FR2443462A1 - PROCESS FOR THE PREPARATION OF SUBSTITUTED QUINAZOLINES, QUINAZOLINES THUS OBTAINED AND METHOD OF TREATING HYPERTENSION USING THEM - Google Patents

PROCESS FOR THE PREPARATION OF SUBSTITUTED QUINAZOLINES, QUINAZOLINES THUS OBTAINED AND METHOD OF TREATING HYPERTENSION USING THEM

Info

Publication number
FR2443462A1
FR2443462A1 FR7930116A FR7930116A FR2443462A1 FR 2443462 A1 FR2443462 A1 FR 2443462A1 FR 7930116 A FR7930116 A FR 7930116A FR 7930116 A FR7930116 A FR 7930116A FR 2443462 A1 FR2443462 A1 FR 2443462A1
Authority
FR
France
Prior art keywords
quinazolines
preparation
treating hypertension
substituted
substituted quinazolines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7930116A
Other languages
French (fr)
Other versions
FR2443462B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of FR2443462A1 publication Critical patent/FR2443462A1/en
Application granted granted Critical
Publication of FR2443462B1 publication Critical patent/FR2443462B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne un composé ayant pour formule :The invention relates to a compound having the formula:

FR7930116A 1978-12-07 1979-12-07 PROCESS FOR THE PREPARATION OF SUBSTITUTED QUINAZOLINES, QUINAZOLINES THUS OBTAINED AND METHOD OF TREATING HYPERTENSION USING THEM Granted FR2443462A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96717378A 1978-12-07 1978-12-07
US6836779A 1979-08-21 1979-08-21

Publications (2)

Publication Number Publication Date
FR2443462A1 true FR2443462A1 (en) 1980-07-04
FR2443462B1 FR2443462B1 (en) 1983-09-23

Family

ID=26748897

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7930116A Granted FR2443462A1 (en) 1978-12-07 1979-12-07 PROCESS FOR THE PREPARATION OF SUBSTITUTED QUINAZOLINES, QUINAZOLINES THUS OBTAINED AND METHOD OF TREATING HYPERTENSION USING THEM

Country Status (15)

Country Link
AT (1) AT374468B (en)
AU (1) AU533427B2 (en)
CA (1) CA1138871A (en)
CH (1) CH645106A5 (en)
DE (1) DE2949395A1 (en)
ES (1) ES8104253A1 (en)
FR (1) FR2443462A1 (en)
GB (1) GB2088874B (en)
IE (1) IE49469B1 (en)
IL (1) IL58898A (en)
IT (1) IT1164812B (en)
NL (1) NL7908849A (en)
PH (1) PH16910A (en)
PT (1) PT70559A (en)
SE (1) SE446181B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0177256A2 (en) * 1984-09-26 1986-04-09 Ortho Pharmaceutical Corporation Process for preparing 5,6-dialkoxy-4-alkyl-2(1h)-quinazolinones
WO2001098250A1 (en) * 2000-06-21 2001-12-27 Portela & Ca Sa Substituted nitrated catechols, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4631283A (en) * 1982-09-30 1986-12-23 Ortho Pharmaceutical Corporation Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids
US4490374A (en) * 1982-09-30 1984-12-25 Ortho Pharmaceutical Corporation 5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use
USD966133S1 (en) * 2020-09-21 2022-10-11 Aileen Martin Sanitizer dispenser

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2092057A1 (en) * 1970-04-20 1972-01-21 Sumitomo Chemical Co

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4129653A (en) * 1977-01-05 1978-12-12 Ortho Pharmaceutical Corporation Substituted pyrrolo [1,2-c] quinazolines and pharmaceutical compositions and methods employing them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2092057A1 (en) * 1970-04-20 1972-01-21 Sumitomo Chemical Co

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CA1972 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0177256A2 (en) * 1984-09-26 1986-04-09 Ortho Pharmaceutical Corporation Process for preparing 5,6-dialkoxy-4-alkyl-2(1h)-quinazolinones
EP0177256A3 (en) * 1984-09-26 1987-04-15 Ortho Pharmaceutical Corporation Process for preparing 5,6-dialkoxy-4-alkyl-2(1h)-quinazolinones
WO2001098250A1 (en) * 2000-06-21 2001-12-27 Portela & Ca Sa Substituted nitrated catechols, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them
EP1167341A1 (en) * 2000-06-21 2002-01-02 Portela & Ca., S.A. Substituted nitrated catechols, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CA1138871A (en) 1983-01-04
IL58898A0 (en) 1980-03-31
IE49469B1 (en) 1985-10-16
PT70559A (en) 1980-01-01
ES486696A0 (en) 1981-04-16
AT374468B (en) 1984-04-25
ATA776379A (en) 1983-09-15
IL58898A (en) 1984-03-30
SE446181B (en) 1986-08-18
AU533427B2 (en) 1983-11-24
IT1164812B (en) 1987-04-15
CH645106A5 (en) 1984-09-14
GB2088874B (en) 1983-09-28
SE7910105L (en) 1980-06-08
NL7908849A (en) 1980-06-10
ES8104253A1 (en) 1981-04-16
IT7951025A0 (en) 1979-12-07
PH16910A (en) 1984-04-10
DE2949395A1 (en) 1980-06-19
GB2088874A (en) 1982-06-16
FR2443462B1 (en) 1983-09-23
IE792364L (en) 1980-06-07
AU5347079A (en) 1980-06-12

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Legal Events

Date Code Title Description
ST Notification of lapse