GB2212738A - Column for chromatography - Google Patents
Column for chromatography Download PDFInfo
- Publication number
- GB2212738A GB2212738A GB8827069A GB8827069A GB2212738A GB 2212738 A GB2212738 A GB 2212738A GB 8827069 A GB8827069 A GB 8827069A GB 8827069 A GB8827069 A GB 8827069A GB 2212738 A GB2212738 A GB 2212738A
- Authority
- GB
- United Kingdom
- Prior art keywords
- column
- hollow
- segment
- segments
- housing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000004587 chromatography analysis Methods 0.000 title claims description 14
- 238000000034 method Methods 0.000 claims description 18
- 230000008569 process Effects 0.000 claims description 14
- 239000002904 solvent Substances 0.000 claims description 14
- 238000000926 separation method Methods 0.000 claims description 12
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 10
- 239000000741 silica gel Substances 0.000 claims description 8
- 229910002027 silica gel Inorganic materials 0.000 claims description 8
- 229920006395 saturated elastomer Polymers 0.000 claims description 6
- 230000009471 action Effects 0.000 claims description 4
- 238000012544 monitoring process Methods 0.000 claims description 4
- 238000003820 Medium-pressure liquid chromatography Methods 0.000 claims description 2
- 238000004880 explosion Methods 0.000 claims description 2
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 2
- 238000012856 packing Methods 0.000 claims description 2
- 239000011148 porous material Substances 0.000 claims description 2
- 238000011084 recovery Methods 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims 17
- 230000005526 G1 to G0 transition Effects 0.000 claims 16
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 12
- 239000011521 glass Substances 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 8
- 230000004308 accommodation Effects 0.000 claims 7
- 239000000945 filler Substances 0.000 claims 7
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 6
- 239000000523 sample Substances 0.000 claims 6
- 230000008901 benefit Effects 0.000 claims 5
- 238000013375 chromatographic separation Methods 0.000 claims 4
- 238000002474 experimental method Methods 0.000 claims 4
- 230000008878 coupling Effects 0.000 claims 3
- 238000010168 coupling process Methods 0.000 claims 3
- 238000005859 coupling reaction Methods 0.000 claims 3
- 239000011877 solvent mixture Substances 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 229910000831 Steel Inorganic materials 0.000 claims 2
- 239000003463 adsorbent Substances 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 238000011161 development Methods 0.000 claims 2
- 239000011261 inert gas Substances 0.000 claims 2
- 238000003825 pressing Methods 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 239000010959 steel Substances 0.000 claims 2
- 239000004809 Teflon Substances 0.000 claims 1
- 229920006362 Teflon® Polymers 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 238000009835 boiling Methods 0.000 claims 1
- 239000005388 borosilicate glass Substances 0.000 claims 1
- 230000008859 change Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 150000001840 cholesterol esters Chemical class 0.000 claims 1
- 238000004440 column chromatography Methods 0.000 claims 1
- 230000003750 conditioning effect Effects 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- DEZRYPDIMOWBDS-UHFFFAOYSA-N dcm dichloromethane Chemical compound ClCCl.ClCCl DEZRYPDIMOWBDS-UHFFFAOYSA-N 0.000 claims 1
- MWPIIMNHWGOFBL-UHFFFAOYSA-N dichloromethane;toluene Chemical compound ClCCl.CC1=CC=CC=C1 MWPIIMNHWGOFBL-UHFFFAOYSA-N 0.000 claims 1
- 238000007598 dipping method Methods 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 239000003344 environmental pollutant Substances 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 238000009659 non-destructive testing Methods 0.000 claims 1
- 239000012466 permeate Substances 0.000 claims 1
- 239000000550 preparative sample Substances 0.000 claims 1
- 238000003908 quality control method Methods 0.000 claims 1
- 238000010079 rubber tapping Methods 0.000 claims 1
- 238000007789 sealing Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 229910001220 stainless steel Inorganic materials 0.000 claims 1
- 239000010935 stainless steel Substances 0.000 claims 1
- 239000010414 supernatant solution Substances 0.000 claims 1
- 239000012780 transparent material Substances 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
- 238000012800 visualization Methods 0.000 claims 1
- 238000003466 welding Methods 0.000 claims 1
- 238000010626 work up procedure Methods 0.000 claims 1
- 230000000717 retained effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6052—Construction of the column body
- G01N30/6069—Construction of the column body with compartments or bed substructure
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/84—Preparation of the fraction to be distributed
- G01N2030/8411—Intermediate storage of effluent, including condensation on surface
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8881—Modular construction, specially adapted therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6047—Construction of the column with supporting means; Holders
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH455187A CH674315A5 (enrdf_load_stackoverflow) | 1987-11-23 | 1987-11-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB8827069D0 GB8827069D0 (en) | 1988-12-21 |
| GB2212738A true GB2212738A (en) | 1989-08-02 |
Family
ID=4278186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8827069A Withdrawn GB2212738A (en) | 1987-11-23 | 1988-11-18 | Column for chromatography |
Country Status (4)
| Country | Link |
|---|---|
| CH (1) | CH674315A5 (enrdf_load_stackoverflow) |
| DE (1) | DE3836343A1 (enrdf_load_stackoverflow) |
| GB (1) | GB2212738A (enrdf_load_stackoverflow) |
| NL (1) | NL8802797A (enrdf_load_stackoverflow) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008542695A (ja) * | 2005-05-23 | 2008-11-27 | ビショフ・アナリューゼンテクニク・ウント−ゲレーテ・ゲーエムベーハー | 固定相と移動相の間において分散させることによって物質を分離する要素及び分離装置の製造方法 |
| JP2011510293A (ja) * | 2008-01-22 | 2011-03-31 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | クロマトグラフィカラムから空気を除去する方法 |
| CN101954202B (zh) * | 2009-07-16 | 2012-07-25 | 中国科学院化学研究所 | 恒压密闭上行层析柱装置及装置的应用方法 |
| CN103752039A (zh) * | 2014-01-07 | 2014-04-30 | 南京诺云生物科技有限公司 | 自支撑模组化色谱柱及其用途 |
| WO2015046566A1 (ja) * | 2013-09-30 | 2015-04-02 | 積水メディカル株式会社 | 収納容器に収納されたカラム及びカラム収納容器 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2119159C1 (ru) * | 1997-02-17 | 1998-09-20 | Владимир Дмитриевич Ефимов | Устройство для хроматографического разделения смеси газов и паров |
| WO2002053256A1 (en) * | 2001-01-05 | 2002-07-11 | Pro-Chem, Inc. | Devices and methods for purification |
| DE102004041806B4 (de) * | 2004-08-25 | 2014-10-16 | Analyticon Discovery Gmbh | Verfahren und Vorrichtung zur Auftrennung von Stoffgemischen |
| CA2584372A1 (en) * | 2004-11-04 | 2006-05-11 | Bio-Rad Pasteur | Stackable chromatography module and chromatography column comprising a stack of such modules |
| RU2349912C1 (ru) * | 2007-07-05 | 2009-03-20 | Владимир Дмитриевич Ефимов | Устройство для хроматографического разделения смеси газов и паров |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1149852A (en) * | 1965-01-22 | 1969-04-23 | Alfred George Wright | Improvements relating to apparatus for performing scientific experiments |
| GB1283677A (en) * | 1970-02-23 | 1972-08-02 | Boehringer Mannheim Gmbh | Combination column |
| WO1984000900A1 (en) * | 1982-09-03 | 1984-03-15 | Hellgren Lars G I | Separable column for chromatography with a detection and signal device and an elution system in combination or separate |
| EP0189611A1 (fr) * | 1985-01-04 | 1986-08-06 | Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) | Procédé pour la séparation chromatographique de macromolécules biologiques |
| US4719011A (en) * | 1985-03-22 | 1988-01-12 | H. T. Chemicals, Inc. | High pressure liquid chromatography columns |
-
1987
- 1987-11-23 CH CH455187A patent/CH674315A5/de not_active IP Right Cessation
-
1988
- 1988-10-25 DE DE19883836343 patent/DE3836343A1/de not_active Withdrawn
- 1988-11-14 NL NL8802797A patent/NL8802797A/nl not_active Application Discontinuation
- 1988-11-18 GB GB8827069A patent/GB2212738A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1149852A (en) * | 1965-01-22 | 1969-04-23 | Alfred George Wright | Improvements relating to apparatus for performing scientific experiments |
| GB1283677A (en) * | 1970-02-23 | 1972-08-02 | Boehringer Mannheim Gmbh | Combination column |
| WO1984000900A1 (en) * | 1982-09-03 | 1984-03-15 | Hellgren Lars G I | Separable column for chromatography with a detection and signal device and an elution system in combination or separate |
| EP0189611A1 (fr) * | 1985-01-04 | 1986-08-06 | Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) | Procédé pour la séparation chromatographique de macromolécules biologiques |
| US4719011A (en) * | 1985-03-22 | 1988-01-12 | H. T. Chemicals, Inc. | High pressure liquid chromatography columns |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9168492B2 (en) * | 2005-05-23 | 2015-10-27 | Bischoff Analysentechnik Und-Geraete Gmbh | Elements for separating substances by distributing between a stationary and a mobile phase, and method for the production of a separating device |
| US20100213112A1 (en) * | 2005-05-23 | 2010-08-26 | Klaus Bischoff | Elements for separating substances by distributing between a stationary and a mobile phase, and method for the production of a separating device, |
| JP2008542695A (ja) * | 2005-05-23 | 2008-11-27 | ビショフ・アナリューゼンテクニク・ウント−ゲレーテ・ゲーエムベーハー | 固定相と移動相の間において分散させることによって物質を分離する要素及び分離装置の製造方法 |
| JP2011510293A (ja) * | 2008-01-22 | 2011-03-31 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | クロマトグラフィカラムから空気を除去する方法 |
| CN101954202B (zh) * | 2009-07-16 | 2012-07-25 | 中国科学院化学研究所 | 恒压密闭上行层析柱装置及装置的应用方法 |
| US20160223501A1 (en) * | 2013-09-30 | 2016-08-04 | Sekisui Medical Co., Ltd. | Column contained in container and column container |
| WO2015046566A1 (ja) * | 2013-09-30 | 2015-04-02 | 積水メディカル株式会社 | 収納容器に収納されたカラム及びカラム収納容器 |
| CN105612425A (zh) * | 2013-09-30 | 2016-05-25 | 积水医疗株式会社 | 收纳于收纳容器的柱以及柱收纳容器 |
| JPWO2015046566A1 (ja) * | 2013-09-30 | 2017-03-09 | 積水メディカル株式会社 | 収納容器に収納されたカラム及びカラム収納容器 |
| US9689848B2 (en) | 2013-09-30 | 2017-06-27 | Sekisui Medical Co., Ltd. | Column contained in container and column container |
| CN105612425B (zh) * | 2013-09-30 | 2017-08-08 | 积水医疗株式会社 | 收纳于收纳容器的柱以及柱收纳容器 |
| CN103752039B (zh) * | 2014-01-07 | 2015-09-30 | 南京诺云生物科技有限公司 | 自支撑模组化色谱柱及其用途 |
| CN103752039A (zh) * | 2014-01-07 | 2014-04-30 | 南京诺云生物科技有限公司 | 自支撑模组化色谱柱及其用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| CH674315A5 (enrdf_load_stackoverflow) | 1990-05-31 |
| DE3836343A1 (de) | 1989-06-01 |
| GB8827069D0 (en) | 1988-12-21 |
| NL8802797A (nl) | 1989-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |