163303B2 (en) * | 1998-05-12 | 2012-04-24 | N.V. Nutricia | Nutritional composition for the treatment of pressure ulcers |
CN102845538A (en) * | 2012-07-03 | 2013-01-02 | 江南大学 | Edible oil product rich in lycopene with cis-configuration and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
GB2274235B (en) | 1996-06-26 |
GB9324188D0 (en) | 1994-01-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Leitzmann | Characteristics and health benefits of phytochemicals | |
Khachik et al. | Lutein, lycopene, and their oxidative metabolites in chemoprevention of cancer | |
Vuong et al. | Plasma β-carotene and retinol concentrations of children increase after a 30-d supplementation with the fruit Momordica cochinchinensis (gac) | |
Ko et al. | Comparison of the antioxidant activities of nine different fruits in human plasma | |
Goluch-Koniuszy | Nutrition of women with hair loss problem during the period of menopause | |
US5904924A (en) | Green nutritional powder composition | |
Botsoglou et al. | Effect of dietary oregano essential oil on performance of chickens and on iron-induced lipid oxidation of breast, thigh and abdominal fat tissues | |
EP1716210B1 (en) | Compositions containing cis-isomers of carotenoids and corresponding method | |
US5976548A (en) | Nutritional supplement composition and use | |
Cao et al. | Increases in human plasma antioxidant capacity after consumption of controlled diets high in fruit and vegetables | |
van het Hof et al. | Bioavailability of lutein from vegetables is 5 times higher than that of β-carotene | |
Müller et al. | Plasma concentrations of carotenoids in healthy volunteers after intervention with carotenoid-rich foods | |
Barua et al. | Xanthophyll epoxides, unlike β-carotene monoepoxides, are not detectibly absorbed by humans | |
Baron et al. | Functional properties of Omani dates (Phoenix dactylifera L.) | |
Gitenay et al. | Comparison of lycopene and tomato effects on biomarkers of oxidative stress in vitamin E deficient rats | |
GB2274235A (en) | Carotenoid food supplement | |
CN101522057A (en) | Stable and bioavailable compositions of isomers of carotenoids for skin and hair | |
WO1998000024A1 (en) | Nutritional supplement composition and use | |
WO1999048487A1 (en) | Multi-carotenoid product | |
Ahmad et al. | Role of by-products of fruits and vegetables in functional foods | |
DE10219139A1 (en) | Supplements for dietetic foods or for treating various illnesses, contain phytamines embedded in the cell structure of plant homogenizates | |
KR20050099310A (en) | Health functional food with white-green fruits and vegetables and manufacturing method thereof | |
Turturică et al. | Carrot–Application in food industry and health benefits–review | |
Challem | Beta-carotene and other carotenoids: promises, failures, and a new vision | |
Mahmoud et al. | Evaluation of a new baby food prepared from Opuntiaficusindica fruit in Wistar rats with either calcium deficient or vitamin A depletion |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
732E | Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977) | ||
PE20 | Patent expired after termination of 20 years |
Expiry date: 20131123 |