GB2235292B - Multiplex immunoassay system using distinguishable tagged ligands - Google Patents

Multiplex immunoassay system using distinguishable tagged ligands

Info

Publication number
GB2235292B
GB2235292B GB9016162A GB9016162A GB2235292B GB 2235292 B GB2235292 B GB 2235292B GB 9016162 A GB9016162 A GB 9016162A GB 9016162 A GB9016162 A GB 9016162A GB 2235292 B GB2235292 B GB 2235292B
Authority
GB
United Kingdom
Prior art keywords
distinguishable
immunoassay system
multiplex immunoassay
tagged ligands
tagged
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB9016162A
Other versions
GB9016162D0 (en
GB2235292A (en
Inventor
Myron J Block
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ord Inc
Original Assignee
Ord Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ord Inc filed Critical Ord Inc
Publication of GB9016162D0 publication Critical patent/GB9016162D0/en
Publication of GB2235292A publication Critical patent/GB2235292A/en
Application granted granted Critical
Publication of GB2235292B publication Critical patent/GB2235292B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
GB9016162A 1989-08-25 1990-07-24 Multiplex immunoassay system using distinguishable tagged ligands Expired - Fee Related GB2235292B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39862189A 1989-08-25 1989-08-25

Publications (3)

Publication Number Publication Date
GB9016162D0 GB9016162D0 (en) 1990-09-05
GB2235292A GB2235292A (en) 1991-02-27
GB2235292B true GB2235292B (en) 1993-09-22

Family

ID=23576097

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9016162A Expired - Fee Related GB2235292B (en) 1989-08-25 1990-07-24 Multiplex immunoassay system using distinguishable tagged ligands

Country Status (5)

Country Link
JP (1) JP2584530B2 (en)
CA (1) CA2021658C (en)
DE (1) DE4024350C2 (en)
FR (1) FR2651327B1 (en)
GB (1) GB2235292B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4047893A (en) * 1992-04-06 1993-11-08 Abbott Laboratories Method and device for detection of nucleic acid or analyte using total internal reflectance
WO2002048690A1 (en) * 2000-12-11 2002-06-20 Varian Australia Pty Ltd Method and apparatus for analysis of multiplexed samples
JP3429282B2 (en) 2001-02-02 2003-07-22 リサーチ・インターナショナル・インコーポレーテッド Automated system and sample analysis method
US20050221363A1 (en) * 2004-04-01 2005-10-06 Rules-Based Medicine, Inc. Universal shotgun assay
US7496245B2 (en) 2004-08-20 2009-02-24 Research International, Inc. Misalignment compensating optical sensor and method
US7842465B2 (en) * 2006-01-17 2010-11-30 Palo Alto Research Center Incorporated Immunocytostaining methods for enhanced dye ratio discrimination in rare event detection
US7651869B2 (en) 2006-03-14 2010-01-26 Research International, Inc. Optical assay apparatus and methods
WO2008106021A1 (en) * 2007-02-26 2008-09-04 Response Biomedical Corporation Comparative multiple analyte assay

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3604927A (en) * 1966-11-16 1971-09-14 Block Engineering Total reflection fluorescence spectroscopy
US3652761A (en) * 1969-09-04 1972-03-28 Corning Glass Works Immunochemical composites and antigen or antibody purification therewith
DE2953610C1 (en) * 1979-03-19 1985-04-11 International Diagnostic Technology, Inc., Santa Clara, Calif. Method for determining an immunologically active substance
JPS5745454A (en) * 1980-09-02 1982-03-15 Fuji Photo Film Co Ltd Immunochemical measuring method for various minor components
JPS585659A (en) * 1981-06-24 1983-01-13 ハイブリテツク　インコ−ポレ−テツド Immunological inhibition test using single clone property antigen
US4582809A (en) * 1982-06-14 1986-04-15 Myron J. Block Apparatus including optical fiber for fluorescence immunoassay
US4471058A (en) * 1982-07-26 1984-09-11 Board Of Trustees Operating Michigan State University Method for the detection and/or determination of a polyvalent antigen using at least two different monoclonal antibodies
US4447546A (en) * 1982-08-23 1984-05-08 Myron J. Block Fluorescent immunoassay employing optical fiber in capillary tube
US4584277A (en) * 1983-04-05 1986-04-22 Syntex (U.S.A.) Inc. Fluorescent multiparameter particle analysis
US4558014A (en) * 1983-06-13 1985-12-10 Myron J. Block Assay apparatus and methods
US4582791A (en) * 1983-10-07 1986-04-15 Syntex (U.S.A.) Inc. Reducing non-specific background in immunofluorescence techniques
US4595661A (en) * 1983-11-18 1986-06-17 Beckman Instruments, Inc. Immunoassays and kits for use therein which include low affinity antibodies for reducing the hook effect
JPH0789116B2 (en) * 1985-06-14 1995-09-27 帝人株式会社 Immunological assay method using monoclonal antibody and kit therefor
JPS6238362A (en) * 1985-08-12 1987-02-19 Chemo Sero Therapeut Res Inst Method for measuring tsh
AU614935B2 (en) * 1986-08-06 1991-09-19 Multilyte Limited Determination of analyte concentration using two labelling markers
US4704891A (en) * 1986-08-29 1987-11-10 Becton, Dickinson And Company Method and materials for calibrating flow cytometers and other analysis instruments
GB8623494D0 (en) * 1986-09-30 1986-11-05 Mackay C D Assay technique
US4954435A (en) * 1987-01-12 1990-09-04 Becton, Dickinson And Company Indirect colorimetric detection of an analyte in a sample using ratio of light signals
JPH0827282B2 (en) * 1987-07-01 1996-03-21 帝人株式会社 Immunological assay method for human protein C, assay reagent and kit thereof
GB2233450B (en) * 1989-06-24 1993-06-30 Univ Wales Medicine Detecting or quantifing multiple analytes with luminescent reagents

Also Published As

Publication number Publication date
CA2021658C (en) 2001-10-09
JPH03272466A (en) 1991-12-04
CA2021658A1 (en) 1991-02-26
DE4024350C2 (en) 2000-03-16
JP2584530B2 (en) 1997-02-26
DE4024350A1 (en) 1991-02-28
GB9016162D0 (en) 1990-09-05
FR2651327B1 (en) 1994-03-11
FR2651327A1 (en) 1991-03-01
GB2235292A (en) 1991-02-27

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Legal Events

Date Code Title Description
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20070724