GB2239798B - Biodegradable injectable microsphere steroid formulations. - Google Patents

Biodegradable injectable microsphere steroid formulations.

Info

Publication number
GB2239798B
GB2239798B GB9024862A GB9024862A GB2239798B GB 2239798 B GB2239798 B GB 2239798B GB 9024862 A GB9024862 A GB 9024862A GB 9024862 A GB9024862 A GB 9024862A GB 2239798 B GB2239798 B GB 2239798B
Authority
GB
United Kingdom
Prior art keywords
injectable microsphere
biodegradable injectable
steroid formulations
steroid
formulations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB9024862A
Other versions
GB9024862D0 (en
GB2239798A (en
Inventor
Gerard Cohen
Jean-Luc Dubois
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB9024862D0 publication Critical patent/GB9024862D0/en
Publication of GB2239798A publication Critical patent/GB2239798A/en
Application granted granted Critical
Publication of GB2239798B publication Critical patent/GB2239798B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GB9024862A 1989-11-15 1990-11-15 Biodegradable injectable microsphere steroid formulations. Expired - Fee Related GB2239798B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR898914976A FR2654337B1 (en) 1989-11-15 1989-11-15 NOVEL BIODEGRADABLE INJECTABLE MICROSPHERES PREPARATION METHOD AND INJECTABLE SUSPENSIONS CONTAINING THEM.

Publications (3)

Publication Number Publication Date
GB9024862D0 GB9024862D0 (en) 1991-01-02
GB2239798A GB2239798A (en) 1991-07-17
GB2239798B true GB2239798B (en) 1993-10-27

Family

ID=9387417

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9024862A Expired - Fee Related GB2239798B (en) 1989-11-15 1990-11-15 Biodegradable injectable microsphere steroid formulations.

Country Status (13)

Country Link
JP (1) JPH03294229A (en)
AT (1) AT400298B (en)
BE (1) BE1005511A4 (en)
CA (1) CA2029940A1 (en)
CH (1) CH681691A5 (en)
DE (1) DE4036425A1 (en)
DK (1) DK270990A (en)
FR (1) FR2654337B1 (en)
GB (1) GB2239798B (en)
IT (1) IT1242010B (en)
LU (1) LU87836A1 (en)
NL (1) NL9002492A (en)
SE (1) SE9003570L (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU222501B1 (en) * 1991-06-28 2003-07-28 Endorecherche Inc. Controlled release pharmaceutical composition containing mpa or mga and process for its preparation
ZA924811B (en) * 1991-06-28 1993-12-29 Endorecherche Inc Controlled release systems and low dose androgens
IL110052A (en) * 1993-06-24 2001-04-30 Lilly Co Eli Pharmaceutical compositions containing benzothiophene derivatives as hypoglycemic compounds
US5910492A (en) * 1995-06-05 1999-06-08 Takeda Chemical Industries, Ltd. Osteogenic promoting pharmaceutical composition
EP2210585A1 (en) 2009-01-16 2010-07-28 Exelgyn SPRM pharmaceutical compositions methods of treatment using them

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0025698A2 (en) * 1979-09-12 1981-03-25 Eli Lilly And Company Controlled release formulations
EP0102265A2 (en) * 1982-07-29 1984-03-07 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
EP0171907A1 (en) * 1984-07-06 1986-02-19 Wako Pure Chemical Industries, Ltd. Use of a copolymer in a controlled drug release composition
EP0330180A1 (en) * 1988-02-24 1989-08-30 Biomaterials Universe, Inc. Polylactic acid type microspheres containing physiologically active substance and process for preparing the same

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2528434B1 (en) * 1982-06-11 1985-07-19 Roussel Uclaf NOVEL 19-NOR STEROIDS SUBSTITUTED IN 11B AND POSSIBLY IN 2, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS A MEDICAMENT
FR2537980B1 (en) * 1982-12-17 1986-12-19 Sandoz Sa OLIGOMERIC HYDROXYCARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE
ES533260A0 (en) * 1983-06-15 1985-02-01 Schering Ag PROCEDURE FOR THE PREPARATION OF 13A-ALQUILGONANOS
GB8327256D0 (en) * 1983-10-12 1983-11-16 Ici Plc Steroid derivatives
JPS60100516A (en) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd Preparation of sustained release microcapsule
DE3347126A1 (en) * 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 11SS-ARYL-ESTRADIENE, THEIR PRODUCTION AND THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM
FR2566779B2 (en) * 1984-06-29 1987-03-06 Roussel Uclaf NOVEL 11B SUBSTITUTED STEROID DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
FR2573657B1 (en) * 1984-11-29 1989-05-12 Roussel Uclaf PRODUCT COMPRISING AN ANTIPROGESTOMIMETIC SUBSTANCE AND A UTEROTONIC SUBSTANCE
DE3533175A1 (en) * 1985-09-13 1987-03-19 Schering Ag ANTIGESTAGES TO SHIFT ENDOMETRIAL MATURATION
FR2596395B1 (en) * 1986-03-26 1989-05-26 Roussel Uclaf NOVEL STEROIDS COMPRISING A SPIRANIC CYCLE IN POSITION 17, THEIR PREPARATION METHOD, THEIR APPLICATION AS MEDICAMENTS AND THE COMPOSITIONS CONTAINING THEM
US4758435A (en) * 1986-08-11 1988-07-19 American Cyanamid Company Estradiol implant composition and method for preparation
DE3633244A1 (en) * 1986-09-26 1988-03-31 Schering Ag ANTIGESTAGE FOR INHIBITING UTERINE PROSTAGLAND INSYNTHESIS
DE3733478A1 (en) * 1987-10-01 1989-04-13 Schering Ag ANTIGESTAGEN AND ANTIOOTROGENIC COMPOUNDS FOR THE INTRODUCTION OF BIRTH AND PREGNANCY, AND THE TREATMENT OF GYNAECOLOGICAL DISORDER AND HORMONE-RELATED TUMORS
EP0310542B1 (en) * 1987-10-01 1994-06-08 Schering Aktiengesellschaft Antigestagenic and antioestrogenic compounds for the treatment of hormone-dependent tumours
DE3744054A1 (en) * 1987-12-21 1989-06-29 Schering Ag USE OF ANTIGESTAGES FOR THE PRODUCTION OF MEDICINAL PRODUCTS
JP2785023B2 (en) * 1987-12-30 1998-08-13 ルセル―ユクラフ Novel derivative of 17β-OH-19-norsteroid substituted at 17α position, process for its preparation, its use as drug and pharmaceutical composition containing it

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0025698A2 (en) * 1979-09-12 1981-03-25 Eli Lilly And Company Controlled release formulations
EP0102265A2 (en) * 1982-07-29 1984-03-07 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
EP0171907A1 (en) * 1984-07-06 1986-02-19 Wako Pure Chemical Industries, Ltd. Use of a copolymer in a controlled drug release composition
EP0172636A1 (en) * 1984-07-06 1986-02-26 Wako Pure Chemical Industries, Ltd. Method for producing a polymer or copolymer of lactic acid and/or glycolic acid
EP0330180A1 (en) * 1988-02-24 1989-08-30 Biomaterials Universe, Inc. Polylactic acid type microspheres containing physiologically active substance and process for preparing the same

Also Published As

Publication number Publication date
DK270990D0 (en) 1990-11-13
ATA231390A (en) 1995-04-15
BE1005511A4 (en) 1993-08-31
IT1242010B (en) 1994-02-02
FR2654337B1 (en) 1994-08-05
DE4036425A1 (en) 1991-05-16
IT9048470A0 (en) 1990-11-13
GB9024862D0 (en) 1991-01-02
SE9003570L (en) 1991-05-16
NL9002492A (en) 1991-06-03
DK270990A (en) 1991-05-16
CH681691A5 (en) 1993-05-14
FR2654337A1 (en) 1991-05-17
CA2029940A1 (en) 1991-05-16
AT400298B (en) 1995-11-27
LU87836A1 (en) 1991-05-07
GB2239798A (en) 1991-07-17
SE9003570D0 (en) 1990-11-09
IT9048470A1 (en) 1992-05-13
JPH03294229A (en) 1991-12-25

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19981115