GB2222949A - Lice control - Google Patents

Lice control Download PDF

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Publication number
GB2222949A
GB2222949A GB8919017A GB8919017A GB2222949A GB 2222949 A GB2222949 A GB 2222949A GB 8919017 A GB8919017 A GB 8919017A GB 8919017 A GB8919017 A GB 8919017A GB 2222949 A GB2222949 A GB 2222949A
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GB
United Kingdom
Prior art keywords
film
copolymer
forming polymer
pharmaceutical composition
plasticiser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB8919017A
Other versions
GB2222949B (en
GB8919017D0 (en
Inventor
Gordon Anthony Elgar
Joanne Heafield
Sandra Therese Antoi Malkowska
Philip John Neale
Derek Allan Prater
Alison Jane Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Publication of GB8919017D0 publication Critical patent/GB8919017D0/en
Publication of GB2222949A publication Critical patent/GB2222949A/en
Application granted granted Critical
Publication of GB2222949B publication Critical patent/GB2222949B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/24—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients to enhance the sticking of the active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • A61K8/8182—Copolymers of vinyl-pyrrolidones. Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/54—Polymers characterized by specific structures/properties
    • A61K2800/542—Polymers characterized by specific structures/properties characterized by the charge
    • A61K2800/5422—Polymers characterized by specific structures/properties characterized by the charge nonionic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/54—Polymers characterized by specific structures/properties
    • A61K2800/542—Polymers characterized by specific structures/properties characterized by the charge
    • A61K2800/5424—Polymers characterized by specific structures/properties characterized by the charge anionic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/594—Mixtures of polymers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Medicinal Preparation (AREA)

Abstract

A method for controlling lice or their ova on a human subject consists of applying to a human subject a topical, pharmaceutical composition comprising a solution of a film-forming polymer, a conditioner and a plasticiser in an aqueous, aqueous alcoholic or alcoholic medium. Preferably the polymer is a carboxyalkylcellulose or a hydroxyalkylcellulose, the conditioner is a quaternary ammonium derivative and the plasticiser is glycerol or a polyalkylene glycol. The composition may also contain a surfactant, a lousicide and/or an insect repellent. Application of the composition forms a thin film on the hair. This film causes the louse not to recognise the host as being a human head with hair. The louse then either leaves the site or fails to infest the site.

Description

A METHOD FOR CONTROLLING LICE OR THEIR OVA The present invention relates to a method for controlling lice or their ova on human subjects.
According to the present invention, there is provided a method for controlling lice or their ova on a human subject comprising applying to the human subject a topical, pharmaceutical composition comprising a solution of d film-forming polymer, a conditioner and a plasticiser in an aqueous, aqueous alcoholic or alcoholic medium.
After application and evaporation of the medium, the film-forming polymer must form a film on the subject's hair. The polymer must also be soluble in aqueous, aqueous alcoholic or alcoholic medium.
Suitab]e polymers are 3. Cellu]ose ethers, such as carboxymethylce3)uloses and hydroxyalkylcelluloses, 2. Povidone and its copolymers, such as povidone-vinyl acetate copolymcr, 3. Vinyl acetate-crotonic acid copolymers, 4. Polyacrylates, polymethacrylates and their copolymers, 5. Alkylvinylether - Maleic acid ester copolymers, 6. Alkylvinylester - Maleic acid ester copolymer, and Of these polymers, the cellulose ethers, especially carboxyalkylcelluloses and hydroxyalkylcelluloses, and povidone copolymers, especially povidoe-vinyl acetate copolymer, are preferred.
The conditioner is present in the composition of this method to ensure adherence of the film forming polymer to the subject's hair.
It (the conditioner) must be compatible with the film forming polymer and the plasticiser and must be soluble in aqueous, aqueous alcoholic or alcoholic medium. Suitable conditioners, such as lecithin, will be well known to those skilled in the pharmaceutical art. Quaternary ammonium derivatives such as 1. Tetraalkylammonium halides, 2. Trialkylbenzylammonium halides, 3. Alkylisoquinolinium halides, 4. Alkylpyridinium halides, 5. Ethoxylated quaternary ammonium phosphates, 6. Quaternised fatty acid amino-amides derived from lanolic acids and mink oil, 7. N-acyl colaminoformylmethyl pyridinium derivatives, and 8. Povidone-quaternised dimethylaminoethyl methacrylate copolymers, are, however, preferred.
The plasticiser is present in the composition of this method to ensure that the film formed by the polymer is flexible and to prevent brittleness. It (the plasticiser) must be compatible with the film forming polymer and the conditioner and must be soluble in aqueous, aqueous alcoholic or alcoholic medium. Suitable materials include derivatives of lanolin, silicones, esters, polyols, such as glycerol and polyalkylene glycols, and glycol ethers.
The medium may contain between 0 and 100t (by weight) water and between 100 and 0% (by weight) alcohol. The alcohol will generally be a CX alkyl alcohol, especially ethanol or isopropanol.
The concentration of the film forming polymer, the conditioner and the plasticiser in the composition of the present method must be sufficient to control lice or their ova on human subjects. The concentrations will also depend, to some extent, on the dosage form required. Suitable concentrations of these ingredients are, t by weight Film forming polymer 0.1-5t, preferably 0.5-38 Conditioner 0.1-5t, preferably 0.5-3% Plasticiser 0.1-5t, preferably 0.5-3% In addition to the polymer, conditioner and plasticiser, the composition of the present method may also contain a surfactant.
Although anionic, cationic or ampholytic surfactants, such as alkyl sulphates, alkyl sulphonates, alkyl aryl sulphonates, alkyl phosphates, glyceride sulphates, alkyl sulphosuccinates, polyethyleneglycol ester sulphates, isethionates, ether sulphates, ether carboxylates, quaternary ammonium salts, sulphonium salts, phosphonium salts and betadines, may be used, non-ionic surfactants are preferred. Suitable non-ionic surfactants include fatty acid alkanolamides, alkyl polyglycol ethers, polyglycol esters, thioethers and sucrose fatty acid esters.
In addition to the above ingredients, the composition of the present method may also contain other pharmaceutically acceptable materials, such as antioxidants, stabilisers, preservatives and perfumes.
The composition may be in any suitable dosage form such as a shampoo lotion, gel or spray.
The present composition may also contain i. A lousicide such as permethrin,carbaryl, malathion or phenothrin, ii. An insect repellent, such as dibutyl phthalate, diethyltoludmide, dimethyl phthalate and ethohexadiol.
The present method is used to control lice or their ova in humans, by applying the composition to a site of infestation or to a site believed to be infested. Alternatively, the composition may be used prophylactically to prevent infestation.
Without wishing to limit the present invention in any way, it is believed that the mode of action of the present composition is as follows: Application of the composition to an appropriate site (e.g.
the head) forms a thin film of the polymer on the hair. The presence of the thin film, which is not detectable by sight, touch or smell, causes the louse not to recognise the host as being, e.g. human head with hair. The louse then either leaves the site (if an infestation is treated) or refuses to infest the site (if the composition is used prophylactically).
In a further aspect of the present invention there is provided a topical, pharmaceutical composition for the control of lice or their ova on a human subject comprising a solution of a film-forming polymer, a conditioner and a plasticiser in an aqueous, aqueous alcoholic or alcoholic medium.
A still further aspect of the present invention provides the use of a film forming polymer, a conditioner and a plasticiser for the manufacture of a topical pharmaceutical composition for the control of lice or their ova on a human subject.
The present method and composition will now be described by way of Example only.
Example 1 A spray composition having the following formulation was prepared, t w/w Hydroxypropylmethyl cellulose 0.75 (Methocel E15, Trade Mark) Povidone-Vinyl Acetate copolymer 0.75 (Kollidon-.VA64, Trade Mark) DK Ester F90W (Trade Mark) 0.2 (Sucrose esters of stearic (70S) and palmitic (30%) acids containing 45% monoesters).
Polyethylene glycol 400 0.5 Polyoxyethylene alkyl ether 1.0 (Brij 58, Trade Mark) Quaternary ammonium polymer 1.0 (Gafquat 755N, Trade Mark) Perfume q.s.
Isopropyl Alcohol 50.0 Water 45.8 Example 2 The composition of Example 1 was prepared except that the isopropyl alcohol was replaced by 95S ethanol.
Example 3 The composition of Example 2 was prepared except that the level of Gafquat 755N (Trade Mark) was raised to 4S (w/w) and the level of 95S ethanol was lowered to 42.8S (w/w).
Example 4 A spray composition having the following formulation was prepared, t w/w Hydroxypropylmethyl cellulose 0.25 (Methocel E15, Trade Mark) Povidone-Vinyl Acetate copolymer 0.25 (Kollidon-VA64 ,Trade Mark) DK Ester F90W (Trade Mark) 0.2 Polyethylene glycol 400 0.5 Brij 58 (Trade Mark) 1.0 Gafquat 755N (Trade Mark) 1.0 Perfume q.s.
95S Ethanol 50.0 Water 46.8 Example 5 A spray composition having the following formulation was prepared, S w/w Hydroxypropylmethyl cellulose 0.75 (Methocel E15, Trade Mark) Hydroxye thylcel lulose 0.75 (Cellobond 45000, Trade Mark) DK Ester F90W (Trade Mark) 0.2 Polyethylene glycol 400 0.5 .Brij 58 (Trade Mdrk) 1.0 Gafquat 755N (Trade mark) 2.0 95S Ethanol 50.0 Water 44.8 Example 6 A gel composition having the following formulation was prepared, % w/w Hydroxypropylmethylcellulose 0.75 (Methocel E15, Trade Mark) Povidone -Vinyl Acetate copolymer 0.75 (Kollidon - VA 64, Trade Mark) DK Ester F90W (Trade Mark) 0.2 Glycerin B.P. 1.0 Quaternary Ammonium Polymer 2.0 (Gafquat 755N, Trade Mark) Carbomer (Carbopol 934P, Trade Mark) 0.35 Tr iethano lamine 0.53 Hydroxybenzoate Preservative 0.13 (Nipastat, Trade Mark) Perfume 1.0 Water 93.29 Example 7 A qel composition having the following formulation was prepared, % w/w Hydroxypropylmethyl cellulose 0.75 (Methocel E15, Trade Mark) Povidone - Vinyl Acetate copolymer 0.75 (Kollidon - VA 64, Trade Mark) DK Ester F90W (Trade Mark) 0.2 Polyethylene Glycol 400 0.5 Quaternary Ammonium Polymer 1.0 (Gafquat 755N, Trade Mark) Carbomer (Carbopol 934P, Trade Mark) 0.5 Triethanolamine 0.75 Polyoxyethylene alkyl ether 1.0 (Brij 58, Trade Mark) Water 94.6 Example 8 The gel composition of Example 11 was prepared except that the level of Carbomer was reduced to 0.1t (w.w), the level of triethanolamine was reduced to 0.15t (w/w) and the level of water was increased to 95.6 (w/w).
Example 9 A gel composition having the following formulation was prepared, t wlw Hydroxypropylmethyl cellulose 2.0 (Methocel E15, Trade mark) Povidone - Vinyl Acetate copolymer 2.0 (Kollidon - VA 64, Trade Mark) DK Ester F90W (Trade Mark) 0.2 Glycerin B.P. 1.0 Quaternary Ammonium Polymer 2.0 (Gafquat 755N, Trade Mark) Carbomer (Carbopol 934P, Trade Mark) 0.35 Triethanolamine 0.53 Water 91.9 Example 10 Trea tment A lotion according to Example 1 was packed in a pump-action spray bottle.
The lotion was sprayed onto the wet hair of a subject and combed through until there was an even application over the hair. The hair was allowed to dry naturally.
Example 11 Treatment A gel according to Example 6 was applied to the wet hair of a subject and combed through until there was an even application over the hair. The hair was allowed to dry naturally.

Claims (23)

1. A method for controlling lice or their ova on a human subject comprising applying to the human subject a topical, pharmaceutical composition comprising a solution of a film-forming polymer, a conditioner and a plasticiser in an aqueous, aqueous alcoholic or alcoholic medium.
2. A method according to claim 1 wherein the film-forming polymer comprises a cellulose ether, povidone, a povidone copolymer, a vinyl acetate-crotonic acid copolymer, a polyacrylate, a polyacrylate copolymer, a polymethacrylate, a polymethacrylate copolymer, an alkylvinylether-maleic acid ester copolymer or an alkylvinylester-maleic acid ester copolymer.
3. A method according to claim 2 wherein the film-forming polymer comprises a cellulose ether.
4. A method according to claim wherein the film-forming polymer comprises a carboxyalkylcellulose or a hydroxyalkylcellulose.
5. A method according to claim 2 wherein the film-forminq polymer comprises a povidone copolymer.
6. A method according to claim 5 wherein the film-forming polymer comprises a povidone-vinyl acetate copolymer.
7. A method according to any one of claims 1 to 6 wherein the conditioner comprises a quaternary ammonium derivative.
8. A method according to claim 7 wherein the conditioner comprises a tetraalkyl ammonium halide, a trialkylbenzylammonium halide, an alkylisoquinolinium halide, an alkylpyridinium halide, an ethoxylated quaternary ammonium phosphate, a quaternised fatty acid amino-amide derived from lanolic acid and mink oil, an N-acyl colaminoformylmethyl pyridinium derivative or a povidone-quaternised dimethylaminoethyl methacrylate copolymer.
9. A method according to any one of claims 1 to 8 wherein the plasticiser comprises lanolin, a silicone, an ester, a polyol or a glycol ether.
10. A method according to claim 9 wherein the plasticiser comprises glycerol or a polyalkylene glycol.
11. A method according to any one of claims 1 to 10 wherein the medium comprises an aqueous alcohol.
12. A method according to any one of claims 1 to 11 wherein the alcohol in the medium comprises ethanol or isopropanol.
13. A method according to any one of claims 1 to 12 wherein the topical, pharmaceutical composition further comprises a surfactant.
14. A method according to claim 13 wherein the surfactant comprises a non-ionic surfactant.
15. A method according to claim 14 wherein the surfactant.
comprises a fatty acid alkanolamide, an alkyl polyglycol ether1 a polyglycol ester, a thioether or a sucrose fatty acid ester.
16. A method according to any one of claims I to 15 wherein the topical, pharmaceutical composition further comprises a lousicide.
17. A method according to claim 16 wherein the lousicide comprises permethrin, carbaryl, malathion or phenothrin.
18. A method according to any one of claims 1 to 17 wherein the topical, pharmaceutical composition further comprises an insect repellent.
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19. A method according to claim 18 wherein the insect repellent comprises dibutyl phthalate, diethyltoluamide, dimethyl phthalate or ethohexadiol.
20. A method for controlling lice or their ova on a human subject substantially as hereinbefore described with particular reference to Example 10.
21. A topical pharmaceutical composition for the control of lice or their ova on a human subject comprising a solution of a film-forming polymer, a conditioner and a plasticiser in an aqueous, aqueous alcoholic or alcoholic medium.
22. A topical pharmaceutical composition substantially as hereinbefore described with particular reference to any one of the Examples 1 to 9.
23. The use of a film forming polymer, a conditioner and a plasticiser for the manufacture of a topical pharmaceutical composition for the control of lice or their ova on a human subject.
GB8919017A 1988-09-15 1989-08-21 Manufacture of a medicament for controlling lice or their ova Expired - Fee Related GB2222949B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888821587A GB8821587D0 (en) 1988-09-15 1988-09-15 Method for controlling lice/their ova

Publications (3)

Publication Number Publication Date
GB8919017D0 GB8919017D0 (en) 1989-10-04
GB2222949A true GB2222949A (en) 1990-03-28
GB2222949B GB2222949B (en) 1992-12-23

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GB8919017A Expired - Fee Related GB2222949B (en) 1988-09-15 1989-08-21 Manufacture of a medicament for controlling lice or their ova

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Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2232354A (en) * 1989-02-28 1990-12-12 Charwell Consumer Prod Pediculicidal compositions containing piperonal
US5112515A (en) * 1990-02-09 1992-05-12 Euroceltique, S.A. Phenothrin shampoo
EP0555427A1 (en) * 1991-06-27 1993-08-18 AMIDON, Gordon L. Bioactive composition
FR2696902A1 (en) * 1992-10-21 1994-04-22 Health Business Dev Compsns. for control of ectoparasites, esp. lice - comprising antiparasitic agent and film-forming acrylic] polymer
WO1994026235A1 (en) * 1993-05-08 1994-11-24 Wella Aktiengesellschaft Hair care product
WO1995000104A1 (en) * 1993-06-23 1995-01-05 Wella Aktiengesellschaft Aqueous hair-fixing agent in the form of a sprayable highly viscous gel
US5496852A (en) * 1989-02-28 1996-03-05 Charwell Consumer Products, Ltd. Louse repellent
WO1997045012A1 (en) * 1996-05-28 1997-12-04 Ben Gurion University Of The Negev Topical pediculicidal compositions
WO1998023150A1 (en) * 1996-11-26 1998-06-04 Schering-Plough Healthcare Products Inc. Insect repellent emulsions
US6596291B2 (en) * 1997-12-05 2003-07-22 Thomas A. Bell Compositions and methods for treating surfaces infected with ectoparasitic insects
US6605643B1 (en) 1997-11-24 2003-08-12 Schering-Plough Healthcare Products, Inc. Insect repellent emulsions
US6663876B2 (en) 2002-04-29 2003-12-16 Piedmont Pharmaceuticals, Llc Methods and compositions for treating ectoparasite infestation
WO2004084630A1 (en) * 2003-03-24 2004-10-07 Safi Bijan Head lice medication and treatment
GB2404587A (en) * 2003-08-02 2005-02-09 Ssl Int Plc Parasiticidal composition
WO2006017232A1 (en) * 2004-07-12 2006-02-16 Taro Pharmaceuticals Industries Ltd. Topical gel formulation comprising insecticide and its preparation thereof
WO2006017263A1 (en) * 2004-07-12 2006-02-16 Taro Pharmaceutical Industries Ltd. Topical gel formulation comprising organophosphate insecticide and its preparation thereof
US7977324B2 (en) 2005-07-06 2011-07-12 Taro Pharmaceuticals North America, Inc. Process for preparing malathion for pharmaceutical use
US8158139B2 (en) 2004-07-12 2012-04-17 Taro Pharmaceuticals North America, Inc. Topical gel formulation comprising organophosphate insecticide and preparation thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2058103A (en) * 1979-08-23 1981-04-08 Bristol Myers Co An aqueous hair conditioning composition containing a silicone polymer and a cationic polymer and method for conditioning hair
EP0256691A2 (en) * 1986-07-31 1988-02-24 Neutrogena Corporation Hair conditioner base
EP0260641A2 (en) * 1986-09-18 1988-03-23 Kao Corporation Emulsion type hair cosmetic
GB2205747A (en) * 1987-06-17 1988-12-21 Colgate Palmolive Co Hair rinse conditioner
GB2206045A (en) * 1987-06-11 1988-12-29 Colgate Palmolive Co Shine hair conditioner

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2058103A (en) * 1979-08-23 1981-04-08 Bristol Myers Co An aqueous hair conditioning composition containing a silicone polymer and a cationic polymer and method for conditioning hair
EP0256691A2 (en) * 1986-07-31 1988-02-24 Neutrogena Corporation Hair conditioner base
EP0260641A2 (en) * 1986-09-18 1988-03-23 Kao Corporation Emulsion type hair cosmetic
GB2206045A (en) * 1987-06-11 1988-12-29 Colgate Palmolive Co Shine hair conditioner
GB2205747A (en) * 1987-06-17 1988-12-21 Colgate Palmolive Co Hair rinse conditioner

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5496852A (en) * 1989-02-28 1996-03-05 Charwell Consumer Products, Ltd. Louse repellent
GB2232354B (en) * 1989-02-28 1992-09-23 Charwell Consumer Prod Pediculicidal compositions
GB2232354A (en) * 1989-02-28 1990-12-12 Charwell Consumer Prod Pediculicidal compositions containing piperonal
US5696158A (en) * 1989-02-28 1997-12-09 Unicliffe Limited Louse repellent
US5112515A (en) * 1990-02-09 1992-05-12 Euroceltique, S.A. Phenothrin shampoo
EP0555427A1 (en) * 1991-06-27 1993-08-18 AMIDON, Gordon L. Bioactive composition
EP0555427A4 (en) * 1991-06-27 1994-07-06 Gordon L Amidon Bioactive composition
FR2696902A1 (en) * 1992-10-21 1994-04-22 Health Business Dev Compsns. for control of ectoparasites, esp. lice - comprising antiparasitic agent and film-forming acrylic] polymer
WO1994026235A1 (en) * 1993-05-08 1994-11-24 Wella Aktiengesellschaft Hair care product
US5879669A (en) * 1993-05-08 1999-03-09 Wella Aktiengesellschaft Aqueous hair fixing composition containing a water-soluble hair fixing polymer and a thickener
WO1995000104A1 (en) * 1993-06-23 1995-01-05 Wella Aktiengesellschaft Aqueous hair-fixing agent in the form of a sprayable highly viscous gel
WO1997045012A1 (en) * 1996-05-28 1997-12-04 Ben Gurion University Of The Negev Topical pediculicidal compositions
WO1998023150A1 (en) * 1996-11-26 1998-06-04 Schering-Plough Healthcare Products Inc. Insect repellent emulsions
US6605643B1 (en) 1997-11-24 2003-08-12 Schering-Plough Healthcare Products, Inc. Insect repellent emulsions
US6596291B2 (en) * 1997-12-05 2003-07-22 Thomas A. Bell Compositions and methods for treating surfaces infected with ectoparasitic insects
US6663876B2 (en) 2002-04-29 2003-12-16 Piedmont Pharmaceuticals, Llc Methods and compositions for treating ectoparasite infestation
US8815270B2 (en) 2002-04-29 2014-08-26 Piedmont Pharmaceuticals, Llc Methods and compositions for treating ectoparasite infestation
US8178116B2 (en) 2002-04-29 2012-05-15 Piedmont Pharmaceuticals, Llc Methods and compositions for treating ectoparasite infestation
WO2004084630A1 (en) * 2003-03-24 2004-10-07 Safi Bijan Head lice medication and treatment
AU2004262971B2 (en) * 2003-08-02 2009-02-19 Lrc Products Limited Parasiticidal composition
GB2404587B (en) * 2003-08-02 2008-05-14 Ssl Int Plc Parasiticidal composition
WO2005013930A1 (en) * 2003-08-02 2005-02-17 Lrc Products Limited Parasiticidal composition
GB2404587A (en) * 2003-08-02 2005-02-09 Ssl Int Plc Parasiticidal composition
WO2006017263A1 (en) * 2004-07-12 2006-02-16 Taro Pharmaceutical Industries Ltd. Topical gel formulation comprising organophosphate insecticide and its preparation thereof
WO2006017232A1 (en) * 2004-07-12 2006-02-16 Taro Pharmaceuticals Industries Ltd. Topical gel formulation comprising insecticide and its preparation thereof
US8012498B2 (en) 2004-07-12 2011-09-06 Sandhya Goyal Topical gel formulation comprising organophosphate insecticide and preparation thereof
US8158139B2 (en) 2004-07-12 2012-04-17 Taro Pharmaceuticals North America, Inc. Topical gel formulation comprising organophosphate insecticide and preparation thereof
US7977324B2 (en) 2005-07-06 2011-07-12 Taro Pharmaceuticals North America, Inc. Process for preparing malathion for pharmaceutical use
US8039657B2 (en) 2005-07-06 2011-10-18 Taro Pharmaceuticals North America, Inc. Process for preparing malathion for pharmaceutical use
US8536155B2 (en) 2005-07-06 2013-09-17 Taro Pharmaceuticals North America, Inc. Process for preparing malathion for pharmaceutical use
US8957238B2 (en) 2005-07-06 2015-02-17 Taro Pharmaceuticals North America, Inc. Process for preparing malathion for pharmaceutical use

Also Published As

Publication number Publication date
GB2222949B (en) 1992-12-23
GB8919017D0 (en) 1989-10-04
GB8821587D0 (en) 1988-10-12

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