GB2088874B - Substituted quinazolones for the treatment of hypertension and bradycardia and as cardiotonic agents - Google Patents

Substituted quinazolones for the treatment of hypertension and bradycardia and as cardiotonic agents

Info

Publication number
GB2088874B
GB2088874B GB8138698A GB8138698A GB2088874B GB 2088874 B GB2088874 B GB 2088874B GB 8138698 A GB8138698 A GB 8138698A GB 8138698 A GB8138698 A GB 8138698A GB 2088874 B GB2088874 B GB 2088874B
Authority
GB
United Kingdom
Prior art keywords
bradycardia
hypertension
treatment
cardiotonic agents
quinazolones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8138698A
Other versions
GB2088874A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of GB2088874A publication Critical patent/GB2088874A/en
Application granted granted Critical
Publication of GB2088874B publication Critical patent/GB2088874B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB8138698A 1978-12-07 1979-12-07 Substituted quinazolones for the treatment of hypertension and bradycardia and as cardiotonic agents Expired GB2088874B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96717378A 1978-12-07 1978-12-07
US6836779A 1979-08-21 1979-08-21

Publications (2)

Publication Number Publication Date
GB2088874A GB2088874A (en) 1982-06-16
GB2088874B true GB2088874B (en) 1983-09-28

Family

ID=26748897

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8138698A Expired GB2088874B (en) 1978-12-07 1979-12-07 Substituted quinazolones for the treatment of hypertension and bradycardia and as cardiotonic agents

Country Status (15)

Country Link
AT (1) AT374468B (en)
AU (1) AU533427B2 (en)
CA (1) CA1138871A (en)
CH (1) CH645106A5 (en)
DE (1) DE2949395A1 (en)
ES (1) ES8104253A1 (en)
FR (1) FR2443462A1 (en)
GB (1) GB2088874B (en)
IE (1) IE49469B1 (en)
IL (1) IL58898A (en)
IT (1) IT1164812B (en)
NL (1) NL7908849A (en)
PH (1) PH16910A (en)
PT (1) PT70559A (en)
SE (1) SE446181B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4631283A (en) * 1982-09-30 1986-12-23 Ortho Pharmaceutical Corporation Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids
US4490374A (en) * 1982-09-30 1984-12-25 Ortho Pharmaceutical Corporation 5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use
US4751304A (en) * 1984-09-26 1988-06-14 Ortho Pharmaceutical Corporation Process for preparing 5,6-dialkoxy-4-alkyl-2(1H)-quinazolinones
GB0015228D0 (en) * 2000-06-21 2000-08-16 Portela & Ca Sa Substituted nitrated catechols, their use in the treatment of some central and peripheral nervous system disorders
USD966133S1 (en) * 2020-09-21 2022-10-11 Aileen Martin Sanitizer dispenser

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2118315C3 (en) * 1970-04-20 1975-04-03 Sumitomo Chemical Co., Ltd., Osaka (Japan) 2- (1H) -quinazolinone derivatives, processes for their preparation and pharmaceuticals containing these compounds
US4129653A (en) * 1977-01-05 1978-12-12 Ortho Pharmaceutical Corporation Substituted pyrrolo [1,2-c] quinazolines and pharmaceutical compositions and methods employing them

Also Published As

Publication number Publication date
CA1138871A (en) 1983-01-04
IL58898A0 (en) 1980-03-31
IE49469B1 (en) 1985-10-16
PT70559A (en) 1980-01-01
ES486696A0 (en) 1981-04-16
AT374468B (en) 1984-04-25
ATA776379A (en) 1983-09-15
FR2443462A1 (en) 1980-07-04
IL58898A (en) 1984-03-30
SE446181B (en) 1986-08-18
AU533427B2 (en) 1983-11-24
IT1164812B (en) 1987-04-15
CH645106A5 (en) 1984-09-14
SE7910105L (en) 1980-06-08
NL7908849A (en) 1980-06-10
ES8104253A1 (en) 1981-04-16
IT7951025A0 (en) 1979-12-07
PH16910A (en) 1984-04-10
DE2949395A1 (en) 1980-06-19
GB2088874A (en) 1982-06-16
FR2443462B1 (en) 1983-09-23
IE792364L (en) 1980-06-07
AU5347079A (en) 1980-06-12

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Legal Events

Date Code Title Description
817A Application for correction of clerical errors now open to opposition (sect. 117/1977)
711A Proceeding under section 117(1) patents act 1977
PCNP Patent ceased through non-payment of renewal fee