GB2176477B - Manufacture of diphenhydramine - Google Patents

Manufacture of diphenhydramine

Info

Publication number
GB2176477B
GB2176477B GB08612792A GB8612792A GB2176477B GB 2176477 B GB2176477 B GB 2176477B GB 08612792 A GB08612792 A GB 08612792A GB 8612792 A GB8612792 A GB 8612792A GB 2176477 B GB2176477 B GB 2176477B
Authority
GB
United Kingdom
Prior art keywords
diphenhydramine
manufacture
benzhydrol
dimethylaminoethanol
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08612792A
Other versions
GB8612792D0 (en
GB2176477A (en
Inventor
Roger N Brummel
James Vande Vusse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of GB8612792D0 publication Critical patent/GB8612792D0/en
Publication of GB2176477A publication Critical patent/GB2176477A/en
Application granted granted Critical
Publication of GB2176477B publication Critical patent/GB2176477B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A process for the manufacture of diphenhydramine comprises reacting approximately equimolar amounts of benzhydrol and beta -dimethylaminoethanol in the presence of a slight molar excess of p-toluenesulfonic acid at the boiling point of toluene.
GB08612792A 1985-06-11 1986-05-27 Manufacture of diphenhydramine Expired GB2176477B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74346485A 1985-06-11 1985-06-11

Publications (3)

Publication Number Publication Date
GB8612792D0 GB8612792D0 (en) 1986-07-02
GB2176477A GB2176477A (en) 1986-12-31
GB2176477B true GB2176477B (en) 1988-09-14

Family

ID=24988874

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08612792A Expired GB2176477B (en) 1985-06-11 1986-05-27 Manufacture of diphenhydramine

Country Status (4)

Country Link
AU (1) AU589967B2 (en)
DE (1) DE3617343A1 (en)
FR (1) FR2599365B1 (en)
GB (1) GB2176477B (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH288586A (en) * 1950-07-28 1953-01-31 Haco Ges Ag Process for the preparation of a salt of a basic ether.
GB932436A (en) * 1960-11-03 1963-07-24 Dausse Lab Diphenyl methane derivatives and their preparation
HU187204B (en) * 1982-12-28 1985-11-28 Richter Gedeon Vegyeszet Process for producing new diethyl-amino-alkoxy-benzhydrol derivatives, acid additional salts, and quaternary salts and pharmaceutical compositions contatining them

Also Published As

Publication number Publication date
GB8612792D0 (en) 1986-07-02
FR2599365A1 (en) 1987-12-04
GB2176477A (en) 1986-12-31
FR2599365B1 (en) 1989-10-13
AU589967B2 (en) 1989-10-26
AU5769386A (en) 1987-11-26
DE3617343A1 (en) 1987-11-26

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19930527