GB2089672A - Processes for substitution of aromatic compounds - Google Patents

Abstract

The present invention provides a process for the preparation of compounds of the general formula <IMAGE> wherein A represents the residue of an aromatic ring forming the whole of a part of a monocyclic or polycyclic, at least partially-aromatic, carbocyclic and /or heterocyclic ring system, optionally bearing one or more other substituents inert to the reactants here employed, and R represents an optionally-substituted alkyl, alkenyl, alkynyl or benzyl group having up to 12 carbon atoms. According to the process of the invention such compounds are prepared by causing an aromatic compound of the general formula: <IMAGE> wherein A is as defined above and X represents a chlorine, bromine or iodone atom, to react with an alcoholate of the general formula: <IMAGE> in which M represents an alkali metal or an alkaline earth metal atom; n is the valency of M; and P is as defined above, in the presence of a catalytically- effective amount of an active catalyst mixture comprising: (i) a formic acid ester of an organic alcohol having the general formula: R2-O-CO-H (V> in which R<2> represents an optionally-substituted alkyl, alkenyl, alkynyl or benzyl group having upto 12 carbon atoms; and (ii) a cuprous salt; in a liquid medium which is a solvent for the catalyst mixture and in which the compound of formula II is at least partially soluble, under substantially anhydrous conditions and a non-oxidising atmosphere, to yield the desired corresponding compound of formula VI.

Description

SPECIFICATION Processes for substitution of aromatic organic compounds The present invention relatesto processes for substitution of aromatic organic compounds, in particular to processes for the introduction of one or more alkoxy or aralkyloxy substituents in place of corresponding halogen substituents upon an aromatic nucleus. The invention of course further extends to the substituted aromatic compounds thus produced and, moreover, it also includes the catalytic systems employed therein.

The simplest of alkoxy substituents is the methoxy group, which is moreover probably the one most commonly encountered, occurring with remarkable frequency in the structures of biologically-active compounds. There are numerous existing commercial syntheses, and many more potentially-important syntheses, in which it is necessary either directly or indirectly to introduce an alkoxy or aralkyloxy substituent, usually a methoxy group, into an aromatic ring system.

Since indirect routes by their nature tend to be economically less attractive than direct ones, there have been a number of proposals in the past decade based on techniques giving direct replacement of one or more halogen atoms by a corresponding number of alkoxy groups. Of the various proposal made, the following may be mentioned: 1. The preparation of 1,3,5 - triaikoxybenzenes from 1,3,5-trihalobenzenes using an alkali metal methoxide or ethoxide in the presence of a cop per salt e.g. cuprous iodided, and an aprotic sol vent e.g. dimethylformamide at 80" to 200"C (see British Patent Specification No. 1,431,501).

2. The preparation of 3,5 - dialkoxy - 4 - hydrox ytoluenes from 3,5 - dihalo - 4 - hydroxytoluenes using an alkali metal alkoxide in the presence of both a copper catalyst e.g. cuprous iodide or chloride, and an amide catalyst e.g. dimethylfor mamide in a solvent at 40 to 2000C (see Japanese Patent Publication No. 094,329/80). A similar reac tion employing indole substrates is disclosed in Japanese Patent Publication No. 127,368/80.

3. The preparation of atomatic ethers from aromatic bromides using an alkali metal alkoxide in the presence of a cuprous halide or oxide at a temp erature of from 40 to 1600C, preferably in dimethylformamide as solvent (see U.S. Patent Specification No.4,218,567).

4. The use of a complex of a copper salt and a phos phorus, arsenic or antimony containing ligand as a catalyst for the reaction of an aryl halide with an alkali metal alkoxide or aryloxide at elevated temperatures usually above 100"C and up to 250"C. (see British Patent Specification No.

2,025,403).

The above procedures all suffer from one or more of the following disadvantages: (i) Lack of general application, (ii) A requirement to use expensive solvents, which must be recovered if the process is to be worked economically, (iii) A requirement to use expensive catalysts and/or (iv) The production of extraneous products by side reactions.

We have now found surprisingly that by the use of a relatively inexpensive catalyst comprising a formate and a cuprous salt, aromatic halogen compounds may be reacted with metal alkoxides or aralkyloxides more cleanly and in a process which can employ, and preferably does employ, inexpensive solvents such as alcohols, and which moreover is a process applicable to a wide variety of substrate molecules.

Our research has now shown that by use of a liquid reaction medium containing copper in solution it is possible to achieve methoxylation, and within limits other alkoxylations, of many aromatic compounds, and indeed to do so in a clean and reproducible manner, with acceptable and usually good yields, at temperatures normally below 100 C, and at ambient or near-ambient pressures.

Accordingiy, the present invention provides a process for the preparation of a compound of the general formula

wherein A represents the residue of an aromatic ring forming the whole or a part of a monocyclic or polycyclic, at least partially-aromatic, carbocyclic and/or heterocyclic ring system, optionally bearing one or more other substituents inert to the reactants here employed, and R represents an optionallysubstituted alkyl, alkenyl, alkynyl or benzyl group hav ing up to 12 carbon atoms, which process comprises causing an aromatic compound of the general formula:

wherein A is as defined above and X represents a chlorine, bromine or iodine atom, to react with an alcoholate of the general formula: M0+[O - R]P- (Ill) in which M represents an alkali metal or an alkaline earth metal atom; n is the valcny of M; and R is as defined above, in the presence of a catalyticallyeffective amount of an active catalyst mixture comprising: -(i) a formic acid ester of an organic alcohol con veniently referred to as a "formate", having the general formula: Certain of the chemical formulae appearing in the printed specification were submitted in formal form after the date of filing.

R2-O-CO-H (V) in which R2 represents an optionally-substituted alkyl, alkenyl, alkynyl or benzyl group having up to 12 carbon atoms; and -(ii) a cuprous salt; in a liquid medium which is a solventforthe catalyst mixture and in which the compound of formula II is at least partially soluble, under substantially an hydros conditions and a non-oxidising atmosphere, to yield the desired compound of formula VI.

As appears above, and will further appear from the Examples hereinafter given, the ring system of the aromatic organic compound of general formula II used as starting material, and thus correspondingly of the aromatic organic compound of general for mula Vl which is the desired final product of the processes of this invention, can be of the most diverse nature.Purely for purposes of illustration, end thus without any limitation upon the scope of this invention, it can be said that the organic residue of general formula:

(wherein A has its previously-assigned meaning) may represent the residue of: - a fused polycyclic carbocyclic wholly-aromatic compound such astetracyclic chrysene or benzant hracene, tricyclic anthracene or phenanthrene or bicyclic naphthalene etc.; - a non-fused polycyclic carbocyclic whollyaromatic compound such as ortho-, meta- orparaphenoxybenzene etc.; - a fused polycyclic partially-heterocyclic wholly-aromatic compound such as bicyclic quinoline or indole etc.; - a non-fused polycyclic partially-heterocyclic wholly-aromatic compound such as the phenyl pyridines, and naphthyl thiophenes etc.; - a monocyclic carbocyclic wholly-aromatic compound such as benzene, toluene, etc.;; - a monocyclic heterocyclic wholly-aromatic compound such as pyridine, furan, thiophene etc.; - a fused polycyclic carbocyclic partiallyaromatic compound such as tetralin, fluorene, indene etc.; - a non-fused, polycyclic, carbocyclic partiallyaromatic compound such asortho-, meta- and para-cyclohexylbenzene etc.; - a fused, polycyclic, partially-heterocyclic, partially-aromatic compound such as tetrahydroquinoline, dihydroindole etc.; or - a non-fused, polycyclic, partially-heterocyclic, partially-aromatic compound such as ortho-, metaand para-cyclo hexyl-pyrid ine etc.

It will of course be further appreciated that the organic residues of general formula VII above may if desired be substituted, bearing not only one or more additional reactive X-substituents but also additional preferably non-reactive substituents, the terms "reactive" and "non-reactive" here referring of course not to reactivity in the abstract but only to reactivity in the context of the rcactants and reaction conditions encountered in the process of this invention.

What will be either "reactive or "non-reactive" in that context should be normally predictable by any competent chemist, bearing in mind the nature and location of other electrophilic and/or nucleophilic substituents (if any) present upon the aromatic ring system -and prediction can be checked and empirically verified or varied by simple experiment.

Nothing further need therefore be said as regards possible substitution upon the aromatic ring system; but in case it may be helpful the following additional guidance will nevertheless be offered. Certain substituents may give lower yields because of their reactivity, namely those which contain acidic protons such as acyl groups, but otherwise most if not all of the commonly-encountered substituents may be present without detriment, including some which might have been expected to retard the kind of nucleophilic substitution involved in the processes of this invention, such as acetamido and hydroxy groups.

Substituents which are not "non-reactive" and which would lead to poor reactions are, for example, nitroalkyl side chains having protons ato the nitrogroup, and any side chain bearing exceptionally acidic protons (pK < 12).

Substituents which are not "non-reactive", but which would still give a clean reaction (although with concomitant reaction of the substituent) are, for example, benzyl halides which would give benzyl methyl ethers.

Under some conditions halogen substituents can effectively be "non-reactive" e.g. chloro groups in the presence of bromo groups react so much more slowly that a chloro-methoxy product may readily be obtained from a chloro-bromo starting material.

Amino groups are a special case, in that they react with the formate to give formanilides, thus deactivating the catalyst Acylation, especially acetylation of the amine eliminates this difficulty.

As regards the substituent X in the aromatic organic compound of general formula II above which is used as starting material it has already been indicated that X can represent chlorine, bromine or iodine, and this is believed to be correct, so long as it be understood that this statement assumes that the reaction conditions are suitably chosen to bring about the desired reaction, and that the yield will not necessarily be always high.

At the practical level of everyday chemistry, iodine-substituted aromatic organic compounds are nowadays so expensive to prepare that they tend to be encountered only in the laboratory, not in industrial perparative techniques. Hence for most pur- poses it can be assumed that X in the aromatic organic compound of general formula II will be either chlorine or bromine.

We have found that in some reactions chlorinesubstituted starting materials work well in the processes of this invention, especially when the chloro-group to be replaced has been suitably acti vated; and the relative ease and economy of introducing chlorine into the aromatic ring structure recommends the use of such a chlorine-substituted starting material wherever possible.

Nevertheless we have found that in general the reaction will proceed most reliably, under the mildest conditions, to provide a good clean yield of the desired end-product when X is bromine. The use of such bromine-substituted starting materials is thus a very much preferred feature of this invention.

Thus, in the context of what has been said above the compound of general formula II is preferably a compound of the formula:

wherein Y is oxygen, sulphur or nitrogen, q is 1 or 2 and each R3, which may be the same or different, is halogen, especially Cl, OH, alkoxy, aryloxy, WHO, -CH(OMe)u -CO2 alkyl, aryl, alkyl, -(CH2)mOalkyl, -(CH2)m-halogen, especially Cl, -(CH2)mNHB where B is a blocking group such as an acyl group e.g. acetyl, and m is 1,2 or 3, ortwo groups R3 together form a 5-,6- or 7-membered carbocyclic or heterocyclic ring.In the aforementioned groups alkyl is preferably C,-to C, more preferably C,-, C2- or C3-alkyl, and mis preferably 1.

Especially preferred are compounds offormulae VIII and X wherein each R3 which may be the same or different is CI, OH, alkoxy (especially methoxy), -CH(OMe)2, -CH2CI ortwo groups R3 together form a 6-membered carbocyclic or heterocyclic ring.

As regards the alcoholate of general formula Ill, it should first be recognized that this must bear the -O-R group which it is wished to introduce into the aromatic organic compound of general formula II in replacement for the X substituent thereon. Thus were the desired ultimate product of the synthesis is destined to bear some particular-O-R group there is little or no freedom of choice as regards the nature of the R grouping.

That being understood, the R grouping may be an unsubstituted, straight- or branched-chain alkyl or cycloalkyl group with from 1 to 12 carbon atoms, an unsubstituted straight- or branched-chain alkenyl or cyclo-alkenyl group having one or more double bonds and with from 2 to 12 carbon atoms, an unsubstituted straight- or branched-chain alkynyl or cycloalkynyl group having one or more triple bonds and with from 2 to 12 carbon atoms (it being understood that any "cyclo" group must contain at least 3 carbon atoms) or a benzyl group; or the R grouping may be any of the aforesaid alkyl, alkenyl, alkynyl or benzyl groups bearing one or more substituents inert under the conditions of the processes of this invention.Such inert substituents should be apparent to competent chemists but it may be added, by way of example, and as useful general guidance that inert substituents which may be present include hyd roxy, p-hydrnxyethyloxy and alkoxyca rbonyl groups, e.g. methoxycarbonyl groups.

There are however some circumstances under which there may be an element of choice available in the selection of the R-O- grouping, and where any such freedom of choice does exist it is usually most advantageous to employ the relatively short-chain R groupings. One reason for this preference is that the previous preparation of the alcoholates proceeds with much greater ease the shorter the length of the R grouping.

Specifically, it is preferred to employ alcoholates of general formula Ill wherein the number of carbon atoms present in the R group does not exceed 6; preferably those wherein it does not exceed 4; and, in order of increasing preference, especially those wherein the number of carbon atoms present in the R group is 3,2 or above all 1.

The alcoholate of general formula III used in the processes of this invention may be one wherein M represents an alkaline earth metal atom, but it is generally very much better in view of their greater reactivity to employ alkali metal alcoholates, and above all those wherein M represents a lithium, potassium or most especially a sodium atom.

Thus in terms of reactivity, economy and indeed desirability in the final synthesis product the alcoholate of general formula Ill best employed will most frequently be sodium methoxide, Na.O.CH3.

The reaction takes place in the liquid phase, and in fact must be performed either in solution in a suitable solvent, or under slurry conditions in a liquid medium, provided the substrate of formula II is at least partially soluble in the liquid medium. In principle any aliphatic or arylaliphatic organic alcohol can be employed as a suitable solvent or liquid medium where the alcoholate is not isolated. Where the alcoholate is isolated other solvents or liquid media may be used alone or together with said alcoholic medium. However practical problems exist in obtaining the isolated alcoholates sufficiently free of hydroxides (which inactivate the catalyst) and of course other solvents are more expensive that say methanol or ethanol. On the other hand in the case of butoxide or benzyloxide, the use of, for example, tetrahydrofuran may be advantageous.

It is preferred to use as the liquid medium an aliphatic alcohol ofthe general formula: R1-OH (IV) in which R' represents an optionally-substituted alkyl, alkenyl, alkynyl or benzyl group having up to 12 carbon atoms.

It is, of course, most convenient to form the alcoholate in situ, by dissolving an alkali metal or alkaline earth metal in an alcohol which is to serve as the liquid medium for the reaction; and accordingly it is much preferred that such an alcohol should be the same as that present in the alcoholate. For that and other reasons the alcohol will mostfrequently be methanol. The presence of any significant amount of water will inactivate the reaction, and the reaction medium therefore rnust be substantially an hydrous. That requirement does not however preclude the use of cemmercially-available "anhydrous" grades of reactants, such as the commercially- available anhydrous grade of methanol which contains about 0.03% water.

The reaction can be successfully performed only in the presence of the formate of general formula V. Since higher formates where R2 has more than three carbon atoms could pose a purification problem, this component can most conveniently and cheaply be the formic acid ester of the same alcohol as that which serves as the reaction medium. Very frequently the formate employed will thus be methyl formate.

As we see the matter at present, the formate will virtually always be introduced as such, but is should not be overlooked that in principle it is possible, and sometimes it may be practical, to create the formic acid ester in situ where the reaction medium is an alcohol by introducing carbon monoxide into the reaction medium, perhaps under pressure. This consideration moreover may recommend the use of carbon monoxide as the non-oxidising atmosphere under which the reaction should be performed.

In the case where R, R' and R2 are not the same, it will be understood that the product obtained could be one in which the substituent or OR' or perhaps OR2 rather than OR since the following equilibria exist: [R-O] - + R,OH =[R,6)] - + ROH LROj- + R2OCOH[R2-o] - + ROCOH R2OCOH + R, Old =R2GH + R,OCOH The majorsubstituent species present in the reaction mixture and resulting from the above equilibria will usually depend on two factors.First, the nature of R, R' and R2, the group with the smaller or smallest number of carbon atoms tending to be more reactive and, secondly, the concentration of the three components. Since it will usually be the case that the relative concentrations will be: R'OH > [R-O] O,M"+ QnMn+ > > R2GCOH this means in effect that the substituentchoice is between R and R1 and therefore it is preferred that R=R' unless [R10] can is much less reactive than [ROlOn In general the alcoholate, the formate and the alcohol or other liquid medium may be employed in the following amounts (in moles per mole of substrate of formula II):: General Range Preferred Range Alcoholate about 0.9 to about 10 about 3 to about 5 Formate about 0.01 to about 3 about 0.1 to about 1.5 Alcohol or other liquid medium about 1 to about 100 about 10 to about 40 The cuprous salt or salts employed as part of the catalyst system may in principle be any cuprous salt which is solubilised by the formate / alcoholate / liquid medium mixture. Specifically it has been found possible to employ cuprous chloride, cuprous sulphate, cuprous iodide, cuprous sulphite and above all cuprous bromide.

The cuprous salt(s) may and usually will be introduced into the reaction medium as such, but can if desired also be added in other forms. Thus, it is for instance possible to add cupric salt(s) e.g. CuBr2, and a reducing agent such as sodium sulphite, so that these shall react together to form the corresponding cuprous salt(s) in situ.

In addition, cuprous oxide can be added to serve as the source of cuprous moiety in the reaction mixture - possibly since it displaces formic acid from the formate, and reacts therewith to create cuprous formate.

In general, the cuprous salt(s) may be employed in an amount of from about 0.01 to about 3 moles per mole ofsubstrate, preferably in an amount of from 0.1 to about 0.6 moles per mole of substrate.

The reaction conditions of temperature and possibly even pressure which are optimum for the reaction between any particular pair or reaction partners in the presence of any chosen catalyst system should be determined empirically. As general gui dance it can however be said that within our experi ence the reaction can always be made to proceed well at temperature not exceeding about 1200C, typ ically less than about 100 C and usually indeed at temperatures of less than about 80"C - and that normal good practice requires that the reaction should whenever possible be operated at a tempera ture as low as is consistent with achievement of an adequate yield within an acceptable operating period, and preferably at ambient pressure.

As already indicated above, the substituent most frequently to be introduced by the processes of this invention will be the methoxy group, and in that event the reactant catalyst system of choice will be sodium methoxide in the presence of methyl for mate and dissolved usually in methanol. Using such a system the reaction normally can best be con ducted under reflux of the methanolic solvent, namely at about 75"C under ambient pressures.

When the reaction is conducted under reflux of the alcoholic solvent present in the reaction mixture the refluxing alcohol will itself create the necessary inert atmosphere so long as reflux is taking place. Before reflux has commenced it is however necessary to establish the requisite inert atmosphere by flushing out the reaction vessel with any convenient inert gas, normally nitrogen but possibly (in the circums tances envisaged above) carbon monoxide.

So far as we have been able to ascertain, the reaction herein disclosed seems to be quite general, in that we have not found it to fail with any reaction partners upon which we have yet attempted to perform it Its wide applicability and considerable practical value will both be appreciated from the fact that we have employed it successfully in the following commercially-valuable reactions, namely:: -the methoxylation of bromobenzene; -the methoxylation of m - chlorobromobenzene; -the methoxylation of o - bromophenol; -the methoxylation ofp - bromophenol; -the methoxylation of o - bromoanisole; -the methoxylation ofp - bromoanisole; -the methoxylation of 6 - bromo - 1 - acetyl 1,2,3,4 - tetrahydroquinoline; -the methoxylation of 5 - bromovanillin; -the methoxylation of 3 - bromothiophene; -the methoxylation ofp - bromobenzyl bromide; -the methoxylation of o - bromo - acep tophenone; -the methoxylation of 1 - bromo - naphthalene; -the trimethoxylation of tribromobenzene; -the ethoxylation ofp - bromoanisole; and -the isopropoxylation of bromobenzene.

The alkoxylation reaction of this invention is reliable, reproducible, clean and efficient. In a few instances we have observed thatthe halogen substituent X on the aromatic organic compound may to a limited extent be replaced by hydrogen rather than by the intended -O-R substituent, but in our experience any such side-reaction will at most take place to an extent of less than 10% and then only when a non-preferred Cur source (e.g. Cu2O) or solvent (e.g.

tert-butanol) is used. The reaction product is thus remarkably free from unwanted by-products, and remarkably clean as compared with the ditry reaction product of classical procedures. The relatively low temperatures at which the reactions according to this invention can be performed also naturally contribute to the cleanliness of the product. While one might expect aryl coupling and nucleophilic substitution by amino and hydroxyl groups present in the substrate, we have not so far observed any such effects.

The mechanism of the reaction herein disclosed is not at present fully understood. It seems likely that the alcoholate, the formate or a decomposition product of the formate and the aromatic substrate of general formula il together form some kind of complex about the copper atom which so-to-speak "delivers" the grouping R-O-to the aromatic nucleus, replacing the halogen substituent X thereon.

Whatever the mechanism of the reaction, it is a fact that the reaction works well. The catalyst system employed according to this invention is essentially homogeneous, which may be contrasted with the heterogeneous systems based on copper metal used conventionally, and which no doubt accounts both for the high activity and the reliability of the process of this invention.

The only significant drawback is the high degree of sensitivity of the catalyst to oxidation. This not only means that the reaction must effectively be carried out in substantially air-free conditions, thus under a non-oxidising atmosphere of a gas such as nitrogen, but also that it is difficult to have the catalyst system prepared in advance. While the in situ preparation of the catalyst system each time it is required does not in itself present any great problems, it makes it prac ticallyvery difficult indeed to recover the catalyst system after the reaction for reuse at some future time.

This invention of course extends to the alkoxylated aromatic organic compounds of general formula VI obtained by the process herein disclosed. Also it extends, despite what has been said above, to a catalyst system suitable for use in the present process, namely a catalyst system which comprises a formate of general formula V, a catalytically-effective amount of a cuprous salt and an alcoholate of general formula Ill, said catalyst system being substantially an hydros and otherwise protected against oxidative breakdown. Preferably, the system is also blended with an alcohol of general formula IV and/or another said liquid medium as described above.

Protection against oxidative breakdown of the catalyst system can be achieved most surely by preparing, storing and using the catalyst system under an atmosphere of non-oxidising gas or vapor (including alcohol vapour during reflux) but it could also be assisted by inclusion therein of a stabilizer.

We have observed that, for reasons which we do not at present understand, these catalyst systems are best stabilized by the presence of significant amounts of aromatic organic compounds therein.

The halogenated aromatic organic compounds of general formula II used as starting material in the previously-described processes will serve this func tipn as aromatic stabilizers; and indeed so too will the alkoxy/aralkyloxy aromatic organic compounds of general formula VI formed as end-product of those processes. Hence when the catalyst system is prepared in situ at the outset of the process and discarded at its end there is an aromatic stabilizer (of one kind or another) already present throughout the relevant period, and it is quite unnecessary then to add any additional aromatic stabilizer. Supposing however that the catalyst system is, for any reason, to be prepared beforehand and stored pending need, then it will very desirably include some suitable aromatic compound as stabilizer.That aromatic stabilizer compound is qualified as "suitable" merely to exclude the fairly unlikely possibility that it might bear substituents which are not inert under the prevailing conditions. The inclusion of for instance phenol in the alcoholic or other liquid medium for the reaction is usually convenient and effective in this regard. Moreover, benzyl alcohol is likely to be an effective stabilizer in benzyloxyations.

In order that the invention may be well understood examples will now be given to show the preparation, in more detail, but only by way of illustration, of certain useful alkoxylated aromatic compounds, as follows: Example 1: Methoxylation of Bromobenzene to yield Anisole Sodium (2.39, 0.1 mole) was dissolved in methanol (50 ml), bromobenzene (16g, 0.1 mole) was added, and this reaction mixture was flushed with nitrogen and heated to 50"C. Methyl formate (69, 0.1 mole) was then added, followed bycuprous bromide (1.49, 0.01 mole). The resultant pale yellow-green mixture was refluxed for7 hours at about 70 C.

The methanol was distilled off, and dilute hydrochloric acid was added to dissolve the copper salts; the oil was extracted into ether, and thereafter separated therefrom by removal of the solvent The resultant pale yellow oil was submitted to GLC analysis which showed that it consisted as to 56% of the desired anisole, the balance of 44% being unreacted bromobenzene.

Example 2: Methoxylation of Bromobenzene (in the presence ofphenol) to yield Anisole.

The procedure of Example 1 was repeated, but in the presence of phenol (3.8 gram, 0.4 mole) which was added to the reaction mixture at the outset Contrary to expectation the oil recovered contained no detectable trace of diphenyl ether; but, quite unexpectedly, sampling showed upon TLC analysis that substantially 100% conversion of bromobenzene to anisole had been achieved after only 5 hours reflux.

Example 3: Methoxylation ofm - Chlore Bromobenzene to yield in - Chloro -Anisole m - Chlorobromobenzene (19.29, 0.1 mole) was dissolved in a solution of sodium methoxide (0.4 mole) in methanol (100 ml), and this reaction mixture was flushed with nitrogen. Methyl formate (3.69, 0.06 mole) was added, followed by cuprous bromide (2.99, 0.02 mole). The resultant suspension was refluxed for 9 hours, until the reaction was judged by TLC to be complete.

The crude reaction mixture was acidified, and extracted into isopropyl acetate. The solvent was removed by evaporation at 20"C, to give a pale yellow liquid (14.19; 99%), whose infra-red spectrum was identical to that of authentic m - chloroanisole as recorded in the Aldrich catalogue. GLC analysis showed one product peak, with a higher retention time than the starting material (Bentone/OVI, 180").

GC-MS shows no detachablem - bromo - anisole and only a very small quantity of dimethyl - resorcinol.

Example 4: Methoxylation ofo-Bromophenol to yield Guaiacoi 2 - Bromophenol (17.39., 0.1 mole) was dissolved in a solution of sodium methoxide (329 0.6 mole) in methanol (98 ml) and this mixture was flushed with nitrogen. It should be noted that the extra equivalents of the sodium methoxide base were added in order to neutralize the phenol. Methyl formate (3.69, 0.06 mole) was then added, followed by cuprous bromide (2.99, 0.02 mole).

A vigorous reaction occurred on the addition of the cuprous bromide, and TLC showed the reaction to be virtually complete after 30 minutes.

After 1.3/4 hours the reaction mixture was worked up, and the product was isolated as a quantitative yield of a red oil. This was identified as guaiacol by comparison of the infra-red spectrum with an authentic specimen as recorded in the Aldrich catalogue. Bulb-to-bulb distillation of a sample yielded a colourless solid, m.pt. = 28"C (lit. 28"C).

Example 5: Methoxylation ofp - Bromophenol to yield p - MethoxyPhenol 4 - Bromophenol (7.1 g, 0.05 mole) was dissolved in a solution of sodium methoxide (0.3 mole) in methanol (60 ml), and this mixture was flushed with nitrogen. Methyl formate (1.5g, 0.03 mole) was then added, followed by cuprous bromide (1.29, 0.01 mole).

This mixture was reacted under reflux at a temperature of about 7G"C. After 7 hours reflux, TLC showed no appreciable traces of residual starting material.

The reaction product was worked up to give a yellow-brown oil, which crystallised slowly. Bulbto-bulb distillation of a sample gave a colourless solid, m.pt. = 50 - 51 C (lit 53", 55"C). Yield =5.1 = (100%) of crude material, whose infra-red spectrum is comparable with that of an authentic specimen as recorded in the Aldrich Catalogue.

Example 6: Methoxylation ofo - Bromo -Anisole to yield Veratrole o - Bromoanisole (18.79, 0.1 mole) was dissolved in a solution of sodium methoxide (0.4 mole) in methanol (96 ml). Then methyl formate (3.69, 0.06 mole) was added, followed by cuprous bromide (2.99, 0.02 mole).

The course of the reaction was followed by TLC, which showed that it had gone to completion after about 2 hours.

After 3 hours the reaction product was worked up, in the same manner as in Example 1 except that the extraction solvent employed was isopropyl acetate.

A dark liquid (12.99,93%) was obtained. Its infra-red spectrum was identical to that of authentic veratrole as recorded in the Aldrich Catalogue. Bulb-to-bulb distillation was effectively quantitative, but eliminated the colour two yield a colourless liquid.

Example 7: Methoxylation ofp - Bromo - Anisole to yield p - Methoxy - Anisole p - Bromoanisole (78.79, 0.1 mole) was dissolved in a solution of sodium methoxide (0.4 mole) in methanol (96 ml), and the mixture was flushed with nitrogen. Methyl formate (3.6 g, 0.06 mole) was added thereto, followed by cuprous bromide (2.99, 0.02 mole).

As in Example 6 the course of the reaction was followed by TLC, which showed that it had gone to completion after 4 hours.

The reaction product was worked up as in Example 6. On stripping off the solvent pale pink crystals (12.99,93%) were obtained, m.pt. = 53"C (lit. 56"C).

Their infra-red spectrum proved to be identical with that of the authentic product as recorded in the Aldrich catalogue.

Example 8: Methoxylation of6 - Bromo - 1- Acetyl 1,2,3,4 - Tetrahydroquinoline with subsequent hydrolysis to yield 6 - Methoxy - 1,2,3,4 - Tetrahydro quinollna 6- Bromo - 1 - acetyl - 1,2,3,4 -tetrahydroquinoline (239, 0.132 mole) was dissolved in a solution of sodium methoxide (0.528 moles) in methanol (91 ml), and the mixture flushed with nitrogen. Then methyl formate (4.89, 0.078 mole) was added, followed by cuprous bromide (3.99, 0.026 mole).

The reaction was carried out as described in Example 1, its course being followed by TLC. After 1 hours TLC showed no starting material, and 2 major products -which corresponded to 6 - methoxy 1,2,3,4-tetrahydroquinoline and its amide. This crude product mixture was subjected to brief reflux in 20% aqueous hydrochloric acid in order to hydrolyse residual amide. Yield = 17.1 g (85%) of crude 6 methoxy -1,2,3,4 - tetrahydroquinoline; the major impurities were tetrahydroquinoline and 6 - methoxyquinoline.

Distillation at reduced pressure gave an 85% recovery of the 6 - methoxy - 1,2,3,4 - tetrahydro quinoline (b.pt. 80"-100"C at 0.2 mm) as a pale to colourless liquid. Its infra-red spectrum was identical to that of authentic material obtained by the hyd rogenation of 6 - methoxyquinoline. Overall yield = 67%.

Example 9: Methoxylation ofo - Bromo Acetophenone to yield o - Methoxy - Acetophenone o - Bromoacetophenone (19.9gm 0.1 mole) was dissolved in a solution of sodium methoxide formed by dissolving sodium (9.29, 0.4 mole) in methanol (80 ml). Then methyl formate (3.69, 0.06 mole) was added, followed by cuprous bromide (2.99, 0.02 mole).

Proceeding in the manner already described in Example 1, the course of the reaction was followed by TLC, which after 2B hours showed the reaction to be complete.

The product was isolated by removal of solvent, taking up in dilute hydrochloric acid and extraction into isopropyl acetate. Distilling off the solvent yielded a black viscous liquid, 16.6g. Bulb-to-bulb distillation yielded 59 of a purified sample, the residue being polymeric-the yield was approxi mately 50% volatile product. Its infra-red spectrum was identical to that of the authentic material in the Aldrich catalogue. Its NMR was as follows: *CH3O-Ar2.5 (3H) single (in CDCI3) CH3.COAr3.78 (3H) single H3,Hs aromatic (6.7-7.0 (2H) complex H4,H6H's (7.1-7.8 (2H) complex which is consistent with the desired o - methoxy acetophenone.

Example 10: Methoxylation of 1- Bromo - Naphthalene to yield 1- Methoxy - Naphthalene 1 - Bromo - naphthalene (20.79, 0.1 mole) was dissolved in a solution of sodium methoxide formed by dissolving sodium (9.29. 0.4 mole) in methanol (100 ml), and flushing with nitrogen. Then methyl formate (3.69, 0.06 mole) was added, followed by cuprous bromide (2.89, 0.02 mole).

Proceeding in the manner described in Example 1, it was found that separation of product and starting material was not easy on TLC, so instead the reaction mixture was refluxed for what was assumed to be the maximum necessary reaction time, namely 8 hours.

The product thus obtained was isolated by removal of solvent, taking up in aqueous hydrochloric acid and extraction with iso-propyl acetate. The residue after removal of the iso-propyl acetate contained copper salts; filtration gave a pale brown liquid (149,89%) whose infra-red spectrum was identical to that of the authentic compound as recorded in the Aldrich catalogue. The purity by normalised GLC was > 98.5%, with < 0.2% starting material.

Example 11: Trimethoxylation of Tribromobenzene to yield Trimethoxybenzene 1,3,5-Tribromobenzene (100g, 0.32 moles) was dissolved in a solution of sodium methoxide in methanol formed by dissolving sodium 449, 1.92 moles) in methanol (480 ml). Methyl formate (18.2 ml, 0.18 moles) then added, followed by cuprous bromide (4,359, 0.03 moles).

The reaction was carried out under reflux for a total of 15.1/4 hours, with an overnight interruption.

Because of that interruption the catalyst was "reinvigorated" when reflux was recommenced, thus after 7.) hours, by adding a further 6 ml of methyl formate followed by 1.5g of cuprous bromide.

Working-up involved stripping off the methanol, neutralisation with dilute sulphuric acid and extraction intc toluene. The organic extract was distilled at 0.2 mm, and a pale yellow product was obtained: 42.99 main fraction (80.5%).

GLC analysis showed 97% of the desired product, and 2% of dimethoxy - monobromobenzene. M.pt. = 48.5 -49.5"C. Recrystallisation from hexane gave a white solid, m.pt = 50-51.5"C (lit 51-30C).

Example 12: Ethoxylation ofp-Bromo-Anisole to yield p-Ethoxy-Anisole 4-Bromoanisole (18.7g, 0.1 mole) was dissolved in an ethanol solution of sodium ethoxide prepared by dissolving sodium (9.2g, 0.4 mole) in ethanol (150 ml). This solution was flushed with nitrogen, then methyl formate (3.69,0.06 mole) was added, followed by acetonitrile (209, 0.5 mole) and cuprous bromide (2.99,0.02 mole).

The reaction was performed as described in Example 1,the acetonitrile being added just prior to the cuprous bromide. Reflux for 14 hours effected almost complete conversion.

The product obtained after reflux was worked up in a manner rather different from that described in Example 1; after distilling off the ethanol, the residue was acidified and then steam distilled, yielding a pearly white product co-condensed with the water.

Filtration and drying yielding 10.89 (70%) of p-ethoxy anisola Further 1.5g (10%) was recovered from the water layer by ether extraction. M.pt. = 30-310C. After recrystallisation from hexane, m.pt. = 34-35 C (lit. 38-390C).

The infra-red spectrum of this product was clean and showed the expected features; but an authentic infra-red spectrum was not available for comparison.

NMR Spectrum (run in CDCI3) chemical shifts (8) Assignment 4-Ethoxy group, p carbon: 1.35 (trp, J = 7Hz) 3H 1-Methoxygroup: 3.70 (s) 4-Ethoxygroup, carbon: 3.95 (qrt,J = 7Hz)2H 2,3,5,6-Hydrogen: 6.73 (AB dx - s) 4H Example 13: ISO-propoxylation of Bromobenzene to yield Iso-propoxy-Benzene Bromobenzene (16g, 0.1 mole) was dissolved in a solution of sodium isopropoxide in iso-propanol formed by dissolving sodium (9.2g, 0.4 mole) in iso-propanol (200 ml) and then distilling off 85 ml thereof to leave 115 ml.The resultant solution was flushed with nitrogen, and then methyl formate (3.6g, 0.06 mole) and cuprous bromide (2.9g, 0.02 mole) were added.

This reaction mixture was refluxed for 9 & hours.

The product was then wor:rJ up in the manner described in Example 1, and a dark liquid was thus obtained. Examination by TLC indicated two com-.

ponents; and GLC showed that about 15% of the desired isopropoxy-benzene had been formed, the rest being unchanged bromobenzene. The infra-red spectrum of the crude product showed appropriate likenesses to that of the authentic material (prepared by phase-transfer catalysed isopropylation of phenol) but obviously was overlaid by that of bromobenzene.

Example 14: Methoxylation of3-Bromothiophene to yield 3-in e thoxythiophene.

3-Bromothiophene (16.3 g, 0.1 mole) was dissolved in a solution of sodium methoxide in methanol formed by åissoltring sodium (9.2 g, 0.4 mole) in methanol (1û0 ml). The reason mixture was flushed with nitrogen and methyl formate (3.6 g, 0.06 moles) then added, followed by cuprous bromide (2.9 g, 0.02 moles).

The reaction was carried out under reflux for 12 hours after which the crude product was isolated from the blue reaction mixture by filtering off insoluble material, addition of 150 ml of water and extraction into ether (3 x 100 ml). After removal of the solvent, two phases were left and the aqueous layer was removed by filtration through phase separation, leaving a light brown mobile liquid (7.7 g, 68%). The infra-red spectrum of the product showed aliphatic C-H stretches below 3000 cm-', a characteristic thiophene ring bend at 753 cm~' and numerous differences from the starting material. its NMR in CDCI3 was as follows::- 3.70 (s) 3 [Hj MeO 6.06 (ddb,J=3,1 [H] 11 H, 6.62 (ddb,J = 6, 1.5)IHr HA 7.04 (ddb,J=6,3 [HJ

which is consistent with it being 3-methoxythiophene.

Example 15: Methoxylation ofp-bromobenzyl brnmide.

Sodium (10.5 g, 0.45 mole) was dissolved in 120 ml of methanol and the reaction flask flushed with nitrogen. p-Bromobenzyl bromide (25 g, 0.1 mole) was added in a number of discrete portions. Awhite precipitate of sodium bromide was formed. Methyl formate (3.6 g, 0.06 mole) and cuprous bromide (2.9 g, 0.02 mole) were then added sequentially, after bringing the temperature to 60"C, and finally the reaction was refluxedfortwo and a half hours when the reaction was complete. After removal of the methanol, the residue was diluted with 100 ml of water and extracted into 3 = 70 ml of ether. After removal of the ether (to which toluene was added to.

azeotrope off water), a yellow liquid was left, 14.9 g (98%). Its IR Spectrum was identical to that of anisyl methyl ether prepared from anisyl alcohol.

A similar yield was obtained starting from p-bromobenzyl chloride.

Example 16: Preparation of syringaldehyde from 5 Bromovanillin.

Bromovanillin (550 g, 2.38 moles) was charged to a 2 litre flask and trimethylorthoformate (330 g, 3.11 moles) and methanol (1200 ml)wee added thereto.

The reaction mixture was stirred and the thusformed suspension warmed to 50 C when 10 drops of conc. HCI were added. A solution of the acetal of bromovanillin formed over a period of about 1 minute with the temperature rising to about 55"C. To prevent crystallisation the acetal solution was maintained at about 50 C until required.

Sodium (225 g, 9.8 moles) was dissolved in methanol (1900 ml) in a 5 litre flask. The solution was cooled to 30"C and about 20% of the already pre pared acetal solution was run into the cooledsolu- tion from a heated dropping funnel. The 5 litre flask was then flushed with nitrogen and cuprous bromide (49 g, 0.34 moles) added, after which the reaction mixture was carefully brought to reflux.

Foaming caused by the emission of carbon monoxide was minimised by efficient stirring, and when the reaction mixture had been at reflux for about 15 minutes the remainder of the acetal solution was carefully added over a period of about 2 hours. During that time any excessive foaming was moderated by stopping the addition. During that time also only slight heating was necessary since the reaction is an exothermic reaction.

Once the whole of the acetal solution had been added, the reaction mixture was refluxed for a further timed period of about 10 hours, and then the solution was allowed to cool to 10 C in orderto pre- cipitatethe sodium salt of syringaldehyde. The solid product was filtered, sucked dry (with the filtrate being retained) and washed with four portions of cold methanol (4 x 120 ml).

The crude salt was returned to the 5 litre flask, suspended in water (1500 ml) and warmed to 50"C.

Conc. HCI (370 ml) was run into the suspension which quickly dissolved and then deposited yellow crystals of syringaldehyde as the solution cooled.

After stirring at about 5"C for about one hour the crude syringaldehyde was filtered off, sucked dry, washed with water and dried at about 60"C. The yield was 360 g (83%).

The liquors were recycled once, less sodium (100 g) being needed to achieve the original sodium methoxide concentration and a greater recovery was obtained since the liquors were saturated with sodium syringaldehyde salt. The recycled liquors gave 429 g of product and thus the overall preparation afforded a total yield of 789 g of product, which is about 91 % of theory. The melting point of the syringaldehyde obtained was 1110 to 112"C.

An analysis by gas layer chromatography showed contamination by one 0.1% of bromovanillin and 0.02% of vanillin.

Example 17: Methoxylation of6- bromo - 1 - scetyl- 1,2,3,4 - tetrahydroquinoline with subsequent hyd rolysisto yield 6- methoxy - 1,2,3,4-tetrahydro- quinoline hydrochloride.

6 - Bromo - 1 - acetyl - 1,2,3,4 - tetrahydroquinoline (112 g, 0.44 mole) was dissolved in a solution of sodium methoxide in methanol prepared by dissolv ing sodium (49 g, 2.13 moles) in methanol (500 ml).

The solution was warmed to 45" to 50 and methyl formate (19.2 g, 0.32 moles) was added over 3 minutes, followed by cuprous bromide (15.2 g, 0.11 mole). The reaction temperature was then raised to 80"C (reflux) and held there for 3 hours. Water (50 ml) was added at the end of this period and reflux continued for a further 2 hours.

Then the methanol solvent was removed at reduced pressure and the residue diluted with water (1000 ml) and isopropyl acetate (200 ml). After removal of a small amount of precipitate by filtration, the organic layer was separated and the aqueous layer extracted with isopropyl acetate (2 x 200 ml). The isopropyl acetate solvent was removed from the combined organic layers by evaporation under vacuum, giving crude 6 - methoxy - 1,2,3,4 tetrahydroquinoline (85.8 g).

The crude product was dissolved in isopropanal (210 ml) and treated with 16% w/w hydrogen chloride in isopropanol (125 ml). On cooling the hyd rochloride salt crystallised out. Filtration and drying gave pure 6 - methoxy - 1,2,3,4 -tetrahydroquinoline hydrochloride, mp 1500 to 152"C (yield 66 g; 75% of theory).

Claims (29)

1. A process for the preparation of a compound of the general formula

wherein A represents the residue of an aromatic ring forming the whole or part of a monocyclic or polycyclic, at least partially-aromatic, carbocyclic and/or heterocyclic ring system, optionally bearing one or more other substituents inert to the reactants here employed, and R represents an optionallysubstituted alkyl, alkenyl, alkynyl or benzyl group having upto 12 carbon atoms, which process comprises causing an aromatic compound of the general formula:

wherein A is as defined above and X represents a chlorine, bromine or iodine atom, to react with an alcoholate of the general formula: M+ [O-R]n (Ill) in which M represents an alkali metal or an alkaline earth metal atom; n isthe valency of M; and R is as defined above, in the presence of a catalytically effective amount of an active catalyst mixture com prising: - (i) a formic acid ester of an organic alcohol hav ing the general formula: R2-O-CO-H (V) in which R2 represents an optionally-substituted ) alkyl, alkenyl, alkynyl or benzyl group having up to 12 carbon atoms; and - (ii) a cuprous salt; in a liquid medium which is a solvent for the catalyst mixture and in which the compound of formula Il is at least partially soluble, under substantially anhydrous conditions and a non-oxidising atmos phere, to yield the desired corresponding compound of formula VI.

2. A process according to claim 1, wherein the ring system of the aromatic organic compound of general formula II used as starting material is a residue of: - a fused polycyclic carbocyclic wholly-aromatic compound; - a non-fused polycyclic carbocyclic wholly aromatic compound; - a fused polycyclic partially-heterocyclic wholly aromatic compound; - a monocyclic carbocyclic wholly-aromatic compound; - a monocyclic heterocyclic wholly-aromatic com pound; - a fused polycyclic carbocyclic partially-aromatic compound; -a non-fused, polycyclic, carbocyclic partially aromatic compound; - a fused polycyclic, partially-heterocyclic, partially-aromatic compound; or -a non-fused, polycyclic, partially-heterocyclic, partially-aromatic compound.

3. A process according to claim 1 or claim 2, wherein the aromatic organic compound offormula II is one in which X is bromine.

4. A process according to any one of the preceding claims, wherein the alcoholate of formula 911 is one in which R contains not more than 6 carbon atoms.

5. A process according to claim 4, wherein R contains 1 or2 carbon atoms.

6. A process according to any one of the preceding claims, wherein the alcoholate offormula Ill is one in which M is lithium, potassium or sodium.

7. A process according to any one of the preceding claims, wherein the liquid medium is an aliphatic alcohol ofthe general formula: R4H (íV) in which R" represents an optionally-substituted alkyl, alkenyl, alkynyl or benzyl group having up to 12 carbon atoms.

8. A process according to claim 7, wherein R and R' are the same and the alcoholate formula III is formed in situ by dissolving an alkali metal or alkaline earth metal in the alcohol which isto serve as the liquid medium for the reaction.

9. A process according to claim 7 of claim 8, wherein the formate of formula V is one in which R2 is the same as Rt.

10. A process according to any one of the preceding claims, wherein the alcoholate of formula Ill is employed in an amount of from 3 to 5 moles per mole of the aromatic compound of formula ll.

11. A process according to any one of the preceding claims, wherein the formic acid ester of formula V is employed in an amount offrom 0.1 to 0.6 moles per mole of the aromatic compound offormula II.

12. A process according to any one of the preceding claims, wherein the cuprous salt (ii) is cuprous chloride, cuprous sulphate, cuprous iodide, cuprous sulphite or cuprous bromide.

13. A process according to anyone of the preceding claims, therein the cuprous salt (ii) is employed in an amount of from 0.1 to 0.6 moles per mole of aromatic compound of formula II.

14. A process according to any one of the preceding claims, wherein the compound of general formula II is a compound of the general formula:

wherein Y is oxygen, sulphur or nitrogen, q is 1 or 2 and each R3 which may be the same or different is halogen, OH, alkoxy, aryloxy, ::HO, WH(OMe)2, v 2-alkyl, aryl, alkyl, -(CHi2)m - Oalkyl, 2Xm halogen, ~(CEI2)m - NHB where B is a blocking group and m is 1,2 or3, ortwo groups R3 together form a 5-, 6- 7-membered carbocyclic or heterocyclic ring.

15. A process according to any one of the preceding claims, wherein the alcohol or other liquid medium is employed in an amountoffrom 10to40 moles per mole of aromatic compound or formula II.

16. A process according to any one of the preceding claims, wherein the reaction is effected at a temperature of less than 80"C.

17. A process according to any one of the preceding claims, wherein the alcoholate of formula Ill is sodium methoxide, the formate of formula V is methyl formate and the liquid medium is methanol.

18. A process as claimed in claim 17, wherein the reaction is carried out at the refluxtemperature of the methanol.

19. A process according to claim 1 and substantially as hereinbefore described with reference to any one of the specific Examples.

20. Acompound of formula VI defined in claim 1 whenever prepared by a process according to any one of the preceding claims.

21. A catalyst system suitable for use in a process according to any one of claims 1 to 18, which catalyst system comprises a formic acid ester of general formula V as defined in claim 1, a catalytically-effective amount of a cuprous salt and an alcoholate of general formula Ill as defined in claim 1, said catalyst system being substantially anhydrous and otherwise protected against oxidative breakdown.

22. A catalyst system according to claim 21, which also includes an alcohol of general formula IV as defined in claim 7 and/or another said liquid medium as defined in claim 1.

23. A catalyst system according to claim 21 or claim 22, wherein protection against oxidative breakdown of the catalyst system is effected by preparing, storing and using the system under an atmosphere of non-oxidising gas or vapour, including alcohol vapour during reflux.

24. A catalyst system according to any one of claims 21 to 23, wherein the system is stabilized by the inclusion of an effective amount of an aromatic organic compound.

25. A catalyst system according to claim 24, wherein the aromatic compound comprises a halogenated aromatic organic compound of general formula II defined in any one of claims 1 to 3 or 14.

26. Acatalyst system according to claim 24 or claim 25, wherein the aromatic compound comprises an aromatic organic compound of general formula VI defined in claim 1.

27. A catalyst system according to claim 24, wherein the aromatic compound is phenol or benzyl alcohol.

28. A catalyst system according to claim 21 substantially as hereinbefore described specifically.

29. The use of an active catalyst mixture compris ing a formic acid ester of general formula V as defined in claim 1 and a cuprous salt in the alkoxylation oraryloxylation of aromatic compounds of the general formula II as defined in claim 1.