GB2220943A - Rhoptry antigen of plasmodium falciparum - Google Patents

Rhoptry antigen of plasmodium falciparum

Info

Publication number
GB2220943A
GB2220943A GB8916546A GB8916546A GB2220943A GB 2220943 A GB2220943 A GB 2220943A GB 8916546 A GB8916546 A GB 8916546A GB 8916546 A GB8916546 A GB 8916546A GB 2220943 A GB2220943 A GB 2220943A
Authority
GB
United Kingdom
Prior art keywords
rhoptry
plasmodium falciparum
antigen
detergent
rhoptry antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB8916546A
Other versions
GB8916546D0 (en
Inventor
Jason Arthur Smythe
Ross Leon Coppel
David James Kemp
Graham Vallancey Brown
Robin Fredric Anders
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Saramane Pty Ltd
Original Assignee
Saramane Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Saramane Pty Ltd filed Critical Saramane Pty Ltd
Publication of GB8916546D0 publication Critical patent/GB8916546D0/en
Publication of GB2220943A publication Critical patent/GB2220943A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A rhoptry antigen of the asexual blood stages of Plasmodium falciparum, is characterised by: (i) having an apparent molecular weight of approximately 55kDa; (ii) being a glycoprotein incorporating myristic acid; (iii) being present in a restricted localisation with merozoites consistent with a rhoptry location; and (iv) being extracted into the detergent phase when parasite antigens are separated by phase partitioning with detergent.
GB8916546A 1987-12-01 1988-12-01 Rhoptry antigen of plasmodium falciparum Withdrawn GB2220943A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPI568687 1987-12-01
PCT/AU1988/000463 WO1989005348A1 (en) 1987-12-01 1988-12-01 Rhoptry antigen of plasmodium falciparum

Publications (2)

Publication Number Publication Date
GB8916546D0 GB8916546D0 (en) 1989-11-01
GB2220943A true GB2220943A (en) 1990-01-24

Family

ID=3772610

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8916546A Withdrawn GB2220943A (en) 1987-12-01 1988-12-01 Rhoptry antigen of plasmodium falciparum

Country Status (8)

Country Link
EP (1) EP0344257A4 (en)
JP (1) JPH02502337A (en)
KR (1) KR900700599A (en)
AU (1) AU608096B2 (en)
GB (1) GB2220943A (en)
IL (1) IL88558A0 (en)
WO (1) WO1989005348A1 (en)
ZA (1) ZA888983B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990015621A1 (en) * 1989-06-19 1990-12-27 Statens Seruminstitut A malaria vaccine
ATE174963T1 (en) * 1990-08-02 1999-01-15 Saramane Pty Ltd CLONING AND EXPRESSION OF A RHOPTRY-ASSOCIATED PROTEIN FROM P. FALCIPARUM

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU569722B2 (en) * 1983-01-28 1988-02-18 Saramane Pty Ltd Expression of plasmodium falciparum polypeptides from cloned cdna
GB8404378D0 (en) * 1984-02-20 1984-03-28 Biogen Nv Dna sequence recombinant dna molecules

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Nature 1987,328,629-632 *
Nature 1988,332,158-161 *
Proc.Natl.Acad.Sci.USA 1986,83,6093-6097 *
Vaccines 1987,87,117-124 *

Also Published As

Publication number Publication date
ZA888983B (en) 1989-08-30
GB8916546D0 (en) 1989-11-01
EP0344257A4 (en) 1990-04-09
AU608096B2 (en) 1991-03-21
JPH02502337A (en) 1990-08-02
WO1989005348A1 (en) 1989-06-15
AU2609588A (en) 1989-07-05
IL88558A0 (en) 1989-07-31
KR900700599A (en) 1990-08-16
EP0344257A1 (en) 1989-12-06

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)