CS254101B1 - Implant with covering layer - Google Patents

Implant with covering layer Download PDF

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Publication number
CS254101B1
CS254101B1 CS546081A CS546081A CS254101B1 CS 254101 B1 CS254101 B1 CS 254101B1 CS 546081 A CS546081 A CS 546081A CS 546081 A CS546081 A CS 546081A CS 254101 B1 CS254101 B1 CS 254101B1
Authority
CS
Czechoslovakia
Prior art keywords
implant
covering layer
jiná
implant according
atom
Prior art date
Application number
CS546081A
Other languages
Czech (cs)
Inventor
Horst Hampel
Manfred Starke
Wolfgang Bethmann
Claus Hamann
Wolfram Knoefler
Original Assignee
Horst Hampel
Manfred Starke
Wolfgang Bethmann
Claus Hamann
Wolfram Knoefler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Horst Hampel, Manfred Starke, Wolfgang Bethmann, Claus Hamann, Wolfram Knoefler filed Critical Horst Hampel
Publication of CS254101B1 publication Critical patent/CS254101B1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/21—Acids
    • A61L2300/214—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/224—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials containing metals, e.g. porphyrins, vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

ΗΜΠΠΑΗΤΑΤ C ΠΟΚΕΚΤΗΕΜΤΠΠΑΗΤΑΤ C ΠΟΚΕΚΤΗΕΜ

OgjiaCTb npHMeHeHHfl Η3θ6ρβΤβΗΗΗ Η3θ6ρβΤβΗΗβ ΠρΗΜβΗΗΜΟ· ΑΠΗ BC6XOrpaHHUeHHbIX ΠΟ ΒρβΜβΗΗ JKH3HH ΗΠΗ ΑΠΗΤβΠΒ*HO HaXOflHntHXCH Β 0ΡΓβΗΗ3Μβ, BaCTHBHO ΗΒΗ nOJIHOCTblO riOKpblTblX ΤβΠΟΜ βΠΠΟΠΠΘΗ-ΤβΤΟΒ. * XapaKTepHCTHKa H3BecTHhix. TexHHHecKHx pemaHHftOgjiaCTb npHMeHeHHfl Η3θ6ρβΤβΗΗΗ Η3θ6ρβΤβΗΗβ ΠρΗΜβΗΗΜΟ · ΑΠΗ BC6XOrpaHHUeHHbIX ΠΟ ΒρβΜβΗΗ JKH3HH ΗΠΗ ΑΠΗΤβΠΒ * HO HaXOflHntHXCH Β 0ΡΓβΗΗ3Μβ, BaCTHBHO ΗΒΗ nOJIHOCTblO riOKpblTblX ΤβΠΟΜ βΠΠΟΠΠΘΗ-ΤβΤΟΒ. * XapaKTepHCTHKa H3BecTHhix. TexHHHecKHx pemaHHft

HaseCTHbl ΠρΗΜβΗβΗΗΗ HMIBiaHTaTOB CO CJIOHMH, ΗΜβΚΜΙξΗΜΗ CBOftCTBa, CXOJKHe CTenoM, č uenbio BocTHxéHHa hx npwHBJíHeMocTH c ταποΜ. ÍIOKPbirae nonynaioT hcxo-AH H3 paSJIHBHblX npHBHH, K8K HanpHMep fljlfl OfínaropajKHBaHHH nOBepXHOCTII ΠΟΑΠΟ-»βκ, ona hx koppo3Hohhoíí saJWHTbi h/hjih απη ynynmeHHH coBMecTHMOCTH HMiuiaHTa-τβ c fejioM.HaseCTHbl ΠρΗΜβΗβΗΗΗ HMIBiaHTaTOB CO CJIOHMH, BOβΚΜΙξΗΜΗ CBOftCTBa, CXOJKHe CTenoM, BocTHxeHHa hx npwHBJiHeMocTH c ταποΜ. IO K K b 3 3 3 3 3 IO IO IO IO IO IO IO IO IO IO IO IO IO IO IO 3 3 3 3 3 3 3 3 B B B B B B

TaKMe HBJIHKJTCH H9BeCTHbIMH ΠΟΚρΜΤΗΗ ΠΟΒβρΧΗΟΟΤΗ HMrtnaHTaTa ΑΠΗ npeAOTBpa-meHHH ecTecTBeHHoň αηΦΦϋβηη hohob ημιιπβητβαηοηηογο MáTepnajia, c noMontbionaccHBaUHH, HanpHMep SixNyH2, hto OHHOBpeMeHHo nonroTaBJíHBaeT φΗ3ΗοηοΓΗπεο"KH aKTHBHyw HMnnaHTauHOHHyio noBepxnocTb, απη AocTHStennHno cymecTByτοκηβστ-BeHHoctH Mewfly noBepxHocTb» ΗΜπηβΗτβτβ η TenoM. 3to nonynaeTCH HaneceHHeMCHCTeMbi cnoeB mra οαηογο cjioh, b 3bbhciimocth ot bhab ημππηητηαηοηηογο Μβτβ-pnajia (πβτβΗτ ΓΛΡ Ν’ 133.518). Taxae nssecTHo, bto yríiepoAcoflep^anBie cjiohna»T BO3MO»HOCTb COBMeCTHMOCTH ΗΜΠΠβΗΤΘΤΒ C ΤβΠΟΜ. ΟβΗβΚΟ 3TH CJIOH ΗΜβΙΟΤ He-AOČTaTOMHo BbicoKy» a&eramo κ ' noBepxH.ocTH ημππηητητη. Ππη ynyniiieHHH anreaHHb xanecTBe npoMeayTOHHbix cjiobb HanocaTCH HanpHMep cjioh H3 BbicoKOTeMnepatyp-HbK ποπΗΜβροΒ, BTo TexHOJiormiecKH TpeSyeT 6oJibmHx 3βτρβτ (πβτβΗτ CIUA 'Ν’ 3.952.334). · .. . ;·TaKMe HBJIHKJTCH H9BeCTHbIMH ΠΟΚρΜΤΗΗ ΠΟΒβρΧΗΟΟΤΗ HMrtnaHTaTa ΑΠΗ npeAOTBpa-meHHH ecTecTBeHHoň αηΦΦϋβηη hohoba ημιιπβητβαηοηηογο MáTepnajia, c noMontbionaccHBaUHH, HanpHMep SixNyH2, HTO OHHOBpeMeHHo nonroTaBJíHBaeT φΗ3ΗοηοΓΗπεο "KH aKTHBHyw HMnnaHTauHOHHyio noBepxnocTb, απη AocTHStennHno cymecTByτοκηβστ-BeHHoctH Mewfly noBepxHocTb» ΗΜπηβΗτβτβ η Teno. 3to nonynaeTCH HaneceHHeMCHCTeMbi cnoeB MRA οαηογο cjioh b 3bbhciimocth ot bhab ημππηητηαηοηηογο Μβτβ-pnajia (πβτβΗτ ΓΛΡ Ν '133 518). tax nssecTHo, BTO yríiepoAcoflep ^ ANBI cjiohna »T BO3MO» HOCTb COBMeCTHMOCTH ΗΜΠΠβΗΤΘΤΒ C ΤβΠΟΜ. ΟβΗβΚΟ 3TH CJIOH ΗΜβΙΟΤ He-AOČTaTOMHo BbicoKy »and & Eram κ' noBepxH.ocTH ημππηητητη. Ππη ynyniiieHHH anreaHHb xanecTBe npoMeayTOHHbix cjiobb HanocaTCH HanpHMep cjioh H3 BbicoKOTeMnepatyp-HbK ποπΗΜβροΒ, BTo TexHOJiormiecKH x 3βτρβτ (πβτβΗτ CIUA '3.9' 3.952.334).

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Uenbio Η3θ6ρβτβΗΗΒ HBJíHeTCB nojiyneiiHe ΗΜίυιβΗτβτοΒ c noBepxHocTHbíM cjioeM,KMesomHM BbicoKyio aflreamo h AoCTynHůM abh odMena BeqecTB, κοτορκβ oCecneMHBa-K)T TO, MTO CHJIbl 6HOXHMHHeCKOÍi CBH3H OCT8JOTCH fleňCTBeHHMMH Β TeneHHe ΑΠΗΤβΠΒ“ηογο nepnofla.Uenbio Η3θ6ρβτβΗΗΒ HBJíHeTCB nojiyneiiHe ΗΜίυιβΗτβτοΒ c noBepxHocTHbíM cjioeM, KMesomHM BbicoKyio aflreamo h AoCTynHůM ABH reward BeqecTB, κοτορκβ oCecneMHBa-K) T TO MTO CHJIbl 6HOXHMHHeCKOÍi CBH3H OCT8JOTCH fleňCTBeHHMMH Β TeneHHe ΑΠΗΤβΠΒ "ηογο nepnofla.

CymecTBO Η3θ6ρβτβΗΗΗ 3aflaaeň Η3θ6ρβΤβΗΗΗ HBAHeTCH Η3ΓΟΤΟΒΙΙβΗΗβ ΗΜΠΠβΗΤΗΤΟΒ, C ynyBineHHOfi CBH-3bW Mexfly CJIO8M Η ΗΜΠΑΒΗΤβΤΟΜ, KOTOpbie flOCTHraiOT HeorpaHHUeHHOň npÓAOJERH-TeJIbHOCTH SCH3HH ΠρΗ nOCTOHHHOM βΗΟΙΙΟΓΗΗβΟΚΟΜ TejIOCJIOXeHHH ΒΚΑβΠΤΟΡΒ. 254101CymecTBO Η3θ6ρβτβΗΗΗ 3aflaaeň Η3θ6ρβΤβΗΗΗ HBAHeTCH Η3ΓΟΤΟΒΙΙβΗΗβ ΗΜΠΠβΗΤΗΤΟΒ C ynyBineHHOfi CBH-3bW Mexfly CJIO8M Η ΗΜΠΑΒΗΤβΤΟΜ, KOTOpbie flOCTHraiOT HeorpaHHUeHHOň npÓAOJERH-TeJIbHOCTH SCH3HH ΠρΗ nOCTOHHHOM βΗΟΙΙΟΓΗΗβΟΚΟΜ TejIOCJIOXeHHH ΒΚΑβΠΤΟΡΒ. 254101

PemeHHe nocTaBJíeHHoň 3a«aw pocTHraeTca tgm, hto ημππηητητ ποκρι,ιτ cnoeM 'opraHHHecKHx MOJieKyji, coflepjKamHx aTOMbi MeTanna, ocočenHo H3 ΜβτβηφταποΗΗβΗΗ-Ha ηπη ero flepHBaTOB. 3.TOT aTOM MeTanna oSecnewHBaeT xopomyto cbh3i> Mejtc/jy HMnnaHTaTOM h cnoeM.ΠρΗ 3TOM OKa3bIBaeTCH βΠΘΓΟΠρΗΗΤΗΜΜ, eCJIH 3ΤΟΤ HTOM ΗΒηΗβΤΟΗ ΒΠβΜβΗΤΟΜ, KO“Topbiň HMeeTCH b HMruiaHTaTe sneMeHTapHo hjih xax cnnae hjih coeflHHeHHe. 3thm.HocTHraeTca to, mto cbh3b MejKfly HMnnaHTaTOM h caoe« hjih ero aflreaHa 3HanH-TejibHO noBbímaeTca h oflHOBpeMeHHO noBepxHocTb HMiuiaHTaTa H3-3a CTpyKTypa hxHMHHecKoro coflepxcaHHa MeTaJi<t>TajioiiHaHHHa aBnaeTCa Taxoň, ητο oHa jjocTynHa«na oCMeHa BemecTB h oSecnenHBaeT o6pa3OBaHHé "nceBHonepHOHOHTyMa". Ηετβη-drrajiouHaHHH jih6o HanbinaeTca, jih6o HanocHTCa MexaHHnecKHM o6pa3OM, npeHMy-mecTBeHHo HaTHpaHHeM BetuecTBa Ha noBepxHocTb ΗΜππβκτβτβ, jih6o HenocpencTBeH-ho o6pa3yeTCíi Ha noBepxHocTH ημπιιηητβτβ. Mto6h ynynniHTb o6pa3OBaHH*e "nepno-flOHTHyMa", mojkho προβοπητβ HaHeceHHe μθτηπΦτΑποηηβηηηη τβκ, hto noBepxnoCTbyBejiHUHBaeTCH cTpyxTypHpoBaHHeM. KpoMe τογο, bo3mo»ho HaHeceHHe Ha Μθτβηφτβ-ϊ·JIOHHaHHH η/hjih ero «epHBaTOB φΗ3ΗΟΠΟΓΗΗβΟΚΗ aKTHBHMX BetUeCTB, B OCOSeHHOCTHaMHHOKHCJIOT.3a «aw pocTHraeTca tgm, hto ημππηητητ ποκρι, ιτ cnoeM 'opraHHecKHx MOJieKyji, coflepjKamHx aTOMbi MeTanna, ocO H3 ΜβτβηφταποΗΗβΗΗ-Ha ηπη ero flepHBaTOB. 3.TOT aTOM MeTanna oSecnewHBaeT xopomyto cbh3i> Mejtc / jy HMnnaHTaTOM h cnoeM.ΠρΗ 3TOM OKa3bIBaeTCH βΠΘΓΟΠρΗΗΤΗΜΜ; 3thm.HocTHraeTca the MTO cbh3b MejKfly HMnnaHTaTOM h caoe «hjih ero-aflreaHa 3HanH TejibHO noBbímaeTca h oflHOBpeMeHHO noBepxHocTb HMiuiaHTaTa H3-3a CTpyKTypa hxHMHHecKoro coflepxcaHHa meta <t> TajioiiHaHHHa aBnaeTCa taxa ητο OHA jjocTynHa« on oCMeHa BemecTB h oSecnenHBaeT o6pa3OBaHHé "nceBHonepHOHOHTyMa" . 6ετβη-drrajiouHaHHH jih6o HanbinaeTca, jih6o HanocHTCa MexaHHnecKHM o6pa3OM, npeHMy-mecTBeHHo HaTHpaHHeM BetuecTBa Ha noBepxHocTb ΗΜππβκτβτβ, jih6o HenocpencTBeH-ho Mto6h ynynniHTb o6pa3OBaHH * e "nepno-flOHTHyMa", my προβοπητβ HaHeceHHe μθτηπΦτΑποηηβηηηη τβκ, hto noBepxnoCTbyBejiHUHBaeTCH cTpyxTypHpoBaHHeM. KpoMe τογο, bo3mo »ho HaHeceHHe Ha Μθτβηφτβ-ϊ · JIOHHaHHH η / hjih ero« epHBaTOB φΗ3ΗΟΠΟΓΗΗβΟΚΗ aKTHBHMX BetUeCTB, B OCOSeHHOCTHaMHHOKHCJIOT.

ΠρΗΜβρ HCnOJIHeHHHΠρΗΜβρ HCnOJIHeHHH

HabSpeTeHHe Μοικβτ SbiTb 6jiH»e oStacHeHo Ha cneflyionHX npHMepax. - HMiuiaHTaT H3 Ti ποκρωτ cnoeM H3 τητηηηπΦτθποηη3Ηηη3. 3τοτ cnoň HartbinaeTcaηρκ flaBJíeHHH í *10-4IIa η πρκ TeMnépaType 500^0. ToJimHHa cnoa 33βηοητ οτ τβΜ-nepaTypw HcnapeHHH η βρθμθηη HcnapeHHH, μορΦοπογηη cjioh saBHCHT ot Tewnepa*-Typbi HMiuiaHŤaTa. o .HabSpeTeHHe biοικβτ SbiTb 6jiH »e oStacHeHo Ha cneflyionHX npHMepax. - HMiuiaHTaT H3 Ti ποκρωτ cnoeM H3 τητηηηπΦτθποηη3Ηηη3. Τ τ ň b b b b b b b b b b b b b b b b b b b b b ^ ^ ^ ToJimHHa cnoa 33βηοητ οτ τβΜ-nepaTypw HcnapeHHH η βρθμθηη HcnapeHHH, μορΦοπογηη cjioh saBHCHT ot Tewnepa * -Typbi HMiuiaHTa. o.

MexaHHHeCKH ΜβΤΘΠφΤΗΠΟΙΙΗΗΗΗΗΟΒΜΗ CJIOň HaHOCHTCH HaTHpaHHeM. XHMHHecKH noJiyneHHbiň ΜεταπφτβηοιίΗβΗΗΗΟΒΜΗ cnoň βο3ηηκηθτ πρκ HarpeBaHHHHMnJiaHTaTa «o 300 °C h flonoJiHHTejibHoň o6pa6oTKH c ΦτηποηηηΗτρηπομ hjih CMecnφΤΒΠΟρΗΗΗΤρΗηΒ H 0“U;HaH6eH3aMHHa . CTpyKTypHpoBaHHe nosepxHocTH ΜθτβηφτβηοηΗβΗΗΗβ ocymecTBjíneTCH nocpe^cTBOMonpeflejieHHOH κομ6ηη3ηηη φΗ3ΗηεεκΗχ η BaKyyMHbix nápaMerpoB. fíonojiHHTejibno mojk-ho floSaBHTb y-ajiaHHH κβκ cnoň, HanpHMep c πομοπιβιο HanbtneHna. Φ 0 P M y JI A Η30ΒΡΕΤΕΗΗΛ 1. HMiuiaHTaT co cjioeM, o τ ji η n a κ» m h &amp; ca TeM, hto cjioíí oSpasoHaa H3 Mojiexyji opraHHnecKoro BeniecTBa, coflepacamHX θτομ MeTanna, HanpHMep Μβτβη-φΤβΗΟΙΙΗβΗΗΗΗ HJIH βΓΟ flepHBaTOB . - 2. HMiuiaHTaT cornacHo nyHKTy 1, o τ ji η n a » πξ h ď c a τβΜ, ητο MeTáa-φτβηοιίΗθΗΗΗ copepjKHŤ aTOM τογο xe MeTanna H3 κοτοροτο oSpasoBan HMnjiaHTaT, 3. HMnJiaHTaT cornacHo nyHKTaM l - 2, o τ ji h a a io m ηΆ c a τβΜ, hto noBepxHocTb ΜβτβπφτηποιίΗΗΗΗΗβ CTpyKTypHpoBaHa. · 4. HMnnaH.TaT cornacHo nyHKTaM 1 - 3, o τ ji η h a ίο πι η fl č a τβΜ, λγγοHa noBepxnoCTb MeTaiHjjTanoiiHaHHHa hjih ero pepHBaTOB HaHeceHbí ΦΗ3Ηοιιογηη6οκη-aKTHBHhie BemeCTBa, B OCOĎeHHOCTH HMHHOKHCHOTbl.MexaHHHeCKH ΜβΤΘΠφΤΗΠΟΙΙΗΗΗΗΗΟΒΜΗ CJIOn HaHOCHTCH HaTHpaHHeM. XHMHHecKH noJiyneHHiH HεταπφτβηοιίΗβΗΗΗΟΒΜΗ cnoň βο3ηηκηθτ πρκ HarpeBaHHHHMnJiaHTaTa «o 300 ° C h flonoJiHHTejibHoň o6pa6oTKH c ΦτηποηηηΗτρηπομ hjih CMecnφΤΒΠΟρΗΗΗΤρΗηΒ H 0“ U; HaH6eH3aMHHa. CTpyKTypHpoBaHHe nosepxHocTH ΜθτβηφτβηοηΗβΗΗΗβ ocymecTBjíneTCH nocpe ^ cTBOMonpeflejieHHOH κομ6ηη3ηηη φΗ3ΗηεεκΗχ η BaKyyMHbix patchMerpoB. fíonojiHHTejibno my my floSaBHTb y-ajiaHHH κβκ cnoň, HanpHMep c πομοπιβιο HanbtneHna. Φ 0 M M A HM ΒΡ HM HM HM HM HM HM HM HM HM HM 1. iu ΗΗΛ HM ΗΗΛ ΗΗΛ HM h h h h h h h h h h h Te TeM, hto cjioíí oSpasoHaa H3 Mojiexyji oprHHnecKoro BeniecTBa, coflepacamHX Tτ Meμμ MeTanna, HanpHMep Μβτβη-φΤβΗΟΙΙΗβΗΗΗΗ HJIH βΓΟ flepHBaTOB. 2. ji na 2. 2. 2. 2. 1 1 1 1 1 1 1 1 1 T T T 3. 3. 3. 3. 3. 3. 3. 3. 3. 3. 3. 3. 3. 3. 3. 3. ca τβΜ, hto noBepxHocTb ΜβτβπφτηποιίΗΗΗΗΗβ CTpyKTypHpoBaHa. · 4. HMnnaH.TaT cornacHo nyHKTaM 1 - 3, o τ ji η h and ίο πι η fl č a τβΜ, λγγοHa noBepxnoCTb MeTaiHjjTanoiiHaHHHa hjih ero pepHBaTOB HaHeceHbí ΦΗ3Ηοιιογηη6οκη-aKTHBHhie BemeCTBa, B OCOĎeHHOCTH HMHHOKHCHOTbl.

AH HO T AUHH íÍMnnaHTaT c ποκρΜΤΗβΜ npHMeHHM jiná Bcex orpaHHaeHHbix no BpeMeHH skh3HHHJIH flnHTeJIBHO HaXOJIHmHXCH B OpraHH3Me, aaCTHHHO HJIH HOJIHOCTblO nOKpMTbIX Té“jiom ajinoiuiaiiTaTOB.AH HO T AUHH ÍMnnHTHTTHTT c c c c c c cppppppppppppp jiná jiná jiná jiná jiná jiná jiná jiná jinácececececececececececececeaeaeaeXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

UeJIb H3O6peTeHHH COCTOHT B HarOTOBJíeHHH ΗΜΠΗΗΙΙΤΗΤΟΒ C HMeiOUIHM BblCOKyroanresHio noBepxHocTHbíM cnoeM, κοτορκβ oÓecnenHBatoT hjih ηιϊητθιιβηογο ΒρδΜβΗΗfleňcTBeHHyio SHoxHMHaecKyio cBH3b, a ero 3aflaaeň HBJíaeTca Η3γοτοβπθηη6 HMiuiaH- .254101 3 tstob , c ynymnejiHoft ceasbio Mexny cnoeM η ημππβητβτομ, κοτορωβ nocTHratoT He-OrpaHHMeHHOft npOAOJIXHTenbHOCTH XH3HH npH COXpaHHOCTH CHOJIOrUMeCKOrO TeJIOCJJO-xeHHfl βκμβητορβ.UeJIb H3O6peTeHHH COCTOHT B HarOTOBJíeHHH ΗΜΠΗΗΙΙΤΗΤΟΒ C HMeiOUIHM BblCOKyroanresHio noBepxHocTHbíM cnoeM, κοτορκβ oÓecnenHBatoT hjih ηιϊητθιιβηογο ΒρδΜβΗΗfleňcTBeHHyio SHoxHMHaecKyio cBH3b and ero 3aflaaeň HBJíaeTca Η3γοτοβπθηη6 HMiuiaH- .254101 3 tstob c ynymnejiHoft ceasbio Mexny cnoeM η ημππβητβτομ, κοτορωβ nocTHratoT He-OrpaHHMeHHOft npOAOJIXHTenbHOCTH XH3HH NPH COXpaHHOCTH CHOJIOrUMeCKOrO TeJIOCJJO-xeHHfl βκμβητορβ.

PemeHHe ποοτβΒηβΗΗοϋ 9anaHH /jocruraeTcn τβΜ, hto enoft oCpasosaH H3 Mone- .Kyn opraHH^ecKoro šemecTBa, coaepttanpix btom Μβτβππβ, HanpHMep ΜβτβηφτβηοηΗβ-HHHa hjih ero nepuBaTOB. ΠρΗ3ΗβΗ0 H3o0peT6HH6M ΠΟ pe3yjlbTaT3M 3KCnepTH3bI, OCymeCTBJléHHOň BeflOMCTBOMno flenaM H9o6peTeHnň η πβτβΗτοΒ fflP. 254101PemeHHe ποοτβΒηβΗΗοϋ 9anaHH / jocruraeTcn τβΜ; ΠρΗ3ΗβΗ0 H3o0peT6HH6M ΠΟ pe3yjlbTaT3M 3KCnepTH3bI, OCymeCTBJLH BeflOMCTBOMno flenaM H9o6peTeHnn η πβτβΗτοΒ fflP. 254101

Claims (4)

4 PŘEDMET . VYNÁLEZU4 SUBJECT. THE INVENTION 1. Implantát a krycí vrstvou, vyznačující se tím, že vrstvaje tvořena molekulami organické hmoty, obsahujícími atomkovu, například metalftalokyaninu nebo jeho derivátů·An implant and a covering layer, characterized in that the layer is composed of molecules of organic matter containing a atom, for example metallothalocyanine or derivatives thereof. 2. Implantát podle bodu 1, vyznačující se tím, že metal-ftalokyanin obsahuje atom téhož kovu, ze kterého je vy-tvořen implantát.2. An implant according to claim 1, wherein the metal phthalocyanine comprises an atom of the same metal from which the implant is formed. 3. Implantát podle bodů 1 až 2, vyznačující se tím, žepovrch metalftalokyaninu je tvořen příčnými vazbami.3. An implant according to any one of claims 1 to 2, wherein said metallocyanine surface is formed by transverse bonds. 4. Implantát podle bodů 1 až 3, vyznačující se tím, žepovrch metalftalokyaninu nebo jeho derivátů jsou nanesenyaktivní hmoty, zejména aminokyseliny. 2541014. An implant according to any one of claims 1 to 3, wherein the metallothocyanine or derivative thereof is a nanesenyactive mass, especially an amino acid. 254101
CS546081A 1980-09-04 1981-07-16 Implant with covering layer CS254101B1 (en)

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DD22371580A DD156312A3 (en) 1980-09-04 1980-09-04 COATED IMPLANT

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CS254101B1 true CS254101B1 (en) 1988-01-15

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CS (1) CS254101B1 (en)
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DE (1) DE3125073A1 (en)
GB (1) GB2082937B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD243855B1 (en) * 1985-12-05 1991-09-19 Chemnitz Tech Hochschule ACTIVE IMPLANT
US4855026A (en) * 1988-06-02 1989-08-08 Spire Corporation Sputter enhanced ion implantation process

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GB2082937B (en) 1984-09-19
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DD156312A3 (en) 1982-08-18

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