GB2082937A - Implant - Google Patents

Implant Download PDF

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Publication number
GB2082937A
GB2082937A GB8125052A GB8125052A GB2082937A GB 2082937 A GB2082937 A GB 2082937A GB 8125052 A GB8125052 A GB 8125052A GB 8125052 A GB8125052 A GB 8125052A GB 2082937 A GB2082937 A GB 2082937A
Authority
GB
United Kingdom
Prior art keywords
implant
layer
phthalocyanine
metallic
coated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB8125052A
Other versions
GB2082937B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Technische Hochschule Karl-Marx-Stadt
Original Assignee
Technische Hochschule Karl-Marx-Stadt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technische Hochschule Karl-Marx-Stadt filed Critical Technische Hochschule Karl-Marx-Stadt
Publication of GB2082937A publication Critical patent/GB2082937A/en
Application granted granted Critical
Publication of GB2082937B publication Critical patent/GB2082937B/en
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/21—Acids
    • A61L2300/214—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/224—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials containing metals, e.g. porphyrins, vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

An implant is provided with a layer of organic molecules which contain a metal atom, more especially of metal phthalocyanine or at least one of its derivatives.

Description

SPECIFICATION Implant The invention can be applied in connection with the use of all allotransplants which are introduced into the organism for a limited time or permanently and which are completely or partly covered by the body surface.
It is known to provide implants with 'body-like' layers in order thus to bring about a toleration of the implant by the body. The coating is effected for various reasons, for example for refining the substrate surface, protecting against corrosion, passivating and/or improving the adaptation of the implant to the body.
For example, it is known to coat implant surfaces so as, on the one hand, to prevent the natural diffusion of the ions of the implant material, in that this material is passivated, e.g. by SiXNyHz, and, at the same time, to produce a physiologically active implant surface in order to bring about a likeness in essence between the implant surface and the implant bed. This happens in that, depending on the type of the implant material, a layer system or a layer is applied (DD-WP 133.518).
It is furthermore known that carbonaceous layers render possible a toleration of the implant in the body. However, these layers lack adhesive strength relative to the implant surface. In order to improve the adhesive strength, there are applied, as intermediate layers, for example layers of hightemperature polymers, which is technologically expensive (US-PS 3.952.334).
The aim of the invention is the production of implants having a firmly adhesive surface layer which is accessible to the metabolism and which ensures that biochemical bonding forces will remain active over prolonged periods of time.
It is the object of the invention to produce implants which, if the biological constitution of the recipient remains the same, will stay in position for an unlimited length of time and to improve the bond between the layer and the implant.
The solution according to the invention consists in that an implant is provided with a layer of organic molecules which contain a metallic atom, more especially of metallic phthalocyanine or its derivatives.
This metallic atom in the metallic phthalocyanine renders possible a good bond between the implant and the layer. In this connection, it has proved to be favourable if the metallic atom is an element which is present in the implant elementally or as an alloy or compound.
It is ensured that the bond between the implant and the layer, or the adhesive strength of the layer, is significantly increased and, at the same time, that, on account of the structure and the chemical composition of the metallic phthalocyanine, the surface of the implant is such that it is accessible to the metabolism and allows for formation of a 'pseudoperidontium'. The metallic phthalocyanine is either vapour-deposited, is applied by mechanical means, preferably by rubbing the substance on the surface of the implant, or is chemically formed directly on the surface of the implant.
In order to improve the formation of the 'pseudoperidontium', the application of the metallic phthalocyanine may be effected in such a way that the surface is enlarged by structuring. It is furthermore possible to add to the metallic phthalocyanine and/or its derivatives physiologically active substances, more especially amino acids.
The invention will be explained in more detail with the aid of exemplified embodiments.
An implant consisting of titanium is provided with a layer of titanyl phthalocyanine. This phthalocyanine layer is vapour-deposited at a pressure of 1 .1 10-4 Pa and a temperature of 5000C. The thickness of the layer is dependent on the evaporation temperature and the time of evaporation; the layer morphology is dependent on the implant temperature.
Mechanically, for example a metallic phthalocyanine layer is applied by rubbing it on.
The chemically produced metallic phthalocyanine layer is formed by heating the implant to 3000 C and by an additional treatment with phthalodinitrile or a mixture of phthalodinitrile and O-cyanogen benzamide.
The structuring of the metallic phthalocyanine surface is effected by a defined combination of the physical and vacuum-engineering parameters. In addition, (E-alinine can be applied as a layer, for example by means of evaporation.
1. A coated implant provided with a layer of organic molecules which contain a metal atom.
2. A coated implant as claimed in claim 1, wherein said organic layer comprises a metal phthalocyanine or at least one of its derivatives.
3. A coated implant as claimed in claim 2, wherein the metal phthalocyanine incorporates a metal which is contained in the implant.
4. A coated implant as claimed in claim 1, 2 or 3, wherein the layer is vapour-deposited.
5. A coated implant as claimed in any one of claims 1 to 4, wherein the layer is applied by a mechanical method, preferably by rubbing the substance onto the surface of the implant.
6. A coated implant as claimed in any one of claims 1 to 5, wherein the layer is chemically formed directly on the surface of the implant.
7. A coated implant as claimed in any one of claims 1 to 6, wherein the surface of the layer is structured.
8. A coated implant as claimed in any one of
**WARNING** end of DESC field may overlap start of CLMS **.

Claims (9)

**WARNING** start of CLMS field may overlap end of DESC **. SPECIFICATION Implant The invention can be applied in connection with the use of all allotransplants which are introduced into the organism for a limited time or permanently and which are completely or partly covered by the body surface. It is known to provide implants with 'body-like' layers in order thus to bring about a toleration of the implant by the body. The coating is effected for various reasons, for example for refining the substrate surface, protecting against corrosion, passivating and/or improving the adaptation of the implant to the body. For example, it is known to coat implant surfaces so as, on the one hand, to prevent the natural diffusion of the ions of the implant material, in that this material is passivated, e.g. by SiXNyHz, and, at the same time, to produce a physiologically active implant surface in order to bring about a likeness in essence between the implant surface and the implant bed. This happens in that, depending on the type of the implant material, a layer system or a layer is applied (DD-WP 133.518). It is furthermore known that carbonaceous layers render possible a toleration of the implant in the body. However, these layers lack adhesive strength relative to the implant surface. In order to improve the adhesive strength, there are applied, as intermediate layers, for example layers of hightemperature polymers, which is technologically expensive (US-PS 3.952.334). The aim of the invention is the production of implants having a firmly adhesive surface layer which is accessible to the metabolism and which ensures that biochemical bonding forces will remain active over prolonged periods of time. It is the object of the invention to produce implants which, if the biological constitution of the recipient remains the same, will stay in position for an unlimited length of time and to improve the bond between the layer and the implant. The solution according to the invention consists in that an implant is provided with a layer of organic molecules which contain a metallic atom, more especially of metallic phthalocyanine or its derivatives. This metallic atom in the metallic phthalocyanine renders possible a good bond between the implant and the layer. In this connection, it has proved to be favourable if the metallic atom is an element which is present in the implant elementally or as an alloy or compound. It is ensured that the bond between the implant and the layer, or the adhesive strength of the layer, is significantly increased and, at the same time, that, on account of the structure and the chemical composition of the metallic phthalocyanine, the surface of the implant is such that it is accessible to the metabolism and allows for formation of a 'pseudoperidontium'. The metallic phthalocyanine is either vapour-deposited, is applied by mechanical means, preferably by rubbing the substance on the surface of the implant, or is chemically formed directly on the surface of the implant. In order to improve the formation of the 'pseudoperidontium', the application of the metallic phthalocyanine may be effected in such a way that the surface is enlarged by structuring. It is furthermore possible to add to the metallic phthalocyanine and/or its derivatives physiologically active substances, more especially amino acids. The invention will be explained in more detail with the aid of exemplified embodiments. An implant consisting of titanium is provided with a layer of titanyl phthalocyanine. This phthalocyanine layer is vapour-deposited at a pressure of 1 .1 10-4 Pa and a temperature of 5000C. The thickness of the layer is dependent on the evaporation temperature and the time of evaporation; the layer morphology is dependent on the implant temperature. Mechanically, for example a metallic phthalocyanine layer is applied by rubbing it on. The chemically produced metallic phthalocyanine layer is formed by heating the implant to 3000 C and by an additional treatment with phthalodinitrile or a mixture of phthalodinitrile and O-cyanogen benzamide. The structuring of the metallic phthalocyanine surface is effected by a defined combination of the physical and vacuum-engineering parameters. In addition, (E-alinine can be applied as a layer, for example by means of evaporation. CLAIMS
1. A coated implant provided with a layer of organic molecules which contain a metal atom.
2. A coated implant as claimed in claim 1, wherein said organic layer comprises a metal phthalocyanine or at least one of its derivatives.
3. A coated implant as claimed in claim 2, wherein the metal phthalocyanine incorporates a metal which is contained in the implant.
4. A coated implant as claimed in claim 1, 2 or 3, wherein the layer is vapour-deposited.
5. A coated implant as claimed in any one of claims 1 to 4, wherein the layer is applied by a mechanical method, preferably by rubbing the substance onto the surface of the implant.
6. A coated implant as claimed in any one of claims 1 to 5, wherein the layer is chemically formed directly on the surface of the implant.
7. A coated implant as claimed in any one of claims 1 to 6, wherein the surface of the layer is structured.
8. A coated implant as claimed in any one of claims 2 to 7, wherein a physiologically active substance, more especially an amino acid, is added to the metal phthalocyanine and/or its derivative.
9. A coated implant substantially as described herein.
GB8125052A 1980-09-04 1981-08-17 Implant Expired GB2082937B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DD22371580A DD156312A3 (en) 1980-09-04 1980-09-04 COATED IMPLANT

Publications (2)

Publication Number Publication Date
GB2082937A true GB2082937A (en) 1982-03-17
GB2082937B GB2082937B (en) 1984-09-19

Family

ID=5526147

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8125052A Expired GB2082937B (en) 1980-09-04 1981-08-17 Implant

Country Status (4)

Country Link
CS (1) CS254101B1 (en)
DD (1) DD156312A3 (en)
DE (1) DE3125073A1 (en)
GB (1) GB2082937B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD243855B1 (en) * 1985-12-05 1991-09-19 Chemnitz Tech Hochschule ACTIVE IMPLANT
US4855026A (en) * 1988-06-02 1989-08-08 Spire Corporation Sputter enhanced ion implantation process

Also Published As

Publication number Publication date
DE3125073A1 (en) 1982-04-15
GB2082937B (en) 1984-09-19
CS254101B1 (en) 1988-01-15
DD156312A3 (en) 1982-08-18

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