GB2187097A - Disinfectant compositions - Google Patents

Disinfectant compositions Download PDF

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Publication number
GB2187097A
GB2187097A GB08704581A GB8704581A GB2187097A GB 2187097 A GB2187097 A GB 2187097A GB 08704581 A GB08704581 A GB 08704581A GB 8704581 A GB8704581 A GB 8704581A GB 2187097 A GB2187097 A GB 2187097A
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GB
United Kingdom
Prior art keywords
composition according
lower alcohol
composition
isopropanol
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB08704581A
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GB8704581D0 (en
GB2187097B (en
Inventor
Martin Vincent Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unilever PLC
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Unilever PLC
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Publication date
Application filed by Unilever PLC filed Critical Unilever PLC
Publication of GB8704581D0 publication Critical patent/GB8704581D0/en
Publication of GB2187097A publication Critical patent/GB2187097A/en
Application granted granted Critical
Publication of GB2187097B publication Critical patent/GB2187097B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/02—Sulfur; Selenium; Tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/26—Phosphorus; Compounds thereof

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Alcoholic microbiocidal compositions which contain reduced alcohol and anti-microbial concentrations, comprise an aqueous solution of a lower alcohol, an acid and an anti-microbially effective amount of an amino- or ammonium-based microbiocide, the pH of the total composition not exceeding 5. The reduced alcohol and microbiocide levels improve safety of handling and suitability for use on surfaces which contact food. The compositions demonstrate both disinfectant and preservative properties.

Description

SPECIFICATION Disinfectant Compositions The present invention relates to disinfectant compositions and, in particular, to compositions comprising an aqueous solution of a lower alcohol and an anti-microbial compound, suitable for, although not restricted to food-processing disinfection and kitchen hygiene.
Hard-surface contamination by bacteria, yeasts and moulds represents a hazard in food processing and kitchen hygiene, and may result in food-poisoning micro-organisms being transferred to food products.
Accordingly, there is a need for disinfectant products which reduce the numbers of micro-organisms on food-contact surfaces to acceptable levels and help to prevent those surfaces from being re-contaminated.
Effective biocidal compositions are known in the art. In general, in order to achieve the necessary level of disinfecting action, they contain either high levels of alcohol, which is undesirable in view of the evident safety hazards during processing, storage and application, or they contain relatively high levels of one or more biocidal compounds, which is also undesirable for application to surfaces coming into contact with food products.
It has now been found that in compositions based on aqueous solutions of alcohol and conventional amino- or ammonium-based anti-microbial compounds, the inclusion of (preferably organic) acids in amounts sufficient to yield acid pH-values, allow a considerable reduction in the levels of both the alcohol component and the biocidal compound. This is particularly surprising since the biocidal compounds of this type are generally thought to be more effective at neutral or alkaline pH values.
Accordingly, the present invention provides a disinfectant composition on the basis of an aqueous solution of a lower alcohol, comprising an acidic compound and an effective amount of an amino- or ammonium-based anti-microbial compound, said composition having a pH which does not exceed 5.
Thus, we have found that the above-defined compositions according to the present invention, not only avoid the aforementioned disadvantages, but also provide disinfectants capable of both disinfecting action at application and preservative action after application, i.e. protecting the treated surface from re-contamination.
One essential component of the composition according to the present invention is an effective amount of an amino- or ammonium-based anti-microbial compound. These compounds, which comprise a tertiary or quaternary nitrogen atom, are well known in the art.
Suitable types include the quaternary ammonium compounds, such as the di(C8-C18)alkyl di(C1-C4) alkyl ammonium halogenides; the amine oxides, such as R1 R2R3NO, wherein R1 and R2 when taken alone are short-chain alkyl radicals or when taken together are a morpholino radical, and R3 is a (C8-C18) alkyl radical; the betaines and sulpho-betaines, such as the (C8-C18 alkyl dimethyl betaines or -sultaines, and the (C8-C18) alkyl amido betaines or -sultaines; the (halogenated) anilides, such as TCC and TBS; and the polymeric bis-guanides, such as chlorhexidine.
Preferably the quaternary ammonium halogenides, in particular didecyl dimethyl ammonium chloride such as Bardac 22 (a registered trademark by Lonza, Switzerland), and the bis-guanides such as Vantocil 1 B (a registered trademark by ICI, United Kingdom) are used.
In general, the anti-microbial compounds are included in amounts of from 5 to 500 ppm, in particular 5 to 100 ppm. Preferred levels of the anti-microbial compound range from 20to 50 ppm.
The second essential component of the compositions according to the present invention is a lower alcohol, i.e. an alkyl alcohol having from 1 to 4 carbon atoms in the alkyl radical, such as ethanol, n-propanol or isopropanol. Of particular advantage have been found ethanol and isopropanol, the latter of which, optionally in admixture with the first, is preferred. Where both are present, the volume ratio of ethanol to isopropanol is preferably from 1:1 to 1:3.
The concentration of the alcohol component is at least 10% v/v and normally lies within the range of from 10 to 50% v/v. Preferred are concentrations in the range of from 15 to 40% v/v, in particular 20 to 40%v/v.
The third essential component of the composition according to the present invention is an acidic compound to provide the composition with a pH of not more than 5. Although both mineral and organic acids capable of providing this pH may suitably be included, when intended for the particular field of application referred to above, it is preferred to use food-grade alkyl carboxylic acids or hydroxyacids.
Suitabie such acids include acetic, citric, fumaric, lactic, malic and tartaric acid, the preferred members of which are citric and lactic acid.
The acidic compound is included in an amount of from 0.1 to 10% by weight, and preferably in an amount of from 2 to 5% by weight. The amount should be sufficient to provide the composition with a pH-value of not more than 5, and preferably with a pH-value of from 2 to 4.
The composition according to the invention further comprises water and, optionally, minor ingredients to improve its effectiveness and/or consumer acceptability. More in particular, the composition may contain minor amounts of surfactants, wetting agents, colouring agents and perfumes.
The compositions according to the invention will normally be applied by spraying or sprinkling thereof onto the surface to be treated, in view whereof the composition may be fixed with a propellant to provide a formulation suitable for use as an aerosol spray.
Alternatively, the compositions may be applied to the surface being impregnated in a substrate of woven or non-woven (e.g. paper) material to form a disinfectant wet wipe.
The invention will now be further illustrated by way of example.
Example 1 Compositions were tested having the following basic formulation: isopropanol 30% v/v acid 0.1 or 1 % by weight didecyl dimethyl ammonium chloride 25 or 50 ppm water balance The compositions were adjusted to pH=by HCI or NaOH.
The anti-microbial activity was measured against two yeasts, Saccharomyces cerevisiae and Zygosaccharomyces rouxii, using the quaternary ammonium compound at a level of 50 ppm, and against one type of bacterium, Escherichia coli, using the quaternary ammonium compound at a level of 25 ppm.
The anti-microbial activity was measured by way of a standard suspension test at 25 C and using a contact time of 5 minutes.
The data in Table 1 demonstrate the significant enhancement of the activity of the quaternary ammonium compound by organic acids, in particular at the 1% by weight levels.
TABLE 1 Log10 reduction in viable counts in the presence of 50 ppm (yeasts) or 25 ppm (E. coli) didecyldimethyl ammonium chloride S. Z. E.
Acid % cerevisiae rouxii coli None added 2.18 0.00 2.10 Orthophosphoric 0.1 2.17 0.00 2.11 0.1 3.87 0.40 4.70 Sulphamic 0.1 2.72 0.08 2.20 1.0 3.45 0.09 4.05 Glycolic 0.1 3.42 0.46 2.47 1.0 > 4.60 3.46 > 5.10 Acetic 0.1 - 2.44 1.0 - -- > 5.73 Acetic:Formic (1:1) 0.1 - 3.74 1.0 > 4.60 > 4.60 > 5.10 Example 2 A composition was formulated comprising 30% v/v isopropanol, 1% by weight acetic acid, 25 ppm of didecyl dimethyl ammonium chloride and water. This composition was compared with the same composition without the ammonium compound to test its anti-microbial activity when sprayed onto Staphylococcus aureus bacteria dried on PCV tiles. The Staphylococcus aureus bacterium has been found to be one of the most resistant vegetative when dried onto hard surfaces and it also constitutes a food-poisoning risk. From Table 2 it is evident that the composition containing both the acid and the ammonium compound is highly effective.
TABLE 2 Spray composition Log10 Bacteria recovered 2 hours after spraying Water 4.2 30% isopropanol+1% acetic acid 4.1 30% isopropanol+1% acetic acid < 2.3 and 25 ppm QAC EXAMPLE 3 Compositions containing 30%v/v of isopropanol, 25 ppm of didecyl dimethyl ammonium chloride, the amounts and types of acids indicated in Table 3 and water were tested in the same manner as in Example 2.
The results in Table 3 clearly indicate that also other types of food-grade organic acids can suitably be used to achieve satisfactory anti-microbial action.
TABLE 3 Log10 reduction in viable bacteria after: Spray liquid 5 min 2h Water 0.1 1.5 Isopropanoi 0.8 2.6 Isopropanol+2% lactic acid 3.7 4.9 Isopropanol+5% lactic acid 4.7 > 5 Isopropanol+2% citric acid 4.2 > 5 Isopropanol+5% citric acid > 5 > 5 Isopropanol+2% acetic acid > 5 > 5 Isopropanol+5% acetic acid > 5 > 5

Claims (14)

1. A disinfectant composition on the basis of an aqueous solution of a lower alcohol, comprising an acidic compound and an effective amount of an amino- or ammonium-based anti-microbial compound, said composition having a pH which does not exceed 5.
2. A composition according to claim 1, wherein the anti-microbial compound is selected from quaternary ammonium, amine oxide, betaine, sulpho-betaine, halogenated anilide, and polymeric bis-guanide compounds.
3. A composition according to either preceding claim, wherein the anti-microbial compound content is from 5 to 500 ppm.
4. A composition according to claim 3, wherein the anti-microbial compound content is from 20 to 50 ppm.
5. A composition according to any preceding claim, wherein the lower alcohol comprises ethanol and/or isopropanol.
6. A composition according to claim 5, wherein the lower alcohol comprises ethanol and isopropanol in a volume ratio offrom 1:1 to 1:3.
7. A composition according to any preceding claim, wherein the lower alcohol content is at least 10% v/v.
8. A composition according to claim 7, wherein the lower alcohol content is from 20 to 40% v/v.
9. A composition according to any preceding claim, wherein the acidic compound is a food-grade alkyl carboxylic acid or hydroxy acid.
10. A composition according to claim 9, wherein the acidic compound is citric acid or lactic acid.
11. A composition according to any preceding claim, wherein the acidic compound content is from 0.1 to 10% by weight.
12. A composition according to claim 11, wherein the acidic compound content is from 2 to 5% by weight.
13. A composition according to any preceding claim, having a pH of from 2 to 4.
14. A disinfectant wipe comprising a substrate impregnated with a composition according to any preceding claim.
GB8704581A 1986-02-28 1987-02-26 Disinfectant compositions Expired - Fee Related GB2187097B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868604986A GB8604986D0 (en) 1986-02-28 1986-02-28 Disinfectant compositions

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GB8704581D0 GB8704581D0 (en) 1987-04-01
GB2187097A true GB2187097A (en) 1987-09-03
GB2187097B GB2187097B (en) 1990-05-23

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GB8704581A Expired - Fee Related GB2187097B (en) 1986-02-28 1987-02-26 Disinfectant compositions

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Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0485079A1 (en) * 1990-11-06 1992-05-13 Zeneca Limited Aqueous composition
US5139788A (en) * 1989-10-17 1992-08-18 Ecolab Inc. Noncontaminating antimicrobial composition
DE4225795A1 (en) * 1992-07-31 1994-02-03 Schuelke & Mayr Gmbh Synergistic Tb-effective combination of carboxylic acids and alcohols
WO1995000613A1 (en) 1993-06-28 1995-01-05 Henkel-Ecolab Gmbh & Co. Ohg Cleaning and disinfecting agent
US5409713A (en) * 1993-03-17 1995-04-25 Ecolab Inc. Process for inhibition of microbial growth in aqueous transport streams
WO1995012021A1 (en) * 1993-10-27 1995-05-04 Zeneca Limited Antimicrobial treatment of textile materials
US5436008A (en) * 1992-12-11 1995-07-25 Ecolab Inc. Sanitizing compositions
EP0707794A1 (en) * 1994-10-21 1996-04-24 Shiseido Company Limited Disinfectant composition
US5578134A (en) * 1994-04-19 1996-11-26 Ecolab Inc. Method of sanitizing and destaining tableware
US5683724A (en) * 1993-03-17 1997-11-04 Ecolab Inc. Automated process for inhibition of microbial growth in aqueous food transport or process streams
WO1997042818A1 (en) * 1996-05-11 1997-11-20 Applied Chemicals Limited Acid food industry sanitizer composition containing a biocidally active surfactant
DE19710256A1 (en) * 1997-03-13 1998-09-17 Henkel Ecolab Gmbh & Co Ohg Disinfection procedures
FR2766371A1 (en) * 1997-07-24 1999-01-29 Cair L G L DISINFECTION, DETERGENCE AND DESCALING PRODUCT FOR MEDICAL EQUIPMENT
US6257253B1 (en) 1994-04-19 2001-07-10 Ecolab Inc. Percarboxylic acid rinse method
US6302968B1 (en) 1994-04-19 2001-10-16 Ecolab Inc. Precarboxylic acid rinse method
EP1372389A2 (en) * 2001-02-28 2004-01-02 Thomas W. Konowalchuk Virucidal compositions
WO2004080179A1 (en) * 2003-03-10 2004-09-23 Xantech Pharmaceuticals, Inc. Surface sanitizing compositions with improved antimicrobial performance
US7045548B2 (en) 2001-02-28 2006-05-16 Life Force Technologies, Inc. Methods of inactivating viruses
EP1820396A1 (en) 2006-02-09 2007-08-22 Gojo Industries, Inc. Composition and method for pre-surgical skin disinfection
WO2007142967A2 (en) * 2006-05-31 2007-12-13 The Dial Corporation Alcohol-containing antimicrobial compositions having improved efficacy
WO2007145886A2 (en) * 2006-06-05 2007-12-21 The Dial Corporation Methods and articles having a high antiviral and antibacterial efficacy
US8034844B2 (en) 2006-05-30 2011-10-11 The Dial Corporation Compositions having a high antiviral efficacy
US8075936B2 (en) 2003-03-05 2011-12-13 Byocoat Enterprises, Inc. Antimicrobial solutions and process related thereto
US8119115B2 (en) 2006-02-09 2012-02-21 Gojo Industries, Inc. Antiviral method
US8337872B2 (en) 2006-06-02 2012-12-25 The Dial Corporation Method of inhibiting the transmission of influenza virus

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1569423A (en) * 1974-07-08 1980-06-18 Johnson & Johnson Potentiated antimicrobial compositions
EP0018492A1 (en) * 1979-04-23 1980-11-12 Hoechst Aktiengesellschaft Aqueous disinfectant solution

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1569423A (en) * 1974-07-08 1980-06-18 Johnson & Johnson Potentiated antimicrobial compositions
EP0018492A1 (en) * 1979-04-23 1980-11-12 Hoechst Aktiengesellschaft Aqueous disinfectant solution

Cited By (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5139788A (en) * 1989-10-17 1992-08-18 Ecolab Inc. Noncontaminating antimicrobial composition
EP0485079A1 (en) * 1990-11-06 1992-05-13 Zeneca Limited Aqueous composition
US5990174A (en) * 1990-11-06 1999-11-23 Zeneca Limited Aqueous composition
DE4225795A1 (en) * 1992-07-31 1994-02-03 Schuelke & Mayr Gmbh Synergistic Tb-effective combination of carboxylic acids and alcohols
US5436008A (en) * 1992-12-11 1995-07-25 Ecolab Inc. Sanitizing compositions
US5683724A (en) * 1993-03-17 1997-11-04 Ecolab Inc. Automated process for inhibition of microbial growth in aqueous food transport or process streams
US5409713A (en) * 1993-03-17 1995-04-25 Ecolab Inc. Process for inhibition of microbial growth in aqueous transport streams
US5674538A (en) * 1993-03-17 1997-10-07 Ecolab Inc. Process for inhibition of microbial growth in aqueous food transport or process streams
WO1995000613A1 (en) 1993-06-28 1995-01-05 Henkel-Ecolab Gmbh & Co. Ohg Cleaning and disinfecting agent
EP0706556B1 (en) * 1993-06-28 1998-03-25 Henkel-Ecolab GmbH & Co. OHG Cleaning and disinfecting agent
WO1995012021A1 (en) * 1993-10-27 1995-05-04 Zeneca Limited Antimicrobial treatment of textile materials
US5700742A (en) * 1993-10-27 1997-12-23 Zeneca Limited Antimicrobial treatment of textile materials
US5578134A (en) * 1994-04-19 1996-11-26 Ecolab Inc. Method of sanitizing and destaining tableware
US6257253B1 (en) 1994-04-19 2001-07-10 Ecolab Inc. Percarboxylic acid rinse method
US6302968B1 (en) 1994-04-19 2001-10-16 Ecolab Inc. Precarboxylic acid rinse method
US5800827A (en) * 1994-10-21 1998-09-01 Shiseido Co., Ltd. Disinfectant composition
EP0707794A1 (en) * 1994-10-21 1996-04-24 Shiseido Company Limited Disinfectant composition
WO1997042818A1 (en) * 1996-05-11 1997-11-20 Applied Chemicals Limited Acid food industry sanitizer composition containing a biocidally active surfactant
DE19710256A1 (en) * 1997-03-13 1998-09-17 Henkel Ecolab Gmbh & Co Ohg Disinfection procedures
FR2766371A1 (en) * 1997-07-24 1999-01-29 Cair L G L DISINFECTION, DETERGENCE AND DESCALING PRODUCT FOR MEDICAL EQUIPMENT
WO1999004631A1 (en) * 1997-07-24 1999-02-04 Cair L.G.L. Disinfecting, detergent and descaling product for medical equipment
US7045548B2 (en) 2001-02-28 2006-05-16 Life Force Technologies, Inc. Methods of inactivating viruses
US8853272B2 (en) 2001-02-28 2014-10-07 Topical Remedy, Llc Method for treating an inflammation or lesion caused by a virus
US7981933B2 (en) 2001-02-28 2011-07-19 Life Force Technologies, Llc Method for treating an inflammation or lesion caused by a virus
EP1372389A2 (en) * 2001-02-28 2004-01-02 Thomas W. Konowalchuk Virucidal compositions
US9737498B2 (en) 2001-02-28 2017-08-22 Topical Remedy, Llc Method for treating an inflammation or lesion caused by a virus
US7268163B2 (en) 2001-02-28 2007-09-11 Life Force Technologies, Inc. Method for treating an inflammation or lesion caused by a virus
US8901172B2 (en) 2001-02-28 2014-12-02 Topical Rememdy, LLC Method for treating an inflammation or lesion caused by a virus
US7902258B2 (en) 2001-02-28 2011-03-08 Life Force Technologies, Llc Methods for preventing lesions caused by viruses of the Herpesviridae or Poxviridae family
AU2002251933B2 (en) * 2001-02-28 2008-01-17 Jack Konowalchuk Virucidal compositions
US7399790B2 (en) 2001-02-28 2008-07-15 Konowalchuk Thomas W Virucidal compositions
EP1372389A4 (en) * 2001-02-28 2004-03-31 Thomas W Konowalchuk Virucidal compositions
US8586115B2 (en) 2003-03-05 2013-11-19 Byocoat Enterprises, Inc. Antimicrobial solutions and process related thereto
US8080269B2 (en) 2003-03-05 2011-12-20 Byocoat Enterprises, Inc. Antimicrobial solutions and process related thereto
US8075936B2 (en) 2003-03-05 2011-12-13 Byocoat Enterprises, Inc. Antimicrobial solutions and process related thereto
WO2004080179A1 (en) * 2003-03-10 2004-09-23 Xantech Pharmaceuticals, Inc. Surface sanitizing compositions with improved antimicrobial performance
CN101023909B (en) * 2006-02-09 2012-06-20 高爽工业公司 Composition and method for pre-surgical skin disinfection
AU2007200521B2 (en) * 2006-02-09 2010-05-27 Gojo Industries Inc. Composition and method for pre-surgical skin disinfection
US8119115B2 (en) 2006-02-09 2012-02-21 Gojo Industries, Inc. Antiviral method
US8323633B2 (en) 2006-02-09 2012-12-04 Gojo Industries, Inc. Antiviral method
US9629361B2 (en) 2006-02-09 2017-04-25 Gojo Industries, Inc. Composition and method for pre-surgical skin disinfection
EP1820396A1 (en) 2006-02-09 2007-08-22 Gojo Industries, Inc. Composition and method for pre-surgical skin disinfection
US10130655B2 (en) 2006-02-09 2018-11-20 Gojo Industries, Inc. Composition and method for pre-surgical skin disinfection
US8034844B2 (en) 2006-05-30 2011-10-11 The Dial Corporation Compositions having a high antiviral efficacy
WO2007142967A3 (en) * 2006-05-31 2008-09-04 Dial Corp Alcohol-containing antimicrobial compositions having improved efficacy
WO2007142967A2 (en) * 2006-05-31 2007-12-13 The Dial Corporation Alcohol-containing antimicrobial compositions having improved efficacy
US8337872B2 (en) 2006-06-02 2012-12-25 The Dial Corporation Method of inhibiting the transmission of influenza virus
WO2007145886A3 (en) * 2006-06-05 2008-09-12 Dial Corp Methods and articles having a high antiviral and antibacterial efficacy
WO2007145886A2 (en) * 2006-06-05 2007-12-21 The Dial Corporation Methods and articles having a high antiviral and antibacterial efficacy

Also Published As

Publication number Publication date
GB8604986D0 (en) 1986-04-09
GB8704581D0 (en) 1987-04-01
GB2187097B (en) 1990-05-23
CA1315196C (en) 1993-03-30

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