GB2166439B - Thienyl condensed pyrazole derivatives - Google Patents

Thienyl condensed pyrazole derivatives

Info

Publication number
GB2166439B
GB2166439B GB08527227A GB8527227A GB2166439B GB 2166439 B GB2166439 B GB 2166439B GB 08527227 A GB08527227 A GB 08527227A GB 8527227 A GB8527227 A GB 8527227A GB 2166439 B GB2166439 B GB 2166439B
Authority
GB
United Kingdom
Prior art keywords
pyrazole derivatives
condensed pyrazole
thienyl
thienyl condensed
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08527227A
Other languages
English (en)
Other versions
GB2166439A (en
GB8527227D0 (en
Inventor
Susumu Takada
Takashi Sasatani
Hirohisa Shindo
Akira Matsushita
Masami Eigyo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of GB8527227D0 publication Critical patent/GB8527227D0/en
Publication of GB2166439A publication Critical patent/GB2166439A/en
Application granted granted Critical
Publication of GB2166439B publication Critical patent/GB2166439B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB08527227A 1984-11-05 1985-11-05 Thienyl condensed pyrazole derivatives Expired GB2166439B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59233511A JPS61112075A (ja) 1984-11-05 1984-11-05 チエニルピラゾロキノリン誘導体

Publications (3)

Publication Number Publication Date
GB8527227D0 GB8527227D0 (en) 1985-12-11
GB2166439A GB2166439A (en) 1986-05-08
GB2166439B true GB2166439B (en) 1988-08-03

Family

ID=16956169

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08527227A Expired GB2166439B (en) 1984-11-05 1985-11-05 Thienyl condensed pyrazole derivatives

Country Status (8)

Country Link
US (1) US4690930A (cg-RX-API-DMAC10.html)
EP (1) EP0182165B1 (cg-RX-API-DMAC10.html)
JP (1) JPS61112075A (cg-RX-API-DMAC10.html)
KR (1) KR900003496B1 (cg-RX-API-DMAC10.html)
CA (1) CA1269983A (cg-RX-API-DMAC10.html)
DE (1) DE3572358D1 (cg-RX-API-DMAC10.html)
ES (1) ES8701173A1 (cg-RX-API-DMAC10.html)
GB (1) GB2166439B (cg-RX-API-DMAC10.html)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814450A (en) * 1984-07-09 1989-03-21 Ciba-Geigy Corporation Certain ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives
US4826854A (en) * 1986-11-25 1989-05-02 Ciba-Geigy Corporation Certain cycloalka-(b)-pyrazolo(3,4-d)-pyridin-3-one derivatives
EP0478964A1 (en) * 1990-09-06 1992-04-08 Shionogi Seiyaku Kabushiki Kaisha Pyrazoloquinoline derivatives
US5442062A (en) * 1991-10-24 1995-08-15 The Upjohn Company Imidazole derivatives and pharmaceutical compositions containing the same
ID16283A (id) * 1996-03-20 1997-09-18 Astra Pharma Prod Senyawa yang berguna dibidang farmasi
GB9713707D0 (en) * 1997-06-27 1997-09-03 Merck Sharp & Dohme Therapeutic agents
WO1999064425A1 (en) * 1998-06-09 1999-12-16 Neurogen Corporation Substituted thienocycloalkylpyrazoles: dopamine receptor subtype specific ligands
US6756382B2 (en) * 1999-06-10 2004-06-29 3M Innovative Properties Company Amide substituted imidazoquinolines
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
SE0202461D0 (sv) * 2002-08-14 2002-08-14 Astrazeneca Ab Novel compounds
US8673932B2 (en) 2003-08-12 2014-03-18 3M Innovative Properties Company Oxime substituted imidazo-containing compounds
JP5128815B2 (ja) 2003-08-27 2013-01-23 スリーエム イノベイティブ プロパティズ カンパニー アリールオキシ置換およびアリールアルキレンオキシ置換イミダゾキノリン
WO2005023190A2 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for cd5+ b cell lymphoma
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
ES2544477T3 (es) 2003-10-03 2015-08-31 3M Innovative Properties Company Imidazoquinolinas sustituidas con alcoxi
CN1906193A (zh) 2003-11-14 2007-01-31 3M创新有限公司 肟取代的咪唑环化合物
EP1682544A4 (en) 2003-11-14 2009-05-06 3M Innovative Properties Co HYDROXYLAMINE SUBSTITUTED IMIDAZO RING COMPOUNDS
MXPA06005910A (es) 2003-11-25 2006-08-23 3M Innovative Properties Co Sistemas de anillo imidazo sustituido y metodos.
EP1701955A1 (en) 2003-12-29 2006-09-20 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
JP2007517044A (ja) 2003-12-30 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー イミダゾキノリニル、イミダゾピリジニル、およびイミダゾナフチリジニルスルホンアミド
CA2559863A1 (en) 2004-03-24 2005-10-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
WO2005123080A2 (en) 2004-06-15 2005-12-29 3M Innovative Properties Company Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US7915281B2 (en) 2004-06-18 2011-03-29 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method
WO2006038923A2 (en) 2004-06-18 2006-04-13 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
WO2006009826A1 (en) 2004-06-18 2006-01-26 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
EP1831221B1 (en) 2004-12-30 2012-08-08 3M Innovative Properties Company Substituted chiral fused 1,2 imidazo 4,5-c ring compounds
ES2392647T3 (es) 2004-12-30 2012-12-12 3M Innovative Properties Company Compuestos tetracíclicos quirales que inducen la biosíntesis de interferón
JP2008530022A (ja) 2005-02-04 2008-08-07 コーリー ファーマシューティカル グループ，インコーポレイテッド 免疫反応調節物質を含む水性ゲル処方物
WO2006086634A2 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
AU2006232377A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
JP2008538550A (ja) 2005-04-01 2008-10-30 コーリー ファーマシューティカル グループ，インコーポレイテッド ウイルス感染および腫瘍性疾患を処置するためのサイトカイン生合成の調節因子としての１−置換ピラゾロ（３，４−ｃ）環状化合物
CN101287411B (zh) 2005-04-28 2013-03-06 普罗秋斯生物医学公司 药物信息系统及其用途
WO2008008432A2 (en) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
US7872002B2 (en) * 2007-06-08 2011-01-18 Helicon Therapeutics, Inc. Therapeutic pyrazoloquinoline derivatives
CN101754681A (zh) * 2007-06-08 2010-06-23 海利空医疗公司 治疗用吡唑并萘啶衍生物
JP2010529144A (ja) * 2007-06-08 2010-08-26 ヘリコン・セラピューティクス・インコーポレーテッド 治療用ピラゾロキノリン尿素誘導体
HUE059078T2 (hu) 2009-02-20 2022-10-28 Enhanx Biopharm Inc Glutation-alapú hatóanyagszállító rendszer
EP2398324B1 (en) * 2009-02-23 2014-09-03 Merck Sharp & Dohme Corp. PYRAZOLO [4,3-c]CINNOLIN-3-ONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US8895580B2 (en) 2009-10-21 2014-11-25 Merck Sharp & Dohme Corp. Quinolinone-pyrazolone M1 receptor positive allosteric modulators
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US8653079B2 (en) 2011-08-15 2014-02-18 Merck Sharp & Dohme Corp. Pyrazolo [4,3-C] cinnolin-3-one M1 receptor positive allosteric modulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3068673D1 (en) * 1979-06-21 1984-08-30 Ciba Geigy Ag Pyrazolo-quinolines, processes for their production, and pharmaceutical compositions containing them
US4312870A (en) * 1979-06-21 1982-01-26 Ciba-Geigy Corporation Pyrazoloquinolines
US4524146A (en) * 1982-12-08 1985-06-18 Ciba-Geigy Corporation Certain -2-heterocycle substituted pyrazoloquinolines
US4479955A (en) * 1983-01-10 1984-10-30 Ciba-Geigy Corporation Heterocycle-fused pyrazolo[3,4-d]pyridin-3-ones as benzodiazepine receptor modulators
FR2549833B1 (fr) * 1983-07-26 1985-11-08 Roussel Uclaf Derives de la pyrazolo /4,3-c/ cinnolin-3-one, leurs sels, procede de preparation, application a titre de medicaments, compositions les renfermant et produits intermediaires

Also Published As

Publication number Publication date
KR860004060A (ko) 1986-06-16
JPH0370706B2 (cg-RX-API-DMAC10.html) 1991-11-08
EP0182165B1 (en) 1989-08-16
ES548534A0 (es) 1986-12-01
GB2166439A (en) 1986-05-08
GB8527227D0 (en) 1985-12-11
US4690930A (en) 1987-09-01
CA1269983A (en) 1990-06-05
EP0182165A1 (en) 1986-05-28
DE3572358D1 (de) 1989-09-21
ES8701173A1 (es) 1986-12-01
KR900003496B1 (ko) 1990-05-21
JPS61112075A (ja) 1986-05-30

Similar Documents

Publication Publication Date Title
GB2166439B (en) Thienyl condensed pyrazole derivatives
SG7089G (en) 1,2,3,9-tetrahydro-3-(imidazol-1-ylmethyl)-4h-carbazol-4-one derivatives
GB2163150B (en) 3-aminopropoxyaryl derivatives
ZW13185A1 (en) Heterocyclic derivatives
GB2155925B (en) Pyrimidylpiperazine derivatives
EP0163324A3 (en) Aminoalkylphenoxy derivatives
GB8400096D0 (en) Sulfonamido-benzamide derivatives
GB2164644B (en) Benzonorbornene derivatives
DE3565267D1 (en) 9a-aza-9a-homoerythromycin derivatives
GB2167584B (en) Phase calculation circuitry
ZW4585A1 (en) Imidazole derivatives
GB2159814B (en) Iminothiazolidine derivatives
GB8709948D0 (en) Herbicidal dihydrothiophene & derivatives
GB8500296D0 (en) Imidazole derivatives
GB2165845B (en) Dioxinopyridine derivatives
GB8513246D0 (en) Imidazole derivatives
GB8401149D0 (en) Furanone derivatives
GB8419223D0 (en) Sulphamoylguanidine derivatives
EP0174271A3 (en) Anthraceme derivatives
GB2158066B (en) Apovincaminol derivatives
ZA85362B (en) Imidazodiazepine derivatives
ZA858408B (en) Substituted azolylmethyl-cyclopropyl-carbinol derivatives
GB8422379D0 (en) Derivatives
GB2169290B (en) Pyrone -3- carboxamide derivatives
GB8721972D0 (en) Condensed pyrazole derivatives

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19971105